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    • 2. 发明授权
    • Fluorescent NIRF activatable probes for disease detection
    • 用于疾病检测的荧光NIRF可激活探针
    • US08834846B2
    • 2014-09-16
    • US13101370
    • 2011-05-05
    • Tao JiWarren M. LeevyWilliam E. McLaughlinYawfui Yong
    • Tao JiWarren M. LeevyWilliam E. McLaughlinYawfui Yong
    • A61B5/00
    • G01N33/587A61K49/0485B82Y5/00B82Y15/00C12Q1/34G01N33/542
    • Fluorescent activatable probes for imaging biological processes and disease detection in vitro and in vivo. There is also described a method for detecting the presence of an enzyme. A sample is contacted with a nanoparticle including a monomer, at least one cleavable spacer comprising at least one fluorescence activation site, and at least two dyes of at least two types. The cleavable spacer is attached at one end to the nanoparticle. The at least two types comprise an energy donor type and an energy acceptor type. At least one dye of one type is embedded in the nanoparticle and the cleavable spacer has at least one dye of the other type attached. The at least two dyes comprise at least one matched pair capable of fluorescence resonance energy transfer. Fluorescence is detected by exposing the sample to a light source, and detecting emitted light with a detector.
    • 用于成像生物过程和体外和体内疾病检测的荧光可激活探针。 还描述了检测酶的存在的方法。 将样品与包含单体的纳米颗粒,至少一个可切割间隔基包含至少一个荧光活化位点和至少两种至少两种类型的染料接触。 可切割间隔物的一端连接到纳米颗粒。 至少两种类型包括能量供体类型和能量受体类型。 至少一种一种染料被包埋在纳米颗粒中,并且可切割间隔物具有至少一种所连接的另一种类型的染料。 所述至少两种染料包含能够进行荧光共振能量转移的至少一个匹配对。 通过将样品暴露于光源并用检测器检测发射光来检测荧光。
    • 8. 发明授权
    • Apparatus and method for multi-modal imaging
    • 多模态成像装置及方法
    • US08050735B2
    • 2011-11-01
    • US12354830
    • 2009-01-16
    • Gilbert FekeDouglas Lincoln VizardWilliam E. McLaughlin
    • Gilbert FekeDouglas Lincoln VizardWilliam E. McLaughlin
    • A61B6/00
    • A61B5/0059A61B5/0035A61B6/00A61B6/4417A61B6/508A61B6/5247
    • An imaging system for imaging an object, including: a support member adapted to receive the object in an immobilized state; a removable phosphor plate assembly adapted to respond to ionizing radiation by emitting visible light; first imaging means for imaging the immobilized object in a first imaging mode to capture a first image; second imaging means for imaging the immobilized object in a second imaging mode, different from the first imaging mode, to capture a second image; and third imaging means for imaging the immobilized object in a third imaging mode, different from the first and second imaging modes, to capture a third image, wherein the first imaging mode uses the phosphor plate assembly and is selected from the group: x-ray mode and low energy radio isotope mode; the second imaging mode uses the phosphor plate assembly and a high energy radio isotope mode, and the third imaging mode is selected from the group: bright-field mode, fluorescence mode and luminescence mode.
    • 一种用于成像对象的成像系统,包括:适于以固定状态接收对象的支撑构件; 适于通过发射可见光来响应电离辐射的可去除的荧光体板组件; 第一成像装置,用于在第一成像模式下成像固定的物体以捕获第一图像; 第二成像装置,用于在与第一成像模式不同的第二成像模式下对固定物体进行成像以捕获第二图像; 以及第三成像装置,用于在与第一和第二成像模式不同的第三成像模式下成像固定的物体,以捕获第三图像,其中第一成像模式使用磷光体板组件,并且选自x射线 模式和低能放射同位素模式; 第二成像模式使用荧光体板组件和高能量放射性同位素模式,并且第三成像模式选自亮场模式,荧光模式和发光模式。
    • 10. 发明授权
    • Apparatus and method for multi-modal imaging
    • 多模态成像装置及方法
    • US07734325B2
    • 2010-06-08
    • US11221530
    • 2005-09-08
    • Douglas L. VizardJoel N. HelferGeorge BrocksieperWilliam E. Mclaughlin
    • Douglas L. VizardJoel N. HelferGeorge BrocksieperWilliam E. Mclaughlin
    • A61B6/00
    • A61B6/5235A61B5/0059A61B6/00A61B6/4417A61B6/508
    • An imaging system for imaging an object. The imaging system includes a support member adapted to receive the object in an immobilized state. The system also includes first means for imaging the immobilized object in a first imaging mode to capture a first image, and second means for imaging the immobilized object in a second imaging mode, different from the first imaging mode, to capture a second image. The first imaging mode is selected from the group: x-ray mode and radio isotopic mode. The second imaging mode is selected from the group: bright-field mode and dark-field mode. A removable phosphor screen is employed when the first image is captured and not employed when the second image is captured. The phosphor screen is adapted to transduce ionizing radiation to visible light. The phosphor screen is adapted to be removable without moving the immobilized object. The system can further include means for generating a third image comprised of the first and second image.
    • 用于成像对象的成像系统。 成像系统包括适于在固定状态下接收物体的支撑构件。 该系统还包括用于在第一成像模式下成像固定的物体以捕获第一图像的第一装置,以及用于在与第一成像模式不同的第二成像模式下成像固定的物体以捕获第二图像的第二装置。 第一种成像模式选自x射线模式和放射同位素模式。 第二种成像模式选自明场模式和暗场模式。 当捕获第一图像并且当捕获第二图像时不使用可移除荧光屏。 荧光屏适于将电离辐射转换成可见光。 荧光屏适于可拆卸而不移动固定的物体。 该系统还可以包括用于生成由第一和第二图像组成的第三图像的装置。