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1. 发明申请

US20050170047A1 Nutritionally enriched maple syrup 审中-公开
标题翻译：营养丰富的枫糖浆
公开(公告)号：US20050170047A1
公开(公告)日：2005-08-04
申请号：US10505552
申请日：2003-02-21
申请人： Yoshiko Watanabe , Luc Bergeron , Toshihiro Ishiguro
发明人： Yoshiko Watanabe , Luc Bergeron , Toshihiro Ishiguro
IPC分类号： A23L1/302 , A23L1/09 , C13B50/00 , A23L1/30
CPC分类号： C13B50/00 , A23L5/00 , A23L29/30 , A23L33/125
摘要： The present invention relates to nutritionally enriched maple syrup, which is enriched in vitamins, and more particularly to nutritionally enriched maple syrup which contains vitamin C in an amount of 50 mg or more based on 100 ml of maple syrup obtained by thermally concentrating a maple sap. The present invention also includes maple syrup enriched in vitamins such as vitamin E and vitamin B1 and other nutrients. According to the present invention, the nutritional value and quality of maple syrup, particularly maple syrup obtained by thermal concentration, can be improved and the range of its use for other foods can be widened. Nutrient enrichment can be carried out by an efficient method suited for industrial scale production. Moreover, the nutritionally enriched maple syrup of the present invention exhibits a well-balanced flavor, and thus it can be widely added to various foods.
摘要翻译：本发明涉及富含维生素的营养丰富的枫糖浆，更特别地涉及营养丰富的枫糖浆，其含有基于通过将枫树汁热收集而获得的100ml枫糖浆的量为50mg以上的维生素C 。本发明还包括富含维生素如维生素E和维生素B 1的其他营养素的枫糖浆。根据本发明，可以提高枫糖浆，特别是通过热浓缩获得的枫糖浆的营养价值和质量，并且可以扩大其用于其它食物的范围。营养丰富可以通过适合工业规模生产的有效方法进行。此外，本发明的营养丰富的枫糖浆显示出均衡的味道，因此可广泛地加入到各种食品中。

2. 发明授权

US4091220A Morpholinocarbonyl alkyl N-benzylpiperazines 失效
标题翻译：吗啉代羰基烷基N-苄基哌嗪
公开(公告)号：US4091220A
公开(公告)日：1978-05-23
申请号：US793356
申请日：1977-05-03
申请人： Toshihiro Ishiguro , Yasushi Sanno
发明人： Toshihiro Ishiguro , Yasushi Sanno
IPC分类号： C07D295/135 , C07D295/182 , C07D295/215 , C07D413/02
CPC分类号： C07D295/182 , C07D295/135 , C07D295/215
摘要： Novel N-benzylpiperazine derivatives of the general formula ##STR1## wherein R.sup.1 and R.sup.2 are same or different and each stands for a hydrogen atom or an acyl group; R.sup.3 stands for a hydrogen atom; a carbamoyl group, an acyl group which is unsubstituted or substituted by mercapto or morpholino, or an alkyl group which is unsubstituted or substituted by hydroxy, aryl or aminocarbonyl represented by the formula ##STR2## wherein each of R.sup.4 and R.sup.5 is a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms or a cyclohexyl group, or R.sup.4 and R.sup.5 form a morpholino or piperidino ring together with the nitrogen atom adjacent thereto, and X stands for a halogen atom, and pharmaceutically acceptable acid addition salts thereof. These compounds and salts thereof have respiratory tract fluid secretion stimulatory properties and are useful as medicines such as respiratory track fluid secretion stimulators.
摘要翻译：新颖的通式为“IMAGE”的N-苄基哌嗪衍生物，其中R1和R2相同或不同，各代表氢原子或酰基; R3代表氢原子; 氨基甲酰基，未取代或被巯基或吗啉代取代的酰基，或未被取代或被羟基，芳基或氨基羰基取代的烷基，其中R 4和R 5各自为氢原子，具有1至3个碳原子的低级烷基或环己基，或者R 4和R 5与其相邻的氮原子一起形成吗啉代或哌啶子基，X代表卤素原子及其药学上可接受的酸加成盐。这些化合物及其盐具有呼吸道液体分泌刺激性质，可用作呼吸道液体分泌刺激剂等药物。

3. 发明授权

US4085116A Novel chromone derivatives 失效
标题翻译：新型色酮衍生物
公开(公告)号：US4085116A
公开(公告)日：1978-04-18
申请号：US669973
申请日：1976-03-24
申请人： Akira Nohara , Toshihiro Ishiguro , Yasushi Sanno
发明人： Akira Nohara , Toshihiro Ishiguro , Yasushi Sanno
IPC分类号： C07D405/04 , A61K31/41 , A61P37/08 , C07D311/22 , C07D257/04
CPC分类号： C07D311/22 , Y10S514/826
摘要： The present invention relates to novel chromone derivatives having effective antiallergic action with low toxicity, which are shown by the following formula (I) ##STR1## wherein R is hydrogen or lower alkyl and A is ##STR2## (R' is hydrogen or lower alkyl) or ##STR3## and their physiologically acceptable salts.
摘要翻译：本发明涉及具有低毒性的有效抗过敏作用的新型色酮衍生物，其由下式（I）表示：其中R为氢或低级烷基，A为（R'为氢或低级烷基）或及其生理上可接受的盐。

4. 发明授权

US5840881A Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility 失效
标题翻译：含有水溶性或水溶性较弱的水溶性化合物的组合物
公开(公告)号：US5840881A
公开(公告)日：1998-11-24
申请号：US437227
申请日：1995-05-08
申请人： Yoshiaki Uda , Takako Yamauchi , Yasushi Nakagawa , Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
发明人： Yoshiaki Uda , Takako Yamauchi , Yasushi Nakagawa , Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
IPC分类号： A23L1/00 , A61K8/73 , A61Q19/00 , C07H7/033 , C07H15/04 , C07H15/256 , C08B30/18 , C08B37/00 , C08B37/02 , C08B37/16 , C12P19/02 , C12P19/04 , C12P19/12
CPC分类号： B82Y5/00 , A23P10/30 , A61K8/738 , A61Q19/00 , C07H15/04 , C07H15/24 , C07H7/033 , C08B30/18 , C08B37/0012 , C08B37/0015 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , A61K2800/56
摘要： A composition is disclosed comprising a water-insoluble or slightly water-soluble compound and a branched cyclodextrin-carboxylic acid. The branched cyclodextrin-carboxylic acid significantly increases the water-solubility of the compound. Also disclosed is a method of enhancing water-solubility of the compound.
摘要翻译：公开了包含水不溶性或微溶于水的化合物和支链环糊精羧酸的组合物。支链环糊精 - 羧酸显着提高了化合物的水溶性。还公开了提高化合物的水溶性的方法。

5. 发明授权

US5635610A Production of saccharide carboxylic acids 失效
公开(公告)号：US5635610A
公开(公告)日：1997-06-03
申请号：US419394
申请日：1995-04-10
申请人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
发明人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
IPC分类号： C07H3/04 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/22 , C07H15/256 , C08B30/18 , C08B31/18 , C08B37/02 , C08B37/16 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , C07H3/00 , C07H5/00 , C07H15/00
CPC分类号： C07H3/04 , C07H15/04 , C07H15/22 , C07H15/24 , C07H15/256 , C07H3/06 , C07H7/033 , C08B30/18 , C08B31/18 , C08B37/0012 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , Y10S435/822
摘要： A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artifact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid and the carboxylic acid so accumulated is harvested and novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield, the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.

6. 发明授权

US4302463A 1-Azaxanthone-3-carboxylic acids and their production 失效
标题翻译： 1-氮杂酮-3-羧酸及其制备
公开(公告)号：US4302463A
公开(公告)日：1981-11-24
申请号：US185954
申请日：1980-09-10
申请人： Toshihiro Ishiguro , Kiyoshi Ukawa , Akira Nohara
发明人： Toshihiro Ishiguro , Kiyoshi Ukawa , Akira Nohara
IPC分类号： A61K31/435 , A61P37/08 , C07D491/04 , C07D491/052 , C07F9/6561 , A61K31/44
CPC分类号： C07D491/04 , C07F9/6561
摘要： Novel 1-azaxanthone-3-carboxylic acid derivatives, which are shown by the following formula (I) ##STR1## wherein R is hydrogen, alkyl, alkoxy or halogen; R.sub.1 and R.sub.2 are the same or different and each is hydrogen, alkyl or alkenyl; and m is 1 or 2; and their physiologically acceptable salts, are usable as effective medicines for preventing and/or treating allergic diseases. The compound of the formula (I) can be produced by reacting a compound of the formula: ##STR2## wherein R and m have the same meaning as defined above; R.sub.3 is carboxyl or group which is convertible into carboxyl through hydrolysis; X is alkyl phosphate radical or halogen, with a compound of the formula: ##STR3## wherein R.sub.1 and R.sub.2 have the same meaning as defined above, or its salt, and conducting hydrolysis, if necessary.
摘要翻译：新的1-氮杂酮-3-羧酸衍生物，其由下式（I）表示：其中R是氢，烷基，烷氧基或卤素; R1和R2相同或不同，各自为氢，烷基或烯基; m为1或2; 及其生理上可接受的盐可用作预防和/或治疗过敏性疾病的有效药物。式（I）的化合物可以通过使下式化合物：其中R和m具有与上述定义相同的含义： R3是羧基或通过水解可转化为羧基的基团; X是烷基磷酸根或卤素，具有下式的化合物：其中R 1和R 2具有与上述相同的含义或其盐，并且如果需要进行水解。

7. 发明授权

US4267332A 3-(Tetrazol-5-yl)-1-azaxanthones 失效
标题翻译： 3-（四唑-5-基）-1-哒嗪酮
公开(公告)号：US4267332A
公开(公告)日：1981-05-12
申请号：US942925
申请日：1978-09-18
申请人： Akira Nohara , Toshihiro Ishiguro , Kiyoshi Ukawa
发明人： Akira Nohara , Toshihiro Ishiguro , Kiyoshi Ukawa
IPC分类号： A61K31/435 , A61K31/436 , A61P37/08 , C07D311/22 , C07D403/04 , C07D491/04 , C07D491/052 , C07D273/01 , A61K31/395
CPC分类号： C07D491/04 , C07D311/22
摘要： Novel 3-(tetrazol-5-yl)-1-azaxanthone and its derivatives, which are shown by the following formula ##STR1## wherein R.sub.1 is hydrogen, amino or hydroxyl; R.sub.2 is alkyl, alkoxy, halogen, nitro, carboxyl, hydroxyl, butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any adjacent carbon atoms or amino group which may be unsubstituted or substituted by at least one alkyl; and m is 0, 1 or 2; and their physiologically acceptable salts, are usable as effective medicines for preventing and/or treating allergic diseases.
摘要翻译：新的3-（四唑-5-基）-1-氮杂呫吨酮及其衍生物，其由下式表示：其中R1是氢，氨基或羟基; R2是烷基，烷氧基，卤素，硝基，羧基，羟基，亚丁二烯基（-CH = CH-CH = CH-），其形成具有任何相邻碳原子的苯环或可以是未取代的或被至少一个烷基取代的氨基 ; m为0,1或2; 及其生理上可接受的盐可用作预防和/或治疗过敏性疾病的有效药物。

8. 发明授权

US5629411A Saccharide carboxylic acids of glycosides 失效
标题翻译：糖苷的糖类羧酸
公开(公告)号：US5629411A
公开(公告)日：1997-05-13
申请号：US419393
申请日：1995-04-10
申请人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
发明人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
IPC分类号： C07H3/04 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/22 , C07H15/256 , C08B30/18 , C08B31/18 , C08B37/02 , C08B37/16 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , C07H15/24
CPC分类号： C07H3/04 , C07H15/04 , C07H15/22 , C07H15/24 , C07H15/256 , C07H3/06 , C07H7/033 , C08B30/18 , C08B31/18 , C08B37/0012 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , Y10S435/822
摘要： A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artifact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid and the carboxylic acid so accumulated is harvested and novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield, the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.
摘要翻译：一种糖类羧酸或其盐的制造方法，其特征在于，属于假葡糖杆菌属并能够将羟甲基和/或半缩醛羟基相关碳原子氧化成羧基的微生物或来自该微生物的神经元被允许作用于羟甲基和/或半缩醛羟基的糖或糖衍生物以产生并累积相应的羧酸，收集所累积的羧酸，并通过上述制备方法产生新的糖类羧酸，并通过方法，从广泛的糖类中，可以高选择性和良好的收率生产具有衍生自羟甲基和/或半缩醛OH基团的羧基的糖酸，所得糖酸对酶降解具有抗性并且具有改善的水溶性其他特点。

9. 发明授权

US3992370A 1 ,1-Dichloro-1a,1b-dihydrodibenzo(b,f)cycloprop(d)azepine-6(1H)-carboxalde hyde 失效
标题翻译： 1,1-二氯-1a，1b-二氢二苯并（b，f）环丙（d）吖庚因-6（1H） - 甲醛
公开(公告)号：US3992370A
公开(公告)日：1976-11-16
申请号：US435965
申请日：1974-01-23
申请人： Kenya Kawashima , Takahiro Saraie , Yasuhiko Kawano , Toshihiro Ishiguro
发明人： Kenya Kawashima , Takahiro Saraie , Yasuhiko Kawano , Toshihiro Ishiguro
IPC分类号： C07D223/32 , C07D231/34 , C07D223/22
CPC分类号： C07D223/32 , C07D231/34
摘要： 1,1-Dichloro-1a, 10b-dihydrodibenzo(b,f)cycloprop(d)azepine-6(1H)-carboxaldehyde is produced in good yield through a reaction between a compound of the general formula ##SPC1##Wherein R stands for hydrogen or formyl group and chloroform. Thus obtained product can be used as a valuable intermediate for synthesizing medicines and is further convertible to known drugs, e.g. 6-(3-dimethylamino)propyl)-1, 1a, 6, 10b-tetrahydrodibenzo(b,f)cycloprop(d)azepine.
摘要翻译：通过下列通式之一的反应，通过下式反应生成1,1-二氯-1a，10b-二氢二苯并（b，f）环丙烷（d）吖庚因-6（1H） - 甲醛：WHEREIN R代表氢或甲酰基组和氯仿。所得产物可用作合成药物的有价值的中间体，并可进一步转化为已知的药物，例如， 6-（3-二甲基氨基）丙基）-1,1a，6,10b-四氢二苯并（b，f）环丙（d）氮杂。

10. 发明授权

US5434061A Production of saccharide carboxylic acids 失效
标题翻译：生产糖类羧酸
公开(公告)号：US5434061A
公开(公告)日：1995-07-18
申请号：US152122
申请日：1993-11-15
申请人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
发明人： Toshihiro Ishiguro , Masahide Oka , Takamasa Yamaguchi , Ikuo Nogami
IPC分类号： C07H3/04 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/22 , C07H15/256 , C08B30/18 , C08B31/18 , C08B37/02 , C08B37/16 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , C12P19/22 , C12P19/14
CPC分类号： C07H3/04 , C07H15/04 , C07H15/22 , C07H15/24 , C07H15/256 , C07H3/06 , C07H7/033 , C08B30/18 , C08B31/18 , C08B37/0012 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , Y10S435/822
摘要： A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artifact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid and the carboxylic acid so accumulated is harvested and novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield, the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.
摘要翻译：一种糖类羧酸或其盐的制造方法，其特征在于，属于假葡糖杆菌属的能够将羟甲基和/或半缩醛羟基相关碳原子氧化成羧基的微生物或来自该微生物的神经元被允许作用于羟甲基和/或半缩醛羟基的糖或糖衍生物以产生并累积相应的羧酸，收集所累积的羧酸，并通过上述制备方法产生新的糖类羧酸，并通过方法，从广泛的糖类中，可以高选择性和良好的收率生产具有衍生自羟甲基和/或半缩醛OH基团的羧基的糖酸，所得糖酸对酶降解具有抗性并且具有改善的水溶性其他特点。

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