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    • 4. 发明授权
    • Detecting targets using mass tags and mass spectrometry
    • 使用质量标签和质谱检测目标
    • US09291597B2
    • 2016-03-22
    • US13805983
    • 2011-07-01
    • Rui HongHong WangMark LefeverJan FroehlichChristopher BieniarzBrian KellyPhillip Miller
    • Rui HongHong WangMark LefeverJan FroehlichChristopher BieniarzBrian KellyPhillip Miller
    • G01N27/62G01N33/68
    • G01N33/6848G01N27/62
    • Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.
    • 本文公开的具体公开的实施方案涉及使用一种或多种各种质量标签,其可以通过直接或间接的酶催化转化特异性沉积在靶上,以提供用于鉴定组织样品中靶标的方法。 质量标签可以用稳定同位素标记,以产生具有相同化学结构但质量不同的质量标签。 使用质谱检测和/或定量通过电离质量标签产生的质量代码。 该方法可用于特定样品中多个目标的多路检测。 在一些实施例中,可以制备分成表示组织样本部分的部分的图,其中,图表部分包括对应于量化数据的数据,其中质量峰的大小被确定并与相应组织的靶的量相关联 样品部分。