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1. 发明授权

US08801694B2 Intravesical drug delivery device 有权
标题翻译：膀胱内药物输送装置
公开(公告)号：US08801694B2
公开(公告)日：2014-08-12
申请号：US11463956
申请日：2006-08-11
申请人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
发明人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
IPC分类号： A61F2/00 , A61M31/00 , A61L29/16 , A61K9/00 , A61L29/06
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

2. 发明申请

US20100152704A1 Method for Intravesical Drug Delivery 有权
标题翻译：膀胱内给药方法
公开(公告)号：US20100152704A1
公开(公告)日：2010-06-17
申请号：US12709551
申请日：2010-02-22
申请人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
发明人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
IPC分类号： A61M25/00 , A61K31/167 , A61K33/04 , A61K31/737 , A61K31/24 , A61K31/407
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

3. 发明授权

US08182464B2 Method for intravesical drug delivery 有权
标题翻译：膀胱内药物输送方法
公开(公告)号：US08182464B2
公开(公告)日：2012-05-22
申请号：US12709551
申请日：2010-02-22
申请人： Heejin Lee , Karen Danielle Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
发明人： Heejin Lee , Karen Danielle Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
IPC分类号： A61M31/00 , A01N43/04 , A01N37/12 , A01N37/44 , A01N43/38 , A01N37/18 , A01N59/02 , A61K31/24 , A61K31/40 , A61K31/16 , A61K33/04
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

4. 发明申请

US20100136517A1 MATRIX STABILIZATION OF AGGREGATION-BASED ASSAYS 审中-公开
标题翻译：基于聚集的测定的矩阵稳定性
公开(公告)号：US20100136517A1
公开(公告)日：2010-06-03
申请号：US12599109
申请日：2008-05-07
申请人： Grace Y. Kim , Christophoros C. Vassiliou , Karen D. Daniel , Michael J. Cima
发明人： Grace Y. Kim , Christophoros C. Vassiliou , Karen D. Daniel , Michael J. Cima
IPC分类号： C12Q1/70 , G01N33/544 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/558
摘要： Methods and apparatus for stabilization of aggregation-based assays are described. In various embodiments, anti-analytes are dispersed within a matrix. A solution containing analytes brought into contact with the matrix, so that analytes may permeate throughout at least a portion of the matrix. In some embodiments, the anti-analytes and analytes are mobile within the matrix. As aggregates form and increase in size, the aggregates become substantially immobile within the matrix. As a result, signals representative of an amount of aggregation within the matrix can remain substantially constant. In various aspects, matrix-stabilized aggregation-based assays provide for reliable quantitative analysis of analyte concentration with test solutions.
摘要翻译：描述了基于聚集的测定法的稳定化方法和装置。在各种实施方案中，抗分析物分散在基质内。含有与基质接触的分析物的溶液，使得分析物可渗透至基质的至少一部分。在一些实施方案中，抗分析物和分析物在基质内是可移动的。随着聚集体的形成和尺寸的增加，聚集体在基质内基本上不能移动。结果，表示矩阵内的聚集量的信号可以保持基本恒定。在各个方面，基于基质稳定聚集的测定提供了使用测试溶液的分析物浓度的可靠定量分析。

5. 发明申请

US20110212163A1 MAGNETIC HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：磁力加热用于药物输送和其他应用
公开(公告)号：US20110212163A1
公开(公告)日：2011-09-01
申请号：US13055195
申请日：2009-07-23
申请人： Todd R. Hoare , Daniel S. Kohane , Robert S. Langer , Mikhail G. Shapiro , Yoon Yeo , Grace Y. Kim , Shahriar R. Khushrushahi
发明人： Todd R. Hoare , Daniel S. Kohane , Robert S. Langer , Mikhail G. Shapiro , Yoon Yeo , Grace Y. Kim , Shahriar R. Khushrushahi
IPC分类号： A61K47/02 , A61K9/127
CPC分类号： A61K9/06 , A61K9/0009 , A61K41/00
摘要： The present invention generally relates to systems and methods for releasing a compound from an article using an external trigger, for example, magnetic fields. One aspect of the invention is generally directed to an article containing a magnetically-susceptible material. Exposure of the magnetically-susceptible material to a magnetic field, such as an oscillating magnetic field, may cause the magnetically-susceptible material to increase in temperature. This increase in temperature may be used, in some embodiments, to cause the release of a drug or other releasable material from the article. For instance, the drug may be contained in a heat-sensitive material in thermal communication with the magnetically-susceptible material, or the drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material in thermal communication with the magnetically-susceptible material. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, or the like.
摘要翻译：本发明一般涉及使用外部触发器（例如磁场）从制品中释放化合物的系统和方法。本发明的一个方面通常涉及含有易磁化物质的制品。将易磁感应材料暴露于诸如振荡磁场的磁场可能导致敏感材料的温度升高。在一些实施方案中，可以使用这种温度升高来引起药物或其它可释放材料从制品中的释放。例如，药物可以包含在与易感材料热连通的热敏材料中，或者药物可以包含在外壳内，该外壳至少部分地由热敏材料隔热与易感材料的通讯。本发明的其它方面涉及制造或使用这些制品的系统和方法，例如通过在受试者内植入制品，涉及这种制品的治疗方法，包括这种制品的试剂盒等。

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