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1. 发明申请

US20060116741A1 Optically controlled microfluidic chip 失效
公开(公告)号：US20060116741A1
公开(公告)日：2006-06-01
申请号：US11156069
申请日：2005-06-17
申请人： Daniel Palanker , Harvey Fishman
发明人： Daniel Palanker , Harvey Fishman
IPC分类号： A61N1/32
CPC分类号： A61N1/0543 , A61M5/14276 , A61M2205/0244 , A61M2205/3306 , A61M2210/0612 , A61N1/36046
摘要： An optically controlled microfluidic chip is provided for administering a fluid to a neuronal site. The chip is made of at least one unit or pixel, each of which constitutively emits fluid in the dark, and reduces emission of fluid in response to light. The individual pixels are capable of being individually controlled, thereby translating a spatial pattern of incident light into a spatial pattern of neuronal stimulation. Each pixel contains a housing, an aperture in the housing, and a reservoir containing fluid that is connected to the aperture. The aperture is designed to allow continuous emission of fluid from the reservoir through the aperture when the pixel is in the dark. Each pixel also includes an optical control, which reduces the emission of fluid from the reservoir through the aperture in response to light.

2. 发明申请

US20200345405A1 HEATED FORCEPS FOR MEIBOMIAN GLAND EXPRESSION 审中-公开
公开(公告)号：US20200345405A1
公开(公告)日：2020-11-05
申请号：US16398731
申请日：2019-04-30
申请人： Harvey Fishman , Arnold Flores
发明人： Harvey Fishman , Arnold Flores
IPC分类号： A61B18/08 , A61B18/18 , A61F9/007
摘要： The heated forceps for Meibomian gland expression disclosed herein may comprise, at least, a forceps and a heating element. The treatment of Meibomian gland dysfunction is benefited by the application of heat to the Meibomian glands during therapeutic manual expression of meibum. The heated forceps for Meibomian gland expression are intended to supply such heat during the manual expression process so as to improve the efficacy of such treatments. The forceps may comprise any appropriate forceps known in the art, and the heating element may be removably attached to the forceps for ease of use and maintenance. In this way the forceps may also be made disposable, while the heating element is reusable.

3. 发明申请

US20210116721A1 PARALLAX ERROR CORRECTING SYSTEM 有权
公开(公告)号：US20210116721A1
公开(公告)日：2021-04-22
申请号：US16670769
申请日：2019-10-31
申请人： Harvey Fishman
发明人： Harvey Fishman
IPC分类号： G02C7/08 , G02C11/00
摘要： A parallax error correcting system is disclosed herein. In one embodiment the system may comprise a smart lens consisting of a liquid crystal layer that may be made opaque, and that may become partially cleared when touched. In another embodiment the system may comprise a manually-operated device that may be positioned over the glasses frame of a wearer to determine the optical center of corrective lenses and prevent parallax error. The device may further comprise a central opening that may be manipulated by an eye care professional based on feedback given by the wearer, and a means for attaching the device to the glasses frame or lenses to prevent reading errors. The system may further comprise an electronic interface and a software application, to provide for additional features and accuracy of readings.

4. 发明授权

US06755530B1 Retinal light processing using carbon nanotubes 有权
标题翻译：使用碳纳米管的视网膜光处理
公开(公告)号：US06755530B1
公开(公告)日：2004-06-29
申请号：US10198672
申请日：2002-07-16
申请人： David J. Loftus , Theodore Leng , Harvey Fishman
发明人： David J. Loftus , Theodore Leng , Harvey Fishman
IPC分类号： A61B300
CPC分类号： A61F9/08 , A61N1/0543 , A61N1/36046 , Y10S977/834 , Y10S977/902
摘要： Method and system for processing light signals received by the eye of a human or other animal, where the eye may be compromised or non-functioning. Incident light is received at first and second pixels in a photodetector array and provides a pixel electrical signal representing the received light. Each of an array of carbon nanotube (CNT) towers is connected to a pixel, has a first tower end penetrating a retinal active layer of the animal and has a second tower end positioned to receive to receive and transport the pixel electrical signal to the retinal active layer. The CNT tower may be coated with a biologically active substance or chemically modified to promote neurite connections with the tower. The photoreceptor array can be provide with a signal altering mechanism that alters at least one of light intensity and wavelength intensity sensed by a first pixel relative to a second pixel, to correct for one or more selected eye problems.
摘要翻译：用于处理由人或其他动物的眼睛接收的光信号的方法和系统，其中眼睛可能被损害或不起作用。在光电检测器阵列中的第一和第二像素处接收入射光，并提供表示所接收的光的像素电信号。碳纳米管（CNT）阵列中的每一个连接到像素，具有穿过动物的视网膜活性层的第一塔端，并且具有第二塔端，其定位成接收并将像素电信号传送到视网膜活动层 CNT塔可以涂覆有生物活性物质或经化学修饰以促进与塔的神经突连接。感光体阵列可以提供改变由第一像素相对于第二像素感测的光强度和波长强度中的至少一个的信号改变机构，以校正一个或多个选定的眼睛问题。

5. 发明申请

US20190223848A1 NON-INVASIVE OCULAR BIOLOGICAL MATERIAL GATHERING DEVICE 审中-公开
公开(公告)号：US20190223848A1
公开(公告)日：2019-07-25
申请号：US15877456
申请日：2018-01-23
申请人： Harvey Fishman , Vera B. Morhenn , Jonathan N. Mansbridge
发明人： Harvey Fishman , Vera B. Morhenn , Jonathan N. Mansbridge
IPC分类号： A61B10/02 , A61B3/00 , A61B3/14
摘要： The biological material gathering device disclosed herein is designed for non-invasive isolation of biological material from an eye, eyelid, or periocular. The device uses a plurality of adhesive beads engaged on a microfiber bundle to harvest biological materials from an individual without the need for penetrating or invasive methods. Such biological materials may then be processed and examined to determine the etiology of pathologies or malignancies affecting the individual. The biological material gathering device preferably comprises a tonometer tip base and housing for use in commonly-available ophthalmological examination devices. The present invention may further comprise video imaging capability so as to register the precise and relative locations of harvested biological materials for later reference. Finally, the biological material gathering device disclosed herein may be made available in kit form for clinical use.

6. 发明申请

US20050027356A1 Microfabricated tissue as a substrate for pigment epithelium transplantation 审中-公开
标题翻译：微生物组织作为色素上皮细胞移植的底物
公开(公告)号：US20050027356A1
公开(公告)日：2005-02-03
申请号：US10767408
申请日：2004-01-28
申请人： Harvey Fishman , Mark Blumenkranz , Stacey Bent , Christina Lee , Philip Huie , Daniel Palanker
发明人： Harvey Fishman , Mark Blumenkranz , Stacey Bent , Christina Lee , Philip Huie , Daniel Palanker
IPC分类号： C12M3/00 , A61F2/14 , A61L27/00 , A61L27/38 , C12N5/06 , A61F2/02
CPC分类号： A61F2/14 , A61L27/3604 , A61L27/3813 , A61L27/3839
摘要： An ocular implant is provided with a substrate and a membranous tissue layer secured to the substrate. Cells such as IPE cells, RPE cells and stem cells are attached on the surface of the membranous tissue layer either in situ or in vivo through cells transplantation. The cells are separated into regions on the surface by creating a pattern on the surface enclosing regions for receiving the cells. The substrate is a bioabsorbable and/or polymeric substrate. Examples of membranous tissue layer are lens capsule, inner limiting membrane, corneal tissue, Bruch's membrane tissue, amniotic membrane tissue, serosal membrane tissue, mucosal membrane tissue and neurological tissue. The membranous tissue layer could have a micropattern of biomolecules. A microfluidic network could be placed onto the microfabricated membranous tissue layer.
摘要翻译：眼部植入物设置有基底和固定到基底的膜组织层。诸如IPE细胞，RPE细胞和干细胞的细胞通过细胞移植原位或体内附着在膜组织层的表面上。通过在用于接收细胞的包围区域的表面上形成图案，将细胞分离成表面上的区域。底物是生物可吸收和/或聚合物底物。膜组织层的实例是晶状体囊，内限膜，角膜组织，布鲁奇膜组织，羊膜组织，浆膜膜组织，粘膜组织和神经组织。膜组织层可以具有生物分子的微图案。微流控网络可以放置在微加工的膜组织层上。

7. 发明申请

US20210282669A1 SYSTEM AND METHOD FOR MONITORING EYE BLINK MECHANICS 有权
公开(公告)号：US20210282669A1
公开(公告)日：2021-09-16
申请号：US16819059
申请日：2020-03-14
申请人： Peter Borden , Harvey Fishman
发明人： Peter Borden , Harvey Fishman
IPC分类号： A61B5/11 , A61B3/113 , A61B3/10 , A61B5/00
摘要： A system and method for monitoring eye blink mechanics is disclosed herein. One or more sensors mounted on an eyeglass frame may record blink mechanics over an extended period of time, typically longer than can be observed by a doctor during the course of a clinical examination, using camera imaging or infrared reflection. The system and method for monitoring eye blink mechanics provides a simultaneous record of blink rate and drying of the tear film, and may also monitor completeness of the individual blink process. Recorded data may be downloaded to a data processing system for analysis, the results of which are used to indicate treatment for DES, DBM, and other blink related pathologies. The system may also provide treatment through feedback based on real-time measurements by training the patient to correct dysfunctional blink mechanics as they are occurring.

8. 发明授权

US07135172B1 Bucky paper as a support membrane in retinal cell transplantation 有权
标题翻译： Bucky纸作为视网膜细胞移植中的支持膜
公开(公告)号：US07135172B1
公开(公告)日：2006-11-14
申请号：US10238515
申请日：2002-09-04
申请人： David J. Loftus , Theodore Leng , Philip Huie , Harvey Fishman
发明人： David J. Loftus , Theodore Leng , Philip Huie , Harvey Fishman
IPC分类号： A01N63/00 , A61F2/14 , A61F2/00
CPC分类号： A61F2/14 , A61L27/08 , A61L27/3813 , A61L27/3834 , A61L27/3869 , A61L2430/16 , B82Y30/00
摘要： A method for repairing a retinal system of an eye, using bucky paper on which a plurality of retina pigment epithelial cells and/or iris pigment epithelial cells and/or stem cells is deposited, either randomly or in a selected cell pattern. The cell-covered bucky paper is positioned in a sub-retinal space to transfer cells to this space and thereby restore the retina to its normal functioning, where retinal damage or degeneration, such as macular degeneration, has occurred.
摘要翻译：使用在其上沉积多个视网膜色素上皮细胞和/或虹膜色素上皮细胞和/或干细胞的巴氏纸来随机或以选定的细胞图案修复眼睛的视网膜系统的方法。细胞覆盖的巴氏纸定位在子视网膜空间中以将细胞转移到该空间，从而将视网膜恢复其正常功能，其中已发生视网膜损伤或变性，例如黄斑变性。

9. 发明申请

US20050214345A1 Artificial biocompatible material as a support for cells in a retinal implant 审中-公开
标题翻译：人造生物相容性材料作为视网膜植入物中的细胞的支持物
公开(公告)号：US20050214345A1
公开(公告)日：2005-09-29
申请号：US11061171
申请日：2005-02-18
申请人： Theodore Leng , Dimitri Yellachich , Philip Huie , Jaan Noolandi , Harvey Fishman
发明人： Theodore Leng , Dimitri Yellachich , Philip Huie , Jaan Noolandi , Harvey Fishman
IPC分类号： A61F2/14 , A61K31/716
CPC分类号： A61F2/14 , A61F9/00 , A61F9/007 , C12N5/062 , C12N2533/30
摘要： A retinal implant is provided that uses an artificial biocompatible material as a support material on which retinal pigment epithelial cells, iris pigment epithelial cells, and/or stem cells can be deposited either in situ or in vivo. The support material has a surface topology that is rough to promote cell adhesion, has surface pits to allow pigment cells to grow into, and has pores to allow for proper diffusion of materials. The support material serves as a substrate for cell growth and as a patch for damaged basement membrane (Bruch's membrane). This cell-coated membrane or pigment cell-enriched membrane is surgically positioned in the sub-retinal space to rescue or restore photoreceptor cell function that may be damaged or threatened by degenerative diseases of the eye, such as age-related macular degeneration.
摘要翻译：提供视网膜植入物，其使用人造生物相容性材料作为支架材料，视网膜色素上皮细胞，虹膜色素上皮细胞和/或干细胞可原位或体内沉积。支撑材料具有粗糙的表面拓扑以促进细胞粘附，具有表面凹坑以允许颜料细胞生长并具有允许材料适当扩散的孔。支撑材料用作细胞生长的底物和用作损伤的基底膜（布鲁赫氏膜）的贴剂。这种细胞包被的膜或色素细胞富集的膜通过外科手术放置在视网膜下部空间中以挽救或恢复可能由于退行性疾病（如年龄相关性黄斑变性）而损伤或受到威胁的感光细胞功能。

10. 发明申请

US20050203601A1 Neural stimulation array providing proximity of electrodes to cells via cellular migration 审中-公开
标题翻译：神经刺激阵列通过细胞迁移提供电极与细胞的接近
公开(公告)号：US20050203601A1
公开(公告)日：2005-09-15
申请号：US11035692
申请日：2005-01-13
申请人： Daniel Palanker , Philip Huie , Alexander Vankov , Harvey Fishman
发明人： Daniel Palanker , Philip Huie , Alexander Vankov , Harvey Fishman
IPC分类号： A61N1/00 , A61N1/04 , A61N1/05 , A61N1/36
CPC分类号： A61N1/0543 , A61N1/36046
摘要： An interface for selective excitation or sensing of neural cells in a biological neural network is provided. The interface includes a membrane with a number of channels passing through the membrane. Each channel has at least one electrode within it. Neural cells in the biological neural network grow or migrate into the channels, thereby coming into close proximity to the electrodes. Once one or more neural cells have grown or migrated into a channel, a voltage applied to the electrode within the channel selectively excites the neural cell(s) in that channel. The excitation of these neural cell(s) will then transmit throughout the neural network (i.e. cells and axons) that is associated with the neural cell(s) stimulated in the channel. An alternative interface provides cell excitation via an array of electrically conductive pillars on a substrate. The pillars have electrically insulated sides and exposed top surfaces, to provide selective cell excitation.
摘要翻译：提供了一种生物神经网络中选择性激发或感应神经细胞的界面。界面包括具有穿过膜的多个通道的膜。每个通道内至少有一个电极。生物神经网络中的神经细胞生长或迁移到通道中，从而接近电极。一旦一个或多个神经细胞已经生长或迁移到通道中，施加到通道内的电极的电压选择性地激发该通道中的神经细胞。然后，这些神经细胞的激发将通过与通道中刺激的神经细胞相关联的神经网络（即细胞和轴突）传递。另一种界面通过衬底上的导电柱阵列提供电池激发。支柱具有电绝缘的侧面和暴露的顶表面，以提供选择性的电池激发。

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