专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07135172B1 Bucky paper as a support membrane in retinal cell transplantation 有权
标题翻译： Bucky纸作为视网膜细胞移植中的支持膜
公开(公告)号：US07135172B1
公开(公告)日：2006-11-14
申请号：US10238515
申请日：2002-09-04
申请人： David J. Loftus , Theodore Leng , Philip Huie , Harvey Fishman
发明人： David J. Loftus , Theodore Leng , Philip Huie , Harvey Fishman
IPC分类号： A01N63/00 , A61F2/14 , A61F2/00
CPC分类号： A61F2/14 , A61L27/08 , A61L27/3813 , A61L27/3834 , A61L27/3869 , A61L2430/16 , B82Y30/00
摘要： A method for repairing a retinal system of an eye, using bucky paper on which a plurality of retina pigment epithelial cells and/or iris pigment epithelial cells and/or stem cells is deposited, either randomly or in a selected cell pattern. The cell-covered bucky paper is positioned in a sub-retinal space to transfer cells to this space and thereby restore the retina to its normal functioning, where retinal damage or degeneration, such as macular degeneration, has occurred.
摘要翻译：使用在其上沉积多个视网膜色素上皮细胞和/或虹膜色素上皮细胞和/或干细胞的巴氏纸来随机或以选定的细胞图案修复眼睛的视网膜系统的方法。细胞覆盖的巴氏纸定位在子视网膜空间中以将细胞转移到该空间，从而将视网膜恢复其正常功能，其中已发生视网膜损伤或变性，例如黄斑变性。

2. 发明申请

US20050214345A1 Artificial biocompatible material as a support for cells in a retinal implant 审中-公开
标题翻译：人造生物相容性材料作为视网膜植入物中的细胞的支持物
公开(公告)号：US20050214345A1
公开(公告)日：2005-09-29
申请号：US11061171
申请日：2005-02-18
申请人： Theodore Leng , Dimitri Yellachich , Philip Huie , Jaan Noolandi , Harvey Fishman
发明人： Theodore Leng , Dimitri Yellachich , Philip Huie , Jaan Noolandi , Harvey Fishman
IPC分类号： A61F2/14 , A61K31/716
CPC分类号： A61F2/14 , A61F9/00 , A61F9/007 , C12N5/062 , C12N2533/30
摘要： A retinal implant is provided that uses an artificial biocompatible material as a support material on which retinal pigment epithelial cells, iris pigment epithelial cells, and/or stem cells can be deposited either in situ or in vivo. The support material has a surface topology that is rough to promote cell adhesion, has surface pits to allow pigment cells to grow into, and has pores to allow for proper diffusion of materials. The support material serves as a substrate for cell growth and as a patch for damaged basement membrane (Bruch's membrane). This cell-coated membrane or pigment cell-enriched membrane is surgically positioned in the sub-retinal space to rescue or restore photoreceptor cell function that may be damaged or threatened by degenerative diseases of the eye, such as age-related macular degeneration.
摘要翻译：提供视网膜植入物，其使用人造生物相容性材料作为支架材料，视网膜色素上皮细胞，虹膜色素上皮细胞和/或干细胞可原位或体内沉积。支撑材料具有粗糙的表面拓扑以促进细胞粘附，具有表面凹坑以允许颜料细胞生长并具有允许材料适当扩散的孔。支撑材料用作细胞生长的底物和用作损伤的基底膜（布鲁赫氏膜）的贴剂。这种细胞包被的膜或色素细胞富集的膜通过外科手术放置在视网膜下部空间中以挽救或恢复可能由于退行性疾病（如年龄相关性黄斑变性）而损伤或受到威胁的感光细胞功能。

3. 发明申请

US20050203601A1 Neural stimulation array providing proximity of electrodes to cells via cellular migration 审中-公开
标题翻译：神经刺激阵列通过细胞迁移提供电极与细胞的接近
公开(公告)号：US20050203601A1
公开(公告)日：2005-09-15
申请号：US11035692
申请日：2005-01-13
申请人： Daniel Palanker , Philip Huie , Alexander Vankov , Harvey Fishman
发明人： Daniel Palanker , Philip Huie , Alexander Vankov , Harvey Fishman
IPC分类号： A61N1/00 , A61N1/04 , A61N1/05 , A61N1/36
CPC分类号： A61N1/0543 , A61N1/36046
摘要： An interface for selective excitation or sensing of neural cells in a biological neural network is provided. The interface includes a membrane with a number of channels passing through the membrane. Each channel has at least one electrode within it. Neural cells in the biological neural network grow or migrate into the channels, thereby coming into close proximity to the electrodes. Once one or more neural cells have grown or migrated into a channel, a voltage applied to the electrode within the channel selectively excites the neural cell(s) in that channel. The excitation of these neural cell(s) will then transmit throughout the neural network (i.e. cells and axons) that is associated with the neural cell(s) stimulated in the channel. An alternative interface provides cell excitation via an array of electrically conductive pillars on a substrate. The pillars have electrically insulated sides and exposed top surfaces, to provide selective cell excitation.
摘要翻译：提供了一种生物神经网络中选择性激发或感应神经细胞的界面。界面包括具有穿过膜的多个通道的膜。每个通道内至少有一个电极。生物神经网络中的神经细胞生长或迁移到通道中，从而接近电极。一旦一个或多个神经细胞已经生长或迁移到通道中，施加到通道内的电极的电压选择性地激发该通道中的神经细胞。然后，这些神经细胞的激发将通过与通道中刺激的神经细胞相关联的神经网络（即细胞和轴突）传递。另一种界面通过衬底上的导电柱阵列提供电池激发。支柱具有电绝缘的侧面和暴露的顶表面，以提供选择性的电池激发。

4. 发明授权

US08101169B2 Ocular gene therapy using avalanche-mediated transfection 有权
标题翻译：使用雪崩介导转染的眼基因治疗
公开(公告)号：US08101169B2
公开(公告)日：2012-01-24
申请号：US11505249
申请日：2006-08-15
申请人： Thomas W. Chalberg, Jr. , Mark Blumenkranz , Daniel V. Palanker , Alexander Vankov , Philip Huie, Jr. , Michael F. Marmor , Michele P. Calos
发明人： Thomas W. Chalberg, Jr. , Mark Blumenkranz , Daniel V. Palanker , Alexander Vankov , Philip Huie, Jr. , Michael F. Marmor , Michele P. Calos
IPC分类号： A61K48/00
CPC分类号： C12N13/00 , A61K48/00 , C12N15/87
摘要： The present invention provides a method of treating an ocular disease in a subject. In a first step, a nucleic acid is introduced into cells or a tissue. The nucleic acid is introduced by electron avalanche transfection. With this technique, a high electric field induces a vapor bubble and plasma discharge between an electrode and the surrounding medium. The formation of a vapor bubble generates mechanical stress. Plasma discharge through the ionized vapor in the bubble enables connectivity between the electrode and the surrounding medium, so that mechanical stress and electric field are applied simultaneously, which results in permeabilization of the cells or tissue. This permeabilization in turn allows the nucleic acid to enter the cell or tissue. Cells or tissue containing the nucleic acid are then transplanted into an ocular region of the subject.
摘要翻译：本发明提供一种治疗受试者眼部疾病的方法。在第一步骤中，将核酸引入细胞或组织。通过电子雪崩转染引入核酸。利用这种技术，高电场在电极和周围介质之间引起蒸汽气泡和等离子体放电。气泡的形成产生机械应力。通过气泡中的电离蒸汽的等离子体放电使得电极和周围介质之间能够连接，使得同时施加机械应力和电场，这导致细胞或组织的透化。这种渗透反过来又允许核酸进入细胞或组织。然后将含有核酸的细胞或组织移植到受试者的眼部区域。

5. 发明申请

US20100174021A1 Three-dimensionally shaped interpenetrating network hydrogels 审中-公开
标题翻译：三维形状的互穿网络水凝胶
公开(公告)号：US20100174021A1
公开(公告)日：2010-07-08
申请号：US12653293
申请日：2009-12-11
申请人： Philip Huie, JR. , Dale Jon Waters , Curtis W. Frank , Christopher N. Ta , Ariane C. Tom
发明人： Philip Huie, JR. , Dale Jon Waters , Curtis W. Frank , Christopher N. Ta , Ariane C. Tom
IPC分类号： C08K5/06 , C08J3/00
CPC分类号： A61L27/52
摘要： Three-dimensionally (3-D) shaped interpenetrating double network (IPN) hydrogel based on a first network and a second network are provided. The 3-D shape is characterized by a non-uniform distribution of the second network (e.g. carboxylic acid groups) when in hydrated state. The 3-D shape can further be characterized by changes in the radius of curvature of the shape. The 3-D IPN hydrogel is created by applying a non-uniform illumination pattern to polymerize the second network of monomers within a layer of a first network. In hydrated state, the second network causes a swelling force that is resisted by the first network. The non-uniformal distribution of the second network with the first network is responsible for the 3-D of the resulting IPN. The invention can find use in ophthalmic applications as well as non-ophthalmic applications.
摘要翻译：提供了基于第一网络和第二网络的三维（3-D）形状互穿双网络（IPN）水凝胶。当处于水合状态时，3-D形状的特征在于第二网络（例如羧酸基团）的不均匀分布。 3-D形状可以进一步由形状的曲率半径的变化来表征。通过施加不均匀照明图案以在第一网络的层内聚合单体的第二网络来产生3-D IPN水凝胶。在水合状态下，第二网络引起第一网络抵抗的膨胀力。第二个网络与第一个网络的不均匀分布负责所产生的IPN的3-D。本发明可用于眼科应用以及非眼科应用。

6. 发明申请

US20080038814A1 Nanotube mat with an array of conduits for biological cells 审中-公开
标题翻译：具有生物细胞管道阵列的纳米管垫
公开(公告)号：US20080038814A1
公开(公告)日：2008-02-14
申请号：US11893018
申请日：2007-08-13
申请人： Philip Huie
发明人： Philip Huie
IPC分类号： C12M1/00
CPC分类号： C12N5/0068 , A61L27/50 , A61L2400/12 , A61L2400/18 , B82Y5/00 , C12M23/12 , C12M23/20 , C12N2533/10 , C40B40/02
摘要： A nanotube mat containing one or more hydrogels is provided. The nanotube mat/hydrogel device allows for the formation of conduits partially or completely through the thickness of the device. The device could be used as support or host device for biological cells, an agent delivery device or a prosthetic interface. Carbon nanotubes and hydrogels are used to develop the device provide mechanical stability, are biocompatible, will support cell growth, allow for patterning of biological cells, allow its surfaces to be derivatized with growth factors, molecules, nutrients, inhibitory factors, ligands, transduction molecules or morphogenic factors, and would allow the formation of conduits to guide cells, neurites and axons to be hosted or grown. The hydrogel(s) within the device has(have) a dry and a hydrated state useful for creating a film layer at the surfaces of the device (or components thereof) or encapsulating or surrounding the content within the conduits.
摘要翻译：提供了含有一种或多种水凝胶的纳米管垫。纳米管垫/水凝胶装置允许部分地或完全地通过装置的厚度形成导管。该装置可以用作生物细胞的支持物或宿主装置，药剂递送装置或假肢界面。碳纳米管和水凝胶用于开发该器件提供机械稳定性，是生物相容的，将支持细胞生长，允许生物细胞的图案化，允许其表面被生长因子，分子，营养物，抑制因子，配体，转导分子衍生或形态发生因子，并且将允许形成导管以引导要宿主或生长的细胞，神经突和轴突。装置内的水凝胶具有（具有）干燥和水合状态，用于在装置（或其部件）的表面处形成膜层或者封装或围绕导管内的内容物。

7. 发明授权

US07255871B2 Nanotube mat with an array of conduits for biological cells 失效
标题翻译：具有生物细胞管道阵列的纳米管垫
公开(公告)号：US07255871B2
公开(公告)日：2007-08-14
申请号：US10431334
申请日：2003-05-06
申请人： Philip Huie, Jr. , Harvey A. Fishman
发明人： Philip Huie, Jr. , Harvey A. Fishman
IPC分类号： A61F2/00 , C12N5/00 , C12M1/00 , C12Q1/00
CPC分类号： C12N5/0068 , A61L27/50 , A61L2400/12 , A61L2400/18 , B82Y5/00 , C12M23/12 , C12M23/20 , C12N2533/10 , C40B40/02
摘要： A nanotube mat is provided with an array of conduits to support, direct growth, select or interface one or more biological cells or cell processes. The carbon nanotube mat provides mechanical stability, is biocompatible, will support cell growth, can desirably be derivatized with growth factors, molecules, nutrients, inhibitory factors, ligands, transduction molecules or morphogenic factors, and would allow the formation of conduits to guide cells and cell extensions to be hosted or grown. The conduits could take any size or shape to support, direct growth, select or interface one or more cells or processes. In general the conduits could be channels, discontinuous channels, tapered channels or walls. The nanotube mat could be used to interface biological cells with other cells, tissue or structures that have electrical, mechanical, magnetic means, or optical means. The nanotube mat could also incorporate chemicals, analytes, drugs, lips, carbohydrates, secretory products or the like.
摘要翻译：纳米管垫被提供有一系列管道以支持，直接生长，选择或接合一个或多个生物细胞或细胞过程。碳纳米管垫提供机械稳定性，是生物相容的，将支持细胞生长，可以期望地被生长因子，分子，营养物，抑制因子，配体，转导分子或形态发生因子衍生，并且将允许形成导管以引导细胞和单元格扩展名被托管或增长。导管可以采取任何尺寸或形状来支持，直接生长，选择或接合一个或多个细胞或过程。通常，导管可以是通道，不连续通道，锥形通道或壁。纳米管垫可用于将生物细胞与具有电，机械，磁性装置或光学装置的其它细胞，组织或结构相接触。纳米管垫也可以掺入化学品，分析物，药物，嘴唇，碳水化合物，分泌产物等。

8. 发明授权

US06939378B2 Microfabricated tissue as a substrate for pigment epithelium transplantation 失效
标题翻译：微生物组织作为色素上皮细胞移植的底物
公开(公告)号：US06939378B2
公开(公告)日：2005-09-06
申请号：US09872513
申请日：2001-06-01
申请人： Harvey A. Fishman , Mark Blumenkranz , Stacey Francine Bent , Christina Lee , Philip Huie, Jr. , Daniel V. Palanker
发明人： Harvey A. Fishman , Mark Blumenkranz , Stacey Francine Bent , Christina Lee , Philip Huie, Jr. , Daniel V. Palanker
IPC分类号： C12M3/00 , A61F2/14 , A61L27/00 , A61L27/38 , C12N5/06
CPC分类号： A61F2/14 , A61L27/3604 , A61L27/3813 , A61L27/3839
摘要： Methods and apparatus for modifying membranous tissue, growing cells on modified membranous tissue, and for transplantation of modified tissues and modified tissues with attached cells are provided. In particular, the invention provides methods and apparatus for modifying membranous tissue such as lens capsule tissue and inner limiting membrane tissue, for growing cells such as iris pigment epithelial (IPE) cells and retinal pigment epithelial (RPE) cells on modified membranous tissue, and for modifying membranous tissue and growing cells on biodegradable polymer substrates. A method of modifying membranous tissues comprises depositing micropatterns of biomolecules onto membranous tissue with a contacting surface such as a stamp; other methods include mechanical ablation, photoablation, ion beam ablation, and modification of membranous tissues via the action of proteolytic enzymes.
摘要翻译：提供了修饰膜组织，在修饰的膜组织上生长细胞，以及用于移植修饰的组织和经连接的细胞的修饰组织的方法和装置。特别地，本发明提供了用于在改良的膜组织上生长诸如虹膜色素上皮（IPE）细胞和视网膜色素上皮（RPE）细胞的细胞的膜组织例如晶状体囊组织和内限制膜组织的方法和装置，以及用于修饰可生物降解的聚合物基质上的膜组织和生长细胞。修饰膜组织的方法包括用生物分子的微图案沉积在膜组织上，其中接触表面例如印记; 其他方法包括机械消融，光消融，离子束消融，以及通过蛋白水解酶的作用修饰膜组织。

9. 发明授权

US06976997B2 Artificial cornea 失效
标题翻译：人造角膜
公开(公告)号：US06976997B2
公开(公告)日：2005-12-20
申请号：US10465040
申请日：2003-06-18
申请人： Jaan Noolandi , Christopher Ta , Philip Huie, Jr. , Alan J. Smith , Robert Waymouth , Mark Blumenkranz
发明人： Jaan Noolandi , Christopher Ta , Philip Huie, Jr. , Alan J. Smith , Robert Waymouth , Mark Blumenkranz
IPC分类号： A61L27/00 , A61F20060101 , A61F2/14 , A61F2/16 , A61L27/34 , A61L27/54 , A61L27/56
CPC分类号： B82Y30/00 , A61F2/142 , A61L27/34 , A61L27/54 , A61L27/56 , A61L2300/406 , A61L2300/414 , A61L2300/43 , A61L2300/432 , C08L89/06
摘要： The invention provides implants suitable for use as an artificial cornea, and methods for making and using such implants. Artificial corneas having features of the invention may be two-phase artificial corneas, or may be three phase artificial corneas. These artificial corneas have a flexible, optically clear central core and a hydrophilic, porous skirt, both of which are biocompatible and allow for tissue integration. A three-phase artificial cornea will further have an interface region between the core and skirt. The artificial corneas have a high degree of ocular tolerance, and allow for tissue integration into the skirt and for epithelial cell growth over the surface of the prosthesis. The use of biocompatible material avoids the risk of disease transmission inherent with corneal transplants, and acts to minimize post-operative inflammation and so to reduce the chance or severity of tissue necrosis following implantation of the synthetic cornea onto a host eye.
摘要翻译：本发明提供适合用作人造角膜的植入物，以及制造和使用这种植入物的方法。具有本发明特征的人造角膜可以是两相人造角膜，也可以是三相人造角膜。这些人造角膜具有柔性的，光学透明的中心芯和亲水的，多孔的裙部，两者都是生物相容的并且允许组织整合。三相人造角膜还将具有在芯部和裙部之间的界面区域。人造角膜具有高度的眼部耐受性，并且允许组织整合到裙部中并且允许在假体表面上的上皮细胞生长。生物相容材料的使用避免了角膜移植固有的疾病传播的风险，并且起作用以使术后炎症最小化，从而降低植入人工角膜后的组织坏死的机会或严重程度。

10. 发明授权

US08283171B2 Method and apparatus for avalanche-mediated transfer of agents into cells 有权
标题翻译：将雪崩介导的试剂转移到细胞中的方法和装置
公开(公告)号：US08283171B2
公开(公告)日：2012-10-09
申请号：US13042934
申请日：2011-03-08
申请人： Alexander Vankov , Thomas W. Chalberg , Philip Huie, Jr. , Daniel V. Palanker
发明人： Alexander Vankov , Thomas W. Chalberg , Philip Huie, Jr. , Daniel V. Palanker
IPC分类号： C12N15/87 , C12N13/00
CPC分类号： C12N13/00
摘要： The present invention provides a method and apparatus for transferring an agent into a cell. The method includes the steps of providing an agent outside of a cell and generating a vapor bubble and a plasma discharge between an avalanche electrode and a conductive fluid surrounding the cell. The vapor bubble and plasma discharge generate a mechanical stress wave and an electric field, respectively. The combination of this mechanical stress wave and electric field results in permeabilization of the cell, which in turn results in transfer of the agent into the cell.
摘要翻译：本发明提供了一种将药剂转移到细胞中的方法和装置。该方法包括以下步骤：在电池外部提供一种试剂，并在雪崩电极和围绕电池的导电流体之间产生蒸汽气泡和等离子体放电。蒸气泡和等离子体放电分别产生机械应力波和电场。这种机械应力波和电场的组合导致电池的透化，这进而导致试剂转移到电池中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式