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1. 发明授权

US08217035B2 Pyrimidine derivatives used as PI-3-kinase inhibitors 有权
标题翻译：用作PI-3-激酶抑制剂的嘧啶衍生物
公开(公告)号：US08217035B2
公开(公告)日：2012-07-10
申请号：US12161537
申请日：2007-01-22
申请人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Xiaohua Xin
发明人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Xiaohua Xin
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

2. 发明申请

US20100249126A1 PYRIMIDINE DERIVATIVES USED AS PI-3-KINASE INHIBITORS 有权
标题翻译：用作PI-3-激酶抑制剂的吡嗪衍生物
公开(公告)号：US20100249126A1
公开(公告)日：2010-09-30
申请号：US12161537
申请日：2007-01-22
申请人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel J. Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Meritt , Charles Voliva , Marion Wiesmann , Xiahua Xin
发明人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel J. Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Meritt , Charles Voliva , Marion Wiesmann , Xiahua Xin
IPC分类号： A61K31/5377 , C07D413/14 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

3. 发明授权

US08563549B2 Pyrimidine derivatives used as PI-3 kinase inhibitors 有权
标题翻译：用作PI-3激酶抑制剂的嘧啶衍生物
公开(公告)号：US08563549B2
公开(公告)日：2013-10-22
申请号：US13471111
申请日：2012-05-14
申请人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Ataliah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel J. Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Meritt , Charles Voliva , Marion Wiesmann , Xiahua Xin
发明人： Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Ataliah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel J. Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Meritt , Charles Voliva , Marion Wiesmann , Xiahua Xin
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

4. 发明申请

US20070027150A1 2-Amino-quinazolin-5-ones 审中-公开
标题翻译： 2-氨基 - 喹唑啉-5-酮
公开(公告)号：US20070027150A1
公开(公告)日：2007-02-01
申请号：US11404372
申请日：2006-04-14
申请人： Cornelia Bellamacina , Abran Costales , Brandon Doughan , Susan Fong , Zhenhai Gao , Thomas Hendrickson , Barry Levine , Xiaodong Lin , Timothy Machajewski , Christopher McBride , William Antonios-McCrea , Maureen McKenna , Kris Mendenhall , Alice Rico , Cynthia Shafer , X. Wang , Yi Xia , Yasheen Zhou
发明人： Cornelia Bellamacina , Abran Costales , Brandon Doughan , Susan Fong , Zhenhai Gao , Thomas Hendrickson , Barry Levine , Xiaodong Lin , Timothy Machajewski , Christopher McBride , William Antonios-McCrea , Maureen McKenna , Kris Mendenhall , Alice Rico , Cynthia Shafer , X. Wang , Yi Xia , Yasheen Zhou
IPC分类号： A61K31/5377 , A61K31/517 , C07D413/02 , C07D403/02
CPC分类号： C07D401/14 , C07D239/84 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D409/10 , C07D413/10 , C07D417/10 , C07D417/12 , C07D417/14
摘要： 2-Amino-quinazolin-5-one compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the 2-amino-quinazolin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cell proliferative diseases.
摘要翻译： 2-氨基 - 喹唑啉-5-酮化合物，立体异构体，互变异构体，药用盐和前药; 包括药学上可接受的载体和一种或多种2-氨基 - 喹唑啉-5-酮化合物的组合物，单独或与至少一种另外的治疗剂组合。将2-氨基 - 喹唑啉-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法用于预防或治疗细胞增殖性疾病。

5. 外观设计

USD872565S1 Siding hook 有权
公开(公告)号：USD872565S1
公开(公告)日：2020-01-14
申请号：US29673281
申请日：2018-12-13
申请人： Thomas Hendrickson
设计人： Thomas Hendrickson

6. 发明申请

US20070034090A1 Household Appliance Warning/Alert Device 审中-公开
标题翻译：家用电器警告/报警装置
公开(公告)号：US20070034090A1
公开(公告)日：2007-02-15
申请号：US11462700
申请日：2006-08-05
申请人： Thomas Hendrickson
发明人： Thomas Hendrickson
IPC分类号： A47J37/12
CPC分类号： A47J36/32 , G04F1/005
摘要： A device for providing warnings to users of household appliances having an electronic audio playback circuit (24) preprogrammed with a predetermined audio message. A power source (28) to supply power to said electronic audio playback circuit (24). A speaker or transducer (22) for converting output from said electronic audio playback circuit into audio signals. A physical displacement-activated switch (20). A housing (18) for enclosing said electronic audio playback circuit (24), speaker or transducer (22), and physical-displacement-activated switch (20). A means (26) for attaching said housing to a household appliance lid or door.
摘要翻译：一种用于向具有预编程有预定音频消息的电子音频回放电路（24）的家用电器用户提供警告的装置。电源（28），用于向所述电子音频回放电路（24）供电。一种用于将来自所述电子音频回放电路的输出转换成音频信号的扬声器或换能器（22）。物理位移激活开关（20）。用于封闭所述电子音频回放电路（24），扬声器或换能器（22）和物理位移激活开关（20）的外壳（18）。一种用于将所述壳体附接到家用电器盖或门的装置（26）。

7. 发明申请

US20050080121A1 Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis 失效
标题翻译：杀虫病毒化合物和组合物，其药物用途和用于其合成的材料
公开(公告)号：US20050080121A1
公开(公告)日：2005-04-14
申请号：US10626827
申请日：2003-07-23
申请人： Ye Hua , Hiep Luu , Fora Chan , Theodore Johnson , Siegfried Reich , Donald Skalitsky , Yi Yang , Thomas Hendrickson , Shao Chu , Brian Eastman
发明人： Ye Hua , Hiep Luu , Fora Chan , Theodore Johnson , Siegfried Reich , Donald Skalitsky , Yi Yang , Thomas Hendrickson , Shao Chu , Brian Eastman
IPC分类号： A61K31/216 , A61K31/235 , A61K31/381 , A61K31/4015 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/4192 , A61K31/427 , A61K31/4439 , A61K31/47 , A61K31/498 , A61P31/14 , A61P43/00 , C07C233/85 , C07C237/22 , C07C237/36 , C07C275/16 , C07D207/26 , C07D209/42 , C07D215/48 , C07D231/14 , C07D241/44 , C07D249/06 , C07D333/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , A61K31/4196 , A61K31/4025 , A61K31/4178 , C07D43/02
CPC分类号： C07D207/26 , C07C237/22 , C07C275/16 , C07D209/42 , C07D215/48 , C07D231/14 , C07D241/44 , C07D249/06 , C07D333/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12
摘要： Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
摘要翻译：下式的化合物：其中式变数如本公开内容所定义，有利地抑制或阻断微乳蛋白酶3C蛋白酶的生物学活性。这些化合物以及含有这些化合物的药物组合物可用于治疗感染一种或多种微小核糖核酸病毒如RVP的患者或宿主。还描述了制备这些化合物的中间体和合成方法。

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