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1. 发明专利

JP2006116212A Regeneration inductive sheet for mesenchymal tissue and production process thereof 有权
标题翻译：生殖组织再生诱导片及其生产工艺
公开(公告)号：JP2006116212A
公开(公告)日：2006-05-11
申请号：JP2004309878
申请日：2004-10-25
申请人： Gc Corp , Hiroshima Univ , Two Cells Co Ltd , 国立大学法人広島大学 , 株式会社ジーシー , 株式会社ツーセル
发明人： KAWADA TOSHITSUGU , AMAI KAORU , TSUJI KOICHIRO , YAMANAKA KATSUYUKI
IPC分类号： A61L27/00 , A61K35/32 , A61K35/34
CPC分类号： A61L27/3804 , A61F2/2846 , A61F2/3094 , A61F2002/30062 , A61F2210/0004 , A61K35/35 , A61K2035/124 , A61L27/3633 , A61L27/3641 , A61L27/3839 , A61L31/005 , C12N5/0663 , C12N2533/40
摘要： PROBLEM TO BE SOLVED: To provide an easily moldable regeneration inductive sheet giving aimed form and maintaining a necessary strength to secure a regeneration space for a supporting tissue, being degradable and absorbable after passage of a required period and further having an ability to induce efficient regeneration of a mesenchymal tissue and a process for a production thereof. SOLUTION: The mesenchymal tissue regeneration inductive sheet is produced by absorption of a culture solution in a porous sheet prepared by lyophilization of a biologically absorbable polymer material dissolved in an organic solvent, seeding of proliferated mesenchymal cells extracted from a body tissue and followed by differentiation of the mesenchymal cells to a mesenchymal tissue precursor cells and adhering between the mesenchymal tissue precursor cells differentiated from the mesenchymal cells collected from a body tissue on a porous sheet containing a culture solution and extracellular substrate secreted during the differentiation process of the mesenchymal cells to the mesenchymal tissue precursor cells. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种容易成型的再生感应板，其给出目标形式并保持必要的强度以确保支撑组织的再生空间，在所需时间段之后可降解和吸收，并且还具有诱导间充质组织的有效再生及其制备方法。解决方案：通过将溶解在有机溶剂中的生物可吸收聚合物材料冻干制备的多孔片中的培养溶液吸收，从身体组织中提取的增殖的间充质细胞接种，然后进行培养，产生间充质组织再生感应性片通过将间充质细胞分化为间充质组织前体细胞，并且在从含有培养液的多孔片材上收集的来自间质培养基的间充质细胞和间充质细胞分化过程中分泌的细胞外基质之间的间充质组织前体细胞之间的粘附到间充质组织前体细胞。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2011067175A Method for culturing mesenchymal stem cell 有权
标题翻译：培养细胞干细胞的方法
公开(公告)号：JP2011067175A
公开(公告)日：2011-04-07
申请号：JP2009222981
申请日：2009-09-28
申请人： Gc Corp , Two Cells Co Ltd , 株式会社ジーシー , 株式会社ツーセル
发明人： SAKAI YUUDAI , YAMANAKA KATSUYUKI , TAKEDA MIKA , OKURA TOMOHISA , TSUJI KOICHIRO
IPC分类号： C12N5/07
CPC分类号： C12N5/0663 , C12N2500/50
摘要： PROBLEM TO BE SOLVED: To provide a method for culturing mesenchymal stem cells, which efficiently selects and proliferates mesenchymal stem cells without requiring a separator of exclusive use and complicated separation operation. SOLUTION: One or more of bone marrow liquid, cord blood, peripheral blood, synovial membrane and amnion are seeded in a liquid medium that is filled in a container and comprises water having a specific gravity of 1.06-1.10 g/mL at 37°C as a main component and a culture is carried out on the ceiling surface of the container at 37±2°C to culture the mesenchymal stem cells. Preferably the specific gravity of the liquid medium is adjusted by using at least one selected from silica fine powder coated with a polyvinylpyrrolidone, a water-soluble copolymer of sucrose and epichlorohydrin and a water-soluble compound containing a triiodo aromatic ring. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种培养间充质干细胞的方法，其能够有效地选择和增殖间充质干细胞，而不需要专用分离器和复杂的分离操作。解决方案：将一种或多种骨髓液，脐带血，外周血，滑膜和羊膜接种在装在容器中的液体培养基中，并包含比重为1.06-1.10g / mL的水 37℃作为主要成分，并在37±2℃的容器的顶棚表面进行培养，以培养间充质干细胞。优选地，通过使用选自涂覆有聚乙烯吡咯烷酮的二氧化硅细粉末，蔗糖和表氯醇的水溶性共聚物和含有三碘芳环的水溶性化合物中的至少一种来调节液体介质的比重。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2012143416A Dental implant and surface treatment method of dental implant 审中-公开
标题翻译：牙科植入物的牙科植入物和表面处理方法
公开(公告)号：JP2012143416A
公开(公告)日：2012-08-02
申请号：JP2011004444
申请日：2011-01-13
申请人： Gc Corp , 株式会社ジーシー
发明人： TAKAGI TAKAMITSU , YAMANAKA KATSUYUKI , NOGUCHI TSUYOSHI
IPC分类号： A61C8/00 , A61L27/00
CPC分类号： A61C8/0012 , A61C8/0015 , A61C2008/0046 , A61L27/06 , A61L27/56 , A61L31/022 , A61L31/146
摘要： PROBLEM TO BE SOLVED: To provide an implant that has macro pores having an inner diameter with the level of several tens of μm and micro pores having an inner diameter of 1-2 μm while having pores with the nanometer level in the surface.SOLUTION: The implant has the surface that has the macro pores having the inner diameter with the level of several tens of μm and micro pores having the inner diameter of 1-2 μm and comprises nano discharge craters having an inner diameter with the level of several tens of nm. The surface treatment method includes steps of producing the macro pores having the inner diameter with the level of several tens of μm by acid treatment of the surface; producing the micro pores having the inner diameter of 1-2 μm by blast treatment of the implant surface; and producing the nano discharge craters having an inner diameter with the level of several tens of nm by anodic oxidation treatment of the implant surface.
摘要翻译：要解决的问题：提供具有内径为几十μm的微孔和内径为1-2μm的微孔的植入物，同时具有表面纳米级的孔。解决方案：植入物具有具有内径为几十μm的宏观孔的表面和内径为1-2μm的微孔，并且包括具有内径的纳米放电坑水平几十nm。表面处理方法包括通过对表面进行酸处理来制造具有数十μm的内径的大孔的步骤; 通过种植体表面的喷砂处理产生内径为1-2μm的微孔; 通过对植入物表面进行阳极氧化处理，制造具有数十nm的内径的纳米放电坑。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2011041647A Bioabsorbable membrane body for tissue regeneration induction 审中-公开
标题翻译：用于组织再生诱导的生物体膜组织
公开(公告)号：JP2011041647A
公开(公告)日：2011-03-03
申请号：JP2009191010
申请日：2009-08-20
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , YAMANAKA KATSUYUKI , SAKAI YUUDAI , YAMAMOTO JUNPEI , SUDA YOKO , KANEKO TADASHI
IPC分类号： A61L27/00 , A61C13/00 , A61P1/02 , A61P19/00
摘要： PROBLEM TO BE SOLVED: To provide a bioabsorbable membrane body for tissue regeneration induction which is deformed to conform to an affected area and maintains the form after the deformation. SOLUTION: The bioabsorbable membrane body of guided tissue regeneration includes a conventional bioabsorbable membrane for tissue regeneration induction having a porous, sheetlike structure and an auxiliary material which is mounted on the bioabsorbable membrane for tissue regeneration induction, is formed by molding by drying the solvent of a solution in which bioabsorbable macromolecules are dissolved without freezing and drying or by thermoforming, and does not have a porous structure for maintaining the form of the bioabsorbable membrane body for tissue regeneration induction which is deformed to conform to the affected area. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于组织再生诱导的生物可吸收膜体，其变形以符合受影响的区域并且在变形后保持形状。解决方案：引导组织再生的生物可吸收膜体包括用于组织再生诱导的常规生物可吸收膜，具有多孔的片状结构和安装在用于组织再生诱导的生物可吸收膜上的辅助材料，通过干燥成型而形成其中生物可吸收的大分子在没有冷冻干燥或热成型的情况下溶解的溶液的溶剂，并且不具有用于维持变形以符合受影响区域的组织再生诱导的生物可吸收膜体的形式的多孔结构。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2009000012A Cell culture vessel 审中-公开
标题翻译：细胞培养基
公开(公告)号：JP2009000012A
公开(公告)日：2009-01-08
申请号：JP2007161689
申请日：2007-06-19
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMANAKA KATSUYUKI , YAMAMOTO KATSUSHI , SUDA YOKO , KANEKO TADASHI
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： C12M23/20 , C12M23/30
摘要： PROBLEM TO BE SOLVED: To provide a cell culture vessel capable of carrying out stationary culture of cells having superior cell adhesiveness, even without performing surface treatment, such as, plasma treatment and flattening the shape thereof, by heating to about 70°C and readily disposable after use.
SOLUTION: The cell culture vessel for carrying out the stationary culture of the cells is formed into a structure, in which at least the base in the vessel is constituted of a smooth biodegradable polymer material, having a contact angle with the water of 60-80°. There are modes in which the whole vessel is constituted of the biodegradable polymer material, and a sheet material of the biodegradable polymer material is installed at the bottom in the vessel. At least one kind selected from among polyglycolic acid, polylactic acid, a lactic acid-glycolic acid copolymer, polyamino acid, polymalic acid, polydioxane, poly-ε-caprolactone, a lactic acid-ε-caprolactone copolymer and copolymers thereof is preferable as the biodegradable polymer material.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种能够进行具有优异的细胞粘附性的细胞的静止培养的细胞培养容器，即使不进行表面处理，例如等离子体处理和使其形状变平，通过加热至约70° 并且使用后容易一次性使用。解决方案：用于进行细胞静止培养的细胞培养容器形成为其中至少容器中的碱由光滑的可生物降解的聚合物材料构成的结构，其具有与水的接触角 60-80°。存在整个容器由生物可降解聚合物材料构成的模式，并且生物可降解聚合物材料的片材安装在容器的底部。选自聚乙醇酸，聚乳酸，乳酸 - 乙醇酸共聚物，聚氨基酸，聚丙酸，聚二恶烷，聚ε-己内酯，乳酸-ε-己内酯共聚物及其共聚物中的至少一种优选为可生物降解的聚合物材料。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2005145952A Caries-preventing composition 审中-公开
标题翻译：预防组合物
公开(公告)号：JP2005145952A
公开(公告)日：2005-06-09
申请号：JP2004260622
申请日：2004-09-08
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMANAKA KATSUYUKI , SATO TAKUYA , YOSHII HIDEKAZU , WATANABE YOSHIKO
IPC分类号： A61K8/00 , A61K8/21 , A61K8/64 , A61K8/73 , A61Q11/00 , A61K7/16 , A61K7/18
摘要： PROBLEM TO BE SOLVED: To obtain a caries-preventing composition having an efficiently inhibiting effect on demineralization and accelerating re-calcification, and excellent in preservation stability for a long period.
SOLUTION: This caries-preventing composition characterized by being used by applying on the teeth is constituted with (a) 1-30 wt.% casein phosphopeptide-amorphous calcium phosphate complex (CPP-ACP) and/or casein phosphopeptide-amorphous calcium fluoride phosphate complex (CPP-ACFP), (b) 0.01-10 wt.% sodium carboxymethylcellulose having 0.7-1.0 etherification degree, (c) 0.5-40 wt.% thickening agent, (e) 0.01-5.0 wt.% at least 1 kind of fluorine compound selected from sodium fluoride, tin fluoride and monofluoro sodium phosphate, which may be blended as necessary, and (d) the balance of water.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：获得对脱矿质和加速再钙化有效抑制作用的长期保存稳定性优异的防龋剂组合物。（a）1-30重量％的酪蛋白磷酸肽 - 无定形磷酸钙复合物（CPP-ACP）和/或酪蛋白磷酸肽 - 无定形的蛋白质磷酸钙复合物（CPP-ACFP），（b）0.01-10重量％的具有0.7-1.0醚化度的羧甲基纤维素钠，（c）0.5-40重量％增稠剂，（e）0.01-5.0重量％至少一种选自氟化钠，氟化锡和一氟磷酸钠的氟化合物，根据需要可以混合，和（d）余量的水。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2011062356A Bioabsorbable membrane for guided tissue regeneration and manufacturing method of the same 审中-公开
标题翻译：用于指导组织再生的生物可溶性膜及其制造方法
公开(公告)号：JP2011062356A
公开(公告)日：2011-03-31
申请号：JP2009215934
申请日：2009-09-17
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMANAKA KATSUYUKI , YAMAMOTO KATSUSHI , SAKAI YUUDAI , KANEKO TADASHI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a bioabsorbable membrane for guided tissue regeneration which is bioabsorbable like a conventional bioabsorbable membrane for guided tissue regeneration but is not torn at a part where a thread is sewn even when a thread is used, and is used for securing a space where tissues, such as periodontal tissues or bone tissues, start regenerating in a dental medical field or the like.
SOLUTION: In the bioabsorbable membrane for guided tissue regeneration 1 for giving a space for regenerating a tissue to guide the tissue to the space, a reinforcement portion 3 which does not have a hole at a prescribed part of one or both side of the membrane including porous portions 2 is formed. In order to manufacture the bioabsorbable membrane for guided tissue regeneration 1, solution solving bioabsorbable high polymers is poured into a mold, the solution is freeze-dried, and evaporated to manufacture a membrane including the porous portions 2, prescribed parts of the membrane including the porous portions 2 is heat-melted from one or both side to form the reinforcement portion 3 which does not have a hole at a prescribed part on the membrane surface including the porous portions 2.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于引导组织再生的生物可吸收膜，其是生物可吸收的，如常规生物可吸收膜，用于引导组织再生，但即使在使用线时也不会在缝合线的部分处被撕裂，并且是用于确保诸如牙周组织或骨组织的组织在牙科医疗领域等中开始再生的空间。解决方案：在用于引导组织再生的生物可吸收膜1中，用于给予组织再生以将组织引导到空间的空间，在第一或第二侧的一侧或两侧的规定部分不具有孔的加强部3 形成包括多孔部分2的膜。为了制造用于引导组织再生的生物可吸收膜1，将解决生物可吸收性高聚物的溶液倒入模具中，将溶液冷冻干燥并蒸发以制造包括多孔部分2的膜，包括多孔部分2从一侧或两侧加热熔化，以形成在包括多孔部分2的膜表面上的规定部分处不具有孔的加强部3。（C）2011，JPO＆INPIT

8. 发明专利

JP2009291304A Bone graft substitute 审中-公开
标题翻译：骨髓替代品
公开(公告)号：JP2009291304A
公开(公告)日：2009-12-17
申请号：JP2008145820
申请日：2008-06-03
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , YAMANAKA KATSUYUKI , SAKAI YUUDAI , SUDA YOKO , KANEKO TADASHI
IPC分类号： A61L27/00 , A61C8/00 , A61F2/28
CPC分类号： A61L27/12 , A61L27/227 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： PROBLEM TO BE SOLVED: To provide a bone graft substitute having an appropriate absorption period in a living body and high osteoconductivity. SOLUTION: This bone graft substitute contains a carbonate apatite and an osteoinductive factor. The osteoinductive factor is preferably at least one selected from a group including BMP (a bone morphogenetic factor), GDF (a growth differentiation factor), TGF-β (a transformation growth factor), FGF (a fibroblast growth factor), IGF (an insulin-like growth factor), PDGF (a platelet-derived growth factor), BDNF (a brain-derived nerve growth factor), and NGF (a nerve growth factor), and the bone graft substitute has open pores, preferably having a diameter of 50 to 1,000 μm and/or a diameter of 5 μm or less, with porosity of 20 to 80%. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供在生物体中具有适当吸收期的骨移植物替代物和高的骨传导性。解决方案：这种骨移植物替代物含有碳酸盐磷灰石和骨诱导因子。骨诱导因子优选为选自BMP（骨形态发生因子），GDF（生长分化因子），TGF-β（转化生长因子），FGF（成纤维细胞生长因子），IGF（an 胰岛素样生长因子），PDGF（血小板衍生生长因子），BDNF（脑源性神经生长因子）和NGF（神经生长因子），骨移植物替代物具有开放孔，优选具有直径为50〜1000μm，和/或直径为5μm以下，孔隙率为20〜80％。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2007289634A Bioabsorbable tube and its manufacturing method 审中-公开
标题翻译：可生物管及其制造方法
公开(公告)号：JP2007289634A
公开(公告)日：2007-11-08
申请号：JP2006244528
申请日：2006-09-08
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , YAMANAKA KATSUYUKI , SUDA YOKO , KANEKO TADASHI
IPC分类号： A61L27/00
CPC分类号： A61B17/1128 , A61B2017/00004 , A61L27/18 , A61L27/50 , A61L27/58 , C08L67/04
摘要： PROBLEM TO BE SOLVED: To provide a bioabsorbable tube and its manufacturing method low in costs and ready to complete a set of multiple tubes differing in thickness, inner diameter and outer configuration, in comparison with conventional bioabsorbable tubes. SOLUTION: The manufacturing method for the bioabsorbable tube is that a bioabsorbable polymer material sheet produced by drying up a solvent of a solution of a bioabsorbable polymer is wound into a tubular shape, and then at lease doubled areas near the tubular sheet's outer peripheral side end edges are fused or welded together into a tube, or otherwise that the bioabsorbable polymer material sheet produced by freeze-drying up the solvent of the solution of the bioabsorbable polymer is wound into a tubular shape, and then it is further wound by another bioabsorbable polymer material sheet produced by non-freeze-drying up the solvent of the solution of the bioabsorbable polymer into a tubular shape, followed by fusing or welding together at least doubled areas near the outer peripheral side end edges of the outside bioabsorbable polymer material sheet, thus forming a double-layer bioabsorbable tube. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：与传统的生物可吸收管相比，提供低成本的生物可吸收管及其制造方法，并准备完成一组不同厚度，内径和外部构型的多个管。生物可吸收管的制造方法是通过将生物可吸收性聚合物的溶液的溶剂干燥而生成的生物体吸收性聚合物材料片卷绕成管状，然后在管状片材的外部附近的至少两倍的区域外周侧端缘熔接或焊接在一起成管，否则通过将生物可吸收性聚合物溶液的溶剂冷冻干燥而制造的生物可吸收聚合物材料片被卷绕成管状，然后进一步被另一种生物可吸收聚合物材料片，其通过将生物可吸收聚合物溶液的溶剂冷冻干燥成管状形状，然后将外部生物可吸收性聚合物材料的外周侧端缘附近的至少两倍的区域熔合或焊接在一起从而形成双层生物可吸收管。版权所有（C）2008，JPO＆INPIT

10. 发明专利

JP2006034485A Bioabsorptive granular porous bone filling material and manufacturing method therefor 有权
标题翻译：生物颗粒多孔骨填充材料及其制造方法
公开(公告)号：JP2006034485A
公开(公告)日：2006-02-09
申请号：JP2004216887
申请日：2004-07-26
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , YAMANAKA KATSUYUKI , SUDA YOKO , KANEKO TADASHI
IPC分类号： A61L27/00 , A61B17/56 , A61K6/00
CPC分类号： A61L27/58 , A61L27/18 , A61L27/56 , A61L2430/02 , C08L67/04
摘要： PROBLEM TO BE SOLVED: To provide a granular porous bone filling material made of a bioabsorptive polymer body having a particle diameter of 100-3000 μm which has a small hole structure having a hole diameter of 5-50 μm used for filling a defective section after removing a lesion due to bone tumor, osteomyelitis, or the like, or a defective section after autologous bone transplanting, reinforcement, filling or the like of the jaw bone at the time of embedding a dental implant, and a manufacturing method therefor.
SOLUTION: The polymer body having the small hole structure with the hole diameter of 5-50 μm containing a particulate material is produced by mixing the particulate material with the particle diameter of 100-2000 μm which does not dissolve in an organic solvent and dissolves in a liquid which does not dissolve the bioabsorptive polymer into a solution in which the bioabsorptive polymer is dissolved in the organic solvent, and removing the organic solvent by drying after freezing. The bioabsorptive granular porous bone filling material with the particle diameter of 100-3000 μm is manufactured by sifting through a sieve after pulverizing the polymer body and removing the particulate material by dissolving it in the liquid which does not dissolve the bioabsorptive polymer.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种由具有100-3000μm的生物吸收性聚合物体制成的颗粒状多孔骨填充材料，其具有孔径为5-50μm的小孔结构，用于填充在植入牙植入物时，由于骨肿瘤，骨髓炎等引起的病变，或自体骨移植，加固，填充等后的瑕疵骨缺损部分及其制造方法，。解决方案：通过将不溶于有机溶剂的粒径为100-2000μm的颗粒材料混合制成具有含有颗粒材料的孔直径为5-50μm的小孔结构的聚合物体并且将不溶解生物吸收性聚合物的液体溶解在生物吸收性聚合物溶解于有机溶剂中的溶液中，冷冻后通过干燥除去有机溶剂。粒径为100-3000μm的生物吸收性粒状多孔骨填充材料是在粉碎聚合物体之后筛选筛子，并通过将其溶解在不溶解生物吸收性聚合物的液体中除去颗粒物质而制造的。版权所有（C）2006，JPO＆NCIPI

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