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    • 5. 发明授权
    • 3-Nitropyrazole compounds and anti-microbial compositions
    • 3-硝基吡唑化合物和抗微生物组合物
    • US4172136A
    • 1979-10-23
    • US889594
    • 1978-03-23
    • Herbert BergerRudi GallKurt Stach, deceasedMax ThielWolfgang Vomel
    • Herbert BergerRudi GallKurt Stach, deceasedMax ThielWolfgang Vomel
    • C07D231/16C07D401/02C07D403/02
    • C07D231/16
    • New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO-NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.
    • 新的具有下式的3-硝基吡唑化合物:其中R 1是低级烷基; R2是氢或低级烷基; R3是氰基,羧基或低级烷氧基羰基或基团-CO-NR4R5,其中R4是氢或羟基,氨基甲酰基,烷基氨基甲酰基,二烷基氨基甲酰基,硫代氨基甲酰基,脲基,硫脲基,羟基苯基,吡啶甲基或是低级烷基,烯基或环烷基取代 如果需要,通过氰基,羟基,吡咯烷子基,哌啶子基,氨基,低级烷基氨基,低级二烷基氨基或低级酰基氨基取代基,R 5是氢原子或低级烷基,或者R 4和R 5一起代表低级亚烷基桥; 并且其药理学兼容的药物作为抗微生物药剂,特别是在系统性和在尿道感染中是非常有效的。