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1. 发明申请

US20100218140A1 GRAPHICAL USER INTERFACE FOR MULTI-MODAL IMAGES AT INCREMENTAL ANGULAR DISPLACEMENTS 审中-公开
标题翻译：用于增量角位移的多模式图像的图形用户界面
公开(公告)号：US20100218140A1
公开(公告)日：2010-08-26
申请号：US12716331
申请日：2010-03-03
申请人： Gilbert D. Feke , Douglas O. Wood , William E. McLaughlin , Douglas L. Vizard , Warren M. Leevy , Sean Orton , Willis Morse
发明人： Gilbert D. Feke , Douglas O. Wood , William E. McLaughlin , Douglas L. Vizard , Warren M. Leevy , Sean Orton , Willis Morse
IPC分类号： G09G5/377 , G09G5/02 , G06F3/048
CPC分类号： A61B5/0059 , A61B5/0035 , A61B6/00 , A61B6/4417 , A61B6/5247
摘要： A method for forming a sequence of images of a subject obtains at least first and second image sets of the subject, each image set having a given angular displacement relative to an axis of rotation of the subject, each image set having at least a first component image of a first diagnostic modality at the given angular displacement and a second component image that is co-registered to the first component image at the given angular displacement. The first image set is selected as the selected image set for display. A synthesized image is formed by combining image data for the at least first and second component images of the selected image set and the synthesized image is displayed.
摘要翻译：用于形成被摄体图像序列的方法获得对象的至少第一和第二图像组，每个图像组相对于被摄体的旋转轴具有给定的角位移，每个图像组具有至少第一组分在给定角度位移处的第一诊断模态的图像和在给定的角位移处共同对准第一分量图像的第二分量图像。选择第一个图像集作为显示的所选图像集。通过组合所选图像组的至少第一和第二分量图像的图像数据形成合成图像，并显示合成图像。

2. 发明授权

US08834846B2 Fluorescent NIRF activatable probes for disease detection 有权
标题翻译：用于疾病检测的荧光NIRF可激活探针
公开(公告)号：US08834846B2
公开(公告)日：2014-09-16
申请号：US13101370
申请日：2011-05-05
申请人： Tao Ji , Warren M. Leevy , William E. McLaughlin , Yawfui Yong
发明人： Tao Ji , Warren M. Leevy , William E. McLaughlin , Yawfui Yong
IPC分类号： A61B5/00
CPC分类号： G01N33/587 , A61K49/0485 , B82Y5/00 , B82Y15/00 , C12Q1/34 , G01N33/542
摘要： Fluorescent activatable probes for imaging biological processes and disease detection in vitro and in vivo. There is also described a method for detecting the presence of an enzyme. A sample is contacted with a nanoparticle including a monomer, at least one cleavable spacer comprising at least one fluorescence activation site, and at least two dyes of at least two types. The cleavable spacer is attached at one end to the nanoparticle. The at least two types comprise an energy donor type and an energy acceptor type. At least one dye of one type is embedded in the nanoparticle and the cleavable spacer has at least one dye of the other type attached. The at least two dyes comprise at least one matched pair capable of fluorescence resonance energy transfer. Fluorescence is detected by exposing the sample to a light source, and detecting emitted light with a detector.
摘要翻译：用于成像生物过程和体外和体内疾病检测的荧光可激活探针。还描述了检测酶的存在的方法。将样品与包含单体的纳米颗粒，至少一个可切割间隔基包含至少一个荧光活化位点和至少两种至少两种类型的染料接触。可切割间隔物的一端连接到纳米颗粒。至少两种类型包括能量供体类型和能量受体类型。至少一种一种染料被包埋在纳米颗粒中，并且可切割间隔物具有至少一种所连接的另一种类型的染料。所述至少两种染料包含能够进行荧光共振能量转移的至少一个匹配对。通过将样品暴露于光源并用检测器检测发射光来检测荧光。

3. 发明授权

US08041409B2 Method and apparatus for multi-modal imaging 有权
标题翻译：多模态成像的方法和装置
公开(公告)号：US08041409B2
公开(公告)日：2011-10-18
申请号：US12460010
申请日：2009-07-10
申请人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
发明人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A01K1/031 , A61B5/0035 , A61B6/00 , A61B6/508 , A61B6/5247 , A61D7/04
摘要： A method and apparatus for imaging a subject animal. The method comprises the steps of treating the animal with an x-ray contrast agent and an imaging agent; supporting the animal in an immobilized state on a support member; acquiring an x-ray anatomical image of the animal; acquiring an optical, dark-field image of the animal; and registering the x-ray anatomical image and the optical image, whereby features of the optical image can be observed in relation to features of the anatomical image.
摘要翻译：一种用于成像受试动物的方法和装置。该方法包括用X射线造影剂和成像剂处理动物的步骤; 将动物以固定状态支撑在支撑构件上; 获取动物的x射线解剖图像; 获取动物的光学，暗视野图像; 并记录x射线解剖图像和光学图像，由此可以相对于解剖图像的特征观察光学图像的特征。

4. 发明申请

US20110293529A1 FLUORESCENT NIRF ACTIVATABLE PROBES FOR DISEASE DETECTION 有权
标题翻译：用于疾病检测的荧光近红外激活探针
公开(公告)号：US20110293529A1
公开(公告)日：2011-12-01
申请号：US13101370
申请日：2011-05-05
申请人： Tao Ji , Warren M. Leevy , William E. McLaughlin , Yawfui Yong
发明人： Tao Ji , Warren M. Leevy , William E. McLaughlin , Yawfui Yong
IPC分类号： A61K49/00 , C12Q1/68 , C12Q1/37 , G01N33/53 , B82Y15/00
CPC分类号： G01N33/587 , A61K49/0485 , B82Y5/00 , B82Y15/00 , C12Q1/34 , G01N33/542
摘要： Fluorescent activatable probes for imaging biological processes and disease detection in vitro and in vivo. There is also described a method for detecting the presence of an enzyme. A sample is contacted with a nanoparticle including a monomer, at least one cleavable spacer comprising at least one fluorescence activation site, and at least two dyes of at least two types. The cleavable spacer is attached at one end to the nanoparticle. The at least two types comprise an energy donor type and an energy acceptor type. At least one dye of one type is embedded in the nanoparticle and the cleavable spacer has at least one dye of the other type attached. The at least two dyes comprise at least one matched pair capable of fluorescence resonance energy transfer. Fluorescence is detected by exposing the sample to a light source, and detecting emitted light with a detector.
摘要翻译：用于成像生物过程和体外和体内疾病检测的荧光可激活探针。还描述了检测酶的存在的方法。将样品与包含单体的纳米颗粒，至少一个可切割间隔基包含至少一个荧光活化位点和至少两种至少两种类型的染料接触。可切割间隔物的一端连接到纳米颗粒。至少两种类型包括能量供体类型和能量受体类型。至少一种一种染料被包埋在纳米颗粒中，并且可切割间隔物具有至少一种所连接的另一种类型的染料。所述至少两种染料包含能够进行荧光共振能量转移的至少一个匹配对。通过将样品暴露于光源并用检测器检测发射光来检测荧光。

5. 发明申请

US20100022866A1 TORSIONAL SUPPORT APPARATUS AND METHOD FOR CRANIOCAUDAL ROTATION OF ANIMALS 有权
标题翻译：扭转支撑装置和动物旋转旋转的方法
公开(公告)号：US20100022866A1
公开(公告)日：2010-01-28
申请号：US12475623
申请日：2009-06-01
申请人： Gilbert Feke , Benjamin F. Geldhof , Warren M. Leevy , Mark E. Bridges , William E. McLaughlin , Rao Papineni
发明人： Gilbert Feke , Benjamin F. Geldhof , Warren M. Leevy , Mark E. Bridges , William E. McLaughlin , Rao Papineni
IPC分类号： A61B5/05
CPC分类号： A61B6/508 , A61B5/0059 , A61B5/0082 , A61B5/6887 , A61B6/00 , A61B6/04 , A61B6/4417 , A61B2503/40 , A61D7/04 , A61M5/007
摘要： A torsional support apparatus is disclosed for craniocaudal rotation of test animals to enable multiple-view imaging. The animal is supported in a U-shaped loop of optically transparent material and the loop is moved to apply torsion to the animal to rotate it about its craniocaudal axis. Methods of imaging also are disclosed that use the torsional support technique.
摘要翻译：公开了一种扭转支撑装置，用于测试动物的头颈部旋转，以实现多视图成像。动物被支撑在光学透明材料的U形环中，并且环被移动以向动物施加扭转以围绕其头颅轴旋转。公开了使用扭转支撑技术的成像方法。

6. 发明授权

US08660631B2 Torsional support apparatus and method for craniocaudal rotation of animals 有权
标题翻译：扭转支撑装置和动物头部旋转的方法
公开(公告)号：US08660631B2
公开(公告)日：2014-02-25
申请号：US12475623
申请日：2009-06-01
申请人： Gilbert Feke , Benjamin F. Geldhof , Warren M. Leevy , Mark E. Bridges , William E. McLaughlin , Rao Papineni
发明人： Gilbert Feke , Benjamin F. Geldhof , Warren M. Leevy , Mark E. Bridges , William E. McLaughlin , Rao Papineni
IPC分类号： A61B5/05
CPC分类号： A61B6/508 , A61B5/0059 , A61B5/0082 , A61B5/6887 , A61B6/00 , A61B6/04 , A61B6/4417 , A61B2503/40 , A61D7/04 , A61M5/007
摘要： A torsional support apparatus is disclosed for craniocaudal rotation of test animals to enable multiple-view imaging. The animal is supported in a U-shaped loop of optically transparent material and the loop is moved to apply torsion to the animal to rotate it about its craniocaudal axis. Methods of imaging also are disclosed that use the torsional support technique.
摘要翻译：公开了一种扭转支撑装置，用于测试动物的头颈部旋转，以实现多视图成像。动物被支撑在光学透明材料的U形环中，并且环被移动以向动物施加扭转以围绕其头颅轴旋转。公开了使用扭转支撑技术的成像方法。

7. 发明申请

US20120029346A1 METHOD AND APPARATUS FOR MULTI-MODAL IMAGING 审中-公开
标题翻译：用于多模式成像的方法和装置
公开(公告)号：US20120029346A1
公开(公告)日：2012-02-02
申请号：US13270471
申请日：2011-10-11
申请人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
发明人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A01K1/031 , A61B5/0035 , A61B6/00 , A61B6/508 , A61B6/5247 , A61D7/04
摘要： A method and apparatus for imaging a subject animal. The method comprises the steps of treating the animal with an x-ray contrast agent and an imaging agent; supporting the animal in an immobilized state on a support member; acquiring an x-ray anatomical image of the animal; acquiring an optical, dark-field image of the animal; and registering the x-ray anatomical image and the optical image, whereby features of the optical image can be observed in relation to features of the anatomical image.
摘要翻译：一种用于对受试动物进行成像的方法和装置。该方法包括用X射线造影剂和成像剂处理动物的步骤; 将动物以固定状态支撑在支撑构件上; 获取动物的x射线解剖图像; 获取动物的光学，暗视野图像; 并记录x射线解剖图像和光学图像，由此可以相对于解剖图像的特征观察光学图像的特征。

8. 发明申请

US20090324048A1 Method and apparatus for multi-modal imaging 有权
标题翻译：多模态成像的方法和装置
公开(公告)号：US20090324048A1
公开(公告)日：2009-12-31
申请号：US12460010
申请日：2009-07-10
申请人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
发明人： Warren M. Leevy , Gilbert Feke , Douglas L. Vizard
IPC分类号： G06K9/00 , G01N23/04 , G01N23/223
CPC分类号： A61B5/0059 , A01K1/031 , A61B5/0035 , A61B6/00 , A61B6/508 , A61B6/5247 , A61D7/04
摘要： A method and apparatus for imaging a subject animal. The method comprises the steps of treating the animal with an x-ray contrast agent and an imaging agent; supporting the animal in an immobilized state on a support member; acquiring an x-ray anatomical image of the animal; acquiring an optical, dark-field image of the animal; and registering the x-ray anatomical image and the optical image, whereby features of the optical image can be observed in relation to features of the anatomical image.
摘要翻译：一种用于成像受试动物的方法和装置。该方法包括用X射线造影剂和成像剂处理动物的步骤; 将动物以固定状态支撑在支撑构件上; 获取动物的x射线解剖图像; 获取动物的光学，暗视野图像; 并记录x射线解剖图像和光学图像，由此可以相对于解剖图像的特征观察光学图像的特征。

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