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1. 发明专利

JP2010268817A Reagent kit 有权
标题翻译：试剂盒
公开(公告)号：JP2010268817A
公开(公告)日：2010-12-02
申请号：JP2010187767
申请日：2010-08-25
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： KAJIYAMA TOMOHARU , KANBARA HIDEKI , HARADA KUNIO
IPC分类号： C12M1/34 , G01N35/02
摘要： PROBLEM TO BE SOLVED: To solve the problem that reduction in size and price of a technique for dispensing plural reagents with high accuracy has been difficult because of mechanical complexities. SOLUTION: A small, simple, and inexpensive analyzing apparatus is attained by achieving pressurized dispensation of plural reagents using capillaries and by providing an air layer at capillary tips after dispensation in order to reduce leakage of reagents other than the dispensed reagent. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：解决问题：为了解决由于机械复杂性而难以分离多个试剂高精度的技术的尺寸和价格的降低的问题。解决方案：通过使用毛细管实现多个试剂的加压分配并且在分配之后通过在毛细管尖端处提供空气层以减少除了分配的试剂之外的试剂的泄漏来获得小而简单且便宜的分析装置。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2004347513A Sample transfer device 有权
标题翻译：样品传送装置
公开(公告)号：JP2004347513A
公开(公告)日：2004-12-09
申请号：JP2003146199
申请日：2003-05-23
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： HARADA KUNIO , KAMAHORI MASAO , UEMATSU CHIHIRO , OKANO KAZUNOBU , KANBARA HIDEKI
IPC分类号： G01N35/10 , G01N1/00
摘要： PROBLEM TO BE SOLVED: To reduce cost necessary for liquid sample transfer, to improve transfer accuracy, and to transfer accurately a very small quantity of the liquid sample. SOLUTION: One end of a glass capillary 4 is used as a suction discharge part, and the other end is connected to a syringe or a syringe needle of a syringe pump by a joint without interposing a valve or the like between them, and used as both a pipe and the suction discharge part. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了降低液体样品转移所需的成本，提高转印精度，并精确地转移非常少量的液体样品。解决方案：玻璃毛细管4的一端用作抽吸排出部分，另一端通过接头在注射器泵的注射器或注射器针上连接而不在其间插入阀等，并用作管道和抽吸排放部分。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2004313028A Bioluminescence-measuring device and kit for measuring intracellular atp 审中-公开
公开(公告)号：JP2004313028A
公开(公告)日：2004-11-11
申请号：JP2003108364
申请日：2003-04-11
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： KAMAHORI MASAO , HARADA KUNIO , YAZAWA YOSHIAKI , KANBARA HIDEKI
IPC分类号： G01N33/483 , C12M1/34 , C12Q1/66 , G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide a small simple bioluminescence-measuring device which can simultaneously and highly sensitively detect many samples. SOLUTION: A reactor 1 for performing a bioluminescence reaction for measuring microorganisms and a photodetector 3 for detecting the luminescence from the reactor 1 are closely disposed to correspond to each other as a pair of 1 : 1 in the vertical direction. Furthermore, the reactor 1 and a dispenser 2 equipped with a reagent tank used for injecting reagents are arranged as a pair of 1 : 1 in the vertical direction. The collectively simultaneous injection of reagents into the reactor is performed from the upper vertical direction. The detection of the bioluminescence from the reactor 1 is carried out from the lower vertical direction. COPYRIGHT: (C)2005,JPO&NCIPI

4. 发明专利

JP2004104001A Test sample transfer mechanism 审中-公开
公开(公告)号：JP2004104001A
公开(公告)日：2004-04-02
申请号：JP2002266825
申请日：2002-09-12
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： YAMAOKA SHOSAKU , HARADA KUNIO , SUGAYA MASAKAZU
IPC分类号： H01L21/68 , H01L21/027
摘要： PROBLEM TO BE SOLVED: To provide a structure for improving the degree of transfer precision in a positioning device for a wafer or the like used for an electron beam recording device. SOLUTION: In order that shape distortions of a base and X stage 4 due to the preload of a cross roller guide 3 caused by screws 5 makes no pitching error in the transfer of the X stage 4 and Y stage 2 for improving the degree of the transfer precision in stages, the shape of the base 1 for fixing the cross roller guide 3 is formed in a recess shape, the shape of the Y stage 2 arranged on the base is formed in an integral structure having a rectangular-shaped protrusion extending straight in a vertical direction, and further the shape of the X stage 4 mounted with a substrate arranged on the Y stage 2 is formed in the recess shape. Furthermore, a top table arranged with a length measuring mirror 23 using laser and with a test sample holder 6 that are mounted on the uppermost portion of the X stage is supported at three points to prevent shape distortions of the stages from exercising a harmful effect on the top table 8. COPYRIGHT: (C)2004,JPO

5. 发明专利

JP2014130636A Blood vessel image photographing device and personal authentication device 有权
标题翻译：血管图像摄影装置和个人认证装置
公开(公告)号：JP2014130636A
公开(公告)日：2014-07-10
申请号：JP2014059447
申请日：2014-03-24
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： KONO MIYUKI , UMEMURA SHINICHIRO , MIYATAKE TAKAFUMI , HARADA KUNIO , ITO YOSHITOSHI , UEKI HIRONORI
IPC分类号： G06T1/00 , A61B5/117
摘要： PROBLEM TO BE SOLVED: To provide means for enabling personal authentication, such that psychological resistance is low, it is difficult to forge, and data on which individual features are reflected well can be acquired with good reproducibility, while eliminating or minimizing the need for a maintenance management operation for preventing a device from being stained.SOLUTION: A person authentication device which utilizes a vein pattern of a finger optimizes the quantity of light irradiation by a light source based upon a picked up finger image, and performs emphasis processing on the vein pattern in an image operation for authentication. Consequently, personal authentication such that psychological resistance is low, it is difficult to forge, and authentication precision is high can be performed while eliminating or minimizing the need for a maintenance management operation for preventing infection due to staining of the device and errors of acquired data.
摘要翻译：要解决的问题：为了提供能够进行个人认证的手段，使得心理阻力低，难以锻造，并且可以以良好的再现性获得各个特征被良好反映的数据，同时消除或最小化对用于防止装置被污染的维护管理操作。解决方案：利用手指的静脉图案的个人认证装置基于拾取的手指图像优化光源的光照射量，并对静脉进行加重处理用于认证的图像操作中的模式。因此，心理阻力低的个人认证，难以伪造，并且可以在消除或最小化对由于设备的染色引起的感染和所获取的数据的错误的维护管理操作的需要的同时执行认证精度高。

6. 发明专利

JP2007159491A Gene set used for testing colon cancer 有权
标题翻译：用于测试结肠癌的基因
公开(公告)号：JP2007159491A
公开(公告)日：2007-06-28
申请号：JP2005360974
申请日：2005-12-14
申请人： Canon Inc , Hitachi Ltd , National Cancer Center-Japan , キヤノン株式会社 , 国立がんセンター総長 , 株式会社日立製作所
发明人： MATSUMURA YASUHIRO , MATSUSHITA NAOYUKI , SASAKI HIROMI , YAJIMA SATOSHI , ISHII MIE , YAMAMOTO NOBUKO , KAWAGUCHI MASAHIRO , OKABE TETSUO , TSUNODA HIROYUKI , HARADA KUNIO
IPC分类号： C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/158 , C12Q2600/16
摘要： PROBLEM TO BE SOLVED: To provide a method for early diagnosis of colon cancer by which patients suffering from the colon cancer can be detected with high accuracy as compared with conventional methods. SOLUTION: There is provided the method for screening colon cancer cells in a specimen which is a smear of feces carried out by analyzing the expression levels of at least 2 or more species of genes selected from the genetic cluster having a specific base sequence by using the amount of an mRNA in the specimen or analyzing the expression levels of gene products by using an antibody against the gene products. Furthermore, a primer specifically amplifying the genes and a probe for detecting the genes specifically hybridizing with the genes are provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：与常规方法相比，提供一种可以高精度地检测结肠癌患者的结肠癌的早期诊断方法。提供了通过分析选自具有特定碱基序列的遗传簇中的至少2种或更多种基因的表达水平进行的粪便污迹的样品中筛选结肠癌细胞的方法。通过使用标本中的mRNA的量或通过使用针对基因产物的抗体来分析基因产物的表达水平。此外，提供了特异性扩增基因的引物和用于检测与基因特异性杂交的基因的探针。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2006177837A Luminescence detection apparatus 审中-公开
标题翻译：发光检测装置
公开(公告)号：JP2006177837A
公开(公告)日：2006-07-06
申请号：JP2004372619
申请日：2004-12-24
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： KANBARA HIDEKI , KAJIYAMA TOMOHARU , HARADA KUNIO , KAMAHORI MASAO
IPC分类号： G01N21/76 , C12M1/00 , C12M1/34 , G01N21/78 , G01N35/02
CPC分类号： G01N21/03 , G01N21/6428 , G01N21/6452 , G01N21/76
摘要： PROBLEM TO BE SOLVED: To provide a luminescence detection apparatus of a compact constitution capable of easily determining DNA base sequences at low costs.
SOLUTION: The luminescence detection apparatus 1 includes a plurality of reaction cells 6 having a transparent bottom part; liquid feeding parts 19 provided with capillaries 18 positioned above the reaction cells 6 and made to correspond in one-to-one to the reaction cells 19; and a photo-detection part 29 having a plurality of photo-detection elements 24 arranged closely to the lower surfaces of the reaction cells 6 and made to correspond in one-to-one to the reaction cells 6. By injecting a reagent solution from the liquid feeding part 19 to the reaction cells 6, luminescence generated in the reaction cells 6 is separately detected by the plurality of photo-detection elements 24 of the photo-detection part 29.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：解决的问题：提供能够以低成本容易地确定DNA碱基序列的致密构造的发光检测装置。解决方案：发光检测装置1包括具有透明底部的多个反应池6; 液体供给部分19设置有设置在反应单元6上方并且一对一地对应于反应单元19的毛细管18; 以及具有多个光检测元件24的光检测部29，该多个光检测元件24与反应单元6的下表面紧密相邻配置，并与反应单元6一一对应。通过从液体供给部分19到反应池6中，反应池6中产生的发光被光检测部分29的多个光检测元件24单独检测。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2005052148A Photo-emission detecting apparatus 审中-公开
标题翻译：照相检测装置
公开(公告)号：JP2005052148A
公开(公告)日：2005-03-03
申请号：JP2004292139
申请日：2004-10-05
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： KAMAHORI MASAO , HARADA KUNIO , KANBARA HIDEKI
IPC分类号： G01N21/76 , C12M1/00 , C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a compact, simple DNA sequence and mutation-detecting apparatus that simultaneously detects a number of samples with high sensitivity.
SOLUTION: A plurality of reaction cells 27 for performing DNA extension reaction and bioluminescence reaction, and a photo detector 29 for detecting photo-emission from the reaction cells are adherently arranged while they correspond by one to one in a vertical direction. Additionally, the plurality of reaction cells and a capillary 25 for injecting a reagent are arranged while they correspond by one to one in a vertical direction, a reagent is injected collectively and simultaneously to the reaction cells from an upper, vertical direction, and the photo-emission from the reaction cells is detected from a lower, vertical direction.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种紧凑，简单的DNA序列和突变检测装置，其同时以高灵敏度检测多个样品。解决方案：用于进行DNA延伸反应和生物发光反应的多个反应池27和用于检测来自反应池的光发射的光电检测器29在垂直方向对应一对一的情况下被贴合地布置。另外，多个反应单元和用于注入试剂的毛细管25在垂直方向上一一对应的同时排列，试剂从上，下垂直方向共同注入反应室，同时照射从较低的垂直方向检测来自反应池的发射。版权所有（C）2005，JPO＆NCIPI

9. 发明专利

JP2005046065A Method and system for retrieving cell 有权
标题翻译：用于检测细胞的方法和系统
公开(公告)号：JP2005046065A
公开(公告)日：2005-02-24
申请号：JP2003281978
申请日：2003-07-29
申请人： Hitachi Ltd , National Cancer Center-Japan , 国立がんセンター総長 , 株式会社日立製作所
发明人： MATSUMURA YASUHIRO , MATSUSHITA NAOYUKI , TSUNODA HIROYUKI , HARADA KUNIO
IPC分类号： C12M1/00 , C12N1/02 , C12N5/06 , C12N5/08 , G01N33/574
CPC分类号： G01N33/574
摘要： PROBLEM TO BE SOLVED: To provide a method and a system for retrieving cells from excreta in order to examine colon cancer from the ordinary excreta of multispecimen. SOLUTION: The method for retrieving cancer cells comprises the step of preparing specimens obtained by adding a buffer solution at room temperature to a sampled ordinary excreta, the step of adsorbing cancer cells in the specimens freed from impurities to a solid carrier, and the step of retrieving the cancer cells thus adsorbed. The system for retrieving the cancer cells is also provided. COPYRIGHT: (C)2005,JPO&NCIPI

10. 发明专利

JP2004164652A Individual authentication device 有权
公开(公告)号：JP2004164652A
公开(公告)日：2004-06-10
申请号：JP2003393268
申请日：2003-11-25
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： KONO MIYUKI , UMEMURA SHINICHIRO , MIYATAKE TAKAFUMI , HARADA KUNIO , ITO YOSHITOSHI , UEKI HIRONORI
IPC分类号： A61B5/117 , G06F1/00 , G06F15/00 , G06F21/20 , G06T1/00 , G06T7/00
摘要： PROBLEM TO BE SOLVED: To provide a means capable of performing an individual authentication with low psychological resistance and difficulty of forgery by acquiring data satisfactorily reflecting the characteristic of an individual with good reproducibility while dispensing with or minimizing a maintenance and management work for preventing the contamination of a device. SOLUTION: In an individual authentication device using a vain pattern of a finger, the emission quantity of a light source is optimized on the basis of a taken finger image, and emphasis processing of the vain pattern is performed in an image operation for authentication. According to this, an individual authentication with low psychological resistance, difficulty of forgery and high authentication precision can be realized while dispensing with or minimizing the maintenance and management work for preventing an infection by contamination of the device or an error of acquired data. COPYRIGHT: (C)2004,JPO

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