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1. 发明授权

US06932990B2 Carbohydrate absorption inhibitor and method for manufacturing the same 失效
标题翻译：碳水化合物吸收抑制剂及其制造方法
公开(公告)号：US06932990B2
公开(公告)日：2005-08-23
申请号：US10343488
申请日：2001-07-26
申请人： Yotaro Konishi , Michio Aitani , Hiroshi Yamaguchi , Tsutomi Arimuba , Tadashi Okada , Hiromichi Murai
发明人： Yotaro Konishi , Michio Aitani , Hiroshi Yamaguchi , Tsutomi Arimuba , Tadashi Okada , Hiromichi Murai
IPC分类号： A61K36/185 , A61P3/04 , A61P3/08 , A61P3/10 , A61P43/00 , C07D311/62 , C07D493/06 , A61K35/78
CPC分类号： C07D493/06 , A61K36/185 , C07D311/62
摘要： This invention provides carbohydrate absorption inhibitor derived from evening primrose seed which is significantly effective to prevent and cure diabetes mellitus and prevent obesity, and the manufacturing method of the same.Carbohydrate absorption inhibitor in this invention is characterized that the effective component is an alcohol extract of evening primrose seed. The aforementioned evening primrose seed is preferably a defatted evening primrose seed. Extracting solvent of the aforementioned evening primrose seed is preferably ethanol, or preferably a 70 to 85% (v/v) aqueous ethanol. Also, this invention is characterized that the carbohydrate absorption inhibitor is an effective component of polyphenol derived from evening primrose seed. The polyphenol is preferably one or more substances selected from among gallic acid, ellagic acid, catechin, pentagalloylglucose, procyanidin, and proantocyanidin. The manufacturing method of the carbohydrate absorption inhibitor in this invention is characterized to be composed of the following processes A to C. Process A: evening primrose is compressed, oil is separated then the compressed cake is obtained. Process B: The aforementioned compressed cake is defatted in fat-soluble organic solvent, and defatted substance is obtained. Process C: The aforementioned defatted substance is extracted by alcohol, and then this extracted liquid is concentrated or evaporated.
摘要翻译：本发明提供了源自月见草种子的碳水化合物吸收抑制剂，其对于预防和治疗糖尿病并预防肥胖有显着的效果及其制造方法。本发明的碳水化合物吸收抑制剂的特征在于有效成分是月见草种子的醇提取物。上述的月见草种子优选是脱脂的月见草种子。上述月见草种子的提取溶剂优选为乙醇，优选70-85％（v / v）乙醇水溶液。此外，本发明的特征在于碳水化合物吸收抑制剂是源自月见草种子的多酚的有效成分。多酚优选为选自没食子酸，鞣花酸，儿茶素，五加酰基葡萄糖，原花青素和原花青素中的一种以上的物质。本发明的碳水化合物吸收抑制剂的制造方法的特征在于以下方法A〜C。方法A：将月见草被压缩，分离油分，得到压缩饼。方法B：将上述压缩饼在脂溶性有机溶剂中脱脂，得到脱脂物质。方法C：将上述脱脂物质用醇萃取，然后将该提取液浓缩或蒸发。

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