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1. 发明专利

JP2011041647A Bioabsorbable membrane body for tissue regeneration induction 审中-公开
标题翻译：用于组织再生诱导的生物体膜组织
公开(公告)号：JP2011041647A
公开(公告)日：2011-03-03
申请号：JP2009191010
申请日：2009-08-20
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , YAMANAKA KATSUYUKI , SAKAI YUUDAI , YAMAMOTO JUNPEI , SUDA YOKO , KANEKO TADASHI
IPC分类号： A61L27/00 , A61C13/00 , A61P1/02 , A61P19/00
摘要： PROBLEM TO BE SOLVED: To provide a bioabsorbable membrane body for tissue regeneration induction which is deformed to conform to an affected area and maintains the form after the deformation. SOLUTION: The bioabsorbable membrane body of guided tissue regeneration includes a conventional bioabsorbable membrane for tissue regeneration induction having a porous, sheetlike structure and an auxiliary material which is mounted on the bioabsorbable membrane for tissue regeneration induction, is formed by molding by drying the solvent of a solution in which bioabsorbable macromolecules are dissolved without freezing and drying or by thermoforming, and does not have a porous structure for maintaining the form of the bioabsorbable membrane body for tissue regeneration induction which is deformed to conform to the affected area. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于组织再生诱导的生物可吸收膜体，其变形以符合受影响的区域并且在变形后保持形状。解决方案：引导组织再生的生物可吸收膜体包括用于组织再生诱导的常规生物可吸收膜，具有多孔的片状结构和安装在用于组织再生诱导的生物可吸收膜上的辅助材料，通过干燥成型而形成其中生物可吸收的大分子在没有冷冻干燥或热成型的情况下溶解的溶液的溶剂，并且不具有用于维持变形以符合受影响区域的组织再生诱导的生物可吸收膜体的形式的多孔结构。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2011062356A Bioabsorbable membrane for guided tissue regeneration and manufacturing method of the same 审中-公开
标题翻译：用于指导组织再生的生物可溶性膜及其制造方法
公开(公告)号：JP2011062356A
公开(公告)日：2011-03-31
申请号：JP2009215934
申请日：2009-09-17
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMANAKA KATSUYUKI , YAMAMOTO KATSUSHI , SAKAI YUUDAI , KANEKO TADASHI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a bioabsorbable membrane for guided tissue regeneration which is bioabsorbable like a conventional bioabsorbable membrane for guided tissue regeneration but is not torn at a part where a thread is sewn even when a thread is used, and is used for securing a space where tissues, such as periodontal tissues or bone tissues, start regenerating in a dental medical field or the like.
SOLUTION: In the bioabsorbable membrane for guided tissue regeneration 1 for giving a space for regenerating a tissue to guide the tissue to the space, a reinforcement portion 3 which does not have a hole at a prescribed part of one or both side of the membrane including porous portions 2 is formed. In order to manufacture the bioabsorbable membrane for guided tissue regeneration 1, solution solving bioabsorbable high polymers is poured into a mold, the solution is freeze-dried, and evaporated to manufacture a membrane including the porous portions 2, prescribed parts of the membrane including the porous portions 2 is heat-melted from one or both side to form the reinforcement portion 3 which does not have a hole at a prescribed part on the membrane surface including the porous portions 2.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于引导组织再生的生物可吸收膜，其是生物可吸收的，如常规生物可吸收膜，用于引导组织再生，但即使在使用线时也不会在缝合线的部分处被撕裂，并且是用于确保诸如牙周组织或骨组织的组织在牙科医疗领域等中开始再生的空间。解决方案：在用于引导组织再生的生物可吸收膜1中，用于给予组织再生以将组织引导到空间的空间，在第一或第二侧的一侧或两侧的规定部分不具有孔的加强部3 形成包括多孔部分2的膜。为了制造用于引导组织再生的生物可吸收膜1，将解决生物可吸收性高聚物的溶液倒入模具中，将溶液冷冻干燥并蒸发以制造包括多孔部分2的膜，包括多孔部分2从一侧或两侧加热熔化，以形成在包括多孔部分2的膜表面上的规定部分处不具有孔的加强部3。（C）2011，JPO＆INPIT

3. 发明专利

JP2009291304A Bone graft substitute 审中-公开
标题翻译：骨髓替代品
公开(公告)号：JP2009291304A
公开(公告)日：2009-12-17
申请号：JP2008145820
申请日：2008-06-03
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , YAMANAKA KATSUYUKI , SAKAI YUUDAI , SUDA YOKO , KANEKO TADASHI
IPC分类号： A61L27/00 , A61C8/00 , A61F2/28
CPC分类号： A61L27/12 , A61L27/227 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： PROBLEM TO BE SOLVED: To provide a bone graft substitute having an appropriate absorption period in a living body and high osteoconductivity. SOLUTION: This bone graft substitute contains a carbonate apatite and an osteoinductive factor. The osteoinductive factor is preferably at least one selected from a group including BMP (a bone morphogenetic factor), GDF (a growth differentiation factor), TGF-β (a transformation growth factor), FGF (a fibroblast growth factor), IGF (an insulin-like growth factor), PDGF (a platelet-derived growth factor), BDNF (a brain-derived nerve growth factor), and NGF (a nerve growth factor), and the bone graft substitute has open pores, preferably having a diameter of 50 to 1,000 μm and/or a diameter of 5 μm or less, with porosity of 20 to 80%. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供在生物体中具有适当吸收期的骨移植物替代物和高的骨传导性。解决方案：这种骨移植物替代物含有碳酸盐磷灰石和骨诱导因子。骨诱导因子优选为选自BMP（骨形态发生因子），GDF（生长分化因子），TGF-β（转化生长因子），FGF（成纤维细胞生长因子），IGF（an 胰岛素样生长因子），PDGF（血小板衍生生长因子），BDNF（脑源性神经生长因子）和NGF（神经生长因子），骨移植物替代物具有开放孔，优选具有直径为50〜1000μm，和/或直径为5μm以下，孔隙率为20〜80％。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2013236737A Therapeutic method for injured area of bone 审中-公开
标题翻译：骨骼受伤区域的治疗方法
公开(公告)号：JP2013236737A
公开(公告)日：2013-11-28
申请号：JP2012111420
申请日：2012-05-15
申请人： Gc Corp , 株式会社ジーシー , Teikyo Univ , 学校法人帝京大学
发明人： YAMANAKA KATSUYUKI , KANEKO TADASHI , SAKAI YUUDAI , WATABE YOSHIOSHI , MATSUSHITA TAKASHI , ABE TETSUSHI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a therapeutic method capable of regenerating a bone tissue even when the injured area of the bone is large.SOLUTION: A therapeutic method includes: a step of culturing chondrocytes sown in a porous body; or a step of culturing a chondrocytes by differentiating stem cells to be differentiated into chondrocytes sown in the porous body into chondrocytes; and a step of implanting the porous body where the chondrocytes are cultured.
摘要翻译：要解决的问题：提供即使当骨的受损区域较大时能够再生骨组织的治疗方法。解决方案：治疗方法包括：培养播放在多孔体中的软骨细胞的步骤; 或通过将待分化的干细胞分化成多孔体中的软骨细胞来培养软骨细胞进入软骨细胞的步骤; 以及植入软骨细胞培养的多孔体的步骤。

5. 发明专利

JP2012205655A Cell engineering support and production method thereof 审中-公开
标题翻译：细胞工程支持及其生产方法
公开(公告)号：JP2012205655A
公开(公告)日：2012-10-25
申请号：JP2011072061
申请日：2011-03-29
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMANAKA KATSUYUKI , YAMAMOTO KATSUSHI , SAKAI YUUDAI , YAMAMOTO JUNPEI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a porous cell support with a thickness of 2 mm or more, cells are easily seeded in the whole of the support, eliminating any possibility of applying a large force to the cells, and substantially accurately grasping the amount of cells in the support, and to provide a production method thereof.SOLUTION: The cell engineering support includes: an upper portion made of a bioabsorbable polymer block and having a thickness of 2 mm or more which has an average pore diameter of 300 to 3,000 μm, a porosity of 75 to 97%, and a fracture strength of 0.05 to 2 MPa; and a lower portion made of a porous bioabsorbable polymer having an average pore diameter of 2 to 30 μm.
摘要翻译：要解决的问题：为了提供厚度为2mm以上的多孔电池支撑体，电池容易接种在整个支撑体中，消除了对电池施加大的力的任何可能性，并且基本上精确地把握载体中的细胞的量，并提供其制备方法。电池工程支持体包括：由生物可吸收聚合物嵌段制成的上部，其厚度为2mm以上，平均孔径为300〜3000μm，孔隙率为75〜97％，以及断裂强度为0.05〜2MPa; 和由平均孔径为2〜30μm的多孔生物可吸收聚合物制成的下部。版权所有（C）2013，JPO＆INPIT

6. 发明专利

JP2009240605A Cell engineering support and its manufacturing method 审中-公开
标题翻译：细胞工程支持及其制造方法
公开(公告)号：JP2009240605A
公开(公告)日：2009-10-22
申请号：JP2008091991
申请日：2008-03-31
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , YAMANAKA KATSUYUKI , SUDA YOKO , SAKAI YUUDAI , KANEKO TADASHI
IPC分类号： A61L27/00
CPC分类号： A61L27/56 , A61L27/18 , C08L67/04
摘要： PROBLEM TO BE SOLVED: To provide a cell engineering support which is made of a bioabsorbable polymer absorbed in biological tissue and has a high porosity suitable for cell culture in the interior but does not lose the overall strength of the support, and its manufacturing method. SOLUTION: The cell engineering support is turned into a structure in which the periphery of a porous bioabsorbable polymer having the porosity is 50 to 99% is covered with a bioabsorbable polymer having the thickness of 0.01 to 5 mm, and having 10 to 3,000 μm pores, the breaking strength of 0.05 to 0.15 MPa, and the volume accounting for 15 to 90% of the entire support. The cell engineering support manufacturing method involves the covering of a porous bioabsorbable polymer material dried and manufactured after dissolved in an organic solvent and having the porosity of 50 to 99% with a bioabsorbable polymer having the thickness of 0.01 to 5 mm, 10 to 3,000 μm pores, the breaking strength of 0.05 to 0.15 MPa and the volume accounting for 15 to 90% of the entire support. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供由吸收在生物组织中的生物可吸收聚合物制成并且具有适合于内部细胞培养的高孔隙度但不丧失载体的整体强度的细胞工程载体，并且其制造方法。解决方案：将细胞工程载体转变成其孔隙率为50-99％的多孔生物可吸收聚合物的周边覆盖有厚度为0.01至5mm的生物可吸收聚合物，并具有10至 3000微米孔隙，断裂强度为0.05〜0.15MPa，体积占整个支架的15〜90％。细胞工程支持制造方法包括在溶解于有机溶剂中后干燥和制造的多孔生物可吸收聚合物材料的覆盖层，并且具有50至99％的孔隙率的生物可吸收聚合物的厚度为0.01至5mm，10至3,000μm 孔隙，断裂强度为0.05〜0.15MPa，体积占整个支架的15〜90％。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2009195682A Porous cell scaffold and production method thereof 有权
标题翻译：多孔细胞SCAFFOLD及其生产方法
公开(公告)号：JP2009195682A
公开(公告)日：2009-09-03
申请号：JP2008320040
申请日：2008-12-16
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMANAKA KATSUYUKI , SUDA YOKO , YAMAMOTO KATSUSHI , SAKAI YUUDAI , KANEKO TADASHI
IPC分类号： A61L27/00
CPC分类号： C12N5/0655 , C12N5/0062 , C12N5/0653 , C12N5/0654 , C12N2533/30 , C12N2533/40
摘要： PROBLEM TO BE SOLVED: To provide a porous cell scaffold of a 2 mm or more thickness and a production method thereof, easily seeding cells in its scaffold without applying any large force to the cells, and substantially accurately obtaining the amount of cells in the scaffold as well in seeding.
SOLUTION: After filling a guiding solution with kinematic viscosity being 50-450% of that of a culture medium, in a whole continuous small hole structure having hole diameters of 5-3,200 μm and an average hole diameter of 50-1,500 μm, of a sheet-shaped or block-shaped scaffold having a thickness of 2 mm or more, a culture medium with cells being suspended to an upper side of the scaffold is supplied, and the guiding solution from a lower side of the scaffold is sucked by low suction force to thereby cause the culture medium with cells being suspended to enter the whole small hole structure. A water absorber such as a filter paper is preferably used for sucking the guiding solution by low suction force.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题为了提供2mm以上厚度的多孔细胞支架及其制造方法，容易将细胞接种在其支架中而不对细胞施加任何大的力，并且基本上准确地获得细胞数量在脚手架以及播种。
解决方案：在填充具有培养基的50-450％的运动粘度的引导溶液后，在孔直径为5-3,200μm，平均孔径为50-1,500μm的整个连续的小孔结构中的厚度为2mm以上的片状或块状的支架，供给悬浮于脚手架上侧的细胞的培养基，从脚手架的下侧吸引引导溶液通过低抽吸力使得细胞悬浮的培养基进入整个小孔结构。吸滤剂如滤纸优选用于通过低抽吸力吸引引导溶液。版权所有（C）2009，JPO＆INPIT

8. 发明专利

JP2011212105A Granular bone prosthetic material and method of manufacturing the same 审中-公开
标题翻译：颗粒状骨质疏松材料及其制造方法
公开(公告)号：JP2011212105A
公开(公告)日：2011-10-27
申请号：JP2010081230
申请日：2010-03-31
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMANAKA KATSUYUKI , YAMAMOTO KATSUSHI , SAKAI YUUDAI , YAMAMOTO JUNPEI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a granular bone prosthetic material which is easily placed on a lesion and does not easily lose its shape.
SOLUTION: The invention relates to the granular bone prosthetic material composed of a bioabsorbable polymer which has a sponge shape with a small hole structure and has an average particle size of 200-5,000 μm and a projection part which is harder than the polymer, does not have the small hole structure and is projected from the polymer for the length of 2-60% of the polymer particle size, and a method of manufacturing the same. In the granular bone prosthetic material and the method of manufacturing the same, it is preferable that the bioabsorbable polymer is at least one kind selected from the polymer of L-lactic acid, D-lactic acid, glycolic acid, ε-caprolactone, dioxane and malic acid or the copolymer thereof.
COPYRIGHT: (C)2012,JPO&INPIT

9. 发明专利

JP2009226148A Production method of cell-technological block-like support 有权
标题翻译：细胞技术类似支持的生产方法
公开(公告)号：JP2009226148A
公开(公告)日：2009-10-08
申请号：JP2008078388
申请日：2008-03-25
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , YAMANAKA KATSUYUKI , SUDA YOKO , SAKAI YUUDAI , KANEKO TADASHI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a production method of a cell-engineering block-like support used as a substitute for biotissue, having superior morphological stability, allowing a user to seed and/or culture cells in its interior and consisting of a bioabsorbable polymer material having a wide void.
SOLUTION: The sheet-like bioabsorbable polymer material with the thickness of 0.01-1 mm is brought together irregularly, put in a mold and pressurized and heated to produce this cell-engineering block-like cell support having a continuous amorphous void occupying 10-90% in porosity. Preferably, the sheet-like bioabsorbable polymer material has pores of 5-100 μm produced by dissolving the bioabsorbable polymer material in organic solvent, and freeze-drying it, or pores with the diameter of 0.1-3 mm is formed on the sheet-like bioabsorbable polymer material produced by dissolving the bioabsorbable polymer material in the organic solvent and drying it. It is preferable to use the oblong sheet-like bioabsorbable polymer material with the length of 5-50 mm, the width of 0.1-20 mm and the thickness of 0.01-1 mm.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了提供用作生物组织的替代物的细胞工程化块状载体的制备方法，具有优异的形态稳定性，允许使用者在其内部种子和/或培养细胞并由具有宽空隙的生物可吸收聚合物材料。解决方案：将厚度为0.01-1mm的片状生物可吸收聚合物材料不规则地放在一起，放入模具中并进行加压和加热以产生具有连续无定形空隙占据的这种细胞工程的块状细胞载体孔隙度为10-90％。优选地，片状生物可吸收聚合物材料具有通过将生物可吸收聚合物材料溶解在有机溶剂中而制备的5-100μm孔，并将其冷冻干燥，或者在片状物上形成直径为0.1-3mm的孔通过将生物可吸收聚合物材料溶解在有机溶剂中并将其干燥而生产的生物可吸收聚合物材料。优选使用长度为5-50mm，宽度为0.1-20mm，厚度为0.01-1mm的长方形片状生物可吸收聚合物材料。版权所有（C）2010，JPO＆INPIT

10. 发明专利

JP2009034190A Cannula 审中-公开
标题翻译：冠状动脉
公开(公告)号：JP2009034190A
公开(公告)日：2009-02-19
申请号：JP2007199178
申请日：2007-07-31
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , SAKAI YUUDAI
IPC分类号： A61B10/02 , A61B17/34
CPC分类号： A61B10/025 , A61B10/0283 , A61B17/3472 , A61B2010/0258
摘要： PROBLEM TO BE SOLVED: To provide a cannula with very high air-tightness in such a state as penetrating the bone cortex of bone tissue, suitable as a bone marrow biopsy needle for the hard bone tissue such as jaw bones, and easily operated with weak force to pierce the bone cortex of bone tissue. SOLUTION: A support cylinder 1 having an insertion port 1a for inserting a stylet S at the rear end is fixed to the distal end of the cannula, and a male screw part 2 is formed in the outer surface of the distal end of the cannula. A cutting blade part 2a, recessed in the center axial direction and having a self-tap mechanism at one end edge of the recess, is formed along the axial direction in the distal end side of the male screw part 2. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种在穿透骨组织的骨皮质的状态下具有非常高的气密性的套管，适合作为硬骨组织如颚骨的骨髓活检针，并且容易以弱力刺穿骨组织的骨皮质。解决方案：具有用于在后端插入探针S的插入口1a的支撑筒1固定到插管的远端，并且在螺钉部2的远端的外表面中形成有阳螺纹部2 套管。在外螺纹部2的前端侧沿着轴向形成有在中心轴方向上凹陷并且在凹部的一个端部边缘处具有自动分接机构的切割刀片部分2a。版权所有：（C）2009，JPO＆INPIT

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