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    • 1. 发明授权
    • Composition and method for stabilizing fluorescent particles
    • 用于稳定荧光颗粒的组合物和方法
    • US08877505B2
    • 2014-11-04
    • US13382509
    • 2011-02-01
    • Eric MayAlexandra NagyJerome Kosmeder
    • Eric MayAlexandra NagyJerome Kosmeder
    • G01N21/64C12Q1/68G01N33/533C09K11/02G01N33/58B82Y15/00
    • C09K11/025B82Y15/00C09K11/883G01N33/533G01N33/588Y10S977/774Y10S977/902Y10T436/108331
    • Embodiments of a composition for stabilizing fluorescent signal of nanoparticles and methods for its use are disclosed. In some embodiments, the composition has a pH from 7 to 10 and includes borate, protein and/or protein hydrolysate, an amine, a preservative, and a nonionic surfactant. In particular embodiments, the amine is an N-ethanol substituted amine, such as ethanolamine, diethanolamine, triethanolamine, N-methyldiethanolamine, N,N-dimethylethanolamine, or a combination thereof. In some embodiments, a fluorescent particle solution, such as a quantum dot solution or quantum dot conjugate solution, is diluted in the composition and stored at 4° C. In certain embodiments, the fluorescence intensity of the diluted fluorescent particle remains substantially the same when stored at 4° C. for at least one month or at least three months. In particular embodiments, a diluted quantum dot conjugate is used to detect a hybridized probe or a protein antigen.
    • 公开了用于稳定纳米颗粒的荧光信号的组合物的实施方案及其使用方法。 在一些实施方案中,组合物具有7至10的pH,并且包括硼酸盐,蛋白质和/或蛋白质水解产物,胺,防腐剂和非离子表面活性剂。 在具体实施方案中,胺是N-乙醇取代的胺,例如乙醇胺,二乙醇胺,三乙醇胺,N-甲基二乙醇胺,N,N-二甲基乙醇胺或其组合。 在一些实施方案中,将荧光颗粒溶液(例如量子点溶液或量子点共轭物溶液)在组合物中稀释并在4℃下储存。在某些实施方案中,稀释的荧光颗粒的荧光强度保持基本相同,当 在4℃下储存至少一个月或至少三个月。 在具体实施方案中,使用稀释的量子点缀合物来检测杂交的探针或蛋白质抗原。
    • 8. 发明申请
    • COMPOSITION AND METHOD FOR STABILIZING FLUORESCENT PARTICLES
    • 用于稳定荧光颗粒的组合物和方法
    • US20120122094A1
    • 2012-05-17
    • US13382509
    • 2011-02-01
    • Eric MayAlexandra NagyJerome Kosmeder
    • Eric MayAlexandra NagyJerome Kosmeder
    • G01N21/64C12Q1/68B82Y15/00
    • C09K11/025B82Y15/00C09K11/883G01N33/533G01N33/588Y10S977/774Y10S977/902Y10T436/108331
    • Embodiments of a composition for stabilizing fluorescent signal of nanoparticles and methods for its use are disclosed. In some embodiments, the composition has a pH from 7 to 10 and includes borate, protein and/or protein hydrolysate, an amine, a preservative, and a nonionic surfactant. In particular embodiments, the amine is an N-ethanol substituted amine, such as ethanolamine, diethanolamine, triethanolamine, N-methyldiethanolamine, N,N-dimethylethanolamine, or a combination thereof. In some embodiments, a fluorescent particle solution, such as a quantum dot solution or quantum dot conjugate solution, is diluted in the composition and stored at 4° C. In certain embodiments, the fluorescence intensity of the diluted fluorescent particle remains substantially the same when stored at 4° C. for at least one month or at least three months. In particular embodiments, a diluted quantum dot conjugate is used to detect a hybridized probe or a protein antigen.
    • 公开了用于稳定纳米颗粒的荧光信号的组合物的实施方案及其使用方法。 在一些实施方案中,组合物具有7至10的pH,并且包括硼酸盐,蛋白质和/或蛋白质水解产物,胺,防腐剂和非离子表面活性剂。 在具体实施方案中,胺是N-乙醇取代的胺,例如乙醇胺,二乙醇胺,三乙醇胺,N-甲基二乙醇胺,N,N-二甲基乙醇胺或其组合。 在一些实施方案中,将荧光颗粒溶液(例如量子点溶液或量子点共轭物溶液)在组合物中稀释并在4℃下储存。在某些实施方案中,稀释的荧光颗粒的荧光强度保持基本相同,当 在4℃下储存至少一个月或至少三个月。 在具体实施方案中,使用稀释的量子点缀合物来检测杂交的探针或蛋白质抗原。