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1. 发明专利

IL257233A Monoclonal antibodies against bcma 未知
公开(公告)号：IL257233A
公开(公告)日：2021-06-30
申请号：IL25723318
申请日：2018-01-30
申请人： ENGMAB SARL , MINH DIEM VU , KLAUS STREIN , OLIVER AST , MARINA BACAC , CAMILLE DELON , LYDIA JASMIN DUERNER , ANNE FREIMOSER GRUNDSCHOBER , CHRISTIAN KLEIN , EKKEHARD MOESSNER , SAMUEL MOSER , PABLO UMANA , TINA WEINZIERL
发明人： MINH DIEM VU , KLAUS STREIN , OLIVER AST , MARINA BACAC , CAMILLE DELON , LYDIA JASMIN DUERNER , ANNE FREIMOSER-GRUNDSCHOBER , CHRISTIAN KLEIN , EKKEHARD MOESSNER , SAMUEL MOSER , PABLO UMANA , TINA WEINZIERL
IPC分类号： A61K39/00 , A61K39/395 , C07K16/28 , C07K16/46
摘要： The invention relates to new antibodies against BCMA, their manufacture and use.

2. 发明专利

IL266424D0 Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma 未知
公开(公告)号：IL266424D0
公开(公告)日：2019-06-30
申请号：IL26642419
申请日：2019-05-02
申请人： ENGMAB SARL , MINH DIEM VU , KLAUS STREIN , BRUNO DAVID LOURENCO PAIVA , JESUS FERNANDO SAN MIGUEL IZQUIERDO
发明人： MINH DIEM VU , KLAUS STREIN , BRUNO DAVID LOURENCO PAIVA , JESUS FERNANDO SAN MIGUEL IZQUIERDO
IPC分类号： C07K20060101
摘要： The invention relates to a bispecific antibody specifically binding to human B cell maturation antigen (BCMA) and to human CD3ε (CD3) together with an immunotherapeutic drug for combined use in treating multiple myeloma.

3. 发明专利

IL257233D0 Monoclonal antibodies against bcma 未知
公开(公告)号：IL257233D0
公开(公告)日：2018-03-29
申请号：IL25723318
申请日：2018-01-30
申请人： ENGMAB SARL , MINH DIEM VU , KLAUS STREIN , OLIVER AST , MARINA BACAC , CAMILLE DELON , LYDIA JASMIN DUERNER , ANNE FREIMOSER GRUNDSCHOBER , CHRISTIAN KLEIN , EKKEHARD MOESSNER , SAMUEL MOSER , PABLO UMANA , TINA WEINZIERL
发明人： MINH DIEM VU , KLAUS STREIN , OLIVER AST , MARINA BACAC , CAMILLE DELON , LYDIA JASMIN DUERNER , ANNE FREIMOSER-GRUNDSCHOBER , CHRISTIAN KLEIN , EKKEHARD MOESSNER , SAMUEL MOSER , PABLO UMANA , TINA WEINZIERL
IPC分类号： C07K20060101
摘要： The invention relates to new antibodies against BCMA, their manufacture and use.

4. 发明授权

US5116843A Tricyclic benzimidazole compounds, pharmaceutical compositions and methods of use 失效
标题翻译：三聚苯并咪唑化合物，药物组合物及其使用方法
公开(公告)号：US5116843A
公开(公告)日：1992-05-26
申请号：US543350
申请日：1990-06-25
申请人： Alfred Mertens , Wolfgang von der Saal , Erwin Boehm , Klaus Strein
发明人： Alfred Mertens , Wolfgang von der Saal , Erwin Boehm , Klaus Strein
IPC分类号： A61K31/47 , A61K31/495 , A61P7/02 , C07D471/04 , C07D471/10 , C07D487/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要： The present invention provides tricyclic benzimidazoles of the formula ##STR1## wherein R.sub.1 is a phenyl radical of the general formula: ##STR2## wherein R.sub.2, R.sub.3 and R.sub.4 can be the same or different as in claim 1. For A, B, C and D are understood those compounds where one or two of A, B, C or D are nitrogen. These compounds are useful to inhibit the aggregation of thrombocytes and erythrocytes, lower blood pressure and can increase the power of the heart.

5. 发明授权

US4985448A Ureidoindoles, pharmaceutical compositions and methods for erythrocyte and thrombocyte aggregation inhibition 失效
标题翻译：脲基吲哚，用于红细胞和血小板聚集抑制的药物组合物和方法
公开(公告)号：US4985448A
公开(公告)日：1991-01-15
申请号：US307417
申请日：1989-02-06
申请人： Harald Zilch , Alfred Mertens , Wolfgang Von Der Saal , Erwin Boehm , Klaus Strein
发明人： Harald Zilch , Alfred Mertens , Wolfgang Von Der Saal , Erwin Boehm , Klaus Strein
IPC分类号： A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61P7/02 , C07D209/34 , C07D209/54 , C07D215/38 , C07D215/54 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
CPC分类号： C07D209/34 , C07D209/54 , C07D215/38 , C07D215/54 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Lactam compounds of the formula ##STR1## in which: R is hydrogen, alkyl or cycloalkyl;R.sup.1 is hydrogen, alkyl, alkenyl or cycloalkyl;R.sup.2 is alkyl, alkenyl, cyano or a carbonyl substituted hydroxyl, alkyl, alkoxy, amino, alkylamino or hydrazino; orR.sup.1 and R.sup.2 together represent alkylidene cycloalkylidene; orR.sup.1, R.sup.2 and the adjacent carbon atom form a spirocyclic ring;n is 0 or 1;A is a --Co--NH--, --NH--CO--NH-- or --O--CO--NH--;X is a valency bond, alkylene or alkenylene; andR.sup.3 is optionally substituted phenyl, pyridyl, methylenedioxyphenyl or a five-membered heterocycle; or when X is a valency bond, R.sup.3 can also be an optionally substituted alkyl or alkino group, or cycloalkyl. The compounds are useful for the inhibition of erythrocyte and thrombocyte aggregation.
摘要翻译：式（I）的内酰胺化合物，其中：R为氢，烷基或环烷基; R1是氢，烷基，烯基或环烷基; R2是烷基，烯基，氰基或羰基取代的羟基，烷基，烷氧基，氨基，烷基氨基或肼基; 或者R1和R2一起表示亚烷基亚环烷基; 或R 1，R 2和相邻碳原子形成螺环; n为0或1; A是-Co-NH-，-NH-CO-NH-或-O-CO-NH-; X是价键，亚烷基或亚烯基; 并且R 3是任选取代的苯基，吡啶基，亚甲二氧基苯基或五元杂环; 或当X是价键时，R 3也可以是任选取代的烷基或烷基或环烷基。该化合物可用于抑制红细胞和血小板聚集。

6. 发明授权

US4863945A Pyrrolobenzimidazoles and pharmaceutical compositions containing them 失效
标题翻译：吡咯并苯并咪唑和含有它们的药物组合物
公开(公告)号：US4863945A
公开(公告)日：1989-09-05
申请号：US131367
申请日：1987-12-10
申请人： Walter-Gunar Friebe , Alfred Mertens , Klaus Strein , Erwin Boehm
发明人： Walter-Gunar Friebe , Alfred Mertens , Klaus Strein , Erwin Boehm
IPC分类号： A61K31/40 , A61P7/02 , A61P9/04 , A61P9/12 , C07D487/04
CPC分类号： C07D487/04
摘要： Pyrrolobenzimidazoles of the formula: ##STR1## are useful for treatment of heart and circulatory diseases. R.sub.1 is substituted phenyl; or optionally substituted naphthyl or a five- or six-membered heterocyclic group which can be condensed with a phenyl ring to form a bicyclic radical. R.sub.2 is hydrogen, alkyl, alkenyl or cycloalkenyl; R.sub.3 is alkyl, alkenyl or hydroxyalkyl or with R.sub.2 together forms cycloakylene; or R.sub.2 and R.sub.3 together form alkylidene or cycloalkylidene. R.sub.4 is hydrogen or lower alkanoyl. X is a valency bond, alkylene, vinylene, imino or carbonylamino. T stands for two hydrogen atoms. When X is a valency bond, R.sub.1 can also be hydrogen, hydrocarbyl which may also contain oxygen, amino, sulfur, carbonyl and sulfonyl groups. When X is imino or carbonylamino or when R.sub.1 is a bicyclic radical, T can also be oxygen. The compounds also include the tautomers and physiologically acceptable salts with inorganic and organic acids.
摘要翻译：下式的吡咯并苯并咪唑：可用于治疗心脏和循环系统疾病。 R1是取代的苯基; 或任选取代的萘基或可与苯环缩合形成双环基团的五元或六元杂环基。 R2是氢，烷基，烯基或环烯基; R3是烷基，烯基或羟基烷基或与R2一起形成亚环烷基; 或者R 2和R 3一起形成亚烷基或亚环烷基。 R4是氢或低级烷酰基。 X是价键，亚烷基，亚乙烯基，亚氨基或羰基氨基。 T代表两个氢原子。当X是价键时，R 1也可以是氢，也可以含有氧，氨基，硫，羰基和磺酰基的烃基。当X是亚氨基或羰基氨基时，或当R1是双环基时，T也可以是氧。化合物还包括与无机和有机酸形成的互变异构体和生理上可接受的盐。

7. 发明授权

US4780474A Use of alkylenediamine derivatives for the treatment of blood flow disturbances and pharmaceutical compositions containing them 失效
标题翻译：使用亚烷基二胺衍生物治疗血流紊乱和含有它们的药物组合物
公开(公告)号：US4780474A
公开(公告)日：1988-10-25
申请号：US6275
申请日：1987-01-20
申请人： Erwin Bohm , Jens-Peter Holck , Wolfgang Kampe , Herbert Leinert , Bernd Muller-Beckmann , Klaus Strein
发明人： Erwin Bohm , Jens-Peter Holck , Wolfgang Kampe , Herbert Leinert , Bernd Muller-Beckmann , Klaus Strein
IPC分类号： C07D295/20 , A61K31/135 , A61K31/165 , A61K31/22 , A61K31/33 , A61K31/415 , A61K31/505 , A61K31/535 , A61K31/5375 , A61P7/00 , A61P9/00 , C07C67/00 , C07C213/00 , C07C217/84 , C07C231/00 , C07C233/25 , C07C233/78 , C07C235/44 , C07C235/46 , C07C235/50 , C07C237/22 , C07C237/34 , C07C239/00 , C07C241/00 , C07C253/00 , C07C255/54 , C07C275/00 , C07C313/00 , C07C323/36 , C07C323/60 , C07D231/38 , C07D231/56 , C07D239/54 , C07D521/00 , A61K31/40 , A61K31/405 , A61K31/41
CPC分类号： A61K31/505 , A61K31/135 , A61K31/165 , A61K31/415
摘要： The present invention is concerned with the use of compounds of the general formula: ##STR1## wherein A is an optionally substituted phenyl or heteroaromatic radical, R.sub.6 and R.sub.7 are hydrogen or lower alkyl, X is an alkylene chain containing up to 6 carbon atoms, Y is a valency bond or a >C.dbd.O group and B is an optionally substituted phenyl or heteroaromatic radical, as well as of their pharmacologically acceptable salts for the treatment of blood flow disturbances. The present invention also provides pharmaceutical compositions which contain these compounds.
摘要翻译：本发明涉及以下通式的化合物的用途：其中A是任选取代的苯基或杂芳族基团，R 6和R 7是氢或低级烷基，X是含有至多6个亚烷基的亚烷基链碳原子，Y是价键或> C = O基团，B是任选取代的苯基或杂芳族基团，以及它们的药理学上可接受的盐用于治疗血流紊乱。本发明还提供含有这些化合物的药物组合物。

8. 发明授权

US4710510A Pyrrolobenzimidazoles, pharmaceutical compositions containing them, and use of them to treat certain heart and circulatory diseases 失效
标题翻译：吡咯并苯并咪唑，含有它们的药物组合物，以及它们用于治疗某些心脏和循环系统疾病
公开(公告)号：US4710510A
公开(公告)日：1987-12-01
申请号：US807260
申请日：1985-12-10
申请人： Alfred Mertens , Jens-Peter Holck , Wolfgang Kampe , Bernd Muller-Beckmann , Klaus Strein , Wolfgang Schaumann
发明人： Alfred Mertens , Jens-Peter Holck , Wolfgang Kampe , Bernd Muller-Beckmann , Klaus Strein , Wolfgang Schaumann
IPC分类号： A61K31/415 , A61K31/4184 , A61P9/00 , A61P9/04 , C07D209/34 , C07D209/42 , C07D487/04 , A61K31/55
CPC分类号： C07D487/04 , C07D209/34 , C07D209/42
摘要： The present invention provides new pyrrolobenzimidazoles of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or an alkyl, alkenyl or cycloalkyl radical; R.sub.2 is a hydrogen atom, cyano group or alkyl or alkenyl radical or a carbonyl group substituted by hydroxyl, alkyl, alkoxy, amino, alkylamino, dialkylamino or hydrazino or together with R.sub.1 forms a cycloalkylene radical or R.sub.1 and R.sub.2 together form an alkylidene or cycloalkylidene radical; R.sub.3, R.sub.4 and R.sub.5, which can be the same or different, each represent a hydrogen atom or an alkanesulphonyloxy, trifluoromethanesulphonyloxy, alkanesulphonylamino, trifluoromethanesulphonylamino, N-alkyl-alkanesulphonylamino, N-alkyl-trifluoromethanesulphonylamino, alkylsulphenylmethyl, alkylsulphinylmethyl or alkylsulphonylmethyl radical, a carbonyl group substituted by hydroxyl, alkoxy, amino, alkylamino or dialkylamino, a sulphonyl group substituted by amino, alkylamino, dialkylamino or cyclic imino, whereby a methylene group in the 4-position can be replaced by a sulphur or oxygen atom, an alkylcarbonylamino, aminocarbonylamino or alkylaminocarbonylamino radical, an alkylthio, alkylsulphinyl or alkylsulphonyl radical, a nitro, halogen, amino, hydroxyl, alkyl, trifluoromethyl, alkoxy, alkenyloxy, alkynyloxy, cyanoalkoxy, carboxyalkoxy, alkoxycarbonylalkoxy, dialkylamino, 1-imidazolyl or cyano group; X is a valency bond, a C.sub.1 -C.sub.4 alkylene radical or a vinyl radical; and T is an oxygen or sulphur atom; the tautomers thereof and the physiologically acceptable salts thereof with inorganic and organic acids.The present invention also provides processes for the preparation of these compounds and pharmaceuticals containing them for the prophylaxis and treatment of heart and circulatory diseases.
摘要翻译：本发明提供了以下通式的新的吡咯并苯并咪唑：其中R 1是氢原子或烷基，烯基或环烷基; R2是氢原子，氰基或烷基或烯基或被羟基，烷基，烷氧基，氨基，烷基氨基，二烷基氨基或肼基取代的羰基或与R1一起形成亚环烷基，或者R 1和R 2一起形成亚烷基或亚环烷基激进; 可以相同或不同的R 3，R 4和R 5各自表示氢原子或烷磺酰氧基，三氟甲磺酰氧基，烷磺酰氨基，三氟甲磺酰氨基，N-烷基 - 烷磺酰氨基，N-烷基 - 三氟甲磺酰氨基，烷基亚磺酰基甲基，烷基亚磺酰基甲基或烷基磺酰基甲基，羰基被羟基，烷氧基，氨基，烷基氨基或二烷基氨基取代的基团，被氨基，烷基氨基，二烷基氨基或环状亚氨基取代的磺酰基，其中4-位中的亚甲基可以被硫或氧原子，烷基羰基氨基，氨基羰基氨基或烷基氨基羰基氨基，烷硫基，烷基亚磺酰基或烷基磺酰基，硝基，卤素，氨基，羟基，烷基，三氟甲基，烷氧基，烯氧基，炔氧基，氰基烷氧基，羧基烷氧基，烷氧基羰基烷氧基，二烷基氨基，1-咪唑基或氰基; X是价键，C1-C4亚烷基或乙烯基; 和T是氧或硫原子; 其互变异构体及其与无机和有机酸的生理上可接受的盐。本发明还提供了制备这些化合物的方法和含有它们的药物用于预防和治疗心脏和循环系统疾病。

9. 发明授权

US5373019A Pharmaceutical lactam compositions for inhibition of erythrocyte and thrombocyte aggregation 失效
标题翻译：用于抑制红细胞和血小板聚集的药物内酰胺组合物
公开(公告)号：US5373019A
公开(公告)日：1994-12-13
申请号：US640445
申请日：1991-01-11
申请人： Harald Zilch , Alfred Mertens , Wolfgang Von Der Saal , Erwin Boehm , Klaus Strein
发明人： Harald Zilch , Alfred Mertens , Wolfgang Von Der Saal , Erwin Boehm , Klaus Strein
IPC分类号： A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61P7/02 , C07D209/34 , C07D209/54 , C07D215/38 , C07D215/54 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , B07D209/30 , B07D209/32 , B07D209/34
CPC分类号： C07D209/34 , C07D209/54 , C07D215/38 , C07D215/54 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention provides compounds and pharmaceutical compositions containing indolones of the general formula: ##STR1## These indolones where n.dbd.o and the pharmaceutical compositions containing these compounds are used for the treatment of diseases in which erythrocyte and thrombocyte aggregation play an important part, especially for the inhibition of aggregation of these cells.
摘要翻译：本发明提供含有以下通式的吲哚酮的化合物和药物组合物：其中n = 0的这些吲哚酮和含有这些化合物的药物组合物用于治疗其中红细胞和血小板聚集起重要作用的疾病特别是抑制这些细胞聚集的部分。

10. 发明授权

US4863949A Aminopropanol derivatives, processes for the preparation thereof, the use thereof and pharmaceutical compositions containing them 失效
标题翻译：氨基丙醇衍生物，其制备方法，其用途和含有它们的药物组合物
公开(公告)号：US4863949A
公开(公告)日：1989-09-05
申请号：US98719
申请日：1987-09-21
申请人： Herbert Simon , Helmut Michel , Wolfgang Bartsch , Klaus Strein
发明人： Herbert Simon , Helmut Michel , Wolfgang Bartsch , Klaus Strein
IPC分类号： C07D521/00 , A61K31/13 , A61K31/165 , A61K31/17 , A61K31/215 , A61K31/27 , A61K31/33 , A61K31/445 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/02 , C07C67/00 , C07C203/02 , C07C231/00 , C07C233/00 , C07C233/12 , C07C233/34 , C07C235/10 , C07C313/00 , C07C315/04 , C07C317/18 , C07C317/20 , C07C317/28 , C07C317/30 , C07C317/46 , C07C319/20 , C07C323/20 , C07D209/04 , C07D209/08 , C07D209/34 , C07D209/42 , C07D209/82 , C07D215/22 , C07D215/227 , C07D235/06 , C07D311/18
CPC分类号： C07D209/08 , C07C255/00 , C07D209/34 , C07D209/42 , C07D215/227 , C07D311/18
摘要： The present invention provides compounds of the general formula: ##STR1## wherein Ar is a substituted or unsubstituted aromatic or heteroaromatic radical, A is a straight-chained or branched alkylene chain containing up to 8 carbon atoms, a --CH.sub.2 -- group of which can be replaced by a cycloalkylene radical containing 3 to 7 carbon atoms, B is a straight-chained mono- or bicyclic, optionally branched, saturated or unsaturated alkylene chain containing up to 12 carbon atoms, a --CH.sub.2 -- group of which can be replaced by a cycloalkylene radical containing 3 to 7 carbon atoms and/or up to two --CH.sub.2 -- groups of which can be replaced by an oxygen or a sulphur atom or by an --S(.dbd.O) or --S(.dbd.O).sub.2 group, X is a valency bond, an oxygen atom or an --NR.sup.1 group, in which R.sup.1 is a hydrogen atom or a straight-chained or branched, saturated or unsaturated alkyl or nitroxyalkyl radical containing up to 6 carbon atoms or R.sup.1, together with the nitrogen atom of the --NR.sup.1 -- group and a --CH.sub.2 -- group of the chain B, can form a heteroaliphatic ring containing 4 to 6 carbon atoms and n is 1, 2 or 3; and the physiologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them. Furthermore, the present invention is concerned with the use of these compounds for the treatment and/or prophylaxis of heart and circulatory diseases.
摘要翻译：本发明提供以下通式的化合物：其中Ar是取代或未取代的芳族或杂芳族基团，A是含有至多8个碳原子的直链或支链亚烷基链，-CH 2 - 基团其中可以被含有3至7个碳原子的亚环烷基代替，B是含有至多12个碳原子的直链单环或双环，任选支链，饱和或不饱和的亚烷基链，其中-CH 2 - 基团可以可以被含有3至7个碳原子的亚环烷基和/或最多两个-CH 2 - 基团取代，其中可以被氧或硫原子或-S（= O）或-S（= O）取代） 2基团，X是价键，氧原子或-NR 1基团，其中R 1是氢原子或含有至多6个碳原子的直链或支链，饱和或不饱和的烷基或硝基烷基或R 1，一起与-NR 1基团的氮原子和链B的-CH 2 - 基团可以相同 rm是含有4至6个碳原子的杂脂族环，n为1,2或3; 及其生理上可接受的盐。本发明还提供了制备这些化合物的方法和含有它们的药物组合物。此外，本发明涉及这些化合物用于治疗和/或预防心脏和循环系统疾病的用途。

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