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1. 发明授权

US09744139B2 Modular ingestible drug delivery capsule 有权
公开(公告)号：US09744139B2
公开(公告)日：2017-08-29
申请号：US13262841
申请日：2010-04-02
申请人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
发明人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
IPC分类号： A61K9/48 , A61K9/00 , A61M31/00
CPC分类号： A61K9/4808 , A61K9/0009 , A61K9/0097 , A61M31/002
摘要： An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).

2. 发明授权

US08852155B2 Medicine reservoir for drug delivery device 有权
标题翻译：药物输送装置药库
公开(公告)号：US08852155B2
公开(公告)日：2014-10-07
申请号：US13390110
申请日：2010-08-09
申请人： Hans Zou , Jeff Shimizu , Lucian Remus Albu
发明人： Hans Zou , Jeff Shimizu , Lucian Remus Albu
IPC分类号： A61M5/178 , A61M31/00
CPC分类号： A61M31/00 , A61M31/002
摘要： A medicine reservoir (10) is provided for use with a drug delivery device (50). The medicine reservoir (10) is arranged for comprising a drug (13) and comprises a dispensing hole (15) for dispensing the drug (13) into an environment of the drug delivery device (50). The medicine reservoir (10) further comprises a deformable plug (14) which plug (14) is removable by pressure caused by a dispensing action of the drug delivery device (50).
摘要翻译：提供药物贮存器（10）以与药物输送装置（50）一起使用。药液贮存器（10）被布置成包括药物（13），并且包括用于将药物（13）分配到药物输送装置（50）的环境中的分配孔（15）。药物储存器（10）还包括可变形插塞（14），该插塞（14）可以由药物输送装置（50）的分配动作引起的压力移除。

3. 发明申请

US20130197440A1 MEDICINE RESERVOIR FOR DRUG DELIVERY DEVICE 有权
标题翻译：药物储存器用于药物递送装置
公开(公告)号：US20130197440A1
公开(公告)日：2013-08-01
申请号：US13390110
申请日：2010-08-09
申请人： Hans Zou , Jeff Shimizu , Lucian Remus Albu
发明人： Hans Zou , Jeff Shimizu , Lucian Remus Albu
IPC分类号： A61M31/00
CPC分类号： A61M31/00 , A61M31/002
摘要： A medicine reservoir (10) is provided for use with a drug delivery device (50). The medicine reservoir (10) is arranged for comprising a drug (13) and comprises a dispensing hole (15) for dispensing the drug (13) into an environment of the drug delivery device (50). The medicine reservoir (10) further comprises a deformable plug (14) which plug (14) is removable by pressure caused by a dispensing action of the drug delivery device (50).
摘要翻译：提供药物贮存器（10）以与药物输送装置（50）一起使用。药液贮存器（10）被布置成包括药物（13），并且包括用于将药物（13）分配到药物输送装置（50）的环境中的分配孔（15）。药物储存器（10）还包括可变形插塞（14），该插塞（14）可以由药物输送装置（50）的分配动作引起的压力移除。

4. 发明申请

US20120116358A1 MODULAR INGESTIBLE DRUG DELIVERY CAPSULE 有权
标题翻译：模块不可食用药物输送胶囊
公开(公告)号：US20120116358A1
公开(公告)日：2012-05-10
申请号：US13262841
申请日：2010-04-02
申请人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
发明人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
IPC分类号： A61M37/00
CPC分类号： A61K9/4808 , A61K9/0009 , A61K9/0097 , A61M31/002
摘要： An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).
摘要翻译：提供用于输送药物的可摄取胶囊（10），所述胶囊（10）包括第一模块（11）和第二模块（12）。第一模块（11）具有至少一个用于包含一定量药物的药物隔室（13）。药物隔室（13）由具有嵌入的导电加热丝（15）的箔（14）密封。第二（12）模块包括用于向加热丝（15）提供电脉冲以便通过熔化箔（14）打开药物隔室（13）的电子器件（18）。第一模块（11）和第二模块（12）包括用于将第一模块（11）固定到第二模块（12）的可互操作的连接装置（19），使得电热丝（15）电连接到电子装置）。

5. 发明申请

US20100045309A1 METHOD AND APPARATUS FOR MEASURING FLUID PROPERTIES, INCLUDING PH 审中-公开
标题翻译：用于测量流体特性的方法和装置，包括PH
公开(公告)号：US20100045309A1
公开(公告)日：2010-02-25
申请号：US12521015
申请日：2007-12-26
申请人： Han Zou , Lucian Remus Albu , Jeff Shimizu , Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Adam Schleicher , Frits Tobi De Jongh
发明人： Han Zou , Lucian Remus Albu , Jeff Shimizu , Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Adam Schleicher , Frits Tobi De Jongh
IPC分类号： G01R27/26
CPC分类号： A61B5/053 , A61B5/073 , A61B5/14539 , A61B5/42
摘要： A fluid sensor for use within the gastro-intestinal tract of a human being is disclosed. The sensor includes a sensing coil which is immersible in the sample fluid of the gastro-intestinal tract; a signal generator in electrical with the sensing coil for applying an electrical current pulse to the sensing coil; a signal receiver in communication with the sensing coil for measuring an electrical reflection relative to said electrical current pulse; and a data processor for receiving the electrical reflection and for calculating data representative of at least one property, such as pH of the sample fluid based on the electrical reflection. The fluid sensor can also include a reference coil for calibrating the sensing coil. The sensor coil and reference coil can be encapsulated in a swallowable pill shell. The sensor coil can also function as an antenna for transmitting and receiving signals to/form a remote location.
摘要翻译：公开了一种在人胃肠道内使用的流体传感器。该传感器包括一感测线圈，该感测线圈可浸入胃肠道的样品流体中; 与所述感测线圈电连接以将电流脉冲施加到所述感测线圈的信号发生器; 与传感线圈通信的信号接收器，用于测量相对于所述电流脉冲的电反射; 以及数据处理器，用于接收电反射并且用于计算代表至少一个性质的数据，例如基于电反射的样品流体的pH。流体传感器还可以包括用于校准感测线圈的参考线圈。传感器线圈和参考线圈可以封装在可吞咽的药丸壳中。传感器线圈还可以用作用于向/形成远程位置发送和接收信号的天线。

6. 发明授权

US10046109B2 Drug delivery device with compressible drug reservoir 有权
公开(公告)号：US10046109B2
公开(公告)日：2018-08-14
申请号：US13390111
申请日：2010-08-10
申请人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
发明人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
IPC分类号： A61M5/145 , A61M31/00
摘要： A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug de delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).

7. 发明授权

US09687638B2 Swallowable medication capsule 有权
公开(公告)号：US09687638B2
公开(公告)日：2017-06-27
申请号：US14006901
申请日：2012-03-23
申请人： Hans Zou , Jeff Shimizu
发明人： Hans Zou , Jeff Shimizu
IPC分类号： A61M31/00 , A61K9/48
CPC分类号： A61M31/00 , A61K9/4808 , A61M31/002
摘要： The invention relates to a swallowable medication capsule capable 200 of dispensing fluid medicine stored in a medication compartment 211 through a valveless exit hole 207. A vent hole 206 enables ventilation of an actuator cavity 212 which houses an actuator used for displacing a surface 205 which separates the medication cavity 211 and the actuator cavity 212. By locating the vent and exit holes close to each other so that contact with contracting parts of the gastrointestinal tract and the exterior surface 221 is not able to prohibit a pressure passageway between the vent and exit holes, creation of a pressure difference of pressures in the medication and actuator cavity is prohibited.

8. 发明授权

US09227011B2 Miniaturized threshold sensor 有权
标题翻译：小型阈值传感器
公开(公告)号：US09227011B2
公开(公告)日：2016-01-05
申请号：US12442961
申请日：2007-09-27
申请人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman , Anke Pierik , Judith Margaret Rensen
发明人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman , Anke Pierik , Judith Margaret Rensen
IPC分类号： G08B1/08 , A61M5/142 , A61B5/07 , A61M5/172
CPC分类号： A61M5/14276 , A61B5/073 , A61B2562/0214 , A61M5/1723 , A61M2005/1726 , A61M2210/1053
摘要： A sensor comprising a plurality of electrodes having a miniature size and a lower power consumption and a coating exterior to the electrodes, wherein the coating interacts with a target condition thereby producing a change in an electrical property of the electrodes, wherein the change is transduced into an electrical signal by the electrodes. Further a system for medication delivery comprising such sensor and a pill.
摘要翻译：一种传感器，包括具有微小尺寸和较低功率消耗的多个电极以及电极外部的涂层，其中所述涂层与目标条件相互作用，从而产生电极的电性能的变化，其中所述变化被转换成电极的电信号。另外，用于药物输送的系统包括这种传感器和丸剂。

9. 发明申请

US20110092959A1 ELECTRONIC PILL COMPRISING A PLURALITY OF MEDICINE RESERVOIRS 有权
标题翻译：包含多种药物储存的电子药丸
公开(公告)号：US20110092959A1
公开(公告)日：2011-04-21
申请号：US12992613
申请日：2009-06-18
申请人： Hans Zou , Jeff Shimizu , Lucian R. Albu , Johan F. Dijksman
发明人： Hans Zou , Jeff Shimizu , Lucian R. Albu , Johan F. Dijksman
IPC分类号： A61M37/00 , B65B3/04
CPC分类号： A61M31/002
摘要： Electronic pill (1, 11, 21) comprising a plurality of medicine reservoirs (2, 12, 22), each of the reservoirs comprising a discharge opening (3, 13, 23) covered by a removable cover (6, 16, 26). The pill comprises at least one actuator responsive to control circuitry for removing the cover from the discharge opening (3, 13, 23). The actuator can for example be a spring loaded piston (4) breaking a foil cover when dispensing the medicament. 5 Alternatively, the cover can be a rotatable disk (16) or cylinder (26) with an opening (17, 27) which can be brought in line with the discharge opening of a reservoir under the action of the actuator.
摘要翻译：包括多个药物储存器（2,12,22）的电子药丸（1,11,21），每个储存器包括由可移除的盖（6,16,26）覆盖的排出口（3,13,33）。所述药丸包括响应于控制电路的至少一个致动器，用于从所述排放开口（3,13,33）移除所述盖。致动器可以例如是在分配药物时破坏箔盖的弹簧加载的活塞（4）。或者，盖可以是具有开口（17,27）的可旋转盘（16）或圆筒（26），该开口可在致动器的作用下与储存器的排出口一致。

10. 发明申请

US20110089050A1 METHOD AND APPARATUS FOR CHEMICAL ANALYSIS OF FLUIDS 有权
标题翻译：流体化学分析方法与装置
公开(公告)号：US20110089050A1
公开(公告)日：2011-04-21
申请号：US12673845
申请日：2008-08-29
申请人： Lucian R. Albu , Hans Zou , Jeff Shimizu
发明人： Lucian R. Albu , Hans Zou , Jeff Shimizu
IPC分类号： G01N27/413 , G01N27/416
CPC分类号： A63B69/0002 , A63B69/3641 , A63B2069/0008 , A63B2209/00 , A63B2210/50 , A63B2225/09 , A63B2225/093
摘要： An apparatus and method for electrochemical fluid analysis comprises a chamber (1202) having a depth dimension for accommodating a volume of a fluid under test, first and second electrodes (A1) disposed within the chamber and extending along the depth dimension in spaced relation with each other, and a soluble solid, such as an annealed polymer, e.g. EUDRAGIT occupying a lateral gap between the first and second electrodes. The rate of dissolution as monitored by electrochemical impedance spectroscopy (EIS) of the soluble solid within the fluid depends on the chemical concentration of a corresponding analyte present in solution in the fluid. In one embodiment a silicon-based integrated circuit device defining an upper margin includes an array of electrodes disposed along said upper margin to permit direct exposure of the electrode array to the fluid under test. The device is constructed using CMOS technology.
摘要翻译：用于电化学流体分析的装置和方法包括具有用于容纳待测流体体积的深度尺寸的腔室（1202），设置在腔室内的第一和第二电极（A1），并且沿与所述腔室间隔开的深度尺寸延伸另一种和可溶性固体，例如退火的聚合物，例如 EUDRAGIT占据第一和第二电极之间的横向间隙。通过流体中可溶性固体的电化学阻抗谱（EIS）监测的溶解速率取决于流体中溶液中存在的相应分析物的化学浓度。在一个实施例中，限定上边缘的硅基集成电路器件包括沿着所述上边缘设置的电极阵列，以允许电极阵列直接暴露于待测流体。该器件采用CMOS技术构建。

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