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1. 发明专利

JP2013236737A Therapeutic method for injured area of bone 审中-公开
标题翻译：骨骼受伤区域的治疗方法
公开(公告)号：JP2013236737A
公开(公告)日：2013-11-28
申请号：JP2012111420
申请日：2012-05-15
申请人： Gc Corp , 株式会社ジーシー , Teikyo Univ , 学校法人帝京大学
发明人： YAMANAKA KATSUYUKI , KANEKO TADASHI , SAKAI YUUDAI , WATABE YOSHIOSHI , MATSUSHITA TAKASHI , ABE TETSUSHI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a therapeutic method capable of regenerating a bone tissue even when the injured area of the bone is large.SOLUTION: A therapeutic method includes: a step of culturing chondrocytes sown in a porous body; or a step of culturing a chondrocytes by differentiating stem cells to be differentiated into chondrocytes sown in the porous body into chondrocytes; and a step of implanting the porous body where the chondrocytes are cultured.
摘要翻译：要解决的问题：提供即使当骨的受损区域较大时能够再生骨组织的治疗方法。解决方案：治疗方法包括：培养播放在多孔体中的软骨细胞的步骤; 或通过将待分化的干细胞分化成多孔体中的软骨细胞来培养软骨细胞进入软骨细胞的步骤; 以及植入软骨细胞培养的多孔体的步骤。

2. 发明专利

JP2009240605A Cell engineering support and its manufacturing method 审中-公开
标题翻译：细胞工程支持及其制造方法
公开(公告)号：JP2009240605A
公开(公告)日：2009-10-22
申请号：JP2008091991
申请日：2008-03-31
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , YAMANAKA KATSUYUKI , SUDA YOKO , SAKAI YUUDAI , KANEKO TADASHI
IPC分类号： A61L27/00
CPC分类号： A61L27/56 , A61L27/18 , C08L67/04
摘要： PROBLEM TO BE SOLVED: To provide a cell engineering support which is made of a bioabsorbable polymer absorbed in biological tissue and has a high porosity suitable for cell culture in the interior but does not lose the overall strength of the support, and its manufacturing method. SOLUTION: The cell engineering support is turned into a structure in which the periphery of a porous bioabsorbable polymer having the porosity is 50 to 99% is covered with a bioabsorbable polymer having the thickness of 0.01 to 5 mm, and having 10 to 3,000 μm pores, the breaking strength of 0.05 to 0.15 MPa, and the volume accounting for 15 to 90% of the entire support. The cell engineering support manufacturing method involves the covering of a porous bioabsorbable polymer material dried and manufactured after dissolved in an organic solvent and having the porosity of 50 to 99% with a bioabsorbable polymer having the thickness of 0.01 to 5 mm, 10 to 3,000 μm pores, the breaking strength of 0.05 to 0.15 MPa and the volume accounting for 15 to 90% of the entire support. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供由吸收在生物组织中的生物可吸收聚合物制成并且具有适合于内部细胞培养的高孔隙度但不丧失载体的整体强度的细胞工程载体，并且其制造方法。解决方案：将细胞工程载体转变成其孔隙率为50-99％的多孔生物可吸收聚合物的周边覆盖有厚度为0.01至5mm的生物可吸收聚合物，并具有10至 3000微米孔隙，断裂强度为0.05〜0.15MPa，体积占整个支架的15〜90％。细胞工程支持制造方法包括在溶解于有机溶剂中后干燥和制造的多孔生物可吸收聚合物材料的覆盖层，并且具有50至99％的孔隙率的生物可吸收聚合物的厚度为0.01至5mm，10至3,000μm 孔隙，断裂强度为0.05〜0.15MPa，体积占整个支架的15〜90％。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2009195682A Porous cell scaffold and production method thereof 有权
标题翻译：多孔细胞SCAFFOLD及其生产方法
公开(公告)号：JP2009195682A
公开(公告)日：2009-09-03
申请号：JP2008320040
申请日：2008-12-16
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMANAKA KATSUYUKI , SUDA YOKO , YAMAMOTO KATSUSHI , SAKAI YUUDAI , KANEKO TADASHI
IPC分类号： A61L27/00
CPC分类号： C12N5/0655 , C12N5/0062 , C12N5/0653 , C12N5/0654 , C12N2533/30 , C12N2533/40
摘要： PROBLEM TO BE SOLVED: To provide a porous cell scaffold of a 2 mm or more thickness and a production method thereof, easily seeding cells in its scaffold without applying any large force to the cells, and substantially accurately obtaining the amount of cells in the scaffold as well in seeding.
SOLUTION: After filling a guiding solution with kinematic viscosity being 50-450% of that of a culture medium, in a whole continuous small hole structure having hole diameters of 5-3,200 μm and an average hole diameter of 50-1,500 μm, of a sheet-shaped or block-shaped scaffold having a thickness of 2 mm or more, a culture medium with cells being suspended to an upper side of the scaffold is supplied, and the guiding solution from a lower side of the scaffold is sucked by low suction force to thereby cause the culture medium with cells being suspended to enter the whole small hole structure. A water absorber such as a filter paper is preferably used for sucking the guiding solution by low suction force.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题为了提供2mm以上厚度的多孔细胞支架及其制造方法，容易将细胞接种在其支架中而不对细胞施加任何大的力，并且基本上准确地获得细胞数量在脚手架以及播种。
解决方案：在填充具有培养基的50-450％的运动粘度的引导溶液后，在孔直径为5-3,200μm，平均孔径为50-1,500μm的整个连续的小孔结构中的厚度为2mm以上的片状或块状的支架，供给悬浮于脚手架上侧的细胞的培养基，从脚手架的下侧吸引引导溶液通过低抽吸力使得细胞悬浮的培养基进入整个小孔结构。吸滤剂如滤纸优选用于通过低抽吸力吸引引导溶液。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2011041647A Bioabsorbable membrane body for tissue regeneration induction 审中-公开
标题翻译：用于组织再生诱导的生物体膜组织
公开(公告)号：JP2011041647A
公开(公告)日：2011-03-03
申请号：JP2009191010
申请日：2009-08-20
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , YAMANAKA KATSUYUKI , SAKAI YUUDAI , YAMAMOTO JUNPEI , SUDA YOKO , KANEKO TADASHI
IPC分类号： A61L27/00 , A61C13/00 , A61P1/02 , A61P19/00
摘要： PROBLEM TO BE SOLVED: To provide a bioabsorbable membrane body for tissue regeneration induction which is deformed to conform to an affected area and maintains the form after the deformation. SOLUTION: The bioabsorbable membrane body of guided tissue regeneration includes a conventional bioabsorbable membrane for tissue regeneration induction having a porous, sheetlike structure and an auxiliary material which is mounted on the bioabsorbable membrane for tissue regeneration induction, is formed by molding by drying the solvent of a solution in which bioabsorbable macromolecules are dissolved without freezing and drying or by thermoforming, and does not have a porous structure for maintaining the form of the bioabsorbable membrane body for tissue regeneration induction which is deformed to conform to the affected area. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于组织再生诱导的生物可吸收膜体，其变形以符合受影响的区域并且在变形后保持形状。解决方案：引导组织再生的生物可吸收膜体包括用于组织再生诱导的常规生物可吸收膜，具有多孔的片状结构和安装在用于组织再生诱导的生物可吸收膜上的辅助材料，通过干燥成型而形成其中生物可吸收的大分子在没有冷冻干燥或热成型的情况下溶解的溶液的溶剂，并且不具有用于维持变形以符合受影响区域的组织再生诱导的生物可吸收膜体的形式的多孔结构。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2009000012A Cell culture vessel 审中-公开
标题翻译：细胞培养基
公开(公告)号：JP2009000012A
公开(公告)日：2009-01-08
申请号：JP2007161689
申请日：2007-06-19
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMANAKA KATSUYUKI , YAMAMOTO KATSUSHI , SUDA YOKO , KANEKO TADASHI
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： C12M23/20 , C12M23/30
摘要： PROBLEM TO BE SOLVED: To provide a cell culture vessel capable of carrying out stationary culture of cells having superior cell adhesiveness, even without performing surface treatment, such as, plasma treatment and flattening the shape thereof, by heating to about 70°C and readily disposable after use.
SOLUTION: The cell culture vessel for carrying out the stationary culture of the cells is formed into a structure, in which at least the base in the vessel is constituted of a smooth biodegradable polymer material, having a contact angle with the water of 60-80°. There are modes in which the whole vessel is constituted of the biodegradable polymer material, and a sheet material of the biodegradable polymer material is installed at the bottom in the vessel. At least one kind selected from among polyglycolic acid, polylactic acid, a lactic acid-glycolic acid copolymer, polyamino acid, polymalic acid, polydioxane, poly-ε-caprolactone, a lactic acid-ε-caprolactone copolymer and copolymers thereof is preferable as the biodegradable polymer material.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种能够进行具有优异的细胞粘附性的细胞的静止培养的细胞培养容器，即使不进行表面处理，例如等离子体处理和使其形状变平，通过加热至约70° 并且使用后容易一次性使用。解决方案：用于进行细胞静止培养的细胞培养容器形成为其中至少容器中的碱由光滑的可生物降解的聚合物材料构成的结构，其具有与水的接触角 60-80°。存在整个容器由生物可降解聚合物材料构成的模式，并且生物可降解聚合物材料的片材安装在容器的底部。选自聚乙醇酸，聚乳酸，乳酸 - 乙醇酸共聚物，聚氨基酸，聚丙酸，聚二恶烷，聚ε-己内酯，乳酸-ε-己内酯共聚物及其共聚物中的至少一种优选为可生物降解的聚合物材料。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2011083639A Bioabsorbable granular porous bone prosthetic material 审中-公开
标题翻译：生物体颗粒多孔骨质疏松材料
公开(公告)号：JP2011083639A
公开(公告)日：2011-04-28
申请号：JP2011018368
申请日：2011-01-31
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , YAMANAKA KATSUYUKI , SUDA YOKO , KANEKO TADASHI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a granular porous bone prosthetic material which consists of a bioabsorbable polymer body having a concave part with the width up to 100-2,000 μm on a surface and having a pore structure with a pore diameter of 5-50 μm while a particle diameter is 100-3,000 μm. SOLUTION: By drying and removing the organic solvents after mixing and freezing particulate matter with particle size of 100-2,000 μm, soluble in liquid which does not dissolve the bioabsorbable polymer but insoluble in the organic solvents, in solution where the bioabsorbable polymer is dissolved in organic solvents, the polymer body which contains the particulate matter and has pore structure with pore diameter of 5-50 μm is prepared. After forming the concave part with the width up to 100-2,000 μm on the surface of the polymer body by pulverizing the polymer body and dissolving and removing the particulate matter in the liquid which does not dissolve the bioabsorbable polymer, the polymer body is sifted, so that the bioabsorbable granular porous bone prosthetic material with the particle size of 100-3,000 μm is produced. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：解决的问题：提供一种颗粒状多孔骨修复材料，其由具有在表面上具有高达100-2,000μm的宽度的凹部的生物可吸收性聚合物体组成，并且具有孔径为5的孔结构 -50μm，而粒径为100-3000μm。解决方案：通过在混合和冷冻粒度为100-2,000μm的颗粒物之后干燥除去有机溶剂，溶于不溶于生物可吸收聚合物但不溶于有机溶剂的液体中，在生物可吸收聚合物溶解在有机溶剂中，制备含有颗粒物质并具有孔径为5-50μm的孔结构的聚合物体。通过粉碎聚合物体并在不溶解生物可吸收性聚合物的液体中溶解除去颗粒物质，在聚合物体的表面上形成宽度高达100-2,000μm的凹部，将聚合物体过筛，使得生成粒径为100-3,000μm的生物可吸收的颗粒状多孔骨修复材料。版权所有（C）2011，JPO＆INPIT

7. 发明专利

JP2010082146A Bioloabsorbable tissue regenerating and deriving membrane body 审中-公开
标题翻译：生物可溶性组织再生和衍生膜体
公开(公告)号：JP2010082146A
公开(公告)日：2010-04-15
申请号：JP2008253903
申请日：2008-09-30
申请人： Gc Corp , 株式会社ジーシー
发明人： TAKAGI TAKAMITSU , FUJII NAOTO , KANEKO TADASHI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a bioloabsorbable tissue regenerating and deriving membrane body capable of being deformed in matching to the affected part and capable of keeping the form after deformation. SOLUTION: The bioloabsorbable tissue regenerating and deriving membrane body 1 for imparting a space for regenerating necessary tissue to derive the necessary tissue is constituted of: a bioloabsorbable tissue regenerating and deriving membrane 2 having a porous sheetlike structure; and an auxiliary material 3 mounted on the bioloabsorbable tissue regenerating and deriving membrane 2, and consisting of the bioloabsorbable magnesium alloy to keep the form of the bioloabsorbable tissue regenerating and deriving membrane body 1 deformed in matching to the affected part of a patient. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种生物可吸收组织再生和衍生的膜体，其能够变形以匹配受影响的部位并且能够保持变形后的形状。解决方案：生物可吸收组织再生和衍生膜体1，用于赋予必需组织再生以产生必需组织的空间，由具有多孔片状结构的生物可吸收组织再生和衍生膜2构成; 以及安装在生物可吸收组织再生和衍生膜2上并由生物可吸收镁合金组成的辅助材料3，以保持生物可吸收组织的形式再生和衍生的膜体1与患者的患部匹配变形。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2009226148A Production method of cell-technological block-like support 有权
标题翻译：细胞技术类似支持的生产方法
公开(公告)号：JP2009226148A
公开(公告)日：2009-10-08
申请号：JP2008078388
申请日：2008-03-25
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , YAMANAKA KATSUYUKI , SUDA YOKO , SAKAI YUUDAI , KANEKO TADASHI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To provide a production method of a cell-engineering block-like support used as a substitute for biotissue, having superior morphological stability, allowing a user to seed and/or culture cells in its interior and consisting of a bioabsorbable polymer material having a wide void.
SOLUTION: The sheet-like bioabsorbable polymer material with the thickness of 0.01-1 mm is brought together irregularly, put in a mold and pressurized and heated to produce this cell-engineering block-like cell support having a continuous amorphous void occupying 10-90% in porosity. Preferably, the sheet-like bioabsorbable polymer material has pores of 5-100 μm produced by dissolving the bioabsorbable polymer material in organic solvent, and freeze-drying it, or pores with the diameter of 0.1-3 mm is formed on the sheet-like bioabsorbable polymer material produced by dissolving the bioabsorbable polymer material in the organic solvent and drying it. It is preferable to use the oblong sheet-like bioabsorbable polymer material with the length of 5-50 mm, the width of 0.1-20 mm and the thickness of 0.01-1 mm.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了提供用作生物组织的替代物的细胞工程化块状载体的制备方法，具有优异的形态稳定性，允许使用者在其内部种子和/或培养细胞并由具有宽空隙的生物可吸收聚合物材料。解决方案：将厚度为0.01-1mm的片状生物可吸收聚合物材料不规则地放在一起，放入模具中并进行加压和加热以产生具有连续无定形空隙占据的这种细胞工程的块状细胞载体孔隙度为10-90％。优选地，片状生物可吸收聚合物材料具有通过将生物可吸收聚合物材料溶解在有机溶剂中而制备的5-100μm孔，并将其冷冻干燥，或者在片状物上形成直径为0.1-3mm的孔通过将生物可吸收聚合物材料溶解在有机溶剂中并将其干燥而生产的生物可吸收聚合物材料。优选使用长度为5-50mm，宽度为0.1-20mm，厚度为0.01-1mm的长方形片状生物可吸收聚合物材料。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2006136673A Block-shaped support body for cell technology and manufacturing method therefor 有权
标题翻译：用于细胞技术的片状支撑体及其制造方法
公开(公告)号：JP2006136673A
公开(公告)日：2006-06-01
申请号：JP2004353811
申请日：2004-12-07
申请人： Gc Corp , 株式会社ジーシー
发明人： YAMAMOTO KATSUSHI , YAMANAKA KATSUYUKI , SUDA YOKO , KANEKO TADASHI
IPC分类号： A61L27/00 , C08J9/26 , C08L67/04 , C08L77/00 , C12N1/00
摘要： PROBLEM TO BE SOLVED: To further improve the shape stability of a block-shaped support body for cell technology having a porous structure and composed of a bioabsorbable polymer material and reduce its volume change more even if being immersed in water compared with those of a conventional sponge-shaped support body.
SOLUTION: Polymer bodies contain particulate substances, which are formed by approximately uniformly mixing the particulate substances with grain size of 100-2000 μm in a solution where bioabsorbable polymers are dissolved in an organic solvent, freezing them, drying them and removing the organic solvent therefrom, and have each a micropore structure with the pore diameter of 5-50 μm and are pulverized; then a granular porous material with grain size of 1000-3000 μm, which is formed by dissolving the particulate substances in the solution not dissolving the bioabsorbable polymers and removing them, is put in a mold, heated and pressurized to manufacture the block-shaped support body for the cell technology having infinite-form continuous holes occupying 20-80% of the cross-section area in a three-dimensional net-like structure having a micropore structure with the pore diameter of 5-50 μm, having the elastic coefficient of 0.1-2.5 MPa and, when being immersed in water for 24 hours, having the volume change of 95-105%.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了进一步提高具有多孔结构并由生物可吸收性聚合物材料构成的电池技术的块状支撑体的形状稳定性，并且与其相比较，即使浸入水中也减少其体积变化的常规海绵状支撑体。解决方案：聚合物体含有颗粒物质，其通过将生物可吸收聚合物溶解在有机溶剂中的溶液中大约均匀地混合粒径为100-2000μm的颗粒物质而形成，将其冷冻，干燥并除去有机溶剂，各自具有孔径为5-50μm的微孔结构并被粉碎; 然后通过将颗粒物质溶解在不溶解生物可吸收聚合物的溶液中并除去它们而形成的粒径为1000-3000μm的粒状多孔材料放入模具中，加热和加压以制造块状载体具有无限形连续孔的细胞体在具有孔径为5-50μm的微孔结构的三维网状结构中占据横截面面积的20-80％，其弹性系数为 0.1-2.5MPa，当浸入水中24小时时，体积变化率为95-105％。版权所有（C）2006，JPO＆NCIPI

10. 发明专利

JP2004216119A Support for tissue regeneration, and method of manufacturing the same 有权
标题翻译：用于组织再生的支持及其制造方法
公开(公告)号：JP2004216119A
公开(公告)日：2004-08-05
申请号：JP2003289744
申请日：2003-08-08
申请人： Gc Corp , Kanegafuchi Chem Ind Co Ltd , National Institute Of Advanced Industrial & Technology , 株式会社ジーシー , 独立行政法人産業技術総合研究所 , 鐘淵化学工業株式会社
发明人： NIWA HIDEO , FUKUCHI TAKESHI , SHIMIZU ICHIRO , SATO TADAO , NISHI SATOKO , YAMASHITA KENJI , KANEKO TADASHI , OGUSHI HAJIME , HATTORI KOJI , UEMATSU KOTA
IPC分类号： C12M3/00 , A61L27/00 , A61L27/38 , A61L27/56 , C12N5/00 , C12N5/077 , C12N5/06
CPC分类号： A61L27/3895 , A61L27/3852 , A61L27/56 , A61L2430/06 , C12N5/0068 , C12N5/0655 , C12N2533/40
摘要： PROBLEM TO BE SOLVED: To provide a support for tissue regeneration capable of holding and taking cells in the uniform distribution state at the time of culture, securing the excellent reproduction and survivability, and particularly in case of the cartilage, capable of performing the fixing process such as suture when implanted to an affected part and having the sufficient mechanical strength to bear the compression (weighting) at the initial stage of the implant. SOLUTION: The three-dimensional porous support for tissue regeneration has such a structure that oblong pores whose diameter is 10-500 μm and whose length is 20 μm-1 cm are disposed parallel. The cell dissemination capability of the support is improved by the separation process, the salt elution process of the front layer part or the one face pore enlarging process combining the above processes. Further, as tissue-derived cells or precursor cells are disseminated in the support, the support has the excellent tissue-forming capability and excellent therapeutic effect by culturing the cells in an artificial environment and/or in vivo. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：要解决的问题：为了提供能够在培养时保持和摄取均匀分布状态的细胞的组织再生的支持，确保优异的繁殖和生存性，特别是在软骨的情况下，能够执行固定过程，例如当植入受影响部位时缝合，并且具有足够的机械强度以在植入物的初始阶段承受压缩（加权）。解决方案：用于组织再生的三维多孔载体具有这样的结构，其直径为10-500μm，长度为20μm-1cm的长圆形孔平行设置。通过分离过程，前层部分的盐洗脱过程或组合上述方法的单面扩孔过程，提高了载体的细胞传播能力。此外，由于组织衍生的细胞或前体细胞在支持体中分散，所以通过在人造环境和/或体内培养细胞，支持体具有优异的组织形成能力和优异的治疗效果。版权所有（C）2004，JPO＆NCIPI

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