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1. 发明授权

US06217875B1 Inhibitors of lipoxygenase 失效
标题翻译：脂氧合酶抑制剂
公开(公告)号：US06217875B1
公开(公告)日：2001-04-17
申请号：US09053064
申请日：1998-04-01
申请人： Hiromichi Murai , Tadashi Okada , Hiroyo Yamamoto
发明人： Hiromichi Murai , Tadashi Okada , Hiroyo Yamamoto
IPC分类号： A61K3578
CPC分类号： A61K36/535 , A61K2300/00
摘要： Novel inhibitors of the enzyme action of lipoxygenase, especially 5-lipoxygenase and 12-lipoxygenase that are derived from the extraction of the seeds of the perilla (crispa) or perilla (frutescens) plant. These inhibitors are suitably extracted from these seeds using alcohol, preferably ethanol, to form an extract or more preferably to further extract the alcoholic extract with ethyl acetate and water to partition the active inhibitors to the ethyl acetate. The particularly preferred inhibitors are luteolin and chrysoeriol.
摘要翻译：脂肪氧合酶的酶作用的新型抑制剂，特别是从提取紫苏（紫菜）或紫苏（frutescens）植物的种子得到的5-脂氧合酶和12-脂氧合酶。使用醇，优选乙醇，适当地从这些种子中提取这些抑制剂以形成提取物，或更优选用乙酸乙酯和水进一步提取醇提取物，以将活性抑制剂分配至乙酸乙酯。特别优选的抑制剂是木犀草素和氯菊酯。

2. 发明授权

US06932990B2 Carbohydrate absorption inhibitor and method for manufacturing the same 失效
标题翻译：碳水化合物吸收抑制剂及其制造方法
公开(公告)号：US06932990B2
公开(公告)日：2005-08-23
申请号：US10343488
申请日：2001-07-26
申请人： Yotaro Konishi , Michio Aitani , Hiroshi Yamaguchi , Tsutomi Arimuba , Tadashi Okada , Hiromichi Murai
发明人： Yotaro Konishi , Michio Aitani , Hiroshi Yamaguchi , Tsutomi Arimuba , Tadashi Okada , Hiromichi Murai
IPC分类号： A61K36/185 , A61P3/04 , A61P3/08 , A61P3/10 , A61P43/00 , C07D311/62 , C07D493/06 , A61K35/78
CPC分类号： C07D493/06 , A61K36/185 , C07D311/62
摘要： This invention provides carbohydrate absorption inhibitor derived from evening primrose seed which is significantly effective to prevent and cure diabetes mellitus and prevent obesity, and the manufacturing method of the same.Carbohydrate absorption inhibitor in this invention is characterized that the effective component is an alcohol extract of evening primrose seed. The aforementioned evening primrose seed is preferably a defatted evening primrose seed. Extracting solvent of the aforementioned evening primrose seed is preferably ethanol, or preferably a 70 to 85% (v/v) aqueous ethanol. Also, this invention is characterized that the carbohydrate absorption inhibitor is an effective component of polyphenol derived from evening primrose seed. The polyphenol is preferably one or more substances selected from among gallic acid, ellagic acid, catechin, pentagalloylglucose, procyanidin, and proantocyanidin. The manufacturing method of the carbohydrate absorption inhibitor in this invention is characterized to be composed of the following processes A to C. Process A: evening primrose is compressed, oil is separated then the compressed cake is obtained. Process B: The aforementioned compressed cake is defatted in fat-soluble organic solvent, and defatted substance is obtained. Process C: The aforementioned defatted substance is extracted by alcohol, and then this extracted liquid is concentrated or evaporated.
摘要翻译：本发明提供了源自月见草种子的碳水化合物吸收抑制剂，其对于预防和治疗糖尿病并预防肥胖有显着的效果及其制造方法。本发明的碳水化合物吸收抑制剂的特征在于有效成分是月见草种子的醇提取物。上述的月见草种子优选是脱脂的月见草种子。上述月见草种子的提取溶剂优选为乙醇，优选70-85％（v / v）乙醇水溶液。此外，本发明的特征在于碳水化合物吸收抑制剂是源自月见草种子的多酚的有效成分。多酚优选为选自没食子酸，鞣花酸，儿茶素，五加酰基葡萄糖，原花青素和原花青素中的一种以上的物质。本发明的碳水化合物吸收抑制剂的制造方法的特征在于以下方法A〜C。方法A：将月见草被压缩，分离油分，得到压缩饼。方法B：将上述压缩饼在脂溶性有机溶剂中脱脂，得到脱脂物质。方法C：将上述脱脂物质用醇萃取，然后将该提取液浓缩或蒸发。

3. 发明授权

US08802164B2 Method for promoting carnitine palmitoyltransferase activity using green coffee bean extract 有权
标题翻译：使用绿咖啡豆提取物促进肉碱棕榈酰转移酶活性的方法
公开(公告)号：US08802164B2
公开(公告)日：2014-08-12
申请号：US13038513
申请日：2011-03-02
申请人： Hiroshi Shimoda , Michio Aitani , Tomoko Sugishita , Tadashi Okada , Hiromichi Murai , Emi Yamada
发明人： Hiroshi Shimoda , Michio Aitani , Tomoko Sugishita , Tadashi Okada , Hiromichi Murai , Emi Yamada
IPC分类号： A61K36/74
CPC分类号： A61Q19/00 , A23F5/02 , A61K8/97 , A61K36/74 , A61Q19/06
摘要： (PROBLEMS) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes. (MEANS FOR SOLVING PROBLEMS) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt/wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia. This dietetic composition is usable as a material for foods, drinks, drugs, or skin preparations for external use.
摘要翻译：（问题）提供源自绿咖啡豆的高度安全的饮食组合，通过该饮食组合可以获得优异的饮食效果，并且有助于预防和治疗诸如糖尿病的生活方式相关疾病。（解决问题的手段）一种饮食组合物，其特征在于，含有脱脂生咖啡豆的极性溶剂提取物作为活性成分。优选上述极性溶剂提取物是通过使用含水乙醇，更优选乙醇浓度为40〜90％（wt / wt）的含水乙醇得到的提取物。优选上述脱脂生咖啡豆是通过用N-己烷萃取生咖啡豆而得到的咖啡豆，从而分离出油性成分。建议将上述饮食组合物与选自沙拉提取物，月见草提取物，芝麻素和藤黄的一种或多种组合物组合。这种饮食组合物可用作食品，饮料，药物或外用皮肤制剂的材料。

4. 发明申请

US20090274777A1 Dietetic composition 审中-公开
标题翻译：饮食组成
公开(公告)号：US20090274777A1
公开(公告)日：2009-11-05
申请号：US10569970
申请日：2004-10-05
申请人： Hiroshi Shimoda , Michio Aitani , Tomoko Sugishita , Tadashi Okada , Hiromichi Murai , Emi Yamada
发明人： Hiroshi Shimoda , Michio Aitani , Tomoko Sugishita , Tadashi Okada , Hiromichi Murai , Emi Yamada
IPC分类号： A61K36/74 , A61P3/04
CPC分类号： A61Q19/00 , A23F5/02 , A61K8/97 , A61K36/74 , A61Q19/06
摘要： (Problems) To provide a highly safe dietetic composition originating in green coffee beans by which excellent dietetic effects can be obtained and which contributes to the prevention and treatment of life style-related diseases such as diabetes.(Means for Solving Problems) A dietetic composition characterized by comprising, as the active ingredient, a polar solvent extract of defatted green coffee beans. It is preferable that the above-described polar solvent extract is an extract obtained by using water-containing ethanol, still preferably water-containing ethanol having an ethanol concentration of from 40 to 90% (wt/wt). It is preferable that the above-described defatted green coffee beans are those obtained by extracting green coffee beans with N-hexane to thereby separate oily components therefrom. It is recommended to combine the above-described dietetic composition with one or more members selected from among salacia extract, evening primrose extract, sesamine and garcinia. This dietetic composition is usable as a material for foods, drinks, drugs, or skin preparations for external use.
摘要翻译：（问题）提供源自绿咖啡豆的高度安全的饮食组合，通过该饮食组合可以获得优异的饮食效果，并且有助于预防和治疗诸如糖尿病的生活方式相关疾病。（解决问题的手段）一种饮食组合物，其特征在于，含有脱脂生咖啡豆的极性溶剂提取物作为活性成分。优选上述极性溶剂提取物是通过使用含水乙醇，更优选乙醇浓度为40〜90％（wt / wt）的含水乙醇得到的提取物。优选上述脱脂生咖啡豆是通过用N-己烷萃取生咖啡豆而得到的咖啡豆，从而分离出油性成分。建议将上述饮食组合物与选自沙拉提取物，月见草提取物，芝麻素和藤黄的一种或多种组合物组合。这种饮食组合物可用作食品，饮料，药物或外用皮肤制剂的材料。

5. 发明申请

US20070154575A1 Anti-inflammatory agent 有权
标题翻译：抗炎剂
公开(公告)号：US20070154575A1
公开(公告)日：2007-07-05
申请号：US11585819
申请日：2006-10-25
申请人： Hiroshi Shimoda , Shaojie Shan , Junji Tanaka , Tadashi Okada , Hiromichi Murai
发明人： Hiroshi Shimoda , Shaojie Shan , Junji Tanaka , Tadashi Okada , Hiromichi Murai
IPC分类号： A61K36/906 , A61K31/7008 , A61K8/97
CPC分类号： A61K36/9068 , A61K31/7008 , A61K2300/00
摘要： This invention provides an anti-inflammatory agent or the like which is safer and less adverse and has the great effectiveness to prevent and treat arthritis, or the like. An anti-inflammatory agent or the like in this invention is characterized by comprising anthocyanidin and gingerol as an active substance. Also, the abovementioned anthocyanidin and gingerol are preferably extracted from red ginger.
摘要翻译：本发明提供了一种更安全，更不利且具有预防和治疗关节炎的有效性的抗炎剂等。本发明的抗炎剂等的特征在于，含有花色素和姜油作为活性物质。此外，上述花色素和姜油优选从红姜中提取。

6. 发明授权

US08017162B2 Anti-inflammatory agent 有权
标题翻译：抗炎剂
公开(公告)号：US08017162B2
公开(公告)日：2011-09-13
申请号：US11585819
申请日：2006-10-25
申请人： Hiroshi Shimoda , Shaojie Shan , Junji Tanaka , Tadashi Okada , Hiromichi Murai
发明人： Hiroshi Shimoda , Shaojie Shan , Junji Tanaka , Tadashi Okada , Hiromichi Murai
IPC分类号： A61K36/906 , A61K31/70
CPC分类号： A61K36/9068 , A61K31/7008 , A61K2300/00
摘要： This invention provides an anti-inflammatory agent or the like which is safer and less adverse and has the great effectiveness to prevent and treat arthritis, or the like. An anti-inflammatory agent or the like in this invention is characterized by comprising anthocyanidin and gingerol as an active substance. Also, the abovementioned anthocyanidin and gingerol are preferably extracted from red ginger.
摘要翻译：本发明提供了一种更安全，更不利且具有预防和治疗关节炎的有效性的抗炎剂等。本发明的抗炎剂等的特征在于，含有花色素和姜油作为活性物质。此外，上述花色素和姜油优选从红姜中提取。

7. 发明申请

US20060024396A1 Method of treating diabetes and obesity using carbohydrate absorption inhibitors 审中-公开
标题翻译：使用碳水化合物吸收抑制剂治疗糖尿病和肥胖的方法
公开(公告)号：US20060024396A1
公开(公告)日：2006-02-02
申请号：US10803873
申请日：2004-03-19
申请人： Yotaro Konishi , Michio Aitani , Hiroshi Yamaguchi , Tsutomu Arimura , Tadashi Okada , Hiromichi Murai
发明人： Yotaro Konishi , Michio Aitani , Hiroshi Yamaguchi , Tsutomu Arimura , Tadashi Okada , Hiromichi Murai
IPC分类号： A61K36/30
CPC分类号： C07D493/06 , A61K36/185 , C07D311/62
摘要： This invention provides carbohydrate absorption inhibitor derived from evening primrose seed which is significantly effective to prevent and cure diabetes mellitus and prevent obesity, and the manufacturing method of the same. Carbohydrate absorption inhibitor in this invention is characterized that the effective component is an alcohol extract of evening primrose seed. The aforementioned evening primrose seed is preferably a defatted evening primrose seed. Extracting solvent of the aforementioned evening primrose seed is preferably ethanol, or preferably a 70 to 85% (v/v) aqueous ethanol. Also, this invention is characterized that the carbohydrate absorption inhibitor is an effective component of polyphenol derived from evening primrose seed. The polyphenol is preferably one or more substances selected from among gallic acid, ellagic acid, catechin, pentagalloylglucose, procyanidin, and proantocyanidin. The manufacturing method of the carbohydrate absorption inhibitor in this invention is characterized to be composed of the following processes A to C. Process A: evening primrose is compressed, oil is separated then the compressed cake is obtained. Process B: The aforementioned compressed cake is defatted in fat-soluble organic solvent, and defatted substance is obtained. Process C: The aforementioned defatted substance is extracted by alcohol, and then this extracted liquid is concentrated or evaporated.
摘要翻译：本发明提供了源自月见草种子的碳水化合物吸收抑制剂，其对于预防和治疗糖尿病并预防肥胖有显着的效果及其制造方法。本发明的碳水化合物吸收抑制剂的特征在于有效成分是月见草种子的醇提取物。上述的月见草种子优选是脱脂的月见草种子。上述月见草种子的提取溶剂优选为乙醇，优选70-85％（v / v）乙醇水溶液。此外，本发明的特征在于碳水化合物吸收抑制剂是源自月见草种子的多酚的有效成分。多酚优选为选自没食子酸，鞣花酸，儿茶素，五加酰基葡萄糖，原花青素和原花青素中的一种以上的物质。本发明的碳水化合物吸收抑制剂的制造方法的特征在于以下方法A〜C。方法A：将月见草被压缩，分离油分，得到压缩饼。方法B：将上述压缩饼在脂溶性有机溶剂中脱脂，得到脱脂物质。方法C：将上述脱脂物质用醇萃取，然后将该提取液浓缩或蒸发。

8. 发明申请

US20080261896A1 Testosterone generating and metabolizing enhancer 审中-公开
标题翻译：睾酮产生和代谢增强剂
公开(公告)号：US20080261896A1
公开(公告)日：2008-10-23
申请号：US12081147
申请日：2008-04-11
申请人： Junji Tanaka , Hiroshi Shi-Moda , Shao-Jie Shan , Hiromichi Murai
发明人： Junji Tanaka , Hiroshi Shi-Moda , Shao-Jie Shan , Hiromichi Murai
IPC分类号： A61K31/70 , A61P3/00
CPC分类号： A61K31/70
摘要： A testosterone generating and metabolizing enhancer is proposed in the invention, which increases concentrations of testosterone in both seminal vesicle and bloodstream, and may further promote the gene expression of metabolizing testosterone into 5α-reductase of dihydrotestosterone. The testosterone generating and metabolizing enhancer of the invention is characterized in that an effective component thereof may be phenylethanoid glycosides; said phenylethanoid glycosides may comprise at least one of echinacoside and acteoside, or may comprise both echinacoside and acteoside, more preferably. The testosterone generating and metabolizing enhancer of the invention may be applied in medicines, substances for external uses on skin, and foods and beverages for mammals (including humans); as well as an animal feed for mammals.
摘要翻译：本发明提出了一种睾酮产生和代谢增强剂，其增加了精囊和血液中睾丸激素的浓度，并且可进一步促进代谢睾酮至二氢睾酮5α-还原酶的基因表达。本发明的睾酮产生和代谢增强剂的特征在于其有效成分可以是苯乙醇苷类; 所述苯乙糖苷类可以包含棘皮菊酯和肌动蛋白中的至少一种，或者更优选包含松果子苷和肌动蛋白。本发明的睾酮产生和代谢增强剂可以应用于药物，皮肤外用物质和哺乳动物（包括人）的食品和饮料中; 以及哺乳动物的动物饲料。

9. 发明申请

US20100208231A1 LIGHT WAVE DISTANCE MEASURING SYSTEM AND DISTANCE MEASURING DEVICE 审中-公开
标题翻译：光波距离测量系统和距离测量装置
公开(公告)号：US20100208231A1
公开(公告)日：2010-08-19
申请号：US12531403
申请日：2008-03-14
申请人： Hiromichi Murai
发明人： Hiromichi Murai
IPC分类号： G01C3/08
CPC分类号： G01S17/32 , G01C3/06 , G01S7/491
摘要： Object is to provide a light wave distance measuring system and a light wave distance measuring device which are capable of realizing prolonged measurable distance as well as improved distance measuring accuracy and which enable a distance measuring device to be constructed inexpensively.A light wave code-modulated with a first PN code is transmitted to a target to be distance-measured, and a second PN code which has the same sequence as that of the first PN code but which has a frequency slightly different from that of the first PN code, and a correlation value between the first PN code and the second PN code is converted into a waveform signal having a low frequency, and the light wave reflected from the target to be distance-measured is received by a light receiving element to which the second PN code is applied, and the received light wave is converted into a waveform signal having a low frequency, and a phase difference between the transmitting side correlation signal and the receiving side correlation signal is determined, and a distance to the target to be distance-measured is calculated from the phase difference.
摘要翻译：目的在于提供一种光波距离测量系统和光波距离测量装置，其能够实现长时间的可测量距离以及改进的距离测量精度，并且能够廉价地构造距离测量装置。用第一PN码进行码调制的光波被发送到要进行距离测量的目标，以及第二PN码，其具有与第一PN码相同的序列，但是具有与第一PN码和第一PN码与第二PN码之间的相关值被转换为具有低频的波形信号，并且从目标反射的待测距的光波被光接收元件接收到其中应用第二PN码，并将接收到的光波转换成具有低频的波形信号，并且确定发射侧相关信号和接收侧相关信号之间的相位差，并且确定到目标的距离距离测量由相位差计算。

10. 发明申请

US20130196937A1 AGE PRODUCTION INHIBITOR 审中-公开
标题翻译：年龄生产抑制剂
公开(公告)号：US20130196937A1
公开(公告)日：2013-08-01
申请号：US13576433
申请日：2011-02-10
申请人： Hiroshi Shimoda , Takashi Watanabe , Hiromichi Murai , Masayuki Yoshikawa
发明人： Hiroshi Shimoda , Takashi Watanabe , Hiromichi Murai , Masayuki Yoshikawa
IPC分类号： A61K31/7048 , A61Q19/08 , A61K8/60
CPC分类号： A61K36/736 , A23C9/13 , A23C2240/15 , A23G3/36 , A23G4/06 , A23L33/105 , A61K8/602 , A61K8/97 , A61K31/7024 , A61K31/7028 , A61K31/7032 , A61K31/7048 , A61K36/73 , A61K2236/30 , A61Q19/08 , C07H13/04 , C07H17/07
摘要： Disclosed is an AGE production inhibitor or the like, which effectively inhibits the production of an advanced glycation end product (AGE), while having improved biological safety. Specifically disclosed is an AGE production inhibitor or the like, which contains en extract of cherry tree (preferably blossoms or leaves thereof) and/or a processed product of the extract as an active substance. The AGE production inhibitor or the like contains, as an active substance, at least one compound that is selected from among 1-O-(E)-Caffeoyl-β-D-glucopyranoside, 1-O-(E)-Coumaroyl-β-D-glucopyranoside, 1-O-(E)-Cinnamoyl-β-D-glucopyranoside, Kaempferol 3-O-β-D-glucopyranoside, Quercetin 3-O-β-D-glucopyranoside, Kaempferol 3-O-(6″-malony)-β-D-glucopyranoside, and Quercetin 3-O-(6″-malony)-β-D-glucopyranoside.
摘要翻译：公开了AGE生产抑制剂等，其有效地抑制了晚期糖基化终产物（AGE）的生产，同时具有改善的生物安全性。具体公开的是AGE生产抑制剂等，其含有樱桃树（优选花朵或其叶）的提取物和/或作为活性物质的提取物的加工产物。 AGE生产抑制剂等含有至少一种选自1-O-（E） - 酰基-β-D-吡喃葡萄糖苷，1-O-（E） - 磺基酰基-β-D-吡喃葡萄糖苷的化合物作为活性物质 D-吡喃葡萄糖苷，1-O-（E） - 肉豆蔻基-β-D-吡喃葡萄糖苷，山奈酚3-O-β-D-吡喃葡萄糖苷，槲皮素3-O-β-D-吡喃葡萄糖苷，山奈酚3-O- ' - 马来酸）-β-D-吡喃葡萄糖苷和槲皮素3-O-（6“ - 苹果酸）-β-D-吡喃葡萄糖苷。

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