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1. 发明授权

US08173647B2 PI 3-kinase inhibitors and methods of their use 有权
标题翻译： PI 3激酶抑制剂及其使用方法
公开(公告)号：US08173647B2
公开(公告)日：2012-05-08
申请号：US12449286
申请日：2008-02-06
申请人： Gordana Atallah , Sarah Bartulis , Matthew Burger , Hanne Merritt , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Aaron Smith , Charles Voliva , Allan Wagman , Yanchen Zhang
发明人： Gordana Atallah , Sarah Bartulis , Matthew Burger , Hanne Merritt , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Aaron Smith , Charles Voliva , Allan Wagman , Yanchen Zhang
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D413/14
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, autoimmune and cardiovascular diseases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗特征在于生长因子异常活性，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶（包括增殖性疾病）的疾病中的用途，炎性和阻塞性气道疾病，过敏性疾病，自身免疫性疾病和心血管疾病。

2. 发明申请

US20100048547A1 PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE 有权
标题翻译： PI 3激酶抑制剂及其使用方法
公开(公告)号：US20100048547A1
公开(公告)日：2010-02-25
申请号：US12449286
申请日：2008-02-06
申请人： Gordana Atallah , Sarah Bartulis , Matthew Burger , Hanne Merritt , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Aaron Smith , Charles Voliva , Allan Wagman , Yanchen Zhang
发明人： Gordana Atallah , Sarah Bartulis , Matthew Burger , Hanne Merritt , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Aaron Smith , Charles Voliva , Allan Wagman , Yanchen Zhang
IPC分类号： A61K31/5377 , C07D413/14 , A61K31/538 , A61P29/00 , A61P35/00 , A61P11/00 , A61P37/08 , A61P37/00 , A61P9/00
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D413/14
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, autoimmune and cardiovascular diseases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗特征在于生长因子异常活性，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶（包括增殖性疾病）的疾病中的用途，炎性和阻塞性气道疾病，过敏性疾病，自身免疫性疾病和心血管疾病。

3. 发明授权

US08217035B2 Pyrimidine derivatives used as PI-3-kinase inhibitors 有权
标题翻译：用作PI-3-激酶抑制剂的嘧啶衍生物
公开(公告)号：US08217035B2
公开(公告)日：2012-07-10
申请号：US12161537
申请日：2007-01-22
申请人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Xiaohua Xin
发明人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Xiaohua Xin
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

4. 发明申请

US20100249126A1 PYRIMIDINE DERIVATIVES USED AS PI-3-KINASE INHIBITORS 有权
标题翻译：用作PI-3-激酶抑制剂的吡嗪衍生物
公开(公告)号：US20100249126A1
公开(公告)日：2010-09-30
申请号：US12161537
申请日：2007-01-22
申请人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel J. Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Meritt , Charles Voliva , Marion Wiesmann , Xiahua Xin
发明人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel J. Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Meritt , Charles Voliva , Marion Wiesmann , Xiahua Xin
IPC分类号： A61K31/5377 , C07D413/14 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

5. 发明申请

US20100075965A1 PI3 KINASE INHIBITORS AND METHODS OF THEIR USE 审中-公开
标题翻译： PI3激酶抑制剂及其使用方法
公开(公告)号：US20100075965A1
公开(公告)日：2010-03-25
申请号：US12279148
申请日：2007-02-14
申请人： Zhi-Jie Ni , Sabina Pecchi , Matthew Burger , Wooseok Han , Aaron Smith , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Joelle Verhagen , Yanchen Zhang , Ed Iwanowicz , Tom Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Darren Mark Legrand , Ian Bruce , James Dale , Jiong Lan , Barry Levine , Abran Costales , Jui Liu , Teresa Pick , Daniel Menezes
发明人： Zhi-Jie Ni , Sabina Pecchi , Matthew Burger , Wooseok Han , Aaron Smith , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Joelle Verhagen , Yanchen Zhang , Ed Iwanowicz , Tom Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Darren Mark Legrand , Ian Bruce , James Dale , Jiong Lan , Barry Levine , Abran Costales , Jui Liu , Teresa Pick , Daniel Menezes
IPC分类号： A61K31/5377 , C07D471/04 , C07D487/04 , C07D413/14 , A61K31/437 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.
摘要翻译：磷脂酰肌醇（PI）3激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂联合使用的新化合物在预防或治疗以生长因子，蛋白丝氨酸/苏氨酸激酶，磷脂激酶，G蛋白偶联的异常活性为特征的增殖性疾病中的用途受体和磷酸酶。

6. 发明授权

US08563549B2 Pyrimidine derivatives used as PI-3 kinase inhibitors 有权
标题翻译：用作PI-3激酶抑制剂的嘧啶衍生物
公开(公告)号：US08563549B2
公开(公告)日：2013-10-22
申请号：US13471111
申请日：2012-05-14
申请人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Ataliah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel J. Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Meritt , Charles Voliva , Marion Wiesmann , Xiahua Xin
发明人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Ataliah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel J. Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Meritt , Charles Voliva , Marion Wiesmann , Xiahua Xin
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

7. 发明申请

US20140275003A1 BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS 有权
标题翻译：二胺化合物作为激酶抑制剂
公开(公告)号：US20140275003A1
公开(公告)日：2014-09-18
申请号：US14204823
申请日：2014-03-11
申请人： Paul A. Barsanti , Matthew Burger , Yan Lou , Gisele Nishiguchi , Valery Polyakov , Savithri Ramurthy , Alice Rico , Lina Setti , Aaron Smith , Benjamin Taft , Huw Tanner , Alan DiPesa , Naeem Yusuff
发明人： Paul A. Barsanti , Matthew Burger , Yan Lou , Gisele Nishiguchi , Valery Polyakov , Savithri Ramurthy , Alice Rico , Lina Setti , Aaron Smith , Benjamin Taft , Huw Tanner , Alan DiPesa , Naeem Yusuff
IPC分类号： C07D413/04 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D413/14 , C07D239/48 , A61K31/541 , C07D413/12 , C07D417/12 , C07D239/47 , C07D493/10 , C07D403/04 , C07D237/20 , C07D213/74 , C07D277/42 , C07D239/42
CPC分类号： A61K31/5377 , A61K31/444 , A61K31/501 , A61K31/5375 , A61K31/541 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D213/84 , C07D233/88 , C07D237/20 , C07D237/22 , C07D237/24 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D263/58 , C07D277/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D491/08 , C07D491/107 , C07D493/04 , C07D493/10 , C07D495/04 , C07D498/08 , C07D513/04
摘要： The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
摘要翻译：本发明提供了本文所述的式（I）化合物及其盐，以及这些化合物治疗与Raf激酶活性相关的疾病的治疗用途。本发明还提供包含这些化合物的药物组合物，以及包含这些化合物和治疗性助剂的组合物。

8. 发明申请

US20130109682A1 CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS 审中-公开
标题翻译：循环醚化合物作为激酶抑制剂有用
公开(公告)号：US20130109682A1
公开(公告)日：2013-05-02
申请号：US13807993
申请日：2011-07-04
申请人： Matthew Burger , Yu Ding , Wooseok Han , Mika Lindvall , Gisele A. Nishiguchi , Alice Rico , Aaron Smith , Huw Tanner , Lifeng Wan
发明人： Matthew Burger , Yu Ding , Wooseok Han , Mika Lindvall , Gisele A. Nishiguchi , Alice Rico , Aaron Smith , Huw Tanner , Lifeng Wan
IPC分类号： C07D417/14 , A61K31/444 , A61K45/06 , A61K31/506 , A61K31/501 , A61K31/541 , C07D405/14 , A61K31/497
CPC分类号： C07D417/14 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/541 , A61K45/06 , C07D405/14 , C07D407/04 , C07D407/14 , C07D491/04 , A61K2300/00
摘要： The present invention provides certain compounds of Formula (I): and pharmaceutically acceptable salts thereof, as further described herein. Also provided are formulations comprising compounds of formula I, and a method to use such compounds for treating a disease or condition mediated by Provirus Integration of Maloney Kinase (PIM Kinase), GSK3, PKC, KDR, PDGFRa, FGFR3, FLT3, or cABL.
摘要翻译：本发明提供了本文进一步描述的某些式（I）化合物及其药学上可接受的盐。还提供了包含式I化合物的制剂和使用这些化合物治疗由Maloney激酶（PIM激酶），GSK3，PKC，KDR，PDGFRa，FGFR3，FLT3或cABL的Provirus整合介导的疾病或病症的方法。

9. 发明授权

US08394454B2 Method and apparatus for precursor delivery system for irradiation beam instruments 有权
标题翻译：用于照射束仪的前驱体输送系统的方法和装置
公开(公告)号：US08394454B2
公开(公告)日：2013-03-12
申请号：US12399579
申请日：2009-03-06
申请人： Rocky Kruger , Aaron Smith , Thomas M. Moore
发明人： Rocky Kruger , Aaron Smith , Thomas M. Moore
IPC分类号： C23C16/00 , C23C8/00
CPC分类号： C23C16/4481 , C23C16/45561 , C23C16/48 , C23C16/52 , C23C16/54
摘要： A precursor delivery system for an irradiation beam instrument having a vacuum chamber includes an injection tube for injecting gasses into the vacuum chamber of the instrument and a main gas line having an inlet and an outlet. The outlet is connected to the injection tube, and the inlet is connected to a sequential pair of valves connected to a carrier gas source. A crucible for holding precursor material is selectively connected to the main gas line at a location between the pair of valves and the injection tube. The source of carrier gas may be selectively connected to the inlet by sequential operation of the pair of carrier gas valves, so that pulses of carrier gas assist the flow of precursor material to the injection tube. Rapid purging of the system between precursors is enabled by a valve selectively connecting the main line to an envelope in communication with the instrument vacuum. Methods of CVD and etching using the system are also disclosed.
摘要翻译：具有真空室的照射束装置的前体输送系统包括用于将气体注入仪器的真空室的注入管和具有入口和出口的主气体管线。出口连接到注射管，入口连接到连接到载气源的顺序一对阀。用于保持前体材料的坩埚在一对阀和注射管之间的位置处选择性地连接到主气体管线。载气源可以通过一对载气阀的顺序操作选择性地连接到入口，使得载气的脉冲有助于前体材料流到注射管。通过阀选择性地将主管线连接到与仪器真空连通的外壳，能够快速清洗前体之间的系统。还公开了使用该系统的CVD和蚀刻的方法。

10. 发明申请

US20130025536A1 APPARATUS FOR PRECURSOR DELIVERY SYSTEM FOR IRRADIATION BEAM INSTRUMENTS 有权
标题翻译：用于辐射光束仪器的前驱递送系统的装置
公开(公告)号：US20130025536A1
公开(公告)日：2013-01-31
申请号：US13357741
申请日：2012-01-25
申请人： Rocky Kruger , Aaron Smith , Thomas M. Moore
发明人： Rocky Kruger , Aaron Smith , Thomas M. Moore
IPC分类号： C23C16/452
CPC分类号： C23C16/4481 , C23C16/45561 , C23C16/48 , C23C16/52 , C23C16/54
摘要： A precursor delivery system for an irradiation beam instrument includes an injection tube for injecting gasses into the instrument vacuum chamber and a main gas line having an inlet and an outlet. The outlet is connected to the injection tube, and the inlet is connected to a sequential pair of valves connected to a carrier gas source. A crucible for holding precursor material is selectively connected to the main gas line at a location between the pair of valves and the injection tube. The source of carrier gas may be selectively connected to the inlet by sequential operation of the pair of carrier gas valves, so that pulses of carrier gas assist the flow of precursor material to the injection tube. Rapid purging of the system between precursors is enabled by a valve selectively connecting the main line to an envelope in communication with the instrument vacuum.
摘要翻译：用于照射束仪器的前体传送系统包括用于将气体注入仪器真空室的注入管和具有入口和出口的主气体管线。出口连接到注射管，入口连接到连接到载气源的顺序一对阀。用于保持前体材料的坩埚在一对阀和注射管之间的位置处选择性地连接到主气体管线。载气源可以通过一对载气阀的顺序操作选择性地连接到入口，使得载气的脉冲有助于前体材料流到注射管。通过阀选择性地将主管线连接到与仪器真空连通的外壳，能够快速清洗前体之间的系统。

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