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1. 发明申请

US20150047536A1 TAILGATE-MOUNTED WORK SURFACE 审中-公开
标题翻译： TAILGATE-MOUNTED工作表面
公开(公告)号：US20150047536A1
公开(公告)日：2015-02-19
申请号：US14331990
申请日：2014-07-15
申请人： Greg Parks , John Farrell , Doug Strait , Michael Farrell
发明人： Greg Parks , John Farrell , Doug Strait , Michael Farrell
IPC分类号： B62D63/04 , B62D33/027
CPC分类号： B62D63/04 , B60P3/14 , B62D33/0273
摘要： A portable work surface for use with a vehicle having an extendable rear gate, wherein the rear gate includes first and second latches for securing the rear gate to the body of the vehicle when in a closed position, and wherein the portable work surface includes an elongated platform; a first mounting apparatus attached to one end of the elongated platform, wherein the first mounting apparatus further includes a bracket and pin assembly; a second mounting apparatus attached to the opposite end of the elongated platform, wherein the second mounting apparatus further includes a bracket and pin assembly; and wherein each pin is adapted to cooperate with one of the latches on the rear gate for securely attaching the work surface to the gate when the gate is in the open position.
摘要翻译：一种用于与具有可延伸的后门的车辆一起使用的便携式工作表面，其中所述后门包括用于在处于关闭位置时将所述后门固定到所述车身的第一和第二闩锁，并且其中所述便携式工作表面包括细长平台; 附接到所述细长平台的一端的第一安装装置，其中所述第一安装装置还包括支架和销组件; 附接到所述细长平台的相对端的第二安装装置，其中所述第二安装装置还包括支架和销组件; 并且其中每个销适于与所述后门上的所述闩锁中的一个协作，以在所述门处于打开位置时将所述工作表面牢固地附接到所述门。

2. 发明申请

US20110271878A1 TAILGATE-MOUNTED WORK SURFACE 审中-公开
标题翻译： TAILGATE-MOUNTED工作表面
公开(公告)号：US20110271878A1
公开(公告)日：2011-11-10
申请号：US13071903
申请日：2011-03-25
申请人： Greg Parks , John Farrell , Doug Strait , Michael Farrell
发明人： Greg Parks , John Farrell , Doug Strait , Michael Farrell
IPC分类号： A47B37/00 , A47B13/08
CPC分类号： B62D63/04 , B60P3/14 , B62D33/0273
摘要： A portable work surface for use with a vehicle having an extendable rear gate, wherein the rear gate includes first and second latches for securing the rear gate to the body of the vehicle when in a closed position, and wherein the portable work surface includes an elongated platform; a first mounting apparatus attached to one end of the elongated platform, wherein the first mounting apparatus further includes a bracket and pin assembly; a second mounting apparatus attached to the opposite end of the elongated platform, wherein the second mounting apparatus further includes a bracket and pin assembly; and wherein each pin is adapted to cooperate with one of the latches on the rear gate for securely attaching the work surface to the gate when the gate is in the open position.
摘要翻译：一种用于与具有可延伸的后门的车辆一起使用的便携式工作表面，其中所述后门包括用于在处于关闭位置时将所述后门固定到所述车身的第一和第二闩锁，并且其中所述便携式工作表面包括细长平台; 附接到所述细长平台的一端的第一安装装置，其中所述第一安装装置还包括支架和销组件; 附接到所述细长平台的相对端的第二安装装置，其中所述第二安装装置还包括支架和销组件; 并且其中每个销适于与所述后门上的所述闩锁中的一个协作，以在所述门处于打开位置时将所述工作表面牢固地附接到所述门。

3. 发明授权

US08481270B2 Method for chromogenic detection of two or more target molecules in a single sample 有权
标题翻译：一种样品中两种或更多种靶分子的显色检测方法
公开(公告)号：US08481270B2
公开(公告)日：2013-07-09
申请号：US13059274
申请日：2009-08-21
申请人： Richard Gniewek , Michael Farrell , Hiroaki Nitta , Megan Lehrkamp , Jerome Kosmeder , Brian Daniel Kelly , Thomas Grogan , Fabien Gaire , Mary Padilla , Christopher Bieniarz
发明人： Richard Gniewek , Michael Farrell , Hiroaki Nitta , Megan Lehrkamp , Jerome Kosmeder , Brian Daniel Kelly , Thomas Grogan , Fabien Gaire , Mary Padilla , Christopher Bieniarz
IPC分类号： C12Q1/68 , G01N33/58 , G01N33/53
CPC分类号： C12Q1/6841 , G01N33/53 , G01N33/581 , G01N33/583
摘要： The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first target molecule. Methods further comprise treating the tissue sample with a solution containing a soluble electron-rich aromatic compound prior to or concomitantly with contacting the tissue sample with a hapten-labeled binding moiety and detecting a second target molecule. In one example, the first target molecule is a protein and the second is a nucleic acid sequence, the first target molecule being detected by immunohistochemistry and the second by in situ hybridization. The disclosed method reduces background due to non-specific binding of the hapten-labeled specific binding moiety to an insoluble electron rich compound deposited near the first target molecule.
摘要翻译：本发明提供了用于检测单个组织样品中两种或更多种靶分子的方法和试剂盒，例如用于单一组织样品中的基因和蛋白质双重检测。方法包括用特异性结合第一靶分子的第一结合部分处理组织样品。方法还包括在使组织样品与半抗原标记的结合部分接触或同时检测第二靶分子之前或同时使用含有可溶于富电子的芳族化合物的溶液处理组织样品。在一个实例中，第一靶分子是蛋白质，第二个是核酸序列，第一个靶分子通过免疫组织化学检测，第二个是原位杂交。所公开的方法由于半抗原标记的特异性结合部分与沉积在第一靶分子附近的不溶性富电子化合物的非特异性结合而减少背景。

4. 发明申请

US20110139155A1 METHODS AND APPARATUS FOR MONITORING THE CARDIOVASCULAR CONDITION OF PATIENTS WITH SLEEP DISORDERED BREATHING 有权
标题翻译：用于监测患有睡眠障碍性呼吸的患者的心脏血管病变的方法和装置
公开(公告)号：US20110139155A1
公开(公告)日：2011-06-16
申请号：US12982536
申请日：2010-12-30
申请人： Michael Farrell , Malcolm Hebblewhite , Deidre Stewart , Ann Tisthammer , Maya Vance , Robin Randolph
发明人： Michael Farrell , Malcolm Hebblewhite , Deidre Stewart , Ann Tisthammer , Maya Vance , Robin Randolph
IPC分类号： A61M16/00
CPC分类号： A61B5/7282 , A61B5/0205 , A61B5/4818 , A61B5/742 , A61B5/7475 , A61M16/0051 , A61M16/0066 , A61M16/0069 , A61M16/024 , A61M16/06 , A61M16/085 , A61M16/0875 , A61M2016/0039 , A61M2205/3569 , A61M2205/3592 , A61M2230/04 , G06F19/00 , G06F19/3418
摘要： A method for relating to each other cardiovascular and sleep disordered breathing conditions of a patient. The patient's heart rate and/or detailed echocardiogram data is monitored and recorded continuously or periodically together with sleep disordered breathing information on similar time scales. Changes in the patient's heart rate associated with changes in sleep disordered breathing can then be observed. More specifically, positive airway pressure at therapeutic levels for treatment of sleep disordered breathing is applied while events associated with the treatment of the patient's sleep disordered breathing are detected and recorded. At the same time, information concerning the cardiovascular condition of the patient is stored and the stored information concerning the cardiovascular condition of the patient and the recorded events associated with the treatment of the patient's sleep disordered breathing are related to each other.
摘要翻译：一种与患者相关的心血管和睡眠无序呼吸状况的方法。患者的心率和/或详细的超声心动图数据与类似时间尺度上的睡眠紊乱呼吸信息一起被连续地或周期性地监测和记录。然后可以观察到与睡眠紊乱呼吸相关的患者心率变化。更具体地，应用治疗睡眠呼吸紊乱的治疗水平的气道正压，同时检测和记录与治疗患者睡眠无序呼吸相关的事件。同时，存储关于患者的心血管状况的信息，并且关于患者的心血管状况的存储信息以及与治疗患者睡眠无序呼吸相关联的记录事件彼此相关。

5. 发明申请

US20100184087A1 Haptens, hapten conjugates, compositions thereof and method for their preparation and use 有权
标题翻译：半抗原，半抗原共轭物，其组合物及其制备和使用方法
公开(公告)号：US20100184087A1
公开(公告)日：2010-07-22
申请号：US12660017
申请日：2010-02-17
申请人： Jerome W. Kosmeder , Mark Lefever , Donald Johnson , Michael Farrell , Zhanna Zhilina , Christopher Bieniarz
发明人： Jerome W. Kosmeder , Mark Lefever , Donald Johnson , Michael Farrell , Zhanna Zhilina , Christopher Bieniarz
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , C07D495/04 , C12Q1/6804 , C12Q1/6841 , C12Q1/6886 , G01N33/532 , G01N33/533 , G01N33/58 , G01N33/582 , G01N33/583 , Y10S435/961 , Y10S530/807
摘要： A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels.
摘要翻译：描述了用于执行多路诊断测定的方法，例如样品中两种或更多种不同靶标。一个实施方案包括使样品与特异性结合两个或更多个不同靶标的两个或多个特异性结合部分接触。两个或更多个特异性结合部分与不同的半抗原结合，至少一个半抗原是恶唑，吡唑，噻唑，除二硝基苯基以外的硝基芳基化合物，苯并呋咱，三萜烯，脲，硫脲，旋叶，香豆素，环链烷醇，杂二芳基，偶氮芳基或苯并二氮杂。将样品与两种或更多种可分别检测的不同的抗半抗原抗体接触。两种或更多种不同的抗半抗原抗体可以缀合到不同的可检测标记上。

6. 发明授权

US07642064B2 Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest 有权
标题翻译：酶催化的金属沉积用于增强感兴趣的分析物的检测
公开(公告)号：US07642064B2
公开(公告)日：2010-01-05
申请号：US11015646
申请日：2004-12-20
申请人： Christopher Bieniarz , Michael Farrell
发明人： Christopher Bieniarz , Michael Farrell
IPC分类号： C12Q1/42 , C12Q1/44 , C12Q1/54 , G01N33/53 , G01N33/543 , G01N33/544 , G01N33/551
CPC分类号： C07F9/093 , C07F9/65517 , C07F9/65522 , C07H15/20 , C07H15/24 , C07H15/26 , G01N33/581
摘要： The invention is directed to enhanced methods for detecting an analyte of interest in situ, by immunoassay, or by hybridization comprising binding an enzyme-labeled conjugate molecule to an analyte of interest in the presence of a redox-inactive reductive species and a soluble metal ion. The enzyme catalyzes the conversion of the inactive reductive species to an active reducing agent, which in turn reduces the metal ion to a metal atom thereby providing an enhanced means of detecting the analyte via metal deposition.
摘要翻译：本发明涉及通过免疫测定或通过杂交来检测目的分析物的增强方法，包括在氧化还原惰性还原物质和可溶性金属离子存在下将酶标记的缀合物分子与目的分析物结合。酶催化无活性还原物质转化为活性还原剂，其又将金属离子还原成金属原子，从而提供通过金属沉积检测分析物的增强方法。

7. 发明申请

US20070192680A1 Smart layer rendering 失效
标题翻译：智能层渲染
公开(公告)号：US20070192680A1
公开(公告)日：2007-08-16
申请号：US11356655
申请日：2006-02-16
申请人： Javier Morales , Michael Farrell
发明人： Javier Morales , Michael Farrell
IPC分类号： G06F17/00
CPC分类号： G06F17/2288
摘要： A document can contain multiple print layers. Different layers can be combined to produce different document versions. In this manner, a document can have an English version and a Spanish version sharing graphics layers but having different text layers. A document version specification can be used for producing a certain version of the document. Some documents, however, have many layers and desired layer combinations. A set of document version specifications can be used to ensure that all the desired versions are produced without any version being forgotten or any undesired version being produced. Dividing the layers amongst a set of layer groups helps in creating the specifications. A set of rules can be submitted to a rule module to automatically generate the desired specifications.
摘要翻译：文档可以包含多个打印图层。可以组合不同的层以产生不同的文档版本。以这种方式，文档可以具有共享图形层但具有不同文本层的英文版和西班牙文版本。文档版本规范可用于生成某个版本的文档。然而，一些文件具有许多层和期望的层组合。可以使用一组文档版本规范来确保所有期望的版本都被生成，而不会忘记任何版本被遗忘或任何不需要的版本。在一组图层组之间划分图层有助于创建规格。一组规则可以提交给规则模块，以自动生成所需的规范。

8. 发明申请

US20070172911A1 Biological sample processing composition and method 审中-公开
标题翻译：生物样品处理组成及方法
公开(公告)号：US20070172911A1
公开(公告)日：2007-07-26
申请号：US11652915
申请日：2007-01-12
申请人： Michael Farrell , Christopher Bieniarz , Kurt Reinhardt , Glen Ward , Jerome Kosmeder , Andrew Ghusson , Eric Walk , Guadalupe Manriquez , Thomas Grogan
发明人： Michael Farrell , Christopher Bieniarz , Kurt Reinhardt , Glen Ward , Jerome Kosmeder , Andrew Ghusson , Eric Walk , Guadalupe Manriquez , Thomas Grogan
IPC分类号： G01N1/30 , G01N33/48
CPC分类号： G01N1/30
摘要： A method and composition are disclosed that are useful for processing biological samples. In one aspect, a biological sample such as a tissue section is treated using a histochemical technique and is contacted with a lipid compound during the process to enhance the definition of cellular and sub-cellular features that are observable in the sample when it is viewed microscopically. In other aspects, a coverslipping composition that includes a lipid compound and a method of coverslipping a sample using the coverslipping composition are disclosed.
摘要翻译：公开了可用于处理生物样品的方法和组合物。在一个方面，使用组织化学技术处理诸如组织切片的生物样品，并且在该过程期间与脂质化合物接触以增强在微观观察时在样品中可观察到的细胞和亚细胞特征的定义。在其它方面，公开了一种包括脂质化合物的覆盖组合物和使用盖玻片组合物覆盖样品的方法。

9. 发明申请

US20060262339A1 Document targeting systems and methods 有权
标题翻译：文档定位系统和方法
公开(公告)号：US20060262339A1
公开(公告)日：2006-11-23
申请号：US11094440
申请日：2005-03-31
申请人： William Jacobs , Michael Farrell , David Rumph , Stephen Strasen
发明人： William Jacobs , Michael Farrell , David Rumph , Stephen Strasen
IPC分类号： G06K15/00
CPC分类号： H04N1/58 , G06F3/1297
摘要： A raster image target tracking method, the raster image being a binary raster image or a targeted contone raster image, may include determining target information that corresponds to a target device for the raster image, saving the target information in a memory, comprising the raster image target device to a processing device by which the document is to be processed, and providing a warning message when the document target device does not correspond to the processing device. Also, a compound document analysis and target tracking method may include providing a compound document, analyzing each object of the compound document to determine target information, saving the target information in a memory, comparing the target devices of the respective objects to each other, and providing a warning message to a user when the target devices of the respective objects do not correspond to each other.
摘要翻译：栅格图像目标跟踪方法，作为二进制光栅图像或目标连续色调光栅图像的光栅图像可以包括确定对应于光栅图像的目标装置的目标信息，将目标信息保存在包括光栅图像的存储器中目标设备到文档被处理的处理设备，并且当文档目标设备不对应于处理设备时提供警告消息。此外，复合文档分析和目标跟踪方法可以包括提供复合文档，分析复合文档的每个对象以确定目标信息，将目标信息保存在存储器中，将各个对象的目标设备彼此进行比较，以及当各个对象的目标设备彼此不对应时向用户提供警告消息。

10. 发明申请

US20060250629A1 Methods and systems for automated color proofing 有权
公开(公告)号：US20060250629A1
公开(公告)日：2006-11-09
申请号：US11124352
申请日：2005-05-09
申请人： Javier Morales , Michael Farrell
发明人： Javier Morales , Michael Farrell
IPC分类号： G06F3/12
CPC分类号： H04N1/6011 , H04N1/6052
摘要： Offline proofing systems and methods for color image processing may include receiving a digitized image document to be press printed in a job, determining job status as corresponding to one of a color managed proof and a color managed press, installing a proofer profile as an output profile and a press profile as a simulation profile in response to the job status corresponding to the color managed proof, printing the job by the proof printer as a proof copy in response to the color managed proof, installing the press profile as an output profile and discarding the simulation profile in response to the job status corresponding to the color managed press, and printing the job by the press printer as a press copy in response to the color managed press. The color managed press may be based on a customer contract approval. The proofer profile may correspond to a proof printer and the press profile may correspond to a press printer. These systems and methods may further provide the input file in an RGB space to be translated through a profile connection space to at least one of the simulation profile and the output profile in CMYK space.

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