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1. 发明专利

JP2013116448A Reaction vessel, reaction system and reaction method 有权
标题翻译：反应容器，反应体系和反应方法
公开(公告)号：JP2013116448A
公开(公告)日：2013-06-13
申请号：JP2011265511
申请日：2011-12-05
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： SUGITA NAMI , ASANO YUKAKO
IPC分类号： B01J19/00 , B01F3/08 , B01F5/00 , G01T1/161
摘要： PROBLEM TO BE SOLVED: To provide a reaction vessel capable of both decreasing capacity of a flow passage and forming a multilayer flow.SOLUTION: The reaction vessel for mixing a first and second liquids is composed of: (1) first flow passages, which is a plurality of flow passages each having a constant width and separately formed by a constant width in a width direction, and having a first nozzle on one end side for introducing the first liquid into the flow passage and guiding the first liquid introduced from the first nozzle to the other end side; (2) a second flow passage, which is one or plurality of flow passages each having a constant width and formed between the first flow passages, and having a second nozzle on an outflow end side of the first flow passages for introducing a second liquid into the flow passage; (3) a funnel-like part for contracting a width of the multilayer flow in which a flow of the first liquid discharged from the first flow passage in a belt shape and a flow of the second liquid discharged from the second flow passage in a belt shape are alternately arranged, along the flow; and (4) a processing part for mixing the first and second liquid by the contracted multilayer flow in the funnel-like part.
摘要翻译：要解决的问题：提供能够降低流路的容量并形成多层流动的反应容器。解决方案：用于混合第一和第二液体的反应容器由以下部分组成：（1）第一流动通道，其是具有恒定宽度的多个流动通道，并且在宽度方向上以恒定宽度分开形成，并且在一端侧具有第一喷嘴，用于将第一液体引入流路，将从第一喷嘴导入的第一液体引导到另一端侧; （2）第二流路，其是一个或多个流动通道，每个流动通道具有恒定的宽度并形成在第一流动通道之间，并且在第一流动通道的流出端侧具有用于将第二液体引入的第二喷嘴流路; （3）漏斗状部分，用于收缩多层流的宽度，其中从第一流道排出的第一液体的流动带形状和从第二流道排出的第二液体的流在带形状沿着流动交替排列; 和（4）处理部分，用于通过收缩的多层流将漏斗状部分中的第一和第二液体混合。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2006306751A Diagnostic imaging agent 有权
标题翻译：诊断成像剂
公开(公告)号：JP2006306751A
公开(公告)日：2006-11-09
申请号：JP2005129058
申请日：2005-04-27
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： KAWABATA KENICHI , SUGITA NAMI , SHIRAI TORU , UMEMURA SHINICHIRO
IPC分类号： A61K49/00 , A61B5/055 , A61B8/00
摘要： PROBLEM TO BE SOLVED: To provide a diagnostic imaging agent used in both MRI (magnetic resonance imaging) and ultrasonic diagnostic equipment, having high imaging ability in ultrasonic diagnostic images and transferable from blood vessels to tissues.
SOLUTION: The diagnostic imaging agent contains a liposoluble or amphiphilic paramagnetic material or a super paramagnetic material, a water insoluble material having ≤37°C boiling point and a water insoluble material having >37°C boiling point and is brought to be fine particles with a stabilizer. The agent gives imaging effects in MRI, has little danger in bumping and gives site-specific ultrasonic imaging effects using phase changes from liquid to gas. Owing to those effects, safe diagnosis/therapeutic techniques are provided.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供用于MRI（磁共振成像）和超声诊断设备的诊断成像剂，其在超声诊断图像中具有高成像能力并且可从血管转移到组织。
解决方案：诊断成像剂含有脂溶性或两亲顺磁性材料或超顺磁性材料，具有≤37℃沸点的水不溶性材料和沸点> 37℃的水不溶性物质具有稳定剂的细颗粒。该药物在MRI中提供成像效果，在碰撞中几乎没有危险，并且使用从液体到气体的相变来提供位置特异性超声成像效果。由于这些影响，提供了安全的诊断/治疗技术。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2004325200A In-tissue material concentration measuring apparatus 审中-公开
标题翻译：组织材料浓度测量装置
公开(公告)号：JP2004325200A
公开(公告)日：2004-11-18
申请号：JP2003119199
申请日：2003-04-24
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： KAWABATA KENICHI , SUGITA NAMI , SASAKI KAZUAKI , UMEMURA SHINICHIRO , NAKAJIMA SUSUMU , TAKEMURA TAKESHI , SAKATA ISAO
IPC分类号： G01N21/64 , G01N21/78 , G01N33/483
摘要： PROBLEM TO BE SOLVED: To provide an in-tissue material concentration measuring apparatus for measuring a concentration of a physiologically active material.
SOLUTION: The in-tissue material concentration measuring apparatus sets a tissue sample 1 in a sample holder 2. An excitation light 4 from an excitation light source 3 irradiates the tissue sample 1. A wavelength of the excitation light is selected by a slit 5 controlled by a control part 12. The selected excitation light irradiates the tissue sample 1. After fluorescence 6 reflected from the tissue sample 1 is split by a spectroscope 7, the fluorescence is amplified by an amplifier 8 and introduced into a signal processing part 9. A measured result is displayed on a display 10 and stored in a data storage 11. The apparatus is operated and controlled by a control part 12, measures fluorescence intensity (D) of a chemical based on an optimal excitation wavelength and the local maximal emission wavelength of the chemical, measures autofluorescence intensity (A) of the tissue, displays a ratio D/A on the display 10 and stores it in the data storage 11. The concentration of the in-tissue physiologically active material can be conveniently measured.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于测量生理活性物质浓度的组织内材料浓度测量装置。解决方案：组织内材料浓度测量装置将组织样本1设置在样本保持器2中。来自激发光源3的激发光4照射组织样本1.激发光的波长由狭缝5由控制部分12控制。所选择的激发光照射组织样本1.从组织样本1反射的荧光6被分光镜7分开之后，荧光被放大器8放大并被引入信号处理部分测量结果显示在显示器10上并存储在数据存储器11中。该装置由控制部分12操作和控制，测量化学品基于最佳激发波长和局部最大值的荧光强度（D）化学品的发射波长，测量组织的自发荧光强度（A），在显示器10上显示比例D / A并将其存储在数据存储器11中。组织中的浓度可以方便地测量生理活性物质。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2009051752A Magnetic particle-containing drug carrier and therapeutic device using the same 审中-公开
标题翻译：含有磁性粒子的药物载体和使用该药物的治疗装置
公开(公告)号：JP2009051752A
公开(公告)日：2009-03-12
申请号：JP2007218576
申请日：2007-08-24
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： SUGANO KAZUKO , SUGITA NAMI , TAKAHASHI TERUO , TAKADA KEIJI , MITSUMATA CHIHARU , FUJII SHIGEO
IPC分类号： A61K9/51 , A61K33/24 , A61K41/00 , A61K47/02 , A61K47/32 , A61P35/00
CPC分类号： A61N1/406 , A61K9/0009 , A61K9/127
摘要： PROBLEM TO BE SOLVED: To provide a drug carrier having high heat-generating efficiency by high-frequency induction heating in a state selectively accumulated in a target site. SOLUTION: The drug carrier comprises a medicament 3, magnetic fine particles 2 and a shell 1 covering them and having outer diameter of the shell 1 of ≥10 nm and ≤200 nm. The magnetic fine particles satisfies the relation of 0.8d>σ>0.4d (wherein d is the average particle diameter; and σ is the standard deviation of the particle diameter distribution), and the magnetic fine particle included in the drug carrier generates hysteresis heat by the high-frequency induction heating by the irradiation with an alternating magnetic field. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：通过在选择性地累积在目标部位的状态下通过高频感应加热提供具有高发热效率的药物载体。药物载体包括药物3，磁性细颗粒2和覆盖它们的外壳1，外壳1的外径≥10nm和≤200nm。磁性细颗粒满足0.8d>σ> 0.4d（其中d是平均粒径，σ是粒径分布的标准偏差）的关系，并且药物载体中包含的磁性细颗粒产生滞后热通过用交变磁场的照射进行的高频感应加热。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2009247683A Ultrasonic wave irradiation system 有权
标题翻译：超声波辐射系统
公开(公告)号：JP2009247683A
公开(公告)日：2009-10-29
申请号：JP2008100503
申请日：2008-04-08
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： SUGITA NAMI , YOSHIKAWA HIDEKI , AZUMA TAKASHI , KAWABATA KENICHI
IPC分类号： A61B18/00 , A61B5/055 , A61B6/03 , A61B8/00 , A61B10/00 , A61B19/00 , G06T1/00
摘要： PROBLEM TO BE SOLVED: To provide an ultrasonic wave irradiation system that simply and accurately directs ultrasonic waves.
SOLUTION: The ultrasonic wave irradiation system is provided with at least two light sources 2 for performing the spot irradiation of a subject 10 with laser light, a transducer 3 for irradiating the subject with ultrasonic waves, a detector 4 for imaging the laser light irradiation region on the subject, a display 5 for displaying the image information obtained by the detector, an image processor 6 for processing the image information, and a driving device 7 for moving the transducer. The laser light is irradiated so as to mutually crossing on the ultrasonic wave propagation axis passing through the focus of ultrasonic waves. The image processor obtains, from the image information, the interval between the light spots formed on the subject, and controls the driving device from the obtained light spot interval.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供简单准确地引导超声波的超声波照射系统。解决方案：超声波照射系统设置有至少两个用于用激光进行被检体10的点照射的光源2，用于用超声波照射被检体的换能器3，用于对激光成像的检测器4 用于显示由检测器获得的图像信息的显示器5，用于处理图像信息的图像处理器6，以及用于移动换能器的驱动装置7。照射激光以便在超声波的超声波传播轴上相互交叉。图像处理器从图像信息中获得形成在被摄体上的光点之间的间隔，并从获得的光点间隔控制驱动装置。版权所有（C）2010，JPO＆INPIT

6. 发明专利

JP2007007279A Sonochemical therapy apparatus 有权
标题翻译： SONOCHEMICAL THERAPY APPARATUS
公开(公告)号：JP2007007279A
公开(公告)日：2007-01-18
申请号：JP2005194238
申请日：2005-07-01
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： SUGITA NAMI , KAWABATA KENICHI , AZUMA TAKASHI , UMEMURA SHINICHIRO
IPC分类号： A61B18/00
CPC分类号： A61B8/00 , A61M37/0092 , A61N7/00
摘要： PROBLEM TO BE SOLVED: To provide an apparatus capable of treating the tumor and the like while confirming the generation of air bubbles by cavitation effective for performing a sonochemical therapy.
SOLUTION: This sonochemical therapy device 1 is provided with an ultrasonic irradiation means 2 for a diagnosis, an ultrasonic irradiation means 3 for a therapy, an echo detecting means 2 detecting ultrasonic echo, a diagnostic control means 42, a diagnostic image generation means 441 generating a diagnostic image based on the detected ultrasonic echo, and a therapeutic control means 43 irradiating therapeutic ultrasonic waves via the ultrasonic irradiation means 3 for the therapy; and is characterized in that the therapeutic control means 43 includes a pulse control means 431 controlling to irradiate therapeutic ultrasonic waves at a prescribed pulse number and idle period, and a diagnostic image generation means 441 generates the diagnostic image based on the ultrasonic echo in the idle period of therapeutic ultrasonic waves.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够通过有效进行声化学治疗的空化来确认产生气泡的能够治疗肿瘤等的装置。解决方案：该声化学治疗装置1设置有用于诊断的超声波照射装置2，用于治疗的超声波照射装置3，用于检测超声回波的回波检测装置2，诊断控制装置42，诊断图像生成基于检测到的超声波回波生成诊断图像的装置441;以及经由超声波照射装置3照射治疗超声波进行治疗的治疗控制装置43; 其特征在于，所述治疗控制单元43包括控制以规定的脉冲数和空闲时间照射治疗超声波的脉冲控制单元431，诊断图像生成单元441根据空闲时的超声回波生成诊断图像治疗超声波周期。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2005257425A Immunological examination apparatus and method 有权
标题翻译：免疫检查装置及方法
公开(公告)号：JP2005257425A
公开(公告)日：2005-09-22
申请号：JP2004068645
申请日：2004-03-11
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： SEKI YUUKAI , TSUKAMOTO AKIRA , SUZUKI DAISUKE , YAMAOKA SHOSAKU , SUGITA NAMI , KANDORI AKIHIKO , SAITO KAZUO
IPC分类号： G01N33/53 , G01N27/72 , G01N33/542 , G01N33/553
CPC分类号： G01N33/54373 , G01N27/745
摘要： PROBLEM TO BE SOLVED: To provide an immunological examination technique capable of efficiently examinating antigen-antibody reaction magnetically with high sensitivity using magnetic fine particles and a SQUID magnetic sensor.
SOLUTION: The immunological examination apparatus has: a disk-shaped sample holder 3 for circumferentially holding a prurality of sample containers 2, each of which houses a labelled specimen prepared by labelling a specimen with magnetic fine particles; a rotary means 4 for rotating the holder 3 around its axis; and a magnetic censor 11 for detecting the magnetic field generated from the magnetized labelled specimen in a magnetic shield. The region for holding a different sample container is inserted in the magnetic shield successively by the rotation of the holder 3 and the magnetization of the labelled specimen in the first sample container and the detection of the magnetic field generated from the labelled specimen housed in the second sample container are performed parallelly.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供能够使用磁性细颗粒和SQUID磁性传感器以高灵敏度磁性有效地检测抗原 - 抗体反应的免疫学检查技术。解决方案：免疫检查装置具有：用于周向保持样品容器2的纤维状的盘状样品保持器3，每个容器2容纳通过用磁性细颗粒标记试样而制备的标记样品; 用于使保持器3围绕其轴线旋转的旋转装置4; 以及用于检测在磁屏蔽中从被磁化的标记样本产生的磁场的磁性检测器11。用于保持不同样品容器的区域通过保持器3的旋转和标记样品在第一样品容器中的磁化而相继插入磁屏蔽中，并且检测从第二样品容器中收集的标记样品产生的磁场样品容器平行进行。版权所有（C）2005，JPO＆NCIPI

8. 发明专利

JP2004081645A Ultrasonic therapy apparatus 有权
公开(公告)号：JP2004081645A
公开(公告)日：2004-03-18
申请号：JP2002248206
申请日：2002-08-28
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： KAWABATA KENICHI , SUGITA NAMI , UMEMURA SHINICHIRO , AZUMA TAKASHI
IPC分类号： A61B18/00 , A61N7/00
CPC分类号： A61N7/00 , A61N2007/0078
摘要： PROBLEM TO BE SOLVED: To provide an ultrasonic therapy apparatus suitable for a therapy by low-focusing ultrasound while recognizing a medical agent which stays at a diseased area, decreases a threshold value of the cavitations generated by the ultrasound, and secondarily produces active oxygen by the acoustic cavitations generated by the ultrasound.
SOLUTION: A belt attached to a position (the abdomen) including the diseased area is prepared, and the ultrasonic therapy apparatus has units of ultrasonic irradiation devices attached to an arbitrary position on the belt.
COPYRIGHT: (C)2004,JPO

9. 发明专利

DE10110455A1 Sensitizer for tumor treatment contains a xanthene dye structure and a structure with at least one hydrophilic group and at least one lipophilic group bound to one and the same carbon atom in the molecule 未知
公开(公告)号：DE10110455A1
公开(公告)日：2001-10-11
申请号：DE10110455
申请日：2001-03-05
申请人： HITACHI LTD
发明人： SUGITA NAMI , KAWABATA KENICHI , UMEMURA SHINICHIRO , SASAKI KAZUAKI , SAKATA ISAO
IPC分类号： A61B17/00 , A61B18/00 , A61F7/00 , A61K31/352 , A61K31/353 , A61N7/00 , A61P35/00 , C07D311/82 , C07D311/86
摘要： A sensitizer contains a xanthene dye structure and has a structure such that at least one hydrophilic group and at least one lipophilic group are bound to one and the same carbon atom within the molecule. Independent claims are included for the following: (a) an ultrasonic treatment system comprising: (i) an ultrasonic imaging probe for irradiating a target for treatment in vivo with ultrasound for imaging to obtain a diagnostic ultrasonic image of the target for treatment; (ii) an ultrasonic therapeutic transducer for irradiating the target for treatment with ultrasound; (iii) a controller for adjusting the intensity and/or focus of the ultrasound for treatment based on the diagnostic ultrasonic image; (iv) an ultrasonic transducer for generating bubbles which generate ultrasound for irradiating the target for treatment with administered sensitizer; and (v) a display device for displaying the diagnostic ultrasonic image obtained by the ultrasonic imaging probe and contrasted by the bubbles. The generated bubbles are stabilized by the sensitizer by irradiation with the ultrasound. The target for treatment is irradiated with ultrasound for treatment after the diagnostic ultrasonic image as contrasted by the bubbles is displayed on the display device; (b) a method of ultrasonic therapy involving: the steps of irradiating the target for the treatment in vivo with the ultrasound for imaging as generated from the probe to obtain the diagnostic ultrasonic image of the target for treatment; adjusting the intensity and/or focus of the ultrasound for treatment as generated from the transducer based on the diagnostic ultrasonic image; irradiating the target for treatment with the administered sensitizer; displaying the diagnostic ultrasonic image obtained by the probe and contrasted by the bubbles; and irradiating the target for treatment with ultrasound; and (c) a compound of formula (I). X and Y = halogen or H; Z = alkali metal atom or H; R1 = lipophilic group comprising 3-30C straight alkyl or straight chain alkyl, side-chain-containing alkyl, functional groups derived from a straight chain or side-chain-containing alkyl group by substituting a double bond or a triple bond for part of its single bonds, functional group derived from a straight chain or side-chain-containing alkyl group by binding an aromatic ring to it or functional group derived from a straight chain or side-chain-containing alkyl group by introducing an ether linkage, ester linkage, amido or sulfur into its part; R2 = hydrophilic group comprising at least one of carboxy group, sulfonic acid, a sulfuric acid ester group, hydroxy groups, amine group, quaternary ammonium group, phosphoric acid group or their soluble salts; and R3 = R1, R2 or H.

10. 发明专利

JPH10298112A CONTROL OF CHEMICAL REACTION USING SOLID SURFACE 失效
公开(公告)号：JPH10298112A
公开(公告)日：1998-11-10
申请号：JP11088297
申请日：1997-04-28
申请人： HITACHI LTD
发明人： SUGITA NAMI , MITSUYA MUNEHISA , HASHIZUME TOMIHIRO , WADA YASUO
IPC分类号： C07B51/00 , C07B61/00 , C07B63/00
摘要： PROBLEM TO BE SOLVED: To selectively protect one of the equivalent functional groups among a plurality of functional groups in a polyfunctional compound in its chemical reaction using solid surface. SOLUTION: (1) One functional group in a polyfunctional compound (having chemically equivalent functional groups) reacted on the surface of a solid such as a semiconductor, metal or macromolecular compound (in particular, metal, fine particles of macromolecular compound, porous body) is reacted by the washing in a solution, oxidation treatment, solute molecule adsorption, plasma treatment, ionic beam treatment, light irradiation, etc., (2) the other functional groups in the above compound is chemically reacted, and (3) the one functional group is liberated from the solid surface by hydrolysis, reduction, light irradiation or hydrogen ion concentration change, thus controlling the chemical reaction of the polyfunctional compound bearing a plurality of functional groups to be protected such as hydroxyl, aldehyde and/or carbonyl groups.

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