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1. 发明授权

US4034096A Nitrogen containing derivatives of cyclopenteno-quinolone compounds and bacteriostatic compositions 失效
标题翻译：环戊烯 - 喹诺酮化合物的含氮衍生物和抑菌组合物
公开(公告)号：US4034096A
公开(公告)日：1977-07-05
申请号：US595953
申请日：1975-07-14
申请人： Alfred Rhomberg , Herbert Berger , Kurt Stach, deceased , by Werner Plattner, administrator , Wolfgang Vomel , Winfriede Sauer
发明人： Alfred Rhomberg , Herbert Berger , Kurt Stach, deceased , by Werner Plattner, administrator , Wolfgang Vomel , Winfriede Sauer
IPC分类号： C07D221/16 , C07D215/56
CPC分类号： C07D221/16
摘要： New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.
摘要翻译：其中R是饱和或不饱和脂族烃基，例如烷基和链烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代的新的环戊烯 - 喹诺酮衍生物或取代的（例如烷基单或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

2. 发明授权

US4033967A Cyclopenteno[1,2-h]quinol-4-one derivatives 失效
标题翻译：环戊烯{8 1,2-h {9喹啉-4-酮衍生物
公开(公告)号：US4033967A
公开(公告)日：1977-07-05
申请号：US515790
申请日：1974-10-17
申请人： Alfred Rhomberg , Herbert Berger , Kurt Stach, deceased , Werner Plattner, administrator , Wolfgang Vomel , Winfriede Sauer
发明人： Alfred Rhomberg , Herbert Berger , Kurt Stach, deceased , Werner Plattner, administrator , Wolfgang Vomel , Winfriede Sauer
IPC分类号： C07D215/20 , A61K31/473 , C07D215/06 , C07D215/233 , C07D221/16 , C07D215/56
CPC分类号： C07D221/16
摘要： New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.
摘要翻译：其中R是饱和或不饱和脂族烃基，例如烷基和链烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代的新的环戊烯 - 喹诺酮衍生物或取代的（例如烷基单或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

3. 发明授权

US3988460A Cyclopentenoquinolone compounds for treating bacterial infections 失效
标题翻译：环戊烯诺酮类化合物用于治疗细菌感染
公开(公告)号：US3988460A
公开(公告)日：1976-10-26
申请号：US558101
申请日：1975-03-13
申请人： Alfred Rhomberg , Herbert Berger , Kurt Stach, deceased , by Werner Plattner, executor , Wolfgang Vomel , Winfriede Sauer
发明人： Alfred Rhomberg , Herbert Berger , Kurt Stach, deceased , by Werner Plattner, executor , Wolfgang Vomel , Winfriede Sauer
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： Certain novel cyclopentenoquinolone derivatives of the formula: ##SPC1##WhereinR and X, which may be the same or different, are hydrogen or lower saturated or unsaturated aliphatic hydrocarbyl;Y is hydroxyl or lower alkoxy or lower acyloxy (i.e., alkanoyloxy); andZ is hydrogen or lower alkoxy, or, together with Y, represents an oxo or lower alkenyldioxy radical; and the pharmacologically compatibile salts thereofAre outstandingly effective as anti-microbials, particularly for applications against infections of the urinary tract.
摘要翻译：某些新的环戊烯喹诺酮衍生物，其结构如下：

4. 发明授权

US4105772A 3-Nitropyrazole compounds and anti-microbial compositions 失效
标题翻译： 3-硝基吡唑化合物和抗微生物组合物
公开(公告)号：US4105772A
公开(公告)日：1978-08-08
申请号：US744215
申请日：1976-11-22
申请人： Herbert Berger , Rudi Gall , Kurt Stach, deceased , by Werner Plattner, administrator , Max Thiel , Wolfgang Vomel
发明人： Herbert Berger , Rudi Gall , Kurt Stach, deceased , by Werner Plattner, administrator , Max Thiel , Wolfgang Vomel
IPC分类号： C07D231/16 , A61K31/41 , C07D231/10
CPC分类号： C07D231/16
摘要： New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO--NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof, are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.
摘要翻译：新的具有下式的3-硝基吡唑化合物：其中R 1是低级烷基; R2是氢或低级烷基; R3是氰基，羧基或低级烷氧基羰基或基团-CO-NR4R5，其中R4是氢或羟基，氨基甲酰基，烷基氨基甲酰基，二烷基氨基甲酰基，硫代氨基甲酰基，脲基，硫脲基，羟基苯基，吡啶甲基或是低级烷基，烯基或环烷基取代如果需要，通过氰基，羟基，吡咯烷子基，哌啶子基，氨基，低级烷基氨基，低级二烷基氨基或低级酰基氨基取代基，R 5是氢原子或低级烷基，或者R 4和R 5一起代表低级亚烷基桥; 并且其药理学兼容的药物作为抗微生物剂，特别是在系统性和全球性的治疗中是非常有效的。

5. 发明授权

US3995040A Cyclopenteno-3-carboxyl-4-quinolone derivatives and their bacteriostatic compositions 失效
标题翻译：环戊烯-3-羧基-4-喹诺酮衍生物及其抑菌组合物
公开(公告)号：US3995040A
公开(公告)日：1976-11-30
申请号：US595929
申请日：1975-07-14
申请人： Alfred Rhomberg , Herbert Berger , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
发明人： Alfred Rhomberg , Herbert Berger , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
IPC分类号： C07D221/16 , C07D215/56
CPC分类号： C07D221/16
摘要： New cyclopenteno-quinolone derivatives of the formula ##SPC1##WhereinR is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.
摘要翻译：式WHEREIN R的新的环戊烯 - 喹诺酮衍生物是饱和或不饱和的脂族烃基，例如烷基和烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代或取代的（例如烷基单取代或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

6. 发明授权

US4049811A Compositions using cycloalkano-quinolone derivatives and their method of use 失效
标题翻译：使用环烷 - 喹诺酮衍生物的组合物及其使用方法
公开(公告)号：US4049811A
公开(公告)日：1977-09-20
申请号：US676269
申请日：1976-04-12
申请人： Herbert Berger , Alfred Rhomberg , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
发明人： Herbert Berger , Alfred Rhomberg , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
IPC分类号： C07D221/08 , C07D221/10 , C07D221/16 , A61K31/47
CPC分类号： C07D221/08 , C07D221/10 , C07D221/16
摘要： Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##STR1##wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an alkylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.
摘要翻译：具有以下结构式表征的抗微生物活性的环烷醇 - 喹诺酮衍生物：其中R 1和R 2之一表示氢，卤素，硝基，氨基，羟基，酰氨基，酰氧基，烷氧基或芳氧基，另一个与R 3一起形成含有2至6个碳原子的亚烷基桥，X是氢，可以被卤素，羟基，酰氧基，烷氧基，芳氧基，芳烷氧基，巯基，烷基巯基，芳基巯基，芳基磺酰基和烷基磺酰基中的成员所取代的低级烷基或X为未取代的烯基，包括链二烯基或炔基，Y为羟基，氨基或低级烷氧基，及其药学上可接受的盐。

7. 发明授权

US3966743A Ortho fused cycloalkano-4-quinolone-3-carboxylic acid derivatives 失效
标题翻译：正交稠环亚烷基-4-喹诺酮-3-羧酸衍生物
公开(公告)号：US3966743A
公开(公告)日：1976-06-29
申请号：US504589
申请日：1974-09-09
申请人： Herbert Berger , Alfred Rhomberg , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
发明人： Herbert Berger , Alfred Rhomberg , Kurt Stach , Wolfgang Vomel , Winfriede Sauer
IPC分类号： C07D221/08 , C07D221/10 , C07D221/16 , C07D215/56
CPC分类号： C07D221/16 , C07D221/08 , C07D221/10
摘要： Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##SPC1##Wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an akylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.
摘要翻译：具有抗细菌活性的环烷醇 - 喹诺酮衍生物，其特征在于下式：

8. 发明授权

US4172136A 3-Nitropyrazole compounds and anti-microbial compositions 失效
标题翻译： 3-硝基吡唑化合物和抗微生物组合物
公开(公告)号：US4172136A
公开(公告)日：1979-10-23
申请号：US889594
申请日：1978-03-23
申请人： Herbert Berger , Rudi Gall , Kurt Stach, deceased , Max Thiel , Wolfgang Vomel
发明人： Herbert Berger , Rudi Gall , Kurt Stach, deceased , Max Thiel , Wolfgang Vomel
IPC分类号： C07D231/16 , C07D401/02 , C07D403/02
CPC分类号： C07D231/16
摘要： New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO-NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.
摘要翻译：新的具有下式的3-硝基吡唑化合物：其中R 1是低级烷基; R2是氢或低级烷基; R3是氰基，羧基或低级烷氧基羰基或基团-CO-NR4R5，其中R4是氢或羟基，氨基甲酰基，烷基氨基甲酰基，二烷基氨基甲酰基，硫代氨基甲酰基，脲基，硫脲基，羟基苯基，吡啶甲基或是低级烷基，烯基或环烷基取代如果需要，通过氰基，羟基，吡咯烷子基，哌啶子基，氨基，低级烷基氨基，低级二烷基氨基或低级酰基氨基取代基，R 5是氢原子或低级烷基，或者R 4和R 5一起代表低级亚烷基桥; 并且其药理学兼容的药物作为抗微生物药剂，特别是在系统性和在尿道感染中是非常有效的。

9. 发明授权

US3962242A 3-(5-Nitro-2-furyl)-6-cyano-s-triazolo(4,3-b)pyridazine 失效
标题翻译： 3-（5-硝基-2-呋喃基）-6-氰基-S-三唑（4,3-B）吡啶
公开(公告)号：US3962242A
公开(公告)日：1976-06-08
申请号：US545661
申请日：1975-01-30
申请人： Herbert Berger , Rudi Gall , Max Thiel , Wolfgang Vomel , Winfriede Sauer
发明人： Herbert Berger , Rudi Gall , Max Thiel , Wolfgang Vomel , Winfriede Sauer
IPC分类号： C07D487/04 , C07D237/26
CPC分类号： C07D487/04
摘要： Nitrofuryl-triazolo[4,3-b]pyridazine compounds of the formula ##SPC1##WhereinR.sub.1 is lower alkoxy radical or a saturated 5- or 6-membered heterocyclic ring attached via a cyclic nitrogen atom, which heterocyclic ring can also contain, in addition to said cyclic nitrogen atom, a cyclic oxygen atom or an optionally lower alkylated cyclic nitrogen atom and R.sub.2 is a hydrogen atom or R.sub.1 and R.sub.2 together represent an additional valency bond,Are outstandingly effective as bacteriostats and are particularly useful in the treatment of bacterial infections in the urinary tract.

10. 发明授权

US3957766A Novel nitrofuran compounds and pharmaceutical compositions 失效
标题翻译：新型硝基化合物和药物组合物
公开(公告)号：US3957766A
公开(公告)日：1976-05-18
申请号：US290682
申请日：1972-09-20
申请人： Herbert Berger , Rudi Gall , Hartmut Merdes , Kurt Stach , Winfriede Sauer , Wolfgang Vomel
发明人： Herbert Berger , Rudi Gall , Hartmut Merdes , Kurt Stach , Winfriede Sauer , Wolfgang Vomel
IPC分类号： C07D487/04 , C07D295/06 , C07D295/12 , C07D471/04
CPC分类号： C07D487/04
摘要： Certain novel nitrofuran compounds of the formula: ##SPC1##WhereinHet is an aromatic heterocylic linkage;B is a bond or vinylene;Y is O or S;m is 0 or 1;X is hydrogen, lower alkyl or alkanoyl; andThe R's are variously defined;Are outstandingly effective bacteriostats and bactericides.

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