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1. 发明专利

CA2513311A1 PLANT TRANSFORMATION WITH IN VIVO ASSEMBLY OF A TRAIT 未知
公开(公告)号：CA2513311A1
公开(公告)日：2004-08-12
申请号：CA2513311
申请日：2004-01-30
申请人： ICON GENETICS AG , CON GENETICS INC
发明人： GLEBA YURI , KLIMYUK VICTOR , MARILLONNET SYLVESTRE , GIRITCH ANATOLY
IPC分类号： C12N15/82

2. 发明专利

CA2483145A1 TRANSGENIC PLANTS WITH CONTROLLED DISTRIBUTION OF A TRAIT TOPROGENY 未知
公开(公告)号：CA2483145A1
公开(公告)日：2003-12-11
申请号：CA2483145
申请日：2003-03-21
申请人： ICON GENETICS AG , CON GENETICS INC
发明人： WERNER STEFAN , ICON GENETICS INC , GIRITCH ANATOLY , GLEBA YURI , KLIMYUK VICTOR , ELIBY SERIK , MARILLONNET SYLVESTRE
IPC分类号： A01H1/00 , A01H5/00 , A61K38/00 , A61P43/00 , C12N5/10 , C12N15/09 , C12N15/82
摘要： A process of producing a transgenic multi-cellular plants or parts thereof expressing a trait of interest, said trait having a controlled distribution of said trait to progeny, wherein said process comprises (i) producing a first plant or a cell thereof having in a first locus of a nuclear chromosome a first heterologous nucleotide sequence comprising a first fragment of a nucleotide sequence encoding said trait of interest, (ii) producing a second plant or a cell thereof having in a second locus of a nuclearchomosome homologous to said nuclear chromosome of step (i), a second heterologous nucleotide sequence comprising a second fragment of the nucleotide sequence encoding said trait of interest, and (iii) hybridising said first and said second plant or cells thereof to generate progeny exhibiting said functional trait of interest due to binding between a protein or polypeptide encoded by said firrst heterologous nucleotide sequence and a protein or polypeptide encoded by said second heterologous nucleotide sequence. Further, the invention provides a process of producing hybrid seeds for agriculture.

3. 发明申请

WO2006003018A3 BIOLOGICALLY SAFE TRANSIENT PROTEIN EXPRESSION IN PLANTS 审中-公开
标题翻译：植物中生物安全的瞬时蛋白表达
公开(公告)号：WO2006003018A3
公开(公告)日：2006-05-04
申请号：PCT/EP2005007361
申请日：2005-07-07
申请人： ICON GENETICS AG , MARILLONNET SYLVESTRE , ENGLER CAROLA , MUEHLBAUER STEFAN , HERZ STEFAN , WERNER STEFAN , KLIMYUK VICTOR , GLEBA YURI
发明人： MARILLONNET SYLVESTRE , ENGLER CAROLA , MUEHLBAUER STEFAN , HERZ STEFAN , WERNER STEFAN , KLIMYUK VICTOR , GLEBA YURI
IPC分类号： C12N15/82 , A01H5/12 , C12N15/74
CPC分类号： C12N15/8203 , C12N15/8205 , C12N15/8216 , C12N15/8257
摘要： A process of producing a protein of interest by expression of said protein of interest from a sequence of interest in a plant or in plant leaves, comprising: a) transfecting said plant or said plant leaves by infiltrating said plant or said plant leaves with an Agrobacterium strain in the presence of a complementing factor, said Agrobacterium strain containing in T-DNA a heterelogous DNA sequence having a sequence portion encoding a replicon, wherein said sequence encoding a replicon contains sequences necessary for replicon function of said replicon, said sequences being derived from a plant virus, and said sequence of interest to be expressed from said replicon, b) optionally isolating said protein of interest from said plant or said plant leaves infiltrated in step (a), wherein said Agrobacterium strain is provided with a first genetic modification rendering said Agrobacterium strain defective for transfecting organisms with said T-DNA in the absence of said complementing factor.
摘要翻译：通过在植物或植物叶中表达来自目的序列的所述感兴趣的蛋白质产生感兴趣的蛋白质的方法，包括：a）通过用农杆菌渗入所述植物或所述植物叶片来转染所述植物或所述植物叶子所述农杆菌菌株在T-DNA中含有具有编码复制子的序列部分的异源DNA序列，其中所述编码复制子的序列含有所述复制子复制子功能所必需的序列，所述序列源自植物病毒和所述目的序列从所述复制子表达，b）任选地从步骤（a）中渗入的所述植物或所述植物叶中分离所述感兴趣的蛋白质，其中所述土壤杆菌菌株具有第一遗传修饰呈递所述农杆菌菌株在不存在所述补体因子的情况下用所述T-DNA转染生物体是有缺陷的。

4. 发明申请

WO2005049839A3 RNA VIRUS-DERIVED PLANT EXPRESSION SYSTEM 审中-公开
标题翻译： RNA病毒衍生植物表达系统
公开(公告)号：WO2005049839A3
公开(公告)日：2005-11-03
申请号：PCT/EP2004012743
申请日：2004-11-10
申请人： ICON GENETICS AG , MARILLONNET SYLVESTRE , THOERINGER CAROLA , KLIMYUK VICTOR , GLEBA YURI
发明人： MARILLONNET SYLVESTRE , THOERINGER CAROLA , KLIMYUK VICTOR , GLEBA YURI
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8257 , C12N15/8203 , C12N15/8205 , C12N15/8216 , C12P21/00
摘要： A process of expressing a sequence of interest in a plant, plant part, or plant cell culture, comprising: (a) providing a plant, plant part, or plant cell culture containing in cell nuclei a heterologous DNA having a sequence encoding an RNA replicon operably linked or linkable to a transcription promoter, wherein said sequence encoding an RNA replicon contains (i) sequences for replicon function of said RNA replicon, said sequences being derived from a sequence of a plant RNA virus, (ii) a sequence of interest, whereby said sequences for replicon function exhibit at selected localities of said sequences of said plant RNA virus functionconservative differences from said sequence of said plant RNA virus, said differences causing an increased frequency of replicon formation compared to an RNA replicon not exhibiting said differences; and (b) causing expression of said sequence of interest.
摘要翻译：在植物，植物部分或植物细胞培养物中表达感兴趣的序列的方法，包括：（a）提供在细胞核中含有编码RNA复制子的序列的异源DNA的植物，植物部分或植物细胞培养物其可编码RNA复制子的所述序列包含（i）所述RNA复制子的复制子功能的序列，所述序列衍生自植物RNA病毒的序列，（ii）感兴趣的序列，其中所述用于复制子功能的序列在所述植物RNA病毒功能的所述序列的所选序列的所选位点处表现出与所述植物RNA病毒的所述序列相比的所述差异，所述差异导致复制子形成的频率增加而不显示所述差异的RNA复制子; 和（b）引起所述感兴趣序列的表达。

5. 发明申请

WO2006079546A2 PRODUCTION OF HETERO-OLIGOMERIC PROTEINS IN PLANTS 审中-公开
标题翻译：在植物中生产异源低聚蛋白
公开(公告)号：WO2006079546A2
公开(公告)日：2006-08-03
申请号：PCT/EP2006000721
申请日：2006-01-27
申请人： ICON GENETICS AG , GIRITCH ANATOLY , MARILLONNET SYLVESTRE , KLIMYUK VICTOR , GLEBA YURI
发明人： GIRITCH ANATOLY , MARILLONNET SYLVESTRE , KLIMYUK VICTOR , GLEBA YURI
IPC分类号： C12N15/82 , C12N15/63 , C12N15/67
CPC分类号： C12N15/8251 , C07K14/59 , C12N15/8203 , C12N15/8257 , C12N15/8258
摘要： Process of producing in a plant, in plant tissue, or in plant cells a hetero-oligomeric protein comprising at least a first and a second protein subunit, said process comprising expressing in plant cells at least said first and said second protein subunit by (i) providing to said plant, said plant tissue or said plant cells a plus-sense single-stranded RNA viral vector encoding at least said first and said second protein subunit or (ii) providing to said plant, said plant tissue or said plant cells a first and a second plus- sense single-stranded RNA viral vector, said first viral vector encoding at least said first protein subunit, said second viral vector encoding at least said second protein subunit, whereby at least said first viral vector and said second viral vector are non- competing viral vectors.
摘要翻译：在植物，植物组织或植物细胞中产生包含至少第一和第二蛋白质亚基的杂低聚蛋白的方法，所述方法包括在植物细胞中至少表达所述第一和第二蛋白质亚基（i ）向所述植物，所述植物组织或所述植物细胞提供编码至少所述第一和所述第二蛋白质亚单位的正义单链RNA病毒载体，或（ii）向所述植物提供所述植物组织或所述植物细胞第一和第二正义单链RNA病毒载体，所述第一病毒载体编码至少所述第一蛋白质亚基，所述第二病毒载体编码至少所述第二蛋白质亚基，其中至少所述第一病毒载体和所述第二病毒载体是非竞争的病毒载体。

6. 发明申请

WO2004046360A3 METHOD OF CONTROLLING CELLULAR PROCESSES IN PLANTS 审中-公开
标题翻译：控制植物细胞过程的方法
公开(公告)号：WO2004046360A3
公开(公告)日：2004-08-12
申请号：PCT/EP0313018
申请日：2003-11-20
申请人： ICON GENETICS AG , ICON GENETICS INC , WERNER STEFAN , MARILLONNET SYLVESTRE , KLIMYUK VICTOR , GLEBA YURI
发明人： WERNER STEFAN , MARILLONNET SYLVESTRE , KLIMYUK VICTOR , GLEBA YURI
IPC分类号： C12N15/82 , A01H5/00 , C12N5/10 , C12N15/63 , C12N15/67
CPC分类号： C12N15/8216 , C12N15/8217 , C12N15/8237
摘要： A method of controlling a genetically-modified plant, comprising (a) providing a genetically-modified plant, whereby cells of said genetically-modified plant contain a heterologous nucleic acid and whereby said genetically-modified plant is inactive with regard to a cellular process of interest, (b) switching on said cellular process of interest by directly introducing a polypeptide from a cell-free composition into cells containing said heterologous nucleic acid wherein said polypeptide and said heterologous nucleic acid are mutually adapted such that said polypeptide is capable of switching on said cellular process of interest.
摘要翻译：一种控制遗传修饰植物的方法，包括（a）提供遗传修饰植物，其中所述遗传修饰植物的细胞含有异源核酸，并且由此所述遗传修饰植物对于细胞过程是无活性的（b）通过将来自无细胞组合物的多肽直接引入到含有所述异源核酸的细胞中来开启所述感兴趣的细胞过程，其中所述多肽和所述异源核酸相互适应，使得所述多肽能够接通说感兴趣的细胞过程。

7. 发明申请

WO0246438A3 PROCESSES AND VECTORS FOR PRODUCING TRANSGENIC PLANTS 审中-公开
标题翻译：生产转基因植物的方法和目标
公开(公告)号：WO0246438A3
公开(公告)日：2003-02-27
申请号：PCT/EP0113662
申请日：2001-11-23
申请人： ICON GENETICS AG , GLEBA YURI , KLIMYUK VICTOR , BENNING GREGOR , ELIBY SERIK
发明人： GLEBA YURI , KLIMYUK VICTOR , BENNING GREGOR , ELIBY SERIK
IPC分类号： C12N15/82 , A01H5/00 , C12N5/10
CPC分类号： C12N15/8213 , C12N15/8201 , C12N15/8216 , C12N15/8257 , C12N15/8274
摘要： This invention describes a process for gene expression in plants utilizing translational vectors. Said translational vectors cause a gene of interest to be stably integrated into a transcriptionally active host genomic DNA such that the transcription the gene of interest is controlled by a promoter of the host organism. Said translational vectors are preferably based on internal ribosome entry site (IRES) elements that are of plant origin, plant viral origin, synthetic origin or are isolated from other organisms.
摘要翻译：本发明描述了利用翻译载体在植物中表达基因的方法。所述翻译载体使感兴趣的基因稳定地整合到转录活性的宿主基因组DNA中，使得感兴趣的基因的转录由宿主生物体的启动子控制。所述翻译载体优选基于植物来源，植物病毒来源，合成来源或从其他生物体分离的内部核糖体进入位点（IRES）元件。

8. 发明申请

WO03020938A3 METHOD OF PROTEIN PRODUCTION IN PLANTS 审中-公开
标题翻译：植物蛋白质生产方法
公开(公告)号：WO03020938A3
公开(公告)日：2003-10-02
申请号：PCT/EP0209605
申请日：2002-08-28
申请人： ICON GENETICS AG , DOROKHOV YURII , SKURAT EUGENE , KLIMYUK VICTOR , GLEBA YURI
发明人： DOROKHOV YURII , SKURAT EUGENE , KLIMYUK VICTOR , GLEBA YURI
IPC分类号： A01H5/00 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/82 , C12N15/83 , C12P21/02
CPC分类号： C12N15/8221 , C12N15/8203 , C12N15/8216 , C12N15/8257
摘要： A process of producing a protein or polypeptide of interest in a plant or in plant is provided, comprising: (i) transforming or transfecting a plant of plant cells with a nucleotide sequence having a coding region encoding a fusion protein comprising the protein or polypeptide of interest, a signal peptide functional for targeting said fusion protein to the apoplast, and a polypeptide capable of binding the fusion protein to a cell wall component, (ii) enriching cell wall components having expressed and bound fusion protein, and separating the protein or polypeptide of interest or a protein comprising the protein or polypeptide interest.
摘要翻译：提供了在植物或植物中产生感兴趣的蛋白质或多肽的方法，其包括：（i）用具有编码融合蛋白的编码区的核苷酸序列转化或转染植物细胞植物，所述融合蛋白包含（用于将所述融合蛋白靶向质外体的信号肽，以及能够将融合蛋白与细胞壁组分结合的多肽，（ii）富集具有表达和结合的融合蛋白的细胞壁组分，以及分离蛋白或多肽感兴趣的蛋白质或包含蛋白质或多肽目标的蛋白质。

9. 发明申请

WO02097080A2 AMPLIFICATION VECTORS BASED ON TRANS-SPLICING 审中-公开
标题翻译：基于传输分离的放大矢量
公开(公告)号：WO02097080A2
公开(公告)日：2002-12-05
申请号：PCT/EP0204764
申请日：2002-04-30
申请人： ICON GENETICS AG , KLIMYUK VICTOR , IVANOV PETER , MARILLONNET SYLVESTRE , ZENK MEINHART , GLEBA YURI
发明人： KLIMYUK VICTOR , IVANOV PETER , MARILLONNET SYLVESTRE , ZENK MEINHART , GLEBA YURI
IPC分类号： C12N15/09 , C12N15/63 , C12N15/67 , C12N15/82 , C12N15/00
CPC分类号： C12N15/63 , C12N15/67 , C12N15/8203 , C12N15/8216
摘要： This invention provides process of amplification and/or expression of a sequence of interest in a cell by providing for generating within said cell at least one amplicon by trans-splicing between an RNA sequence designed for being capable of trans-splicing and a target RNA, whereby said amplicon is capable of amplifying in said cell and capable of expressing a sequence of interest.
摘要翻译：本发明提供在细胞中扩增和/或表达感兴趣的序列的方法，其通过在所述细胞内产生至少一个扩增子，通过在设计用于转接的RNA序列与靶RNA之间进行反式剪接，由此所述扩增子能够在所述细胞中扩增并且能够表达感兴趣的序列。

10. 发明申请

WO2005071090A8 TWO-COMPONENT RNA VIRUS-DERIVED PLANT EXPRESSION SYSTEM 审中-公开
标题翻译：双组分RNA病毒衍生植物表达系统
公开(公告)号：WO2005071090A8
公开(公告)日：2006-08-24
申请号：PCT/EP2005000492
申请日：2005-01-19
申请人： ICON GENETICS AG , MARILLONNET SYLVESTRE , THOERINGER CAROLA , KLIMYUK VICTOR , GLEBA YURI
发明人： MARILLONNET SYLVESTRE , THOERINGER CAROLA , KLIMYUK VICTOR , GLEBA YURI
IPC分类号： C12N15/82
CPC分类号： C12N15/8216
摘要： A process for replicating or for replicating and expressing a sequence of interest in a plant, comprising: (i) an RNA replicon or a precursor thereof, said RNA replicon being derived from a plus-sense single stranded RNA virus and comprising at least one sequence of interest; and (ii) a helper replicon, or a precursor thereof, wherein said helper replicon is (a) incapable of systemic movement in said plant both in the presence and in the absence of said RNA replicon (i) and (b) capable of expressing in a plant one or more proteins necessary for systemic movement of said RNA replicon (i), whereby said RNA replicon (i) is capable of replicating or replicating and expressing said sequence of interest in said plant, but unable to move systemically in said plant in the absence of said one or more proteins expressed by said helper replicon (ii).
摘要翻译：一种在植物中复制或表达感兴趣的序列的方法，包括：（i）RNA复制子或其前体，所述RNA复制子衍生自正义单链RNA病毒，并且包含至少一个序列出于兴趣; 辅助复制子或其前体，其中所述辅助复制子是（a）在所述RNA复制子（i）和（b）能够表达的存在和不存在下，在所述植物中不能全身运动在植物中，所述RNA复制子（i）的系统运动所必需的一种或多种蛋白质，其中所述RNA复制子（i）能够在所述植物中复制或复制和表达所述感兴趣的序列，但不能在所述植物中系统地移动在不存在由所述辅助复制子（ii）表达的所述一种或多种蛋白质的情况下。

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