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1. 发明申请

US20090159805A1 APPARATUS AND METHOD FOR MULTI-MODAL IMAGING 有权
标题翻译：多模式成像的装置和方法
公开(公告)号：US20090159805A1
公开(公告)日：2009-06-25
申请号：US12354830
申请日：2009-01-16
申请人： Gilbert Feke , Douglas Lincoln Vizard , William E. McLaughlin
发明人： Gilbert Feke , Douglas Lincoln Vizard , William E. McLaughlin
IPC分类号： G01T1/20
CPC分类号： A61B5/0059 , A61B5/0035 , A61B6/00 , A61B6/4417 , A61B6/508 , A61B6/5247
摘要： An imaging system for imaging an object, including: a support member adapted to receive the object in an immobilized state; a removable phosphor plate assembly adapted to respond to ionizing radiation by emitting visible light; first imaging means for imaging the immobilized object in a first imaging mode to capture a first image; second imaging means for imaging the immobilized object in a second imaging mode, different from the first imaging mode, to capture a second image; and third imaging means for imaging the immobilized object in a third imaging mode, different from the first and second imaging modes, to capture a third image, wherein the first imaging mode uses the phosphor plate assembly and is selected from the group: x-ray mode and low energy radio isotope mode; the second imaging mode uses the phosphor plate assembly and a high energy radio isotope mode, and the third imaging mode is selected from the group: bright-field mode, fluorescence mode and luminescence mode.
摘要翻译：一种用于成像对象的成像系统，包括：适于以固定状态接收对象的支撑构件; 适于通过发射可见光来响应电离辐射的可去除的荧光体板组件; 第一成像装置，用于在第一成像模式下成像固定的物体以捕获第一图像; 第二成像装置，用于在与第一成像模式不同的第二成像模式下对固定物体进行成像以捕获第二图像; 以及第三成像装置，用于在与第一和第二成像模式不同的第三成像模式下成像固定的物体，以捕获第三图像，其中第一成像模式使用磷光体板组件，并且选自x射线模式和低能放射同位素模式; 第二成像模式使用荧光体板组件和高能量放射性同位素模式，并且第三成像模式选自亮场模式，荧光模式和发光模式。

2. 发明授权

US08050735B2 Apparatus and method for multi-modal imaging 有权
标题翻译：多模态成像装置及方法
公开(公告)号：US08050735B2
公开(公告)日：2011-11-01
申请号：US12354830
申请日：2009-01-16
申请人： Gilbert Feke , Douglas Lincoln Vizard , William E. McLaughlin
发明人： Gilbert Feke , Douglas Lincoln Vizard , William E. McLaughlin
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0035 , A61B6/00 , A61B6/4417 , A61B6/508 , A61B6/5247
摘要： An imaging system for imaging an object, including: a support member adapted to receive the object in an immobilized state; a removable phosphor plate assembly adapted to respond to ionizing radiation by emitting visible light; first imaging means for imaging the immobilized object in a first imaging mode to capture a first image; second imaging means for imaging the immobilized object in a second imaging mode, different from the first imaging mode, to capture a second image; and third imaging means for imaging the immobilized object in a third imaging mode, different from the first and second imaging modes, to capture a third image, wherein the first imaging mode uses the phosphor plate assembly and is selected from the group: x-ray mode and low energy radio isotope mode; the second imaging mode uses the phosphor plate assembly and a high energy radio isotope mode, and the third imaging mode is selected from the group: bright-field mode, fluorescence mode and luminescence mode.
摘要翻译：一种用于成像对象的成像系统，包括：适于以固定状态接收对象的支撑构件; 适于通过发射可见光来响应电离辐射的可去除的荧光体板组件; 第一成像装置，用于在第一成像模式下成像固定的物体以捕获第一图像; 第二成像装置，用于在与第一成像模式不同的第二成像模式下对固定物体进行成像以捕获第二图像; 以及第三成像装置，用于在与第一和第二成像模式不同的第三成像模式下成像固定的物体，以捕获第三图像，其中第一成像模式使用磷光体板组件，并且选自x射线模式和低能放射同位素模式; 第二成像模式使用荧光体板组件和高能量放射性同位素模式，并且第三成像模式选自亮场模式，荧光模式和发光模式。

3. 发明授权

US07706501B2 Method and apparatus for measuring long bone density of small-animals 失效
标题翻译：测量小动物长骨密度的方法和装置
公开(公告)号：US07706501B2
公开(公告)日：2010-04-27
申请号：US12204132
申请日：2008-09-04
申请人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
发明人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
IPC分类号： G01N23/083 , G01B15/00
CPC分类号： G01N23/087 , G01N2223/407 , G01N2223/6123
摘要： A method and apparatus are disclosed for measuring long bone density of small animals. A phosphor screen or plate is provided of a type that transduces incident ionizing radiation to emitted light. A small animal is positioned before the phosphor screen or plate and exposed to soft X-radiation having an energy level in the range of 11 to 16 Kev. Light emitted by the phosphor screen or plate is captured using a digital camera and a digital X-ray image is prepared of a long bone of the animal. The X-ray image is transformed into an X-ray density image and a region of interest is defined on the long bone in the X-ray density image. At least one row of pixels is scanned within the region of interest of the X-ray density image. A nonlinear least squares analysis of data obtained from the scanning step is conducted using a cylindrical model for the long bone within the region of interest.
摘要翻译：公开了测量小动物长骨密度的方法和装置。提供了将入射电离辐射转换为发射光的类型的荧光屏或板。将小动物放置在荧光屏或板之前并暴露于能量水平在11至16Kev范围内的软X-辐射。使用数字照相机捕获由荧光屏或板发射的光，并且制备动物的长骨的数字X射线图像。将X射线图像转换为X射线密度图像，并且在X射线密度图像中的长骨上限定感兴趣区域。在X射线密度图像的感兴趣区域内扫描至少一行像素。从扫描步骤获得的数据的非线性最小二乘法分析是使用感兴趣区域内的长骨的圆柱模型进行的。

4. 发明申请

US20090238434A1 Method for reproducing the spatial orientation of an immobilized subject in a multi-modal imaging system 审中-公开
标题翻译：在多模式成像系统中再现固定的被摄体的空间取向的方法
公开(公告)号：US20090238434A1
公开(公告)日：2009-09-24
申请号：US12381599
申请日：2009-03-13
申请人： Gilbert Feke , Rao Papineni , Shoupu Chen , Douglas O. Wood , William E. McLaughlin
发明人： Gilbert Feke , Rao Papineni , Shoupu Chen , Douglas O. Wood , William E. McLaughlin
IPC分类号： G06K9/00
CPC分类号： G06T1/0007 , G06T7/30 , G06T2207/10116 , G06T2207/20092 , G06T2207/30004
摘要： Methods are disclosed for (A) adjusting the physical, spatial orientation of an immobilized subject in a multi-modal imaging system so as substantially to reproduce or match the physical, spatial orientation of a reference subject, wherein the reference subject is either (a) the same or (b) a different subject, either (1) during a prior imaging session for a later imaging session, or, in the case where a plurality of subjects is imaged in one imaging session, (2) during a contemporaneous imaging session; and (B) adjusting the virtual, spatial orientation of an immobilized subject in a set of multi-modal images.
摘要翻译：公开了用于（A）调整多模式成像系统中固定的受试者的物理，空间取向以便基本上重现或匹配参考对象的物理，空间取向的方法，其中参考对象是（a）相同或（b）不同的对象，（1）在先前的成像会话期间用于稍后的成像会话，或者在多个对象在一个成像会话中被成像的情况下，（2）在同时成像会话期间 ; 和（B）在一组多模态图像中调整固定的被摄体的虚拟空间取向。

5. 发明授权

US08660631B2 Torsional support apparatus and method for craniocaudal rotation of animals 有权
标题翻译：扭转支撑装置和动物头部旋转的方法
公开(公告)号：US08660631B2
公开(公告)日：2014-02-25
申请号：US12475623
申请日：2009-06-01
申请人： Gilbert Feke , Benjamin F. Geldhof , Warren M. Leevy , Mark E. Bridges , William E. McLaughlin , Rao Papineni
发明人： Gilbert Feke , Benjamin F. Geldhof , Warren M. Leevy , Mark E. Bridges , William E. McLaughlin , Rao Papineni
IPC分类号： A61B5/05
CPC分类号： A61B6/508 , A61B5/0059 , A61B5/0082 , A61B5/6887 , A61B6/00 , A61B6/04 , A61B6/4417 , A61B2503/40 , A61D7/04 , A61M5/007
摘要： A torsional support apparatus is disclosed for craniocaudal rotation of test animals to enable multiple-view imaging. The animal is supported in a U-shaped loop of optically transparent material and the loop is moved to apply torsion to the animal to rotate it about its craniocaudal axis. Methods of imaging also are disclosed that use the torsional support technique.
摘要翻译：公开了一种扭转支撑装置，用于测试动物的头颈部旋转，以实现多视图成像。动物被支撑在光学透明材料的U形环中，并且环被移动以向动物施加扭转以围绕其头颅轴旋转。公开了使用扭转支撑技术的成像方法。

6. 发明申请

US20100022866A1 TORSIONAL SUPPORT APPARATUS AND METHOD FOR CRANIOCAUDAL ROTATION OF ANIMALS 有权
标题翻译：扭转支撑装置和动物旋转旋转的方法
公开(公告)号：US20100022866A1
公开(公告)日：2010-01-28
申请号：US12475623
申请日：2009-06-01
申请人： Gilbert Feke , Benjamin F. Geldhof , Warren M. Leevy , Mark E. Bridges , William E. McLaughlin , Rao Papineni
发明人： Gilbert Feke , Benjamin F. Geldhof , Warren M. Leevy , Mark E. Bridges , William E. McLaughlin , Rao Papineni
IPC分类号： A61B5/05
CPC分类号： A61B6/508 , A61B5/0059 , A61B5/0082 , A61B5/6887 , A61B6/00 , A61B6/04 , A61B6/4417 , A61B2503/40 , A61D7/04 , A61M5/007
摘要： A torsional support apparatus is disclosed for craniocaudal rotation of test animals to enable multiple-view imaging. The animal is supported in a U-shaped loop of optically transparent material and the loop is moved to apply torsion to the animal to rotate it about its craniocaudal axis. Methods of imaging also are disclosed that use the torsional support technique.
摘要翻译：公开了一种扭转支撑装置，用于测试动物的头颈部旋转，以实现多视图成像。动物被支撑在光学透明材料的U形环中，并且环被移动以向动物施加扭转以围绕其头颅轴旋转。公开了使用扭转支撑技术的成像方法。

7. 发明申请

US20090080608A1 METHOD AND APPARATUS FOR MEASURING LONG BONE DENSITY OF SMALL-ANIMALS 失效
标题翻译：用于测量小动物长骨密度的方法和装置
公开(公告)号：US20090080608A1
公开(公告)日：2009-03-26
申请号：US12204132
申请日：2008-09-04
申请人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
发明人： Douglas L. Vizard , Douglas O. Wood , William E. McLaughlin , Gilbert Feke , Rao Papineni
IPC分类号： G01N23/06
CPC分类号： G01N23/087 , G01N2223/407 , G01N2223/6123
摘要： A method and apparatus are disclosed for measuring long bone density of small animals. A phosphor screen or plate is provided of a type that transduces incident ionizing radiation to emitted light. A small animal is positioned before the phosphor screen or plate and exposed to soft X-radiation having an energy level in the range of 11 to 16 Kev. Light emitted by the phosphor screen or plate is captured using a digital camera and a digital X-ray image is prepared of a long bone of the animal. The X-ray image is transformed into an X-ray density image and a region of interest is defined on the long bone in the X-ray density image. At least one row of pixels is scanned within the region of interest of the X-ray density image. A nonlinear least squares analysis of data obtained from the scanning step is conducted using a cylindrical model for the long bone within the region of interest.
摘要翻译：公开了测量小动物长骨密度的方法和装置。提供了将入射电离辐射转换为发射光的类型的荧光屏或板。将小动物放置在荧光屏或板之前并暴露于能量水平在11至16Kev范围内的软X-辐射。使用数字照相机捕获由荧光屏或板发射的光，并且制备动物的长骨的数字X射线图像。将X射线图像转换为X射线密度图像，并且在X射线密度图像中的长骨上限定感兴趣区域。在X射线密度图像的感兴趣区域内扫描至少一行像素。从扫描步骤获得的数据的非线性最小二乘法分析是使用感兴趣区域内的长骨的圆柱模型进行的。

8. 发明授权

US08203132B2 Apparatus and method for imaging ionizing radiation 有权
标题翻译：用于成像电离辐射的装置和方法
公开(公告)号：US08203132B2
公开(公告)日：2012-06-19
申请号：US12324092
申请日：2008-11-26
申请人： Gilbert Feke , Douglas O. Wood , Douglas L. Vizard
发明人： Gilbert Feke , Douglas O. Wood , Douglas L. Vizard
IPC分类号： G01N23/04
CPC分类号： A61B5/0059 , A61B6/00 , A61B6/4216 , A61B6/5241 , A61B6/583 , G03B42/023 , G21K2004/06
摘要： A system and method are disclosed for capturing a radiographic or autoradiographic image of an object, in which a support member is provided to receive the object in an immobilized state; a phosphor screen is provided to transduce ionizing radiation from the source to visible light; film or a digital capture device is provided for capturing an image using the visible light; and the phosphor screen is moved incrementally to facilitate reduction of phosphor screen mottle.
摘要翻译：公开了一种用于捕获物体的射线照相或放射自显影图像的系统和方法，其中提供支撑构件以在固定状态下接收物体; 提供荧光屏以将从源的电离辐射转换成可见光; 提供电影或数字捕获装置用于使用可见光捕获图像; 并且荧光屏逐渐移动以便于减少荧光屏斑点。

9. 发明授权

US08113702B2 Variable condenser for delivery of illumination including recursively nested circle to-line fiber optic converter cable 失效
标题翻译：用于交付照明的可变冷凝器，包括递归嵌套的圆形到线光纤转换器电缆
公开(公告)号：US08113702B2
公开(公告)日：2012-02-14
申请号：US12431823
申请日：2009-04-29
申请人： Gilbert Feke
发明人： Gilbert Feke
IPC分类号： F21V7/04
CPC分类号： G02B6/04 , G02B6/0008 , G02B26/103
摘要： A variable condenser for delivery of illumination, including a recursively nested circle-to-line fiber optic shape-converting cable and a focusable input lens system. At the input of the fiber optic cable, sets of individual optical fibers comprise successively smaller annuli recursively nested about a common center. At the output of the fiber optic cable, the sets of individual optical fibers comprise pairs of line segments recursively nested about the line midpoint, whereby the nesting level of the pairs of line segments has an exact or an approximate correspondence to the nesting level of the annuli. The output may be split into a plurality of lines, whereby the sets of individual optical fibers are distributed among the plurality of lines. The input lens system has a single adjustable focus means to vary the radius of an illumination spot incident upon the input of the fiber optic cable circle input.
摘要翻译：用于传输照明的可变电容器，包括递归嵌套的圆形到光纤形状转换电缆和可调焦输入透镜系统。在光纤电缆的输入端，各组光纤包括相对较小的环，其相对于公共中心递归地嵌套。在光纤电缆的输出处，各组光纤包括一对线段，其以线中点递归地嵌套，由此线段对的嵌套级别具有与嵌套级别的精确或近似对应关系环形输出可以被分成多条线，由此各组光纤分布在多条线之间。输入透镜系统具有单个可调节聚焦装置，以改变入射到光纤光缆圆输入端的照明点的半径。

10. 发明授权

US08041409B2 Method and apparatus for multi-modal imaging 有权
标题翻译：多模态成像的方法和装置
公开(公告)号：US08041409B2
公开(公告)日：2011-10-18
申请号：US12460010
申请日：2009-07-10
申请人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
发明人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A01K1/031 , A61B5/0035 , A61B6/00 , A61B6/508 , A61B6/5247 , A61D7/04
摘要： A method and apparatus for imaging a subject animal. The method comprises the steps of treating the animal with an x-ray contrast agent and an imaging agent; supporting the animal in an immobilized state on a support member; acquiring an x-ray anatomical image of the animal; acquiring an optical, dark-field image of the animal; and registering the x-ray anatomical image and the optical image, whereby features of the optical image can be observed in relation to features of the anatomical image.
摘要翻译：一种用于成像受试动物的方法和装置。该方法包括用X射线造影剂和成像剂处理动物的步骤; 将动物以固定状态支撑在支撑构件上; 获取动物的x射线解剖图像; 获取动物的光学，暗视野图像; 并记录x射线解剖图像和光学图像，由此可以相对于解剖图像的特征观察光学图像的特征。

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