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1. 发明授权

US4877735A Process for producing 2-keto-L-gulonic acid 失效
标题翻译： 2-酮-L-古洛糖酸的制备方法
公开(公告)号：US4877735A
公开(公告)日：1989-10-31
申请号：US204529
申请日：1988-06-08
申请人： Ikuo Nogami , Takamasa Yamaguchi , Masahide Oka , Hideo Shirafuji
发明人： Ikuo Nogami , Takamasa Yamaguchi , Masahide Oka , Hideo Shirafuji
IPC分类号： C12N1/38 , C12P7/60
CPC分类号： C12P7/60 , C12N1/38 , Y10S435/822
摘要： An improved process for producing 2-keto-L-gulonic acid which comprises culturing a microorganism belonging to the genus Pseudogluconobacter which has an ability to oxidize L-sorbose to 2-keto-L-gulonic acid in a culture medium supplemented with a rare earth element in the presence of L-sorbose.

2. 发明授权

US4904588A Method for producing L-sorbose 失效
标题翻译： L-山梨糖的生产方法
公开(公告)号：US4904588A
公开(公告)日：1990-02-27
申请号：US11826
申请日：1987-02-06
申请人： Ikuo Nogami , Hideo Shirafuji , Takamasa Yamaguchi , Masahide Oka
发明人： Ikuo Nogami , Hideo Shirafuji , Takamasa Yamaguchi , Masahide Oka
IPC分类号： C12P19/02
CPC分类号： C12P19/02 , Y10S435/822 , Y10S435/823
摘要： L-sorbose, an intermediate important in vitamin C synthesis, is produced in higher yield from D-sorbitol by microbiological oxidation using a microorganism which belongs to the genus Gluconobacter and which has decreased ability to grow with D-sorbitol as the single carbon source compared with that of its parent strains.
摘要翻译： L-山梨糖是维生素C合成中重要的中间产物，通过微生物氧化，使用属于葡萄糖酸杆菌属的微生物从D-山梨糖醇得到更高的产率，并且与D-山梨糖醇作为单一碳源相比具有降低的生长能力与其亲本菌株。

3. 发明授权

US5474924A Method for producing 2-keto-L-gulonic acid 失效
标题翻译： 2-酮-L-古洛糖酸的制备方法
公开(公告)号：US5474924A
公开(公告)日：1995-12-12
申请号：US438999
申请日：1989-11-22
申请人： Ikuo Nogami , Hideo Shirafuji , Masahide Oka , Takamasa Yamaguchi
发明人： Ikuo Nogami , Hideo Shirafuji , Masahide Oka , Takamasa Yamaguchi
IPC分类号： C12N1/20 , C12N1/38 , C12P7/60 , C12P39/00 , C12R1/01 , C12R1/07 , C12R1/085 , C12R1/10 , C12R1/11 , C12R1/125 , C12R1/18 , C12R1/185 , C12R1/20 , C12R1/265 , C12R1/37 , C12R1/38 , C12R1/64
CPC分类号： C12R1/01 , C12N1/38 , C12P39/00 , C12P7/60 , Y10S435/822
摘要： 2-keto-L-gulonic acid is in high yield produced by contacting a microorganism of the genus Pseudogluconobacter, either as it is or after processing, with L-sorbose.
摘要翻译： 2-酮-L-古洛糖酸通过将Pseudogluconobacter属的微生物原样或加工后与L-山梨糖接触而获得高产率。

4. 发明授权

US4876195A Process for producing 2-keto-D-glucaric acid 失效
标题翻译： 2-酮基-D-葡糖二酸的制备方法
公开(公告)号：US4876195A
公开(公告)日：1989-10-24
申请号：US946504
申请日：1986-12-19
申请人： Hideo Shirafuji , Takamasa Yamaguchi , Ikuo Nogami
发明人： Hideo Shirafuji , Takamasa Yamaguchi , Ikuo Nogami
IPC分类号： C12P7/42 , C07C59/105 , C12P7/50 , C12P7/58 , C12R1/01
CPC分类号： C12P7/58 , Y10S435/822
摘要： 2-Keto-D-glucaric acid is produced in high yield by contacting raw material saccharides (e.g. D-glucose) with a bacterium belonging to the genus Pseudogluconobacter or processed matters thereof.
摘要翻译：通过将原料糖（例如D-葡萄糖）与属于假葡糖杆菌属的细菌或其加工物接触，可以高产率生产2-酮-D-葡糖二酸。

5. 发明授权

US5840881A Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility 失效
标题翻译：含有水溶性或水溶性较弱的水溶性化合物的组合物
公开(公告)号：US5840881A
公开(公告)日：1998-11-24
申请号：US437227
申请日：1995-05-08
申请人： Yoshiaki Uda , Takako Yamauchi , Yasushi Nakagawa , Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
发明人： Yoshiaki Uda , Takako Yamauchi , Yasushi Nakagawa , Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
IPC分类号： A23L1/00 , A61K8/73 , A61Q19/00 , C07H7/033 , C07H15/04 , C07H15/256 , C08B30/18 , C08B37/00 , C08B37/02 , C08B37/16 , C12P19/02 , C12P19/04 , C12P19/12
CPC分类号： B82Y5/00 , A23P10/30 , A61K8/738 , A61Q19/00 , C07H15/04 , C07H15/24 , C07H7/033 , C08B30/18 , C08B37/0012 , C08B37/0015 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , A61K2800/56
摘要： A composition is disclosed comprising a water-insoluble or slightly water-soluble compound and a branched cyclodextrin-carboxylic acid. The branched cyclodextrin-carboxylic acid significantly increases the water-solubility of the compound. Also disclosed is a method of enhancing water-solubility of the compound.
摘要翻译：公开了包含水不溶性或微溶于水的化合物和支链环糊精羧酸的组合物。支链环糊精 - 羧酸显着提高了化合物的水溶性。还公开了提高化合物的水溶性的方法。

6. 发明授权

US5635610A Production of saccharide carboxylic acids 失效
公开(公告)号：US5635610A
公开(公告)日：1997-06-03
申请号：US419394
申请日：1995-04-10
申请人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
发明人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
IPC分类号： C07H3/04 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/22 , C07H15/256 , C08B30/18 , C08B31/18 , C08B37/02 , C08B37/16 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , C07H3/00 , C07H5/00 , C07H15/00
CPC分类号： C07H3/04 , C07H15/04 , C07H15/22 , C07H15/24 , C07H15/256 , C07H3/06 , C07H7/033 , C08B30/18 , C08B31/18 , C08B37/0012 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , Y10S435/822
摘要： A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artifact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid and the carboxylic acid so accumulated is harvested and novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield, the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.

7. 发明授权

US5434061A Production of saccharide carboxylic acids 失效
标题翻译：生产糖类羧酸
公开(公告)号：US5434061A
公开(公告)日：1995-07-18
申请号：US152122
申请日：1993-11-15
申请人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
发明人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
IPC分类号： C07H3/04 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/22 , C07H15/256 , C08B30/18 , C08B31/18 , C08B37/02 , C08B37/16 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , C12P19/22 , C12P19/14
CPC分类号： C07H3/04 , C07H15/04 , C07H15/22 , C07H15/24 , C07H15/256 , C07H3/06 , C07H7/033 , C08B30/18 , C08B31/18 , C08B37/0012 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , Y10S435/822
摘要： A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artifact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid and the carboxylic acid so accumulated is harvested and novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield, the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.
摘要翻译：一种糖类羧酸或其盐的制造方法，其特征在于，属于假葡糖杆菌属的能够将羟甲基和/或半缩醛羟基相关碳原子氧化成羧基的微生物或来自该微生物的神经元被允许作用于羟甲基和/或半缩醛羟基的糖或糖衍生物以产生并累积相应的羧酸，收集所累积的羧酸，并通过上述制备方法产生新的糖类羧酸，并通过方法，从广泛的糖类中，可以高选择性和良好的收率生产具有衍生自羟甲基和/或半缩醛OH基团的羧基的糖酸，所得糖酸对酶降解具有抗性并且具有改善的水溶性其他特点。

8. 发明授权

US5635611A Production of saccharide carboxylic acids 失效
标题翻译：生产糖类羧酸
公开(公告)号：US5635611A
公开(公告)日：1997-06-03
申请号：US419397
申请日：1995-04-10
申请人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
发明人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
IPC分类号： C07H3/04 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/22 , C07H15/256 , C08B30/18 , C08B31/18 , C08B37/02 , C08B37/16 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , C07H3/00 , C07H5/00 , C07H15/00
CPC分类号： C07H3/04 , C07H15/04 , C07H15/22 , C07H15/24 , C07H15/256 , C07H3/06 , C07H7/033 , C08B30/18 , C08B31/18 , C08B37/0012 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , Y10S435/822
摘要： A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artifact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid and the carboxylic acid so accumulated is harvested and novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield, the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.
摘要翻译：一种糖类羧酸或其盐的制造方法，其特征在于，属于假葡糖杆菌属的能够将羟甲基和/或半缩醛羟基相关碳原子氧化成羧基的微生物或来自该微生物的神经元被允许作用于羟甲基和/或半缩醛羟基的糖或糖衍生物以产生并累积相应的羧酸，收集所累积的羧酸，并通过上述制备方法产生新的糖类羧酸，并通过方法，从广泛的糖类中，可以高选择性和良好的收率生产具有衍生自羟甲基和/或半缩醛OH基团的羧基的糖酸，所得糖酸对酶降解具有抗性并且具有改善的水溶性其他特点。

9. 发明授权

US5629411A Saccharide carboxylic acids of glycosides 失效
标题翻译：糖苷的糖类羧酸
公开(公告)号：US5629411A
公开(公告)日：1997-05-13
申请号：US419393
申请日：1995-04-10
申请人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
发明人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
IPC分类号： C07H3/04 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/22 , C07H15/256 , C08B30/18 , C08B31/18 , C08B37/02 , C08B37/16 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , C07H15/24
CPC分类号： C07H3/04 , C07H15/04 , C07H15/22 , C07H15/24 , C07H15/256 , C07H3/06 , C07H7/033 , C08B30/18 , C08B31/18 , C08B37/0012 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , Y10S435/822
摘要： A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artifact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid and the carboxylic acid so accumulated is harvested and novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield, the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.
摘要翻译：一种糖类羧酸或其盐的制造方法，其特征在于，属于假葡糖杆菌属并能够将羟甲基和/或半缩醛羟基相关碳原子氧化成羧基的微生物或来自该微生物的神经元被允许作用于羟甲基和/或半缩醛羟基的糖或糖衍生物以产生并累积相应的羧酸，收集所累积的羧酸，并通过上述制备方法产生新的糖类羧酸，并通过方法，从广泛的糖类中，可以高选择性和良好的收率生产具有衍生自羟甲基和/或半缩醛OH基团的羧基的糖酸，所得糖酸对酶降解具有抗性并且具有改善的水溶性其他特点。

10. 发明授权

US5518906A Production of d-pantoic acid and d-pantothenic acid 失效
标题翻译： D-泛解酸和泛酸的生产
公开(公告)号：US5518906A
公开(公告)日：1996-05-21
申请号：US480325
申请日：1995-06-07
申请人： Yuichi Hikichi , Takeo Moriya , Hiroshi Miki , Takamasa Yamaguchi , Ikuo Nogami
发明人： Yuichi Hikichi , Takeo Moriya , Hiroshi Miki , Takamasa Yamaguchi , Ikuo Nogami
IPC分类号： C12N1/21 , C12N15/52 , C12P7/42 , C12P13/02 , C12R1/19 , C12P13/06 , C12N9/00 , C12N15/01 , C12N15/70
CPC分类号： C12P7/42 , C12N15/52 , C12P13/02
摘要： A method of producing D-pantothenic acid or a salt thereof characterized by bring a microbe belonging to the family Enterobacteriaceae having resistance to salicylic acid and capable of producing D-pantothenic acid in the presence of .beta.-alanine in contact with .beta.-alanine, preferably wherein a microbe resistant to .alpha.-ketoisovaleric acid and/or .alpha.-ketobutyric acid, and/or .alpha.-aminobutyric acid and/or .beta.-hydroxy-aspartic acid and/or O-methyl-threonine or a microbe transformed with a plasmid DNA carrying the region of a gene involved in biosynthesis of pantothenic acid or a salt thereof or a part thereof, is used, and a method of producing D-pantoic acid or a salt thereof characterized by culturing a microbe resistant to salicylic acid, .alpha.-ketoisovaleric acid and/or .alpha.-ketobutyric acid and/or .alpha.-aminobutyric acid and/or .beta.-hydroxy-aspartic acid and/or O-methyl-threonine and capable of producing D-pantoic acid to accumulate D-pantoic acid or a salt thereof, which is then harvested, and in accordance with these methods, D-pantothenic acid, D-pantoic acid or salts thereof can be efficiently directly obtained microbiologically without using DL-pantoic acid, DL-pantolactone etc. as starting materials.
摘要翻译：一种D-泛酸或其盐的制造方法，其特征在于，在β-丙氨酸接触的情况下，使具有对水杨酸具有抗性的能够产生D-泛酸的家族肠杆菌科的微生物优选其中对α-酮异戊酸和/或α-酮丁酸和/或α-氨基丁酸和/或β-羟基 - 天冬氨酸和/或O-甲基 - 苏氨酸具有抗性的微生物或用携带使用涉及泛酸或其盐或其一部分的生物合成的基因的区域，以及生产D-泛解酸或其盐的方法，其特征在于培养对水杨酸具有抗性的微生物，α-酮异戊酸和/或α-酮丁酸和/或α-氨基丁酸和/或β-羟基 - 天冬氨酸和/或O-甲基 - 苏氨酸，并能够产生D-泛酸以积累D-泛解酸或其盐，然后收获，根据这些方法，可以微生物地直接获得D-泛酸，D-泛解酸或其盐，而不使用DL-泛解酸，DL-泛酸内酯等作为起始原料。

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