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1. 发明授权

US4229580A Preparation of 1-azolyl-3,3-dimethyl-1-phenoxy-butan-2-ones 失效
标题翻译： 1-噻唑基-3,3-二甲基-1-苯氧基 - 丁-2-酮的制备
公开(公告)号：US4229580A
公开(公告)日：1980-10-21
申请号：US885053
申请日：1978-03-09
申请人： Hermann Arold , Hans-Ludwig Elbe , Eckart Kranz , Wolfgang Kramer , Jorg Stetter , Claus Stolzer , Rudolf Thomas
发明人： Hermann Arold , Hans-Ludwig Elbe , Eckart Kranz , Wolfgang Kramer , Jorg Stetter , Claus Stolzer , Rudolf Thomas
IPC分类号： A01N43/50 , A01N43/836 , C07D233/60 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： In the reaction of 1-chloro-3,3-dimethylbutan-2-one with a phenol to form an ether-ketone, halogenating it to form a halogenoether-ketone and reacting it with imidazole or 1,2,4-triazole to form a 1-azolyl-3,3-dimethyl-1-phenoxybutan-2-one of the formula ##STR1## in which X is N or CH,n is an integer from 0 to 4, andY each independently is halogen, phenyl, phenoxy, nitro, alkyl, alkoxy or cycloalkyl,the improvement which comprises effecting all steps successively in an aromatic hydrocarbon or chlorinated aliphatic or aromatic hydrocarbon as solvent without intermediate isolation. The products are obtained in high yield.
摘要翻译：在1-氯-3,3-二甲基丁-2-酮与苯酚反应形成醚 - 酮的反应中，将其卤化形成卤代醚 - 酮并与咪唑或1,2,4-三唑反应形成其中X为N或CH，n为0至4的整数，并且Y各自独立地为卤素，苯基，环烷基，环烷基，苯氧基，硝基，烷基，烷氧基或环烷基，其改进包括在芳族烃或氯化脂族或芳族烃作为溶剂中连续进行所有步骤而不中间分离。以高产率获得产品。

2. 发明授权

US4388465A Preparation of phenoxy-azolyl-butanone derivatives 失效
标题翻译：苯氧基 - 唑基 - 丁酮衍生物的制备
公开(公告)号：US4388465A
公开(公告)日：1983-06-14
申请号：US300071
申请日：1981-09-08
申请人： Hans-Ludwig Elbe , Hermann Arold , Eckart Kranz , Claus Stolzer
发明人： Hans-Ludwig Elbe , Hermann Arold , Eckart Kranz , Claus Stolzer
IPC分类号： A01N43/50 , A01N43/653 , C07D233/60 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： In the preparation of a phenoxy-azolyl-butanone derivative of the formula ##STR1## in which X is a halogen atom,Y is a hydrogen or halogen atom, andAz is an imidazolyl radical or a 1,2,4-triazolyl radical,wherein dichloropinacolin of the formulaCl.sub.2 CH--CO--C(CH.sub.3).sub.3is reacted with an azole of the formulaAz--Hand a phenol of the formula ##STR2## in the presence of an acid-binding agent, the improvement which comprises carrying out the reaction in the presence of a water-immiscible organic solvent at a temperature between about 40.degree. and 150.degree. C., adding to the solvent at a temperature between about 0.degree. and +80.degree. C. a mineral acid, thereby to precipitate the mineral acid salt of the phenoxy-azolyl-butanone derivative, and separating such salt. Surprisingly the product does not hydrolyze when standing in contact with the mineral acid solution. The product is a known fungicide.
摘要翻译：在制备其中X是卤素原子的式“IMAGE”的苯氧基 - 唑基 - 丁酮衍生物的制备中，Y是氢或卤素原子，并且Az是咪唑基或1,2,4-三唑基，其中式Cl2CH-CO-C（CH3）3的二氯青霉素与酸结合剂存在下与式为Az-H的唑和式“IMAGE”的苯酚反应，其改进包括进行在与水不混溶的有机溶剂的存在下在约40℃至150℃的温度下反应，在约0℃至+ 80℃的温度下加入无机酸，从而沉淀出苯氧基 - 唑基 - 丁酮衍生物的无机酸盐，并分离此盐。令人惊讶的是，当与无机酸溶液接触时，产物不会水解。该产品是已知的杀真菌剂。

3. 发明授权

US4130607A Preparation of dithiophosphoric acid diester halides 失效
标题翻译：二硫代磷酸二酯卤化物的制备
公开(公告)号：US4130607A
公开(公告)日：1978-12-19
申请号：US830381
申请日：1977-09-02
申请人： Hermann Arold
发明人： Hermann Arold
IPC分类号： C07F9/20 , C07F9/206
CPC分类号： C07F9/20 , C07F9/206
摘要： A process for the preparation of a dithiophosphoric acid diester halide of the formula ##STR1## IN WHICH R.sup.1 and R.sup.2 each independently is alkyl with 1 to 5 carbon atoms, andHal is halogen, comprising reacting an S-alkyl dihalide of the formula ##STR2## WITH AN ALCOHOL OF THE FORMULAR.sup.2 OHat a temperature of about -5.degree. to -90.degree. C in the presence of about a 5 to 200% molar excess of potassium hydroxide. Advantageously about a 10 to 600% molar excess of alcohol is employed, R.sup.1 is n-propyl, R.sup.2 is ethyl, Hal is chlorine, and the reaction is effected in an aliphatic or aromatic optionally chlorinated hydrocarbon or an ether.
摘要翻译：制备下式的二硫代磷酸二酯卤化物的方法其中R 1和R 2各自独立地为具有1至5个碳原子的烷基，Hal为卤素，包括使式IMA图案的S-烷基二卤化物 >在约5至约200摩尔过量的氢氧化钾的存在下，在约-5至-90℃的温度下加入式R 2 OH的醇。有利地，使用约10至600％摩尔过量的醇，R 1为正丙基，R 2为乙基，Hal为氯，反应在脂族或芳族任选氯代烃或醚中进行。

4. 发明授权

US4091037A Preparation of alkylthiomethylphenols 失效
标题翻译：烷硫基甲基苯酚的制备
公开(公告)号：US4091037A
公开(公告)日：1978-05-23
申请号：US783370
申请日：1977-03-31
申请人： Hermann Arold
发明人： Hermann Arold
IPC分类号： C07C323/16 , C07C20060101 , C07C67/00 , C07C313/00 , C07C149/32 , C07C149/34 , C07C149/36
CPC分类号： C07C319/14
摘要： A process for the preparation of an alkylthiomethylphenol of the formula ##STR1## COMPRISING REACTING A DIALKYLAMINOMETHYLPHENOL OF THE FORMULA ##STR2## WITH A THIOCARBOXYLIC ACID S-ester of the formula ##STR3## in which R.sup.1 is optionally substituted alkyl with 1 to 12 carbon atoms or optionally substituted phenyl, R.sup.2 and R.sup.3 each independently is hydrogen, alkyl with 1 to 5 carbon atoms, halogen or nitro, or together form a benzene ring or cycloalkane ring with 3 to 5 carbon atoms which is fused to the phenyl ring,R.sup.4 and R.sup.5 each independently is alkyl with 1 to 6 carbon atoms, or together with the nitrogen atom form a five- or six-membered heterocyclic ring,R.sup.6 is hydrogen or alkyl with 1 to 6 carbon atoms, and n is 1, 2 or 3.The process may be carried out in a solvent, advantageously at a temperature from about 100.degree. to 150.degree. C, at about normal pressure using phenol as a catalyst with about 0.9 to 1.5 moles of thiocarboxylic acid S-ester per mole of dialkylaminomethylphenol.
摘要翻译：制备式（Ia）的烷基硫代甲基苯酚的方法包括用式“IMAGE”的硫代羧酸S-酯反应式II的二烷基氨基甲基苯酚的方法，其中R 1是具有1至12个碳原子的任选取代的烷基或任选取代的苯基，R 2和R 3各自独立地为氢，具有1至5个碳原子的烷基，卤素或硝基，或一起形成具有3至5个碳原子的苯环或环烷烃环，其与苯环稠合，R4和 R5各自独立地为具有1至6个碳原子的烷基，或与氮原子一起形成五元或六元杂环，R 6为氢或具有1至6个碳原子的烷基，n为1,2或3。

5. 发明授权

US4824960A Preparation of 1-aryl-5-amino-pyrazoles 失效
标题翻译： 1-芳基-5-氨基 - 吡唑的制备
公开(公告)号：US4824960A
公开(公告)日：1989-04-25
申请号：US34300
申请日：1987-04-03
申请人： Bernd Gallenkamp , Hermann Arold
发明人： Bernd Gallenkamp , Hermann Arold
IPC分类号： C07B61/00 , B01J31/00 , B01J31/02 , B01J31/04 , C07D231/06 , C07D231/38 , C07D401/04
CPC分类号： C07D231/38 , C07D401/04
摘要： A process for the preparation of a 1-aryl-5-amino-pyrazole of the formula ##STR1## in which Ar is in each case optionally substituted phenyl or pyridyl, comprising reacting an arylhydrazine of the formulaAr--NH--NH.sub.2with acrylonitrile of the formulaCH.sub.2 .dbd.CH--CNin a first stage in the presence of a diluent at a temperature between about 20.degree. C. and 100.degree. C. to form the arylhydrazine derivative of the formulaAr--NH--NH--CH.sub.2 --CH.sub.2 --CN, andin a second stage contacting such derivative with an oxidizing agent in the presence of a base at a temperature between about 0.degree. C. and 60.degree. C., thereby to effect oxidation and cyclization. The products are known intermediates for herbicides and insecticides.
摘要翻译：制备式“IMAGE”的1-芳基-5-氨基吡唑的方法，其中Ar各自为任选取代的苯基或吡啶基，包括使式Ar-NH-NH 2的芳基肼与在稀释剂存在下，在约20℃至100℃之间的第一阶段中，CH 2 = CH-CN的式CH = CN，形成式Ar-NH-NH-CH 2 -CH 2 CN的芳基肼衍生物，并且在第二阶段中，在约0℃至60℃的温度下，在碱的存在下，使这种衍生物与氧化剂接触，从而进行氧化和环化。该产品是除草剂和杀虫剂的已知中间体。

6. 发明授权

US4154780A Preparation of dithiophosphoric acid diester-halides 失效
标题翻译：二硫代磷酸二酯 - 卤化物的制备
公开(公告)号：US4154780A
公开(公告)日：1979-05-15
申请号：US783371
申请日：1977-03-31
申请人： Reimer Colln , Hermann Arold , Vidyanatha A. Prasad
发明人： Reimer Colln , Hermann Arold , Vidyanatha A. Prasad
IPC分类号： B01J31/00 , B32B27/00 , C07B61/00 , C07F9/20
CPC分类号： C07F9/20 , B32B27/00
摘要： A process for the preparation of a dithiophosphoric acid diester-halide of the formula ##STR1## IN WHICH R.sup.1 is alkyl with 1 to 10 carbon atoms, aralkyl with 1 to 6 carbon atoms in the alkyl radical, or alkoxyalkyl or alkylthioalkyl with 1 to 5 carbon atoms in each alkyl radical,R.sup.2 is alkyl with 1 to 8 carbon atoms, andHal is halogen,Which comprises reacting an S-alkyl or S-aralkyl ester of a dithiophosphoric acid dihalide of the formula ##STR2## WITH ABOUT A 5 TO 300% MOLAR EXCESS OF AN ALCOHOL OF THE FORMULAR.sup.2 OHin the presence of about a 5 to 300% molar excess of a tertiary pyridine base or tertiary aralkyl-alkylamine at a temperature between about -10.degree. and +60.degree. C. Advantageously the tertiary base is pyridine, 2-, 3- or 4-methyl-pyridine, 4-ethyl-pyridine, 5-ethyl-2-methyl-pyridine, 2,4- or 2,6-dimethyl-pyridine, 2,4,6-trimethyl-pyridine, quinoline, isoquinoline, 2-, 4- or 6-methyl-quinoline, 6-chloro-2-methyl-quinoline, 2-chloro-4-methyl-quinoline, 8-chloro-2-methyl-quinoline or dimethylbenzylamine, the reaction is carried out at about 0.degree. to 30.degree. C., the alcohol is ethanol employed in about a 15 to 30% molar excess, about a 20 to 210% molar excess of the tertiary base is employed, R.sup.1 is alkyl with 1 to 8 carbon atoms, aralkyl with 1 to 3 carbon atoms in the alkyl radical, or alkoxyalkyl or alkylthioalkyl with 1 to 3 carbon atoms in each alkyl radical and Hal is chlorine.
摘要翻译：一种制备下式的二硫代磷酸二酯 - 卤化物的方法，其中R1是具有1-10个碳原子的烷基，在烷基中具有1-6个碳原子的芳烷基，或具有1-5个碳原子的烷氧基烷基或烷硫基烷基每个烷基中的碳原子，R 2是具有1至8个碳原子的烷基，Hal是卤素，其包含反应式为“A”的二硫代磷酸二卤化物的S-烷基或S-芳烷基酯在约5-10％摩尔过量的叔吡啶碱或叔芳烷基 - 烷基胺的存在下，在约-10℃和+ 60℃之间的温度下，在摩尔过量的情况下，300摩尔过量的式碱是吡啶，2-，3-或4-甲基 - 吡啶，4-乙基 - 吡啶，5-乙基-2-甲基 - 吡啶，2,4-或2,6-二甲基 - 吡啶，2,4,6 - 三甲基 - 吡啶，喹啉，异喹啉，2-，4-或6-甲基 - 喹啉，6-氯-2-甲基 - 喹啉，2-氯-4-甲基 - 喹啉，8-氯-2-甲基 - 喹啉 e或二甲基苄胺，反应在约0℃至30℃进行，醇为约15至30摩尔过量的乙醇，约20至210摩尔过量的叔碱，R1 具有1至8个碳原子的烷基，在烷基中具有1至3个碳原子的芳烷基，或每个烷基中具有1至3个碳原子的烷氧基烷基或烷硫基烷基，Hal为氯。

7. 发明授权

US5962724A High enantio-selective process for producing pure enantiomeric cyclopentane and cyclopentene-(.beta.)-amino acids 失效
标题翻译：用于生产纯对映异构体环戊烷和环戊烯 - （β） - 氨基酸的高对映选择性方法
公开(公告)号：US5962724A
公开(公告)日：1999-10-05
申请号：US666492
申请日：1996-07-05
申请人： Joachim Mittendorf , Hermann Arold , Peter Fey , Michael Matzke , Hans-Christian Militzer , Klaus-Helmut Mohrs
发明人： Joachim Mittendorf , Hermann Arold , Peter Fey , Michael Matzke , Hans-Christian Militzer , Klaus-Helmut Mohrs
IPC分类号： C07D307/93 , C07C61/35 , C07C67/08 , C07C69/608 , C07C69/74 , C07C69/753 , C07C69/757 , C07C227/32 , C07C229/28 , C07C229/48 , C07C231/02 , C07C231/18 , C07C233/00 , C07C233/58 , C07C255/14 , C07C271/24 , C07D453/00 , C07D453/04 , C07F7/08
CPC分类号： C07C229/48 , C07C227/32 , C07C271/24 , C07C69/74 , C07C2101/08 , Y02P20/55
摘要： The present invention relates to a highly enantioselective process for the preparation of enantiomerically pure cyclopentane- and -pentene .beta.-amino acids of the general formula (I) ##STR1## in which A and L, A and D or E and L, D and E, R.sup.2, R.sup.3, T and R.sup.1 have the meaning given in the description.
摘要翻译： PCT No.PCT / EP95 / 00059 Sec。 371日期：1996年7月5日 102（e）日期1996年7月5日PCT 1995年1月9日PCT PCT。 WO95 / 19337 PCT公开号日期：1995年7月20日本发明涉及用于制备通式（I）的对映体纯的环戊烷 - 和戊烯β-氨基酸的高度对映选择性方法，其中A和L，A和D或E和L， D和E，R2，R3，T和R1具有说明书中给出的含义。

8. 发明授权

US4769458A Process for the preparation of phosphoric acid derivatives and intermediate products 失效
标题翻译：磷酸衍生物和中间产物的制备方法
公开(公告)号：US4769458A
公开(公告)日：1988-09-06
申请号：US925200
申请日：1986-10-31
申请人： Hermann Arold , Fritz Maurer
发明人： Hermann Arold , Fritz Maurer
IPC分类号： A01N57/08 , C07D239/34 , C07D239/36 , C07D239/46 , C07D239/48 , C07D239/52 , C07D239/54 , C07D239/553 , C07D239/56 , C07D239/60 , C07F9/6512 , C07F9/65
CPC分类号： C07D239/34 , A01N57/08 , C07D239/36 , C07D239/47 , C07D239/48 , C07D239/52 , C07D239/553 , C07D239/56 , C07D239/60 , C07F9/65125
摘要： The process which comprises ##STR1## in which R represents hydrogen, alkoxy, alkylamino or dialkylamino or represents optionally substituted radicals from the series comprising alkyl, cycloalkyl and aryl,R.sup.1 represents optionally substituted radicals from the series comprising alkyl, alkoxy, alkylthio, mono- or dialkylamino and phenyl,R.sup.2 represents optionally substituted alkyl,R.sup.3 represents alkyl, alkoxy or aryl,X represents oxygen or sulphur, andY represents halogen or a grouping --OCOR.sup.3.The intermediates do not have to be isolated. Some are new compounds.
摘要翻译：其中R代表氢，烷氧基，烷基氨基或二烷基氨基，或代表从包含烷基，环烷基和芳基的系列中任选取代的基团的方法，其包含 R 1表示任选取代的烷基，R 3表示烷基，烷氧基或芳基，X表示氧或硫，Y表示卤素或分组 - 取代的烷基，烷氧基，烷硫基， OCOR3。中间体不必孤立。有些是新化合物。

9. 发明授权

US4082822A Preparation of dithiophosphoric acid ester dihalides 失效
标题翻译：二氢磷酸酯二糖的制备
公开(公告)号：US4082822A
公开(公告)日：1978-04-04
申请号：US704254
申请日：1976-07-12
申请人： Hans-Joachim Diehr , Hermann Arold
发明人： Hans-Joachim Diehr , Hermann Arold
IPC分类号： B01J21/00 , B01J23/00 , B01J27/00 , B01J31/00 , C07B61/00 , C07F9/20 , C07F9/6512 , C07F9/58 , C07F9/65
CPC分类号： C07F9/20
摘要： A process for the preparation of a dithiophosphoric acid ester dihalide of the formula ##STR1## in which X is chlorine, bromine, fluorine or iodine, andR is an alkyl radical with up to 15 carbon atoms optionally substituted by halogen, by alkoxy or by alkylthio, a cycloaliphatic radical with 5 or 6 ring members, an aralkyl radical with 7 to 15 carbon atoms or an aryl or heterocyclic radical,Comprising reacting a thiol compound of the formulaR--SHwith a thiophosphoryl halide of the formulaPSX.sub.3in the presence of a catalyst selected from the group consisting of a metal, an anhydrous metal halide, a Lewis acid, a nitrogen-alkylated lactam or an N,N-disubstituted carboxylic acid amide or phosphoric acid amide at a temperature of about 0.degree. to 170.degree. C.

10. 发明授权

US4337359A Preparation of dimethyl polysulphides 失效
标题翻译：二甲基多硫化物的制备
公开(公告)号：US4337359A
公开(公告)日：1982-06-29
申请号：US249241
申请日：1981-03-30
申请人： Hermann Arold , Siegbert Humburger , Hans-Joachim Diehr , Helmut Porkert
发明人： Hermann Arold , Siegbert Humburger , Hans-Joachim Diehr , Helmut Porkert
IPC分类号： C07C67/00 , C07C313/00 , C07C319/22 , C07C321/14 , C07F9/165 , C07C148/00
CPC分类号： C07C319/22
摘要： A process for the preparation of a dimethyl polysulphide of the formulaCH.sub.3 --S.sub.x --CH.sub.3in whichx is at least 1, comprising reacting a polysulphide of the formulaM.sub.y S.sub.xin whichM represents an alkali metal atom or alkaline earth metal atom, andy is 1 or 2, with O,O,O-trimethyl thiophosphate of the formula(CH.sub.3 O).sub.3 P.dbd.S.
摘要翻译：一种制备式为CH3-Sx-CH3的二甲基多硫化物的方法，其中x至少为1，包括使式MySx的多硫化物反应，其中M表示碱金属原子或碱土金属原子，y为 1或2，其中式（CH 3 O）3 P = S的O，O，O-三甲基硫代磷酸酯。

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