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1. 发明授权

US09744139B2 Modular ingestible drug delivery capsule 有权
公开(公告)号：US09744139B2
公开(公告)日：2017-08-29
申请号：US13262841
申请日：2010-04-02
申请人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
发明人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
IPC分类号： A61K9/48 , A61K9/00 , A61M31/00
CPC分类号： A61K9/4808 , A61K9/0009 , A61K9/0097 , A61M31/002
摘要： An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).

2. 发明申请

US20120116358A1 MODULAR INGESTIBLE DRUG DELIVERY CAPSULE 有权
标题翻译：模块不可食用药物输送胶囊
公开(公告)号：US20120116358A1
公开(公告)日：2012-05-10
申请号：US13262841
申请日：2010-04-02
申请人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
发明人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
IPC分类号： A61M37/00
CPC分类号： A61K9/4808 , A61K9/0009 , A61K9/0097 , A61M31/002
摘要： An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).
摘要翻译：提供用于输送药物的可摄取胶囊（10），所述胶囊（10）包括第一模块（11）和第二模块（12）。第一模块（11）具有至少一个用于包含一定量药物的药物隔室（13）。药物隔室（13）由具有嵌入的导电加热丝（15）的箔（14）密封。第二（12）模块包括用于向加热丝（15）提供电脉冲以便通过熔化箔（14）打开药物隔室（13）的电子器件（18）。第一模块（11）和第二模块（12）包括用于将第一模块（11）固定到第二模块（12）的可互操作的连接装置（19），使得电热丝（15）电连接到电子装置）。

3. 发明申请

US20100045309A1 METHOD AND APPARATUS FOR MEASURING FLUID PROPERTIES, INCLUDING PH 审中-公开
标题翻译：用于测量流体特性的方法和装置，包括PH
公开(公告)号：US20100045309A1
公开(公告)日：2010-02-25
申请号：US12521015
申请日：2007-12-26
申请人： Han Zou , Lucian Remus Albu , Jeff Shimizu , Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Adam Schleicher , Frits Tobi De Jongh
发明人： Han Zou , Lucian Remus Albu , Jeff Shimizu , Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Adam Schleicher , Frits Tobi De Jongh
IPC分类号： G01R27/26
CPC分类号： A61B5/053 , A61B5/073 , A61B5/14539 , A61B5/42
摘要： A fluid sensor for use within the gastro-intestinal tract of a human being is disclosed. The sensor includes a sensing coil which is immersible in the sample fluid of the gastro-intestinal tract; a signal generator in electrical with the sensing coil for applying an electrical current pulse to the sensing coil; a signal receiver in communication with the sensing coil for measuring an electrical reflection relative to said electrical current pulse; and a data processor for receiving the electrical reflection and for calculating data representative of at least one property, such as pH of the sample fluid based on the electrical reflection. The fluid sensor can also include a reference coil for calibrating the sensing coil. The sensor coil and reference coil can be encapsulated in a swallowable pill shell. The sensor coil can also function as an antenna for transmitting and receiving signals to/form a remote location.
摘要翻译：公开了一种在人胃肠道内使用的流体传感器。该传感器包括一感测线圈，该感测线圈可浸入胃肠道的样品流体中; 与所述感测线圈电连接以将电流脉冲施加到所述感测线圈的信号发生器; 与传感线圈通信的信号接收器，用于测量相对于所述电流脉冲的电反射; 以及数据处理器，用于接收电反射并且用于计算代表至少一个性质的数据，例如基于电反射的样品流体的pH。流体传感器还可以包括用于校准感测线圈的参考线圈。传感器线圈和参考线圈可以封装在可吞咽的药丸壳中。传感器线圈还可以用作用于向/形成远程位置发送和接收信号的天线。

4. 发明申请

US20100063486A1 MEDICAMENT DELIVERY APPARATUS 有权
标题翻译：药物递送装置
公开(公告)号：US20100063486A1
公开(公告)日：2010-03-11
申请号：US12442408
申请日：2007-09-20
申请人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Michel Pardoel , Frits Tobi De Jongh
发明人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Michel Pardoel , Frits Tobi De Jongh
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61B5/073 , A61B5/4839 , A61M31/00
摘要： An electronic capsule (100) is provided. The capsule (100) has a discrete drive element (300) comprising: a housing (109), electronics for making the electronic capsule (100) operable, a pumping mechanism (115) for dosing and displacing a substance, a power source (105) for powering the electronic capsule (100) and enabling the electronics and the pumping mechanism (115) to operate, and a locking mechanism (130); and a discrete payload element (200) comprising: a housing (109), a reservoir (210) for storing the substance, one or more openings (250) in the housing (109) for releasing the substance from the reservoir (210) and a locking mechanism (230) for engaging the drive element locking mechanism (130). Engagement of the drive element locking mechanism (130) with the payload element locking mechanism (230) secures the drive element (300) to the payload element (200), thereby making the electronic capsule (100) operable and specific.
摘要翻译：提供电子胶囊（100）。所述胶囊（100）具有离散驱动元件（300），包括：壳体（109），用于使所述电子胶囊（100）可操作的电子设备，用于计量和移位物质的泵送机构（115），电源（105）），用于对所述电子胶囊（100）供电并使得所述电子设备和所述泵送机构（115）能够操作;以及锁定机构（130）。和离散有效载荷元件（200），包括：壳体（109），用于存储物质的储存器（210），用于将物质从储存器（210）释放的壳体（109）中的一个或多个开口（250）用于接合驱动元件锁定机构（130）的锁定机构（230）。驱动元件锁定机构（130）与有效载荷元件锁定机构（230）的接合将驱动元件（300）固定到有效载荷元件（200），从而使电子胶囊（100）可操作和特定。

5. 发明申请

US20100049012A1 INGESTIBLE ELECTRONIC CAPSULE AND IN VIVO DRUG DELIVERY OR DIAGNOSTIC SYSTEM 有权
标题翻译：不可渗透的电子胶囊和体内药物递送或诊断系统
公开(公告)号：US20100049012A1
公开(公告)日：2010-02-25
申请号：US12515424
申请日：2007-11-05
申请人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Claude Jean-Marie Malaurie , Yvan O.J.G. Droinet , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu
发明人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Claude Jean-Marie Malaurie , Yvan O.J.G. Droinet , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu
IPC分类号： A61B5/07 , A61M37/00
CPC分类号： A61B5/073 , A61B1/00016 , A61B1/041 , A61B5/4839
摘要： An ingestible electronic capsule (100) for introduction into the bodily lumen comprises a circuit board with at least one electronic component (4,5,7,8,9,11, 12, 13, 14). The circuit board is formed from a flex foil (10), thereby reducing the number of components and improving the robustness and reliability of the ingestible electronic capsule (100).
摘要翻译：用于引入人体内腔的可摄入电子胶囊（100）包括具有至少一个电子部件（4,5,7,8,9,11,12,13,14）的电路板。电路板由柔性箔（10）形成，从而减少了组件的数量并提高了可摄取电子胶囊（100）的坚固性和可靠性。

6. 发明申请

US20100056874A1 MEDICAMENT DELIVERY DEVICE, CAPSULE AND IN VIVO MEDICINE DELIVERY OR DIAGNOSTIC SYSTEM 有权
标题翻译：药物输送装置，胶囊和体内药物递送或诊断系统
公开(公告)号：US20100056874A1
公开(公告)日：2010-03-04
申请号：US12515383
申请日：2007-11-06
申请人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu , Ventzeslav Iordanov , Hans Marc Bert Boeve
发明人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu , Ventzeslav Iordanov , Hans Marc Bert Boeve
IPC分类号： A61M31/00 , A61B5/00
CPC分类号： A61M5/14593 , A61B1/041 , A61B5/01 , A61B5/073 , A61B5/14539 , A61B5/4839 , A61M5/14276 , A61M31/002 , A61M2005/14204 , A61M2205/3561
摘要： A medicament delivery device, which comprises a driving mechanism and a housing (1) having a reservoir (2), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (21). The driving mechanism is adapted to press a piston (23) against the flexible wall (21) thereby releasing the substance from the reservoir (2) through an opening (25) in the reservoir (2). This provides for a safe and reliable medicament delivery device.
摘要翻译：一种药物输送装置，其包括驱动机构和具有储存器（2）的壳体（1），其至少部分地填充有物质，并且至少在一侧上用柔性壁（21）密封。驱动机构适于将活塞（23）压靠在柔性壁（21）上，从而通过储存器（2）中的开口（25）将物质从储存器（2）释放。这提供了一种安全可靠的药物输送装置。

7. 发明授权

US09878094B2 Medicament delivery device, capsule and in vivo medicine delivery or diagnostic system 有权
公开(公告)号：US09878094B2
公开(公告)日：2018-01-30
申请号：US12515383
申请日：2007-11-06
申请人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu , Ventzeslav Iordanov , Hans Marc Bert Boeve
发明人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu , Ventzeslav Iordanov , Hans Marc Bert Boeve
IPC分类号： A61M31/00 , A61B5/00 , A61M5/145 , A61B5/07 , A61B5/145 , A61B1/04 , A61B5/01 , A61M5/142
CPC分类号： A61M5/14593 , A61B1/041 , A61B5/01 , A61B5/073 , A61B5/14539 , A61B5/4839 , A61M5/14276 , A61M31/002 , A61M2005/14204 , A61M2205/3561
摘要： A medicament delivery device, which comprises a driving mechanism and a housing (1) having a reservoir (2), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (21). The driving mechanism is adapted to press a piston (23) against the flexible wall (21) thereby releasing the substance from the reservoir (2) through an opening (25) in the reservoir (2). This provides for a safe and reliable medicament delivery device.

8. 发明授权

US09550050B2 Medicament delivery apparatus 有权
标题翻译：药物输送装置
公开(公告)号：US09550050B2
公开(公告)日：2017-01-24
申请号：US12442408
申请日：2007-09-20
申请人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Michel Pardoel , Frits Tobi De Jongh
发明人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Michel Pardoel , Frits Tobi De Jongh
IPC分类号： A61K9/22 , A61M31/00 , A61B5/07 , A61B5/00
CPC分类号： A61M31/002 , A61B5/073 , A61B5/4839 , A61M31/00
摘要： An electronic capsule (100) is provided. The capsule (100) has a discrete drive element (300) comprising: a housing (109), electronics for making the electronic capsule (100) operable, a pumping mechanism (115) for dosing and displacing a substance, a power source (105) for powering the electronic capsule (100) and enabling the electronics and the pumping mechanism (115) to operate, and a locking mechanism (130); and a discrete payload element (200) comprising: a housing (109), a reservoir (210) for storing the substance, one or more openings (250) in the housing (109) for releasing the substance from the reservoir (210) and a locking mechanism (230) for engaging the drive element locking mechanism (130). Engagement of the drive element locking mechanism (130) with the payload element locking mechanism (230) secures the drive element (300) to the payload element (200), thereby making the electronic capsule (100) operable and specific.
摘要翻译：提供电子胶囊（100）。所述胶囊（100）具有离散驱动元件（300），包括：壳体（109），用于使所述电子胶囊（100）可操作的电子设备，用于计量和移位物质的泵送机构（115），电源（105）），用于对所述电子胶囊（100）供电并使得所述电子设备和所述泵送机构（115）能够操作;以及锁定机构（130）。和离散有效载荷元件（200），包括：壳体（109），用于存储物质的储存器（210），用于将物质从储存器（210）释放的壳体（109）中的一个或多个开口（250）用于接合驱动元件锁定机构（130）的锁定机构（230）。驱动元件锁定机构（130）与有效载荷元件锁定机构（230）的接合将驱动元件（300）固定到有效载荷元件（200），从而使电子胶囊（100）可操作和特定。

9. 发明授权

US08852172B2 Ingestible electronic capsule and in vivo drug delivery or diagnostic system 有权
标题翻译：可摄入电子胶囊和体内药物递送或诊断系统
公开(公告)号：US08852172B2
公开(公告)日：2014-10-07
申请号：US12515424
申请日：2007-11-05
申请人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Claude Jean-Marie Malaurie , Yvan O. J. G. Droinet , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu
发明人： Johan Frederik Dijksman , Frits Tobi De Jongh , Michel Gerardus Pardoel , Claude Jean-Marie Malaurie , Yvan O. J. G. Droinet , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Remus Albu
IPC分类号： A61B5/07 , A61B1/04 , A61B5/00 , A61B1/00
CPC分类号： A61B5/073 , A61B1/00016 , A61B1/041 , A61B5/4839
摘要： An ingestible electronic capsule (100) for introduction into the bodily lumen comprises a circuit board with at least one electronic component (4, 5, 7, 8, 9, 11, 12, 13, 14). The circuit board is formed from a flex foil (10), thereby reducing the number of components and improving the robustness and reliability of the ingestible electronic capsule (100).
摘要翻译：用于引入到体腔内的可摄入电子胶囊（100）包括具有至少一个电子部件（4,5,7,8,9,11,12,13,14）的电路板。电路板由柔性箔（10）形成，从而减少了组件的数量并提高了可摄取电子胶囊（100）的坚固性和可靠性。

10. 发明授权

US08990018B2 Method of preparing a swallowable capsule comprising a sensor 有权
标题翻译：制备包含传感器的吞咽胶囊的方法
公开(公告)号：US08990018B2
公开(公告)日：2015-03-24
申请号：US12933891
申请日：2009-03-24
申请人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Petrus Leonardus Adrianus Van Der Made , Michel Gerardus Pardoel , Frits Tobi De Jongh , Johan Gerard Kleibeuker
发明人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Petrus Leonardus Adrianus Van Der Made , Michel Gerardus Pardoel , Frits Tobi De Jongh , Johan Gerard Kleibeuker
IPC分类号： G06F19/00 , A61B5/04 , B65D83/04 , A61B5/07 , A61B5/145 , A61B5/1495
CPC分类号： A61B5/073 , A61B5/14539 , A61B5/1495 , A61B2560/0223
摘要： A kit includes a swallowable capsule (1, 45) with a potentiometric sensor (3), such as a pH sensor, with an unfilled electrolyte cell (31). The kit further includes a separate container (46) containing a liquid electrolyte. The kit can, e.g., be packed in a blister package. After unpacking the capsule the electrolyte cell (31) is filled with the electrolyte.
摘要翻译：试剂盒包括具有电位传感器（3）的吞咽胶囊（1,45），例如pH传感器，其具有未填充的电解质电池（31）。该试剂盒还包括含有液体电解质的单独的容器（46）。试剂盒可以例如包装在泡罩包装中。在拆开胶囊之后，电解质电池（31）充满电解质。

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