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1. 发明专利

JP2007159491A Gene set used for testing colon cancer 有权
标题翻译：用于测试结肠癌的基因
公开(公告)号：JP2007159491A
公开(公告)日：2007-06-28
申请号：JP2005360974
申请日：2005-12-14
申请人： Canon Inc , Hitachi Ltd , National Cancer Center-Japan , キヤノン株式会社 , 国立がんセンター総長 , 株式会社日立製作所
发明人： MATSUMURA YASUHIRO , MATSUSHITA NAOYUKI , SASAKI HIROMI , YAJIMA SATOSHI , ISHII MIE , YAMAMOTO NOBUKO , KAWAGUCHI MASAHIRO , OKABE TETSUO , TSUNODA HIROYUKI , HARADA KUNIO
IPC分类号： C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/158 , C12Q2600/16
摘要： PROBLEM TO BE SOLVED: To provide a method for early diagnosis of colon cancer by which patients suffering from the colon cancer can be detected with high accuracy as compared with conventional methods. SOLUTION: There is provided the method for screening colon cancer cells in a specimen which is a smear of feces carried out by analyzing the expression levels of at least 2 or more species of genes selected from the genetic cluster having a specific base sequence by using the amount of an mRNA in the specimen or analyzing the expression levels of gene products by using an antibody against the gene products. Furthermore, a primer specifically amplifying the genes and a probe for detecting the genes specifically hybridizing with the genes are provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：与常规方法相比，提供一种可以高精度地检测结肠癌患者的结肠癌的早期诊断方法。提供了通过分析选自具有特定碱基序列的遗传簇中的至少2种或更多种基因的表达水平进行的粪便污迹的样品中筛选结肠癌细胞的方法。通过使用标本中的mRNA的量或通过使用针对基因产物的抗体来分析基因产物的表达水平。此外，提供了特异性扩增基因的引物和用于检测与基因特异性杂交的基因的探针。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2005241550A Excreta retrieval container 审中-公开
标题翻译： EXCRETA RETRIEVAL CONTAINER
公开(公告)号：JP2005241550A
公开(公告)日：2005-09-08
申请号：JP2004054346
申请日：2004-02-27
申请人： Hitachi Ltd , National Cancer Center-Japan , 国立がんセンター総長 , 株式会社日立製作所
发明人： MATSUMURA YASUHIRO , MATSUSHITA NAOYUKI , NOGUCHI KIYOTERU , OKANO KAZUNOBU , NAGAI KEIICHI , HARADA KUNIO , TSUNODA HIROYUKI , MITSUYAMA SATOSHI
IPC分类号： G01N33/48
摘要： PROBLEM TO BE SOLVED: To provide a simple retrieval container enabling a subject himself to retrieve the whole excreta.
SOLUTION: This excreta retrieval container has a liquid bag part 1 for storing sampled ordinary excreta, two collars 2, 3 provided so as to be expanded mutually on an opening part of the liquid bag part 1, an adhesive part 5 provided on parts of the collars 2, 3 in contact with buttocks, and a sealing part 6 provided along the periphery of the collars 2, 3, for preventing leak of the stored excreta by sealing the collars 2, 3.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供简单的检索容器，使得受试者能够检索整个排泄物。解决方案：这种排泄物检索容器具有用于储存取样的普通排泄物的液体袋部分1，在液体袋部分1的开口部分相互扩张设置的两个凸环2,3，设置在液体袋部分1的开口部分上的粘合部分5。与臀部接触的套环2,3的部分以及沿着套环2,3的周边设置的密封部6，用于通过密封套环2,3来防止储存的排泄物的泄漏。版权所有（C））2005年，日本特许厅和NCIPI

3. 发明专利

JP2005046065A Method and system for retrieving cell 有权
标题翻译：用于检测细胞的方法和系统
公开(公告)号：JP2005046065A
公开(公告)日：2005-02-24
申请号：JP2003281978
申请日：2003-07-29
申请人： Hitachi Ltd , National Cancer Center-Japan , 国立がんセンター総長 , 株式会社日立製作所
发明人： MATSUMURA YASUHIRO , MATSUSHITA NAOYUKI , TSUNODA HIROYUKI , HARADA KUNIO
IPC分类号： C12M1/00 , C12N1/02 , C12N5/06 , C12N5/08 , G01N33/574
CPC分类号： G01N33/574
摘要： PROBLEM TO BE SOLVED: To provide a method and a system for retrieving cells from excreta in order to examine colon cancer from the ordinary excreta of multispecimen. SOLUTION: The method for retrieving cancer cells comprises the step of preparing specimens obtained by adding a buffer solution at room temperature to a sampled ordinary excreta, the step of adsorbing cancer cells in the specimens freed from impurities to a solid carrier, and the step of retrieving the cancer cells thus adsorbed. The system for retrieving the cancer cells is also provided. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供从排泄物中回收细胞的方法和系统，以便从多特异性的普通排泄物检查结肠癌。解决方案：用于检索癌细胞的方法包括制备通过在室温下加入缓冲溶液至采样的普通排泄物而获得的标本的步骤，将免去杂质的样品中的癌细胞吸附至固体载体的步骤，以及检索这样吸附的癌细胞的步骤。还提供了用于检索癌细胞的系统。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2005241520A Excreta filtration device and excreta filtration method 审中-公开
标题翻译： EXCRETA过滤装置和EXCRETA过滤方法
公开(公告)号：JP2005241520A
公开(公告)日：2005-09-08
申请号：JP2004053615
申请日：2004-02-27
申请人： Hitachi Ltd , National Cancer Center-Japan , 国立がんセンター総長 , 株式会社日立製作所
发明人： MATSUMURA YASUHIRO , MATSUSHITA NAOYUKI , NOGUCHI KIYOTERU , OKANO KAZUNOBU , HARADA KUNIO , TSUNODA HIROYUKI , NAGAI KEIICHI , MITSUYAMA SATOSHI
IPC分类号： G01N33/48 , B04B3/00 , B04B7/00 , B04B7/08 , G01N1/10 , G01N1/28 , G01N33/574
摘要： PROBLEM TO BE SOLVED: To provide an excreta filtration device and an excreta filtration method used for retrieving cells from excreta in order to examine colon cancer from the ordinary excreta of multispecimen.
SOLUTION: This excreta filtration device has a circular cone-shaped or cylindrical filter 1 for filtering a mixture 7 of the ordinary excreta and buffer liquid, a support mechanism 2 having a porous or mesh structure where the filter 1 is mounted, a mechanism 5, 6 for rotating the filter 1 and the support mechanism 2, and a container 3 for sampling filtrate filtered by a centrifugal force provided on the peripheral part of the support mechanism 2.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供排泄物过滤装置和用于从排泄物中回收细胞的排泄物过滤方法，以便从多通道的普通排泄物检查结肠癌。解决方案：该排泄物过滤装置具有用于过滤普通排泄物和缓冲液的混合物7的圆锥形或圆柱形过滤器1，具有安装过滤器1的多孔或网状结构的支撑机构2，用于旋转过滤器1和支撑机构2的机构5,6以及用于对通过设置在支撑机构2的周边部分上的离心力过滤的滤液进行取样的容器3。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2006138815A Vessel for suspending and filtering fecal matter 有权
标题翻译：用于悬挂和过滤废物的船舶
公开(公告)号：JP2006138815A
公开(公告)日：2006-06-01
申请号：JP2004330949
申请日：2004-11-15
申请人： Hitachi Ltd , National Cancer Center-Japan , 国立がんセンター総長 , 株式会社日立製作所
发明人： MATSUMURA YASUHIRO , MATSUSHITA NAOYUKI , TSUNODA HIROYUKI , HARADA KUNIO , OKANO KAZUNOBU , NAGAI KEIICHI
IPC分类号： G01N33/48
CPC分类号： A61B10/0038 , A61B10/0096
摘要： PROBLEM TO BE SOLVED: To provide a vessel for suspending/filtering fecal matter for collecting peeled cancer cells in fecal matter rapidly, easily, and safely.
SOLUTION: A fecal matter treatment kit comprises a syringe 2 having a capacity for sampling 0.5 g or higher fecal matter by sticking the syringe 2 into the fecal matter (a); a grip 3 provided at a fecal matter collecting port and at the outer-periphery section of the syringe at the other end of the fecal matter collecting port; a fecal matter sampling vessel 1 made of a lid member 4 provided at the other end of the fecal matter collecting port; a syringe storage section 21 for storing the syringe (c); a suspension section 22 that is connected to the syringe storage section for suspending the fecal matter; a filtrate reception vessel 23 that is connected to the suspension section and can be separated, and receives the filtrate of the suspended and filtered fecal matter filtrate; a fecal matter treatment vessel body 20, comprising a filter 26 provided at the connection section between the suspension section and the filtrate reception vessel; and a push-out member 30 for moving the fecal matter sampled in the syringe in the fecal matter sampling container to the suspension section, by pushing down or breaking through the lid member.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供用于悬浮/过滤粪便物质的容器，用于快速，容易和安全地收集粪便中的去皮癌细胞。解决方案：粪便处理套件包括注射器2，其具有通过将注射器2粘贴到粪便物质（a）中来取样0.5g或更高粪便物质的能力; 在粪便收集口的另一端处设置在粪便收集口和注射器的外周部的手柄3; 由设置在粪便收集口的另一端的盖部件4构成的粪便取样器1; 用于储存注射器（c）的注射器存储部分21。连接到注射器存储部分用于悬浮粪便的悬挂部分22; 滤液接收容器23，其连接到悬浮部分并且可以分离，并接收悬浮和过滤的粪便滤液的滤液; 粪便处理容器主体20，包括设置在悬挂部分和滤液接收容器之间的连接部分处的过滤器26; 以及推出构件30，用于通过按压或打破盖构件，将粪便取样容器中的注射器中抽取的粪便移动到悬挂部分。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2005241543A Excreta container, cell retrieval device, excreta preservation kit and cell retrieval method 审中-公开
标题翻译： EXCRETA容器，细胞检索装置，EXCRETA保存袋和细胞检索方法
公开(公告)号：JP2005241543A
公开(公告)日：2005-09-08
申请号：JP2004054236
申请日：2004-02-27
申请人： Hitachi Ltd , National Cancer Center-Japan , 国立がんセンター総長 , 株式会社日立製作所
发明人： MATSUMURA YASUHIRO , MATSUSHITA NAOYUKI , NAGAI KEIICHI , OKANO KAZUNOBU , HARADA KUNIO , TSUNODA HIROYUKI , MITSUYAMA SATOSHI , NOGUCHI KIYOTERU
IPC分类号： G01N33/48
摘要： PROBLEM TO BE SOLVED: To provide an excreta container or the like for setting cytological examination as a series of processes wherein sampled ordinary excreta is mixed with buffer liquid, preserved and carried.
SOLUTION: This excreta container comprises a liquid bag part for storing the sampled ordinary excreta and the buffer liquid, and a sealing part provided on the periphery of an opening part of the liquid bag part. The excreta container has a stomacher part for mixing the ordinary excreta and the buffer liquid by hand rubbing or mechanical rubbing from the outside in the liquid bag part, and a cuttable or perforative excreta taking-out cutting part on the bottom part of the liquid bag.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供排泄物容器等用于将细胞学检查作为一系列方法进行，其中取样的普通排泄物与缓冲液混合，保存并携带。解决方案：这种排泄容器包括用于储存取样的普通排泄物和缓冲液的液体袋部分和设置在液体袋部分的开口部分周围的密封部分。排泄物容器具有用于通过手液摩擦或从液体袋部分的外部机械摩擦而混合普通排泄物和缓冲液的口腔部分，以及液袋的底部上的可切割或穿孔的排泄切割部分。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2008306976A Method for screening gene to be used in cancer examination, and gene set 有权
标题翻译：用于筛选在癌症检查和基因组中使用的基因的方法
公开(公告)号：JP2008306976A
公开(公告)日：2008-12-25
申请号：JP2007157478
申请日：2007-06-14
申请人： Canon Inc , National Cancer Center-Japan , キヤノン株式会社 , 国立がんセンター総長
发明人： ISHII MIE , YAMAMOTO NOBUKO , OKABE TETSUO , KAWAGUCHI MASAHIRO , SASAKI HIROMI , YAJIMA SATOSHI , MATSUMURA YASUHIRO , MATSUSHITA NAOYUKI
IPC分类号： C12Q1/06 , C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for early diagnosis of cancer, enabling cancer patients to be detected with higher accuracy, as compared with conventional methods.
SOLUTION: The method is constituted of processes which include using a gene set selected from among a group of genes whose expressions are confirmed in living normal cells and living cancer cells but are not confirmed in necrosed cells, a gene expression in cells retrieved from a relevant patient's feces is analyzed, thereby cancer cells are detected, without setting screening from normal cells.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：与传统方法相比，提供一种癌症早期诊断方法，能够更高精度地检测癌症患者。解决方案：该方法包括使用选自表达在活的正常细胞中表达的基因组和活细胞癌细胞中但在坏死细胞中未证实的基因组的过程，检索到的细胞中的基因表达从相关患者的粪便中分析，从而检测癌细胞，而不设定来自正常细胞的筛选。版权所有（C）2009，JPO＆INPIT

8. 发明专利

JP2010151677A Uterine cancer diagnosis method and uterine cancer diagnosis kit 审中-公开
标题翻译：子宫癌诊断方法和子宫癌诊断包
公开(公告)号：JP2010151677A
公开(公告)日：2010-07-08
申请号：JP2008331273
申请日：2008-12-25
申请人： National Cancer Center-Japan , Olympus Corp , オリンパス株式会社 , 国立がんセンター総長
发明人： KOBAYASHI TAMIYO , MURASE YUMI , MATSUMURA YASUHIRO , KOGA NOBUKATSU , YASUNAGA MASAHIRO
IPC分类号： G01N33/574 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide an uterine cancer diagnosis method, which is a cell base screening method for directly measuring and analyzing cervical cancer and body cancer cells, non-invasive, decreasing test load, and obtaining diagnosis result with high reliability, and a kit used in the diagnosis method.
SOLUTION: According to this uterine cancer diagnosis method, an uterine cancer is diagnosed according to whether an uterine cancer cell is contained in a living body sample. The method includes: (a1) a process of dyeing cells in the living body sample after being fixed in a cell observation container; and (b1) a process of acquiring a microscopic image of the cell dyed in the process (a1), and analyzing the image to detect an uterine cancer cell. The living body sample derives from a womb. A uterine cancer diagnosis kit is also provided which is used in the diagnosis method for the uterine cancer.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种子宫癌诊断方法，其是用于直接测量和分析子宫颈癌和体癌细胞的非侵入性，降低的测试负荷并获得具有高可靠性的诊断结果的细胞基础筛选方法，以及用于诊断方法的试剂盒。解决方案：根据该子宫癌诊断方法，根据子宫癌细胞是否含有活体样本来诊断子宫癌。该方法包括：（a1）固定在细胞观察容器中后，将活体样品中的细胞染色的工序; 和（b1）获得在步骤（a1）中染色的细胞的显微图像并分析该图像以检测子宫癌细胞的过程。活体样本来源于子宫。还提供了用于子宫癌诊断方法的子宫癌诊断试剂盒。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2010151678A Large intestine cancer diagnosis method and kit for large intestine cancer diagnosis 审中-公开
标题翻译：大肠癌诊断方法和大肠癌诊断试剂盒
公开(公告)号：JP2010151678A
公开(公告)日：2010-07-08
申请号：JP2008331274
申请日：2008-12-25
申请人： National Cancer Center-Japan , Olympus Corp , オリンパス株式会社 , 国立がんセンター総長
发明人： KOBAYASHI TAMIYO , MURASE YUMI , MATSUMURA YASUHIRO , KOGA NOBUKATSU , YASUNAGA MASAHIRO
IPC分类号： G01N33/574 , G01N21/78 , G01N33/53 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide a large intestine cancer diagnosis method and a kit for the large intestine cancer diagnosis, non-invasive, decreasing test load, and obtaining diagnosis result with high reliability, and a kit for the method.
SOLUTION: This large intestine cancer diagnosis method includes: a process (a-1) of adding a solid phase support to which a collecting antibody specifically coupled to a cell surface antigen appearing in common to a normal cell derived from a large intestine mucous and a large intestine cancer cell is coupled through a linker to a feces sample and mixing the same to form a large intestine cancer cell-collecting antibody-solid phase support complex; a process (a-2) of collecting the formed complex; a process (a-3) of separating the large intestine cancer cell in the collected complex from the solid phase support; a process (a-4) of fixing the obtained large intestine cancer cell in a cell observation container, and dyeing the same using a detecting antibody specifically coupled to the large intestine cancer cell; and a process (b) of acquiring a microscopic image of the dyed large intestine cancer cell and analyzing the image to detect a large intestine cancer cell. The linker is formed of protein G, protein A or DNA.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供大肠癌诊断方法和用于大肠癌诊断，非侵入性，降低试验负荷并获得高可靠性的诊断结果的试剂盒，以及该方法的试剂盒。解决方案：这种大肠癌诊断方法包括：添加固相支持物的方法（a-1），其中特异性偶联于来自大肠的正常细胞共同出现的细胞表面抗原的收集抗体粘液和大肠癌细胞通过接头与粪便样品偶联并混合，形成大肠癌细胞收集抗体 - 固相支持复合物; 收集形成的络合物的方法（a-2）将收集的复合物中的大肠癌细胞与固相载体分离的方法（a-3）将获得的大肠癌细胞固定在细胞观察容器中的方法（a-4），并使用与大肠癌细胞特异性结合的检测抗体对其进行染色; 以及获取染色的大肠癌细胞的显微图像并分析图像以检测大肠癌细胞的方法（b）。接头由蛋白G，蛋白A或DNA组成。版权所有（C）2010，JPO＆INPIT

10. 发明专利

JP2010180192A Therapeutic agent for urinary bladder cancer 有权
标题翻译：尿路癌癌症治疗药物
公开(公告)号：JP2010180192A
公开(公告)日：2010-08-19
申请号：JP2009027692
申请日：2009-02-09
申请人： National Cancer Center-Japan , Toto Ltd , Toto株式会社 , 国立がんセンター総長
发明人： KANEHIRA YUKITERU , SONEZAKI SHUJI , OGAMI ARIYOSHI , NAKAMURA TOMOMI , MATSUMURA YASUHIRO
IPC分类号： A61K41/00 , A61K9/16 , A61K39/395 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/32 , A61K47/34 , A61K47/42 , A61K47/48 , A61K49/00 , A61P13/10 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To provide a therapeutic agent for urinary bladder cancer which is a titanium oxide-antibody complex imparted with a selective binding ability without losing dispersibility and catalytic activity by modifying an antibody through a linker molecule binding a water-soluble polymer to a titanium oxide complex dispersed in an aqueous solvent with the water-soluble polymer without deteriorating the water-soluble polymer. SOLUTION: The therapeutic agent for the urinary bladder cancer includes: the titanium oxide complex having the water-soluble polymer bound through at least one functional group selected from the group consisting of carboxy, amino, diol, salicylic acid, and phosphoric acid to the surface of titanium oxide particles; the linker molecule bound to the surface thereof; and the antibody bound through the linker molecule. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种赋予选择性结合能力的钛氧化物 - 抗体复合物的尿液治疗剂，而不会通过结合水溶性的接头分子修饰抗体而丧失分散性和催化活性聚合物与水溶性聚合物分散在水性溶剂中的氧化钛络合物，而不会使水溶性聚合物劣化。解决方案：膀胱癌治疗剂包括：具有通过选自羧基，氨基，二醇，水杨酸和磷酸中的至少一个官能团结合的水溶性聚合物的二氧化钛络合物到氧化钛颗粒的表面; 连接分子与其表面结合; 并且抗体通过连接体分子结合。版权所有（C）2010，JPO＆INPIT

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