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1. 发明授权

US07014652B2 Methods for treating prostatitis 失效
标题翻译：治疗前列腺炎的方法
公开(公告)号：US07014652B2
公开(公告)日：2006-03-21
申请号：US10763856
申请日：2004-01-22
申请人： Iulian Cioanta , Richard Barry Klein , Jordan Dimitrakov
发明人： Iulian Cioanta , Richard Barry Klein , Jordan Dimitrakov
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B2017/00274 , A61B2018/00547 , A61H9/0078 , A61H21/00 , A61H2201/0207 , A61H2201/0214 , A61H2201/0242 , A61H2201/0257 , A61H2201/0292 , A61H2201/10 , A61H2201/5007
摘要： Methods, systems, and computer program products for providing thermal therapies or internal thermal massage therapy for treating prostatitis by expanding and contracting a treatment balloon with inflation media and currently applying heat to a portion of the prostatic urethra.
摘要翻译：方法，系统和计算机程序产品，用于通过用膨胀介质扩张和收缩治疗气球并且目前对前列腺尿道的一部分施加热量来提供热治疗或内部热按摩治疗来治疗前列腺炎。

2. 发明授权

US06682555B2 Methods for treating the prostate and inhibiting obstruction of the prostatic urethra using biodegradable stents 失效
标题翻译：使用可生物降解的支架治疗前列腺和抑制前列腺尿道阻塞的方法
公开(公告)号：US06682555B2
公开(公告)日：2004-01-27
申请号：US10011494
申请日：2001-11-13
申请人： Iulian Cioanta , Richard Barry Klein
发明人： Iulian Cioanta , Richard Barry Klein
IPC分类号： A61F206
CPC分类号： A61B18/04 , A61B2017/00274 , A61B2017/22069 , A61B2018/00547 , A61B2018/046 , A61F7/123 , A61M31/00 , A61M2210/166
摘要： Methods of treating the prostate include administering a thermal ablation therapy and inhibiting the obstruction or closure of the prostatic urethral opening by forming a biodegradable stent in situ in the subject such that the stent attaches to the walls of the prostatic urethra. A related method of treating BPH includes thermally treating or ablating localized tissue in the prostate with a treatment catheter and inserting flowable stent material via the treatment catheter into the prostate (either before, during, or after the thermal treatment), forming the flowable stent material so that it defines a stent that remains in position after removal of the treatment catheter to inhibit the closure of the urinary passage. Associated stents and catheters are included.
摘要翻译：治疗前列腺的方法包括施用热消融治疗并通过在受试者中原位形成可生物降解的支架来阻止前列腺尿道开口的阻塞或闭合，使得支架附着在前列腺尿道的壁上。治疗BPH的相关方法包括用处理导管热处理或消融前列腺中的局部组织，并将可流动的支架材料经由治疗导管插入前列腺（在热处理之前，期间或之后），形成可流动的支架材料使得其限定了在移除治疗导管以保持尿路闭合之后保持就位的支架。包括相关的支架和导管。

3. 发明授权

US06716252B2 Prostatic stent with localized tissue engaging anchoring means and methods for inhibiting obstruction of the prostatic urethra 失效
标题翻译：具有局部组织接合锚固手段的前列腺支架和用于抑制前列腺尿道阻塞的方法
公开(公告)号：US06716252B2
公开(公告)日：2004-04-06
申请号：US09837486
申请日：2001-04-18
申请人： Jacob Lazarovitz , Iulian Cioanta , Richard Barry Klein
发明人： Jacob Lazarovitz , Iulian Cioanta , Richard Barry Klein
IPC分类号： A61F204
CPC分类号： A61M25/1011 , A61B18/1492 , A61B2017/00274 , A61B2017/22069 , A61B2018/00547 , A61F2/0027
摘要： A prostatic stent is configured as a unitary body, which is adapted to reside above the sphincter when in position in a subject and allow normal functioning of the sphincter. The stent includes and elongated and substantially narrow conduit, which extends through the sphincter and outside the body of the subject. The conduit is sized and constructed to allow normal operation of the sphincter. The stent also includes and upper and/or an intermediate inflatable portions and may include a second conduit for the introduction of medication to the stent.
摘要翻译：前列腺支架被配置为整体，其适于在处于受试者中的位置时驻留在括约肌上方，并允许括约肌的正常功能。支架包括延伸并且基本上窄的导管，其延伸穿过括约肌并且在受试者的身体外部。导管的尺寸和构造允许括约肌的正常操作。支架还包括上部和/或中间可充气部分，并且可以包括用于将药物引入支架的第二导管。

4. 发明授权

US06758857B2 Treatment catheters with thermally insulated regions 失效
公开(公告)号：US06758857B2
公开(公告)日：2004-07-06
申请号：US10011700
申请日：2001-11-13
申请人： Iulian Cioanta , Richard Barry Klein , Jacob Lazarovitz
发明人： Iulian Cioanta , Richard Barry Klein , Jacob Lazarovitz
IPC分类号： A61F700
CPC分类号： A61B18/04 , A61B2017/00274 , A61B2017/22069 , A61B2018/00547 , A61B2018/046 , A61F7/123 , A61M31/00 , A61M2210/166
摘要： Flexible treatment catheters are configured to be inserted into a body lumen or cavity to deliver heated fluid through at least one fluid lumen therein to thermally treat or ablate a targeted site in a biological subject. The flexible treatment catheters can include improved thermally insulated regions comprising a mixture formed of liquid elastomeric (such as a polyurethane) mixture (which transitions to a solid state) and miniaturized hollow plastic bodies positioned between the outer wall of the treatment catheter and the fluid lumen. The thermally insulated region is configured such that, measured ex vivo, the treatment catheter can present a maximum temperature of below about 45° C. on the external surface of the outer wall of the treatment catheter when the treatment catheter circulates fluid having an inlet temperature of above or between about 60°-62° C. Alternatively or additionally, the treatment catheter can include an elongated insert positioned in a catheter fluid lumen to inhibit the closure of the lumen after exposure to fluids in the treatment catheter at temperatures sufficient to thermal ablate targeted tissue over a thermal ablation treatment period. The treatment catheter can include a urinary drainage lumen with an elongated insert frictionally engaged therewith, the drainage lumen and insert are configured to provide a fluid volume throughput through the drainage lumen of greater than about 20-25 ml/min during and after (for about 12-72 hours after) a thermal ablation session.

5. 发明申请

US20070179586A1 Deployment catheter for medical implant devices 审中-公开
标题翻译：用于医疗植入装置的部署导管
公开(公告)号：US20070179586A1
公开(公告)日：2007-08-02
申请号：US11343626
申请日：2006-01-31
申请人： Gus Aguirre , Iulian Cioanta , Duane Couri , Eamonn P. FitzGerald , Heather Ann Bartholf Harries
发明人： Gus Aguirre , Iulian Cioanta , Duane Couri , Eamonn P. FitzGerald , Heather Ann Bartholf Harries
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2002/9665 , A61F2250/0071
摘要： In a delivery catheter, first and second pods cover one or more prosthetic implants located around a central core, and are connected with one another to move as a unit and to present a continuous outer surface. Two independent release links, each extending from a proximal region of the delivery catheter to an interface with the first and second pods, respectively, and operative to displace the first and second pod, respectively. Applying tension to the release links releases the associated pod, either by displacing it from over the implant or rupturing the exterior of the pod. A user-operable handle at a proximal end of the delivery catheter can activate either or both independent release links. Also provided according to the present invention is a method for the deployment of a prosthetic implant.
摘要翻译：在输送导管中，第一和第二荚覆盖位于中心芯周围的一个或多个假体植入物，并且彼此连接以作为单元移动并呈现连续的外表面。两个独立的释放连接件，分别从输送导管的近侧区域延伸到与第一和第二荚的界面，并分别用于移位第一和第二荚。将张力施加到释放环节释放相关的荚，通过将其从植入物上移位或破坏荚的外部。在输送导管的近端处的用户可操作的手柄可以激活任一个或两个独立的释放连接。根据本发明还提供了一种用于部署假体植入物的方法。

6. 发明申请

US20050192652A1 Thermal treatment systems with enhanced tissue penetration depth using adjustable treatment pressures and related methods 审中-公开
标题翻译：使用可调治疗压力和相关方法增强组织穿透深度的热处理系统
公开(公告)号：US20050192652A1
公开(公告)日：2005-09-01
申请号：US10788735
申请日：2004-02-26
申请人： Iulian Cioanta , Richard Klein
发明人： Iulian Cioanta , Richard Klein
IPC分类号： A61B17/00 , A61B18/04 , A61F7/00 , A61F7/12
CPC分类号： A61F7/12 , A61B2017/00274 , A61B2018/00547 , A61B2018/046 , A61F2007/0054
摘要： Methods, systems and computer program products include pressure monitoring and pressure adjustment devices in closed loop systems which control and adjust the pressure in a closed loop system configured to circulate heated liquid to a treatment balloon and concurrently heats and exerts pressures onto targeted tissue. The systems and methods can adjust the pressure to account for the physiology of the subject and the operational losses due to material relaxation over the duration of the thermal treatment.
摘要翻译：方法，系统和计算机程序产品包括闭环系统中的压力监测和压力调节装置，其控制和调节闭环系统中的压力，所述闭环系统构造成将加热的液体循环到治疗球囊并同时加热并向目标组织施加压力。系统和方法可以调节压力以解决受试者的生理学以及在热处理期间由于材料松弛引起的操作损失。

7. 发明申请

US20110087157A1 Use of Pressure Waves for Stimulation, Proliferation, Differentiation and Post-Implantation Viability of Stem Cells 有权
标题翻译：使用压力波刺激，增殖，分化和植入后的干细胞活力
公开(公告)号：US20110087157A1
公开(公告)日：2011-04-14
申请号：US12900818
申请日：2010-10-08
申请人： Iulian Cioanta , Christopher M. Cashman
发明人： Iulian Cioanta , Christopher M. Cashman
IPC分类号： A61N7/00 , A61M37/00 , C12N13/00
CPC分类号： C12N13/00 , A61N7/00
摘要： Stem cells are proliferated with the application of acoustic pressure waves, including cambium cells of periosteum treated in-vivo with acoustic pressure waves. Following harvesting and viability assessment of in-vivo or in-vitro proliferated stem cells, acoustic pressure waves are applied to enhance in-vivo or in-vitro differentiation either before or after implantation of the stems cells to an organism. Acoustic pressure waves also stimulate an implantation site to enhance viability and to grow desired tissue.
摘要翻译：应用声压波，包括用声压波在体内处理骨膜的形成层，使干细胞增殖。在体内或体外增殖干细胞的收获和活力评估之后，在将茎细胞植入生物体之前或之后，施加声压波以增强体内或体外分化。声压波还刺激植入部位以增强生存力并生长所需组织。

8. 发明申请

US20110034832A1 Usage of Extracorporeal and Intracorporeal Pressure Shock Waves in Medicine 有权
标题翻译：医学中体外和体内压力冲击波的使用
公开(公告)号：US20110034832A1
公开(公告)日：2011-02-10
申请号：US12832932
申请日：2010-07-08
申请人： Iulian Cioanta , Christopher M. Cashman
发明人： Iulian Cioanta , Christopher M. Cashman
IPC分类号： A61H1/00
CPC分类号： A61B17/22012 , A61B17/22004 , A61B17/2202 , A61B17/22022 , A61B17/22029 , A61B17/2255 , A61B2017/00867 , A61B2017/22014 , A61B2017/22024 , A61B2017/22025 , A61B2017/22039 , A61B2017/22054 , A61B2017/22067 , A61B2017/22079 , A61B2017/22082 , A61B2017/22084 , A61H9/0057 , A61H23/008 , A61H2201/14 , A61H2201/1664 , G10K11/28
摘要： A shock wave applicator includes a shock wave generator and an asymmetrical reflector portion in a housing. Asymmetry of the reflector portion is combined with one or more wave generators to produce a variety of focal volumes and wave fronts for medical treatment.
摘要翻译：冲击波施加器包括冲击波发生器和壳体中的不对称反射器部分。反射器部分的不对称性与一个或多个波发生器组合以产生用于医疗的各种焦距体积和波前。

9. 发明申请

US20050054994A1 Catheters with suction capability and related methods and systems for obtaining biosamples in vivo 审中-公开
标题翻译：具有抽吸能力的导管和用于在体内获得生物样品的相关方法和系统
公开(公告)号：US20050054994A1
公开(公告)日：2005-03-10
申请号：US10827741
申请日：2004-04-19
申请人： Iulian Cioanta , Richard Klein , Jacob Lazarovitz
发明人： Iulian Cioanta , Richard Klein , Jacob Lazarovitz
IPC分类号： A61B10/00 , A61B10/02 , A61F2/958 , A61M25/04 , A61B17/20 , A61M1/00
CPC分类号： A61B10/02 , A61B10/0045 , A61B10/007 , A61M25/04 , A61M25/1002 , A61M25/1011
摘要： Methods, systems, and computer program products for obtaining a sample in vivo and/or treating a subject include positioning an elongated transurethral catheter in the prostatic urethra of a subject, the catheter having a bladder anchoring balloon, at least one biosample entry port disposed axially away from the bladder anchoring balloon, and an axially extending biosample flow channel in fluid communication with the biosample entry port held internally in the catheter. The anchoring balloon is inflated to position the catheter so that the fluid entry port is proximate the prostatic urethra of the subject and prostatic fluid is suctioned from the prostatic urethra into the biosample entry port and into the biosample flow channel. The catheter can include a thermal treatment balloon and/or dilatation balloon and the suctioned sample can be obtained concurrently with, during, or proximate in time to the applied treatment. The catheter can be configured to allow urine to drain therethrough during the treatment/collection of the sample while keeping the urine isolated from the collected prostatic fluid sample.
摘要翻译：用于在体内获得样品和/或治疗受试者的方法，系统和计算机程序产品包括将细长的经尿道导管定位在受试者的前列腺尿道中，所述导管具有膀胱锚定球囊，至少一个生物样本入口端口远离气囊锚定气囊，以及轴向延伸的生物样品流动通道，其与保持在导管内部的生物样品入口端口流体连通。锚定球囊被充气以定位导管，使得流体进入端口靠近受试者的前列腺尿道，并且前列腺液体从前列腺尿道吸入生物样本入口并进入生物样本流动通道。导管可以包括热处理球囊和/或扩张球囊，并且抽吸样品可以在施用的治疗时间期间，期间或接近时间获得。导管可以被配置成允许尿液在样品的处理/收集期间从其中排出，同时保持尿液与收集的前列腺液体样品分离。

10. 发明授权

US08728809B2 Use of pressure waves for stimulation, proliferation, differentiation and post-implantation viability of stem cells 有权
标题翻译：使用压力波刺激，增殖，分化和植入后干细胞的生存能力
公开(公告)号：US08728809B2
公开(公告)日：2014-05-20
申请号：US12900818
申请日：2010-10-08
申请人： Iulian Cioanta , Christopher M. Cashman
发明人： Iulian Cioanta , Christopher M. Cashman
IPC分类号： C12N5/074
CPC分类号： C12N13/00 , A61N7/00
摘要： Stem cells are proliferated with the application of acoustic pressure waves, including cambium cells of periosteum treated in-vivo with acoustic pressure waves. Following harvesting and viability assessment of in-vivo or in-vitro proliferated stem cells, acoustic pressure waves are applied to enhance in-vivo or in-vitro differentiation either before or after implantation of the stems cells to an organism. Acoustic pressure waves also stimulate an implantation site to enhance viability and to grow desired tissue.
摘要翻译：应用声压波，包括用声压波在体内处理骨膜的形成层，使干细胞增殖。在体内或体外增殖干细胞的收获和活力评估之后，在将茎细胞植入生物体之前或之后，施加声压波以增强体内或体外分化。声压波还刺激植入部位以增强生存力并生长所需组织。

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