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1. 发明授权

US4730003A Tricyclic compounds for treating heart and circulatory diseases 失效
标题翻译：用于治疗心脏和循环系统疾病的三环化合物
公开(公告)号：US4730003A
公开(公告)日：1988-03-08
申请号：US904094
申请日：1986-09-04
申请人： Wolfgang von der Saal , Alfred Mertens , Herbert Berger , Bernd Muller-Beckmann
发明人： Wolfgang von der Saal , Alfred Mertens , Herbert Berger , Bernd Muller-Beckmann
IPC分类号： A61K31/41 , A61K31/415 , A61K31/42 , A61P9/00 , C07D487/04 , C07D487/10 , C07D498/04 , C07D498/10 , C07D513/04 , C07D513/10
CPC分类号： C07D487/04 , C07D487/10 , C07D513/04 , C07D513/10
摘要： The present invention provides compounds of the general formula: ##STR1## wherein the various substituents are defined hereinbelow. The compounds are used for the treatment and/or prophylaxis of heart and circulatory diseases.
摘要翻译：本发明提供以下通式的化合物：其中各种取代基如下文所定义。该化合物用于治疗和/或预防心脏和循环系统疾病。

2. 发明授权

US4321194A N-Substituted aziridine-2-carboxylic acid derivatives for immuno stimulation 失效
标题翻译： N-取代的氮丙啶-2-羧酸衍生物用于免疫刺激
公开(公告)号：US4321194A
公开(公告)日：1982-03-23
申请号：US59863
申请日：1979-07-23
申请人： Elmar Bosies , Herbert Berger , Wolfgang Kampe , Uwe Bicker , Alfred Grafe
发明人： Elmar Bosies , Herbert Berger , Wolfgang Kampe , Uwe Bicker , Alfred Grafe
IPC分类号： C07D203/08 , A61K31/395 , A61K31/396 , A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P37/04 , C07D203/06 , C07D401/04 , C07D403/06 , C07D405/04 , C07D409/04 , C07D203/10 , C07D203/12 , C07D203/14
CPC分类号： C07D203/06 , Y10S514/885
摘要： Aziridine-2-carboxylic acid derivatives of the formula ##STR1## wherein X is a carboxyl, nitrile, alkoxycarbonyl or carbamoyl group, andR and R.sup.1 are various organic radicals, or pharmacologically acceptable salts thereof, exhibit marked immunostimulant activity, especially in conjunction with added chemotherapeutic agents such as a penicillin, a cephalosporin, a nitrofuran or chloramphenicol. Those compounds are new where X is a cyano group or an alkoxycarbonyl radical and R.sub.1 is a hydrogen atom, but R' is not an unsubstituted alkyl radical or an alkyl radical substituted by hydroxyl, alkoxy, dialkylamino, phenyl, 4-chlorophenyl or 4-methoxyphenyl or a vinyl radical substituted by a phenyl or methyl radical, or a cycloalkyl radical, a phenyl a 4-chlorophenyl, a 4-methoxyphenyl, an s-triazinyl or a pyridinyl radical; or where X is a carbamoyl group and R.sub.1 is a hydrogen atom, R' is not an unsubstituted cyclohexyl, alkyl or benzyl radical; or where X is a cyano group or an alkoxycarbonyl radical and R.sub.1 is a phenyl radical, R' is not an isopropyl, cyclohexyl, phenyl, benzyl or p-chlorobenzyl radical; or where R.sub.1 is a methyl radical, R.sup.1 is not a benzyl, p-chloro- or p- methoxybenzyl radical.
摘要翻译：其中X是羧基，腈，烷氧基羰基或氨基甲酰基的氮杂环丁烷-2-羧酸衍生物，R和R 1是各种有机基团或其药理学上可接受的盐，具有显着的免疫刺激活性，特别是与添加化学治疗剂如青霉素，头孢菌素，硝基呋喃或氯霉素。那些化合物是新的，其中X是氰基或烷氧基羰基，R 1是氢原子，但R'不是未取代的烷基或被羟基，烷氧基，二烷基氨基，苯基，4-氯苯基或4- 甲氧基苯基或被苯基或甲基取代的乙烯基，或环烷基，苯基，4-氯苯基，4-甲氧基苯基，s-三嗪基或吡啶基; 或其中X为氨基甲酰基，R 1为氢原子，R'为未取代的环己基，烷基或苄基; 或其中X为氰基或烷氧基羰基，R 1为苯基，R'不为异丙基，环己基，苯基，苄基或对氯苄基; 或其中R 1是甲基，R 1不是苄基，对氯或对甲氧基苄基。

3. 发明授权

US4835280A Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles 失效
标题翻译：用于合成药物活性吡咯并苯并咪唑的二氢吲哚化合物
公开(公告)号：US4835280A
公开(公告)日：1989-05-30
申请号：US72917
申请日：1987-07-14
申请人： Alfred Martens , Jens-Peter Holck , Herbert Berger , Bernd Muller-Beckman , Klaus Strein , Egon Roesch
发明人： Alfred Martens , Jens-Peter Holck , Herbert Berger , Bernd Muller-Beckman , Klaus Strein , Egon Roesch
IPC分类号： C07D403/12 , C07D405/12 , C07D487/04
CPC分类号： C07D403/12 , C07D405/12 , C07D487/04
摘要： The present invention provides Indolines of the formula: ##STR1## ps useful to provide pharmaceutically active pyrrolobenzimidazoles or tautomers thereof, of the formula: These compounds are useful for treating heart or circulatory diseases, especially those which respond to a change of blood pressure, an increase in cardiac output and/or a change in micro-circulation.
摘要翻译：本发明提供下式的吲哚衍生物：下式的有用的药物活性吡咯并苯并咪唑或其互变异构体：（I）这些化合物可用于治疗心脏或循环系统疾病，特别是那些对血压变化作出反应，心输出量增加和/或微循环变化的疾病。

4. 发明授权

US4410532A N-Substituted aziridine-2-carboxylic acid derivatives and their immuno-stimulation compositions and methods 失效
标题翻译： N-取代的氮丙啶-2-羧酸衍生物及其免疫刺激组合物和方法
公开(公告)号：US4410532A
公开(公告)日：1983-10-18
申请号：US334614
申请日：1981-12-28
申请人： Elmar Bosies , Herbert Berger , Wolfgang Kampe , Uwe Bicker , Alfred Grafe
发明人： Elmar Bosies , Herbert Berger , Wolfgang Kampe , Uwe Bicker , Alfred Grafe
IPC分类号： C07D203/08 , A61K31/395 , A61K31/396 , A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P37/04 , C07D203/06 , C07D401/04 , C07D403/06 , C07D405/04 , C07D409/04 , C07D213/36
CPC分类号： C07D203/06 , Y10S514/885
摘要： A 2-cyanaziridine derivative of the formula ##STR1## wherein R' is a straight-chained or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon radical with up to 8 carbon atoms, which is substituted by an aromatic nitrogen-containing heterocyclic radical with 5 or 6 ring-members and 1, 2 or 3 nitrogen atoms optionally substituted by halogen, alkoxy with up to 8 carbon atoms, alkyl with up to 8 carbon atoms, hydroxyl, carbalkoxy with up to 9 carbon atoms, carbamoyl, dialkylamino the alkyl moieties of which having up to 8 carbon atoms, cycloalkylamino, the cycloalkyl moiety having 3-10 carbon atoms, acetylamino, nitro, cyano, acetyl, alkylthio with up to 8 carbon atoms, alkylsulphinyl with up to 8 carbon atoms, alkylsulphonyl with up to 8 carbon atoms, sulphamoyl, phenyl, trifluoromethyl, phenoxy, acetoxy or methylenedioxy;or a pharmacologically acceptable salt thereof, exhibits immune stimulating activity.
摘要翻译：具有式“IMAGE”的2-氰基氮丙啶衍生物，其中R'是具有至多8个碳原子的直链或支链，饱和或单或多不饱和脂族烃基，其被含芳族含氮杂环基团取代， 5或6个环成员和1,2或3个任选被卤素取代的氮原子，具有至多8个碳原子的烷氧基，至多8个碳原子的烷基，羟基，至多9个碳原子的烷氧基，氨基甲酰基，二烷基氨基烷基其具有至多8个碳原子的部分，环烷基氨基，具有3-10个碳原子的环烷基部分，乙酰氨基，硝基，氰基，乙酰基，具有至多8个碳原子的烷硫基，具有至多8个碳原子的烷基亚磺酰基，烷基磺酰基， 8个碳原子，氨磺酰基，苯基，三氟甲基，苯氧基，乙酰氧基或亚甲二氧基; 或其药理学上可接受的盐显示免疫刺激活性。

5. 发明授权

US3995040A Cyclopenteno-3-carboxyl-4-quinolone derivatives and their bacteriostatic compositions 失效
标题翻译：环戊烯-3-羧基-4-喹诺酮衍生物及其抑菌组合物
公开(公告)号：US3995040A
公开(公告)日：1976-11-30
申请号：US595929
申请日：1975-07-14
申请人： Alfred Rhomberg , Herbert Berger , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
发明人： Alfred Rhomberg , Herbert Berger , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
IPC分类号： C07D221/16 , C07D215/56
CPC分类号： C07D221/16
摘要： New cyclopenteno-quinolone derivatives of the formula ##SPC1##WhereinR is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.
摘要翻译：式WHEREIN R的新的环戊烯 - 喹诺酮衍生物是饱和或不饱和的脂族烃基，例如烷基和烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代或取代的（例如烷基单取代或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

6. 发明申请

US20070158474A1 Dispensing adapter 审中-公开
标题翻译：分配适配器
公开(公告)号：US20070158474A1
公开(公告)日：2007-07-12
申请号：US11563370
申请日：2006-11-27
申请人： Herbert Berger
发明人： Herbert Berger
IPC分类号： B05B1/18 , B05B1/26
CPC分类号： B05C17/00516 , B05B15/652
摘要： In a dispensing adapter (1) for cartridges, cans or tubes adapted for storing and metered dispensing of highly viscous materials, in particular liquids such as adhesives, sealants, foamed-in plastics or the like, through a nozzle head, the nozzle head of the metering nozzle (6, 17) has several spaced-apart openings (7, 25) for discharge of the material.
摘要翻译：在用于盒，罐或管的分配适配器（1）中，适用于通过喷嘴头存储和计量分配高粘度材料，特别是液体，例如粘合剂，密封剂，泡沫塑料等，喷嘴头计量喷嘴（6,17）具有用于排出材料的几个间隔开的开口（7,25）。

7. 发明授权

US4409236A N-Substituted aziridine-2-carboxylic acid derivatives and immuno-stimulation composition and method 失效
标题翻译： N-取代的氮丙啶-2-羧酸衍生物和免疫刺激组合物和方法
公开(公告)号：US4409236A
公开(公告)日：1983-10-11
申请号：US268964
申请日：1981-06-01
申请人： Elmar Bosies , Herbert Berger , Wolfgang Kampe , Uwe Bicker , Alfred Grafe
发明人： Elmar Bosies , Herbert Berger , Wolfgang Kampe , Uwe Bicker , Alfred Grafe
IPC分类号： C07D203/08 , A61K31/395 , A61K31/396 , A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P37/04 , C07D203/06 , C07D401/04 , C07D403/06 , C07D405/04 , C07D409/04 , C07D333/30
CPC分类号： C07D203/06 , Y10S514/885
摘要： Aziridine-2-carboxylic acid derivatives of the formula ##STR1## wherein X is a carboxyl, nitrile, alkoxycarbonyl or carbamoyl group, andR and R.sup.1 are various organic radicals; or pharmacologically acceptable salts thereof, exhibit marked immunostimulant activity, especially in conjunction with added chemotherapeutic agents such as a penicillin, a cephalosporin, a nitrofuran or chloramphenicol. Those compounds are new where X is a cyano group or an alkoxycarbonyl radical and R.sub.1 is a hydrogen atom, but R' is not an unsubstituted alkyl radical or an alkyl radical substituted by hydroxyl, alkoxy, dialkylamino, phenyl, 4-chlorophenyl or 4-methoxyphenyl or a vinyl radical substituted by a phenyl or methyl radical, or a cycloalkyl radical, a phenyl, a 4-chlorophenyl, a 4-methoxyphenyl, an s-triazinyl or a pyridinyl radical; or where X is a carbamoyl group and R.sub.1 is a hydrogen atom, R' is not an unsubstituted cyclohexyl, alkyl or benzyl radical; or where X is a cyano group or an alkoxycarbonyl radical and R.sub.1 is a phenyl radical, R' is not an isopropyl, cyclohexyl, phenyl, benzyl or p-chlorobenzyl radical; or where R.sub.1 is a methyl radical, R.sup.1 is not a benzyl, p-chloro- or p- methoxybenzyl radical.
摘要翻译：其中X是羧基，腈，烷氧基羰基或氨基甲酰基，R和R 1是各种有机基团; 或其药理学上可接受的盐具有显着的免疫刺激活性，特别是与添加的化学治疗剂如青霉素，头孢菌素，硝基呋喃或氯霉素结合使用。那些化合物是新的，其中X是氰基或烷氧基羰基，R 1是氢原子，但R'不是未取代的烷基或被羟基，烷氧基，二烷基氨基，苯基，4-氯苯基或4- 甲氧基苯基或被苯基或甲基取代的乙烯基，或环烷基，苯基，4-氯苯基，4-甲氧基苯基，s-三嗪基或吡啶基; 或其中X为氨基甲酰基，R 1为氢原子，R'为未取代的环己基，烷基或苄基; 或其中X为氰基或烷氧基羰基，R 1为苯基，R'不为异丙基，环己基，苯基，苄基或对氯苄基; 或其中R 1是甲基，R 1不是苄基，对氯或对甲氧基苄基。

8. 发明授权

US4267174A Immune-stimulating and cancerostatic 1-acyl-2-cyanoaziridines 失效
标题翻译：免疫刺激和癌性1-酰基-2-氰基氮丙啶
公开(公告)号：US4267174A
公开(公告)日：1981-05-12
申请号：US916389
申请日：1978-06-16
申请人： Herbert Berger , Rudi Gall , Wolfgang Kampe , Uwe Bicker , Rolf Kuhn
发明人： Herbert Berger , Rudi Gall , Wolfgang Kampe , Uwe Bicker , Rolf Kuhn
IPC分类号： C07D499/64 , A61K31/396 , A61K31/43 , A61K31/495 , A61P31/00 , A61P35/00 , A61P37/04 , C07D203/00 , C07D203/18 , C07D203/24 , C07D231/16 , C07D231/20 , C07D231/22 , C07D307/68 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/06 , C07D487/04 , C07D499/04 , C07F9/564 , F42B3/087 , A61K31/395
CPC分类号： C07D307/68 , C07D203/18 , C07D203/24 , C07D231/16 , C07D231/20 , C07D231/22 , C07F9/564 , Y10S514/885
摘要： 1-Acyl-2-cyanoaziridines of the formula ##STR1## wherein R is an acyl radical of a carboxylic, sulphonic, sulphinic, sulphenic, phosphonic or phosphoric acid,exhibit immune-stimulating and cancerostatic activities.
摘要翻译：其中R是羧酸，磺酸，亚磺酸，磺酸，膦酸或磷酸的酰基的式“IMAGE”的1-酰基-2-氰基氮丙啶表现出免疫刺激和癌症活性。

9. 发明授权

US4033967A Cyclopenteno[1,2-h]quinol-4-one derivatives 失效
标题翻译：环戊烯{8 1,2-h {9喹啉-4-酮衍生物
公开(公告)号：US4033967A
公开(公告)日：1977-07-05
申请号：US515790
申请日：1974-10-17
申请人： Alfred Rhomberg , Herbert Berger , Kurt Stach, deceased , Werner Plattner, administrator , Wolfgang Vomel , Winfriede Sauer
发明人： Alfred Rhomberg , Herbert Berger , Kurt Stach, deceased , Werner Plattner, administrator , Wolfgang Vomel , Winfriede Sauer
IPC分类号： C07D215/20 , A61K31/473 , C07D215/06 , C07D215/233 , C07D221/16 , C07D215/56
CPC分类号： C07D221/16
摘要： New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.
摘要翻译：其中R是饱和或不饱和脂族烃基，例如烷基和链烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代的新的环戊烯 - 喹诺酮衍生物或取代的（例如烷基单或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

10. 发明授权

US3988460A Cyclopentenoquinolone compounds for treating bacterial infections 失效
标题翻译：环戊烯诺酮类化合物用于治疗细菌感染
公开(公告)号：US3988460A
公开(公告)日：1976-10-26
申请号：US558101
申请日：1975-03-13
申请人： Alfred Rhomberg , Herbert Berger , Kurt Stach, deceased , by Werner Plattner, executor , Wolfgang Vomel , Winfriede Sauer
发明人： Alfred Rhomberg , Herbert Berger , Kurt Stach, deceased , by Werner Plattner, executor , Wolfgang Vomel , Winfriede Sauer
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： Certain novel cyclopentenoquinolone derivatives of the formula: ##SPC1##WhereinR and X, which may be the same or different, are hydrogen or lower saturated or unsaturated aliphatic hydrocarbyl;Y is hydroxyl or lower alkoxy or lower acyloxy (i.e., alkanoyloxy); andZ is hydrogen or lower alkoxy, or, together with Y, represents an oxo or lower alkenyldioxy radical; and the pharmacologically compatibile salts thereofAre outstandingly effective as anti-microbials, particularly for applications against infections of the urinary tract.
摘要翻译：某些新的环戊烯喹诺酮衍生物，其结构如下：

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