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1. 发明授权

US06755530B1 Retinal light processing using carbon nanotubes 有权
标题翻译：使用碳纳米管的视网膜光处理
公开(公告)号：US06755530B1
公开(公告)日：2004-06-29
申请号：US10198672
申请日：2002-07-16
申请人： David J. Loftus , Theodore Leng , Harvey Fishman
发明人： David J. Loftus , Theodore Leng , Harvey Fishman
IPC分类号： A61B300
CPC分类号： A61F9/08 , A61N1/0543 , A61N1/36046 , Y10S977/834 , Y10S977/902
摘要： Method and system for processing light signals received by the eye of a human or other animal, where the eye may be compromised or non-functioning. Incident light is received at first and second pixels in a photodetector array and provides a pixel electrical signal representing the received light. Each of an array of carbon nanotube (CNT) towers is connected to a pixel, has a first tower end penetrating a retinal active layer of the animal and has a second tower end positioned to receive to receive and transport the pixel electrical signal to the retinal active layer. The CNT tower may be coated with a biologically active substance or chemically modified to promote neurite connections with the tower. The photoreceptor array can be provide with a signal altering mechanism that alters at least one of light intensity and wavelength intensity sensed by a first pixel relative to a second pixel, to correct for one or more selected eye problems.
摘要翻译：用于处理由人或其他动物的眼睛接收的光信号的方法和系统，其中眼睛可能被损害或不起作用。在光电检测器阵列中的第一和第二像素处接收入射光，并提供表示所接收的光的像素电信号。碳纳米管（CNT）阵列中的每一个连接到像素，具有穿过动物的视网膜活性层的第一塔端，并且具有第二塔端，其定位成接收并将像素电信号传送到视网膜活动层 CNT塔可以涂覆有生物活性物质或经化学修饰以促进与塔的神经突连接。感光体阵列可以提供改变由第一像素相对于第二像素感测的光强度和波长强度中的至少一个的信号改变机构，以校正一个或多个选定的眼睛问题。

2. 发明授权

US07135172B1 Bucky paper as a support membrane in retinal cell transplantation 有权
标题翻译： Bucky纸作为视网膜细胞移植中的支持膜
公开(公告)号：US07135172B1
公开(公告)日：2006-11-14
申请号：US10238515
申请日：2002-09-04
申请人： David J. Loftus , Theodore Leng , Philip Huie , Harvey Fishman
发明人： David J. Loftus , Theodore Leng , Philip Huie , Harvey Fishman
IPC分类号： A01N63/00 , A61F2/14 , A61F2/00
CPC分类号： A61F2/14 , A61L27/08 , A61L27/3813 , A61L27/3834 , A61L27/3869 , A61L2430/16 , B82Y30/00
摘要： A method for repairing a retinal system of an eye, using bucky paper on which a plurality of retina pigment epithelial cells and/or iris pigment epithelial cells and/or stem cells is deposited, either randomly or in a selected cell pattern. The cell-covered bucky paper is positioned in a sub-retinal space to transfer cells to this space and thereby restore the retina to its normal functioning, where retinal damage or degeneration, such as macular degeneration, has occurred.
摘要翻译：使用在其上沉积多个视网膜色素上皮细胞和/或虹膜色素上皮细胞和/或干细胞的巴氏纸来随机或以选定的细胞图案修复眼睛的视网膜系统的方法。细胞覆盖的巴氏纸定位在子视网膜空间中以将细胞转移到该空间，从而将视网膜恢复其正常功能，其中已发生视网膜损伤或变性，例如黄斑变性。

3. 发明申请

US20050214345A1 Artificial biocompatible material as a support for cells in a retinal implant 审中-公开
标题翻译：人造生物相容性材料作为视网膜植入物中的细胞的支持物
公开(公告)号：US20050214345A1
公开(公告)日：2005-09-29
申请号：US11061171
申请日：2005-02-18
申请人： Theodore Leng , Dimitri Yellachich , Philip Huie , Jaan Noolandi , Harvey Fishman
发明人： Theodore Leng , Dimitri Yellachich , Philip Huie , Jaan Noolandi , Harvey Fishman
IPC分类号： A61F2/14 , A61K31/716
CPC分类号： A61F2/14 , A61F9/00 , A61F9/007 , C12N5/062 , C12N2533/30
摘要： A retinal implant is provided that uses an artificial biocompatible material as a support material on which retinal pigment epithelial cells, iris pigment epithelial cells, and/or stem cells can be deposited either in situ or in vivo. The support material has a surface topology that is rough to promote cell adhesion, has surface pits to allow pigment cells to grow into, and has pores to allow for proper diffusion of materials. The support material serves as a substrate for cell growth and as a patch for damaged basement membrane (Bruch's membrane). This cell-coated membrane or pigment cell-enriched membrane is surgically positioned in the sub-retinal space to rescue or restore photoreceptor cell function that may be damaged or threatened by degenerative diseases of the eye, such as age-related macular degeneration.
摘要翻译：提供视网膜植入物，其使用人造生物相容性材料作为支架材料，视网膜色素上皮细胞，虹膜色素上皮细胞和/或干细胞可原位或体内沉积。支撑材料具有粗糙的表面拓扑以促进细胞粘附，具有表面凹坑以允许颜料细胞生长并具有允许材料适当扩散的孔。支撑材料用作细胞生长的底物和用作损伤的基底膜（布鲁赫氏膜）的贴剂。这种细胞包被的膜或色素细胞富集的膜通过外科手术放置在视网膜下部空间中以挽救或恢复可能由于退行性疾病（如年龄相关性黄斑变性）而损伤或受到威胁的感光细胞功能。

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