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1. 发明专利

DE10110455A1 Sensitizer for tumor treatment contains a xanthene dye structure and a structure with at least one hydrophilic group and at least one lipophilic group bound to one and the same carbon atom in the molecule 未知
公开(公告)号：DE10110455A1
公开(公告)日：2001-10-11
申请号：DE10110455
申请日：2001-03-05
申请人： HITACHI LTD
发明人： SUGITA NAMI , KAWABATA KENICHI , UMEMURA SHINICHIRO , SASAKI KAZUAKI , SAKATA ISAO
IPC分类号： A61B17/00 , A61B18/00 , A61F7/00 , A61K31/352 , A61K31/353 , A61N7/00 , A61P35/00 , C07D311/82 , C07D311/86
摘要： A sensitizer contains a xanthene dye structure and has a structure such that at least one hydrophilic group and at least one lipophilic group are bound to one and the same carbon atom within the molecule. Independent claims are included for the following: (a) an ultrasonic treatment system comprising: (i) an ultrasonic imaging probe for irradiating a target for treatment in vivo with ultrasound for imaging to obtain a diagnostic ultrasonic image of the target for treatment; (ii) an ultrasonic therapeutic transducer for irradiating the target for treatment with ultrasound; (iii) a controller for adjusting the intensity and/or focus of the ultrasound for treatment based on the diagnostic ultrasonic image; (iv) an ultrasonic transducer for generating bubbles which generate ultrasound for irradiating the target for treatment with administered sensitizer; and (v) a display device for displaying the diagnostic ultrasonic image obtained by the ultrasonic imaging probe and contrasted by the bubbles. The generated bubbles are stabilized by the sensitizer by irradiation with the ultrasound. The target for treatment is irradiated with ultrasound for treatment after the diagnostic ultrasonic image as contrasted by the bubbles is displayed on the display device; (b) a method of ultrasonic therapy involving: the steps of irradiating the target for the treatment in vivo with the ultrasound for imaging as generated from the probe to obtain the diagnostic ultrasonic image of the target for treatment; adjusting the intensity and/or focus of the ultrasound for treatment as generated from the transducer based on the diagnostic ultrasonic image; irradiating the target for treatment with the administered sensitizer; displaying the diagnostic ultrasonic image obtained by the probe and contrasted by the bubbles; and irradiating the target for treatment with ultrasound; and (c) a compound of formula (I). X and Y = halogen or H; Z = alkali metal atom or H; R1 = lipophilic group comprising 3-30C straight alkyl or straight chain alkyl, side-chain-containing alkyl, functional groups derived from a straight chain or side-chain-containing alkyl group by substituting a double bond or a triple bond for part of its single bonds, functional group derived from a straight chain or side-chain-containing alkyl group by binding an aromatic ring to it or functional group derived from a straight chain or side-chain-containing alkyl group by introducing an ether linkage, ester linkage, amido or sulfur into its part; R2 = hydrophilic group comprising at least one of carboxy group, sulfonic acid, a sulfuric acid ester group, hydroxy groups, amine group, quaternary ammonium group, phosphoric acid group or their soluble salts; and R3 = R1, R2 or H.

2. 发明专利

DE69331692T2 未知
公开(公告)号：DE69331692T2
公开(公告)日：2002-10-24
申请号：DE69331692
申请日：1993-09-14
申请人： HITACHI LTD
发明人： UMEMURA SHINICHIRO , KAWABATA KENICHI , UCHIDA KENKO , YASUDA KENJI , WADA YASUO , HIRAIWA ATSUSHI
IPC分类号： A61B17/22 , A61N7/00 , A61N7/02
摘要： This invention is directed to accomplish an ultrasonic remedial apparatus for generating a living body action such as cavitation suitable for remedy of a malignant tumor, a thrombus and a calculus, an ultrasonic wave diagnostic apparatus for generating cavitation to enhance an ultrasonic echo image of a blood stream, etc., and utilizing its reflection capacity, an ultrasonic chemical reaction promotion apparatus, an ultrasonic washing apparatus, an ultrasonic sterilizer, etc., by providing an ultrasonic irradiation apparatus for efficiently generating acoustic cavitation. Irradiation focus code signals for defining focal positions and sound pressure distribution shapes of irradiation sound fields of a fundamental frequency waves and harmonics are applied from a main control circuit to driving phase generation circuits, respectively. The driving phases thus generated are applied to driving signal generation circuits and the resulting driving signals are applied to device driving circuits, respectively, so that a group of the fundamental frequency devices and a group of harmonic devices are driven, respectively. The driving phases are controlled so that the fundamental frequency wave and the harmonic waves are superposed with one another in a medium near the focus, and acoustic cavitation is generated locally and efficiently.

3. 发明专利

DE69331692D1 未知
公开(公告)号：DE69331692D1
公开(公告)日：2002-04-18
申请号：DE69331692
申请日：1993-09-14
申请人： HITACHI LTD
发明人： UMEMURA SHINICHIRO , KAWABATA KENICHI , UCHIDA KENKO , YASUDA KENJI , WADA YASUO , HIRAIWA ATSUSHI
IPC分类号： A61B17/22 , A61N7/00 , A61N7/02
摘要： This invention is directed to accomplish an ultrasonic remedial apparatus for generating a living body action such as cavitation suitable for remedy of a malignant tumor, a thrombus and a calculus, an ultrasonic wave diagnostic apparatus for generating cavitation to enhance an ultrasonic echo image of a blood stream, etc., and utilizing its reflection capacity, an ultrasonic chemical reaction promotion apparatus, an ultrasonic washing apparatus, an ultrasonic sterilizer, etc., by providing an ultrasonic irradiation apparatus for efficiently generating acoustic cavitation. Irradiation focus code signals for defining focal positions and sound pressure distribution shapes of irradiation sound fields of a fundamental frequency waves and harmonics are applied from a main control circuit to driving phase generation circuits, respectively. The driving phases thus generated are applied to driving signal generation circuits and the resulting driving signals are applied to device driving circuits, respectively, so that a group of the fundamental frequency devices and a group of harmonic devices are driven, respectively. The driving phases are controlled so that the fundamental frequency wave and the harmonic waves are superposed with one another in a medium near the focus, and acoustic cavitation is generated locally and efficiently.

4. 发明专利

DE4205030C2 未知
公开(公告)号：DE4205030C2
公开(公告)日：1997-04-03
申请号：DE4205030
申请日：1992-02-19
申请人： HITACHI LTD
发明人： UMEMURA SHINICHIRO , KAWABATA KENICHI , KAWAGUCHI KOJI , IKEDA HIROSHI
IPC分类号： A61B8/08 , A61B17/22 , A61B17/225 , A61B8/00 , A61H23/00 , H04N5/31

5. 发明专利

DE602008003714D1 Verfahren zur Herstellung eines Diagnose- und Therapiemittels 未知
公开(公告)号：DE602008003714D1
公开(公告)日：2011-01-13
申请号：DE602008003714
申请日：2008-06-26
申请人： HITACHI LTD
发明人： ASAMI REI , KAWABATA KENICHI
IPC分类号： A61K49/22 , A61K9/107 , A61K47/48 , B01F3/04 , B01F3/08

6. 发明专利

DE602007004568D1 未知
公开(公告)号：DE602007004568D1
公开(公告)日：2010-03-18
申请号：DE602007004568
申请日：2007-11-19
申请人： HITACHI LTD
发明人： AZUMA TAKASHI , KAWABATA KENICHI
IPC分类号： G01S15/89 , A61B8/00 , G01S7/52
摘要： An ultrasonic imaging apparatus, detecting a signal peculiar to a contrast agent emitted when liquid formed in a fine particle vaporizes due to ultrasonic waves and imaging space distribution thereof. A narrow band is used for transmission, a broad band is used for a received signal, and in a state of high space resolution of the received signal, a transmission signal and the received signal are discriminated.

7. 发明专利

DE4205030A1 Therapeutic ultrasonic system with transmitter and focusing unit - has monitoring ultrasonic transceiver with directional effect which can be aligned to where harmonic signals are produced 未知
公开(公告)号：DE4205030A1
公开(公告)日：1992-09-03
申请号：DE4205030
申请日：1992-02-19
申请人： HITACHI LTD
发明人： UMEMURA SHINICHIRO , KAWABATA KENICHI , KAWAGUCHI KOJI , IKEDA HIROSHI
IPC分类号： A61B8/08 , A61B17/22
摘要： The position at which the harmonic signals are produced is indicated by the superimposed representation of an echographic image of a pulse shaped ultrasonic wave transmitted from the monitoring ultrasonic transceiver (5.1, 5.2) and an echographic imaging of the signals transmitted from the ultrasonic transmitter with the focusing unit. The system is designed so that the position at which the harmonics are produced can be represented as the point of intersection of the echographic imagings (32.1, 32.2) of the signals for the harmonics of the focused ultrasonic wave by means of the two monitoring ultrasonic transceivers. ADVANTAGE - Establishes exactly whether ultrasonic wave used for treatment is focused at place to be treated. Treatment by focused wave produces no sec. effects at places not being treated.

8. 发明公开

EP1132054A4 ULTRASONIC MEDICAL TREATING DEVICE 审中-公开
标题翻译：医疗设备，超声治疗
公开(公告)号：EP1132054A4
公开(公告)日：2009-03-04
申请号：EP99949356
申请日：1999-10-22
申请人： HITACHI LTD , HITACHI MEDICAL CORP
发明人： AZUMA TAKASHI , KAWABATA KENICHI , UMEMURA SHINICHIRO , SASAKI KAZUAKI , KURODA KATSUHIRO , SHINOMURA RYUICHI , MIWA YUICHI , ISHIDA KAZUNARI , KUBOTA JUN
IPC分类号： H04N7/18 , A61B8/12 , A61B17/00 , A61B18/00 , A61B19/00 , A61N7/02
CPC分类号： A61N7/022 , A61B8/12 , A61B2017/00154 , A61B2017/00274 , A61B2018/00547 , A61B2090/378 , A61B2090/3782
摘要： An ultrasonic medical treating device suited for ultrasonic medical treatment of a prostate, capable of sighting a converging ultrasonic wave for the treatment precisely to a target portion, and preventing displacement from the target portion being irradiated effectively. An ultrasonic transducer (5) for generating a converging ultrasonic wave for treatment is arranged together with an imaging ultrasonic probe (6) in an applicator (4), and an ultrasonic transducer (2) for monitoring the sight of and the position displacement is provided in a catheter inserted in a ureter. Imaging means (7) drives the ultrasonic probe (6) to display an ultrasonic tomogram of the target portion and its vicinity on display means (10). The ultrasonic transducer (2) is driven pulsationally with the same frequency as that of the imaging ultrasonic wave at the timing at which the imaging ultrasonic wave, so that a point sound source image indicating the position of the transducer (2), as viewed from the applicator, is superimposed on the ultrasonic tomogram displayed on the display means (10). The position displacement of the applicator being irradiated with the converging ultrasonic wave can be monitored by monitoring the displacement from the position of the point sound source image at the end of the position adjustment of the applicator.

9. 发明公开

EP0619104A4 ULTRASONIC IRRADIATION APPARATUS AND PROCESSOR USING THE SAME. 失效
标题翻译：超声波辐射装置和使用该装置的处理器。
公开(公告)号：EP0619104A4
公开(公告)日：1996-05-08
申请号：EP93919658
申请日：1993-09-14
申请人： HITACHI LTD
发明人： UMEMURA SHINICHIRO , KAWABATA KENICHI , UCHIDA KENKO , YASUDA KENJI , WADA YASUO , HIRAIWA ATSUSHI
IPC分类号： A61B17/22 , A61N7/00 , A61N7/02 , A61F7/00 , A61B17/36
CPC分类号： A61N7/02 , A61B17/22004 , A61N2007/006 , A61N2007/0078 , A61N2007/0095
摘要： This invention is directed to accomplish an ultrasonic remedial apparatus for generating a living body action such as cavitation suitable for remedy of a malignant tumor, a thrombus and a calculus, an ultrasonic wave diagnostic apparatus for generating cavitation to enhance an ultrasonic echo image of a blood stream, etc., and utilizing its reflection capacity, an ultrasonic chemical reaction promotion apparatus, an ultrasonic washing apparatus, an ultrasonic sterilizer, etc., by providing an ultrasonic irradiation apparatus for efficiently generating acoustic cavitation. Irradiation focus code signals for defining focal positions and sound pressure distribution shapes of irradiation sound fields of a fundamental frequency waves and harmonics are applied from a main control circuit to driving phase generation circuits, respectively. The driving phases thus generated are applied to driving signal generation circuits and the resulting driving signals are applied to device driving circuits, respectively, so that a group of the fundamental frequency devices and a group of harmonic devices are driven, respectively. The driving phases are controlled so that the fundamental frequency wave and the harmonic waves are superposed with one another in a medium near the focus, and acoustic cavitation is generated locally and efficiently.

10. 发明公开

EP2508142A4 ULTRASONIC TREATMENT DEVICE 审中-公开
标题翻译： ULTRASCHALLBEHANDLUNGSGERÄT
公开(公告)号：EP2508142A4
公开(公告)日：2017-05-03
申请号：EP10834558
申请日：2010-12-01
申请人： HITACHI LTD
发明人： ASAMI REI , KAWABATA KENICHI
IPC分类号： A61B17/12 , A61B18/00 , A61F7/00 , A61N7/02
CPC分类号： A61N7/02 , A61B8/481 , A61B2017/00176 , A61B2017/22089 , A61N2007/0039
摘要： There is provided an ultrasonic treatment device that is minimally-invasive and that achieves embolization treatment having a high blood flow blocking effect. To this end, the ultrasonic treatment device is provided with a function to transmit to a target area of a subject both a bubble generation pulse that vaporizes a contrast agent, and a bubble generation pulse that causes the diameter of the formed bubble to increase.
摘要翻译：提供了一种微创并且实现具有高血流阻断效果的栓塞治疗的超声治疗装置。为此，超声波治疗装置具有向对象的目标区域传递使造影剂气化的气泡生成脉冲和使气泡直径增大的气泡生成脉冲的功能。

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