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    • 1. 发明授权
    • Carbohydrate absorption inhibitor and method for manufacturing the same
    • 碳水化合物吸收抑制剂及其制造方法
    • US06932990B2
    • 2005-08-23
    • US10343488
    • 2001-07-26
    • Yotaro KonishiMichio AitaniHiroshi YamaguchiTsutomi ArimubaTadashi OkadaHiromichi Murai
    • Yotaro KonishiMichio AitaniHiroshi YamaguchiTsutomi ArimubaTadashi OkadaHiromichi Murai
    • A61K36/185A61P3/04A61P3/08A61P3/10A61P43/00C07D311/62C07D493/06A61K35/78
    • C07D493/06A61K36/185C07D311/62
    • This invention provides carbohydrate absorption inhibitor derived from evening primrose seed which is significantly effective to prevent and cure diabetes mellitus and prevent obesity, and the manufacturing method of the same.Carbohydrate absorption inhibitor in this invention is characterized that the effective component is an alcohol extract of evening primrose seed. The aforementioned evening primrose seed is preferably a defatted evening primrose seed. Extracting solvent of the aforementioned evening primrose seed is preferably ethanol, or preferably a 70 to 85% (v/v) aqueous ethanol. Also, this invention is characterized that the carbohydrate absorption inhibitor is an effective component of polyphenol derived from evening primrose seed. The polyphenol is preferably one or more substances selected from among gallic acid, ellagic acid, catechin, pentagalloylglucose, procyanidin, and proantocyanidin. The manufacturing method of the carbohydrate absorption inhibitor in this invention is characterized to be composed of the following processes A to C. Process A: evening primrose is compressed, oil is separated then the compressed cake is obtained. Process B: The aforementioned compressed cake is defatted in fat-soluble organic solvent, and defatted substance is obtained. Process C: The aforementioned defatted substance is extracted by alcohol, and then this extracted liquid is concentrated or evaporated.
    • 本发明提供了源自月见草种子的碳水化合物吸收抑制剂,其对于预防和治疗糖尿病并预防肥胖有显着的效果及其制造方法。 本发明的碳水化合物吸收抑制剂的特征在于有效成分是月见草种子的醇提取物。 上述的月见草种子优选是脱脂的月见草种子。 上述月见草种子的提取溶剂优选为乙醇,优选70-85%(v / v)乙醇水溶液。 此外,本发明的特征在于碳水化合物吸收抑制剂是源自月见草种子的多酚的有效成分。 多酚优选为选自没食子酸,鞣花酸,儿茶素,五加酰基葡萄糖,原花青素和原花青素中的一种以上的物质。 本发明的碳水化合物吸收抑制剂的制造方法的特征在于以下方法A〜C。方法A:将月见草被压缩,分离油分,得到压缩饼。 方法B:将上述压缩饼在脂溶性有机溶剂中脱脂,得到脱脂物质。 方法C:将上述脱脂物质用醇萃取,然后将该提取液浓缩或蒸发。
    • 2. 发明申请
    • Method of treating diabetes and obesity using carbohydrate absorption inhibitors
    • 使用碳水化合物吸收抑制剂治疗糖尿病和肥胖的方法
    • US20060024396A1
    • 2006-02-02
    • US10803873
    • 2004-03-19
    • Yotaro KonishiMichio AitaniHiroshi YamaguchiTsutomu ArimuraTadashi OkadaHiromichi Murai
    • Yotaro KonishiMichio AitaniHiroshi YamaguchiTsutomu ArimuraTadashi OkadaHiromichi Murai
    • A61K36/30
    • C07D493/06A61K36/185C07D311/62
    • This invention provides carbohydrate absorption inhibitor derived from evening primrose seed which is significantly effective to prevent and cure diabetes mellitus and prevent obesity, and the manufacturing method of the same. Carbohydrate absorption inhibitor in this invention is characterized that the effective component is an alcohol extract of evening primrose seed. The aforementioned evening primrose seed is preferably a defatted evening primrose seed. Extracting solvent of the aforementioned evening primrose seed is preferably ethanol, or preferably a 70 to 85% (v/v) aqueous ethanol. Also, this invention is characterized that the carbohydrate absorption inhibitor is an effective component of polyphenol derived from evening primrose seed. The polyphenol is preferably one or more substances selected from among gallic acid, ellagic acid, catechin, pentagalloylglucose, procyanidin, and proantocyanidin. The manufacturing method of the carbohydrate absorption inhibitor in this invention is characterized to be composed of the following processes A to C. Process A: evening primrose is compressed, oil is separated then the compressed cake is obtained. Process B: The aforementioned compressed cake is defatted in fat-soluble organic solvent, and defatted substance is obtained. Process C: The aforementioned defatted substance is extracted by alcohol, and then this extracted liquid is concentrated or evaporated.
    • 本发明提供了源自月见草种子的碳水化合物吸收抑制剂,其对于预防和治疗糖尿病并预防肥胖有显着的效果及其制造方法。 本发明的碳水化合物吸收抑制剂的特征在于有效成分是月见草种子的醇提取物。 上述的月见草种子优选是脱脂的月见草种子。 上述月见草种子的提取溶剂优选为乙醇,优选70-85%(v / v)乙醇水溶液。 此外,本发明的特征在于碳水化合物吸收抑制剂是源自月见草种子的多酚的有效成分。 多酚优选为选自没食子酸,鞣花酸,儿茶素,五加酰基葡萄糖,原花青素和原花青素中的一种以上的物质。 本发明的碳水化合物吸收抑制剂的制造方法的特征在于以下方法A〜C。方法A:将月见草被压缩,分离油分,得到压缩饼。 方法B:将上述压缩饼在脂溶性有机溶剂中脱脂,得到脱脂物质。 方法C:将上述脱脂物质用醇萃取,然后将该提取液浓缩或蒸发。
    • 8. 发明授权
    • Endoscope apparatus
    • 内窥镜装置
    • US09044163B2
    • 2015-06-02
    • US13306135
    • 2011-11-29
    • Hiroshi YamaguchiTakaaki Saito
    • Hiroshi YamaguchiTakaaki Saito
    • H04N7/18A61B5/1455A61B5/1459A61B1/00A61B1/06
    • A61B1/0653A61B1/00009A61B1/063A61B1/0638A61B5/14551A61B5/1459
    • The endoscope apparatus includes an illumination unit for irradiating at least three kinds of illumination light having different wavelengths including standard light, first and second reference light onto a biological object, a switching unit for periodically switching the illumination light, an imaging unit for capturing image data by the illumination light in each imaging frame, and an acquisition unit for acquiring biological function information from the captured image data. The irradiation order of illumination light is switched at least in order of the first reference light, the standard light and the second reference light, a standard image by the standard light and reference images by the reference light are acquired, and the biological function information is calculated based on the standard image and the reference images.
    • 所述内窥镜装置包括照射单元,用于将具有标准光,第一和第二参考光的不同波长的至少三种照明光照射到生物体上,用于周期性地切换照明光的切换单元,用于捕获图像数据的成像单元 通过每个成像帧中的照明光,以及用于从捕获的图像数据获取生物功能信息的获取单元。 照射光的照射次序至少按照第一参考光,标准光和第二参照光的顺序切换,通过标准光进行标准图像,并且获取参考光的参考图像,生物学功能信息是 基于标准图像和参考图像计算。