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1. 发明授权

US5571388A Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels thereof 失效
标题翻译：测量近红外和红外荧光标记的DNA，用于检测激光二极管及其合适的标签
公开(公告)号：US5571388A
公开(公告)日：1996-11-05
申请号：US204627
申请日：1994-03-01
申请人： Gabor Patonay , Narasimhachari Narayanan , Lucjan Strekowski , Lyle R. Middendorf , Malgorzata Lipowska
发明人： Gabor Patonay , Narasimhachari Narayanan , Lucjan Strekowski , Lyle R. Middendorf , Malgorzata Lipowska
IPC分类号： C07D209/12 , C07D209/60 , C09B23/00 , C09B23/01 , C12N15/09 , C12Q1/68 , G01N21/64 , G01N27/447 , G01N33/58 , G01N27/26
CPC分类号： C07D209/60 , C09B23/0066 , C12Q1/6816 , C12Q1/6869 , G01N21/6428 , G01N21/6458 , G01N27/447 , G01N27/44721 , G01N27/44726 , Y10S435/968 , Y10S436/80
摘要： To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.
摘要翻译：为了自动序列DNA，用远红外线，近红外或红外荧光染料标记的DNA通过凝胶电泳板或毛细管在多个通道中进行电泳，其中根据凝胶中DNA片段的大小来分离DNA样品电泳板或毛细管进入荧光标记的DNA条带。分离的样品用激光二极管和传感器进行光电扫描，其中激光扫描具有在所述荧光标记的DNA样品的吸收光谱内的波长的扫描光，并且在标记的DNA的发射波长处感测光。

2. 发明授权

US5800995A Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor 失效
公开(公告)号：US5800995A
公开(公告)日：1998-09-01
申请号：US706004
申请日：1996-08-30
申请人： Gabor Patonay , Narasimhachari Narayanan , Lucjan Strekowski , Lyle Richard Middendorf , Malgorzata Lipowska
发明人： Gabor Patonay , Narasimhachari Narayanan , Lucjan Strekowski , Lyle Richard Middendorf , Malgorzata Lipowska
IPC分类号： C07D209/12 , C07D209/60 , C09B23/00 , C09B23/01 , C12N15/09 , C12Q1/68 , G01N21/64 , G01N27/447 , G01N33/58 , G01N33/53
CPC分类号： C07D209/60 , C09B23/0066 , C12Q1/6816 , C12Q1/6869 , G01N21/6428 , G01N21/6458 , G01N27/447 , G01N27/44721 , G01N27/44726 , Y10S435/968 , Y10S436/80
摘要： To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.

3. 发明授权

US06086737A Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor 失效
标题翻译：测量近红外和红外荧光标记的DNA用于检测使用激光二极管和适合的标签
公开(公告)号：US06086737A
公开(公告)日：2000-07-11
申请号：US500691
申请日：1995-07-11
申请人： Gabor Patonay , Narasimhachari Narayanan , John A. Brumbaugh , Lyle Richard Middendorf
发明人： Gabor Patonay , Narasimhachari Narayanan , John A. Brumbaugh , Lyle Richard Middendorf
IPC分类号： C12N15/09 , C07D209/12 , C07D209/60 , C07D209/62 , C09B23/01 , C12Q1/68 , G01N21/64 , G01N27/447 , G01N27/26
CPC分类号： G01N21/6458 , C07D209/12 , C07D209/62 , C09B23/0025 , C09B23/0066 , C12Q1/6816 , C12Q1/6869 , G01N21/6428 , G01N27/447 , G01N27/44721 , G01N27/44726 , Y10S435/968 , Y10S436/80
摘要： To sequence DNA automatically, DNA marked with far infrared, near infrared, or infrared fluorescent dyes are electrophoresed in a plurality of channels through a gel electrophoresis slab or capillary tubes wherein the DNA samples are resolved in accordance with the size of DNA fragments in the gel electrophoresis slab or capillary tubes into fluorescently marked DNA bands. The separated samples are scanned photoelectrically with a laser diode and a sensor, wherein the laser scans with scanning light at a wavelength within the absorbance spectrum of said fluorescently marked DNA samples and light is sensed at the emission wavelength of the marked DNA.
摘要翻译：为了自动序列DNA，用远红外线，近红外或红外荧光染料标记的DNA通过凝胶电泳板或毛细管在多个通道中进行电泳，其中根据凝胶中DNA片段的大小来分离DNA样品电泳板或毛细管进入荧光标记的DNA条带。分离的样品用激光二极管和传感器进行光电扫描，其中激光扫描具有在所述荧光标记的DNA样品的吸收光谱内的波长的扫描光，并且在标记的DNA的发射波长处感测光。

4. 发明授权

US08303936B2 Optical fluorescent imaging 有权
标题翻译：光学荧光成像
公开(公告)号：US08303936B2
公开(公告)日：2012-11-06
申请号：US13525136
申请日：2012-06-15
申请人： Daniel R. Draney , Ananda G. Lugade , Narasimhachari Narayanan , Joy Kovar , D. Michael Olive
发明人： Daniel R. Draney , Ananda G. Lugade , Narasimhachari Narayanan , Joy Kovar , D. Michael Olive
IPC分类号： A61K49/00
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0041 , C07D209/14 , C07D403/14 , C07D493/10 , C07K14/485 , C08B37/0012 , C09B23/0066
摘要： Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
摘要翻译：公开了可用于近红外（NIR）光谱范围内的无创成像的化合物和方法。 NIR对肿瘤检测和跟踪非常敏感。该申请公开了用配体缀合的荧光探针靶向具有肿瘤的细胞表面受体，其特异性地允许相对于可忽略的动物自体荧光检测肿瘤。

5. 发明申请

US20120258048A1 OPTICAL FLUORESCENT IMAGING 有权
标题翻译：光学荧光成像
公开(公告)号：US20120258048A1
公开(公告)日：2012-10-11
申请号：US13525136
申请日：2012-06-15
申请人： Joy Kovar , Jiyan Chen , Daniel R. Draney , D. Michael Olive , William M. Volcheck , Xinshe Xu , Ananda G. Lugade , Narasimhachari Narayanan
发明人： Joy Kovar , Jiyan Chen , Daniel R. Draney , D. Michael Olive , William M. Volcheck , Xinshe Xu , Ananda G. Lugade , Narasimhachari Narayanan
IPC分类号： C07D209/14 , C07D209/60 , A61K49/00
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0041 , C07D209/14 , C07D403/14 , C07D493/10 , C07K14/485 , C08B37/0012 , C09B23/0066
摘要： Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
摘要翻译：公开了可用于近红外（NIR）光谱范围内的无创成像的化合物和方法。 NIR对肿瘤检测和跟踪非常敏感。该申请公开了用配体缀合的荧光探针靶向具有肿瘤的细胞表面受体，其特异性地允许相对于可忽略的动物自体荧光检测肿瘤。

6. 发明申请

US20060280688A1 OPTICAL FLUORESCENT IMAGING 有权
标题翻译：光学荧光成像
公开(公告)号：US20060280688A1
公开(公告)日：2006-12-14
申请号：US11419457
申请日：2006-05-19
申请人： Joy Kovar , Jiyan Chen , Daniel Draney , D. Olive , William Volcheck , Xinshe Xu , Ananda Lugade , Narasimhachari Narayanan
发明人： Joy Kovar , Jiyan Chen , Daniel Draney , D. Olive , William Volcheck , Xinshe Xu , Ananda Lugade , Narasimhachari Narayanan
IPC分类号： A61K49/00 , C07K14/52 , C07K14/54 , C07K14/56 , C07K14/575 , C07K14/745 , C07K16/46 , C08B37/10 , C08B37/00 , C08B30/18 , C07D403/02 , C07D403/14 , C12N9/64
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0041 , C07D209/14 , C07D403/14 , C07D493/10 , C07K14/485 , C08B37/0012 , C09B23/0066
摘要： Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
摘要翻译：公开了可用于近红外（NIR）光谱范围内的无创成像的化合物和方法。 NIR对肿瘤检测和跟踪非常敏感。该申请公开了用配体缀合的荧光探针靶向具有肿瘤的细胞表面受体，其特异性地允许相对于可忽略的动物自体荧光检测肿瘤。

7. 发明授权

US06593148B1 Cyanine dye compounds and labeling methods 失效
标题翻译：花青染料化合物和标记方法
公开(公告)号：US06593148B1
公开(公告)日：2003-07-15
申请号：US09520770
申请日：2000-03-07
申请人： Narasimhachari Narayanan
发明人： Narasimhachari Narayanan
IPC分类号： G01N33533
CPC分类号： C12Q1/6816 , C07D209/12 , C07D209/62 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/086 , C12Q1/6869 , G01N21/6428 , G01N27/44721 , G01N27/44726 , Y10S436/80 , C12Q2563/107 , C12Q2535/101
摘要： A novel cyanine dye having the formula is useful for labeling biological and nonbiological molecules.
摘要翻译：一种新颖的花青染料，具有用于标记生物和非生物分子的配方

8. 发明申请

US20130052637A1 OPTICAL FLUORESCENT IMAGING IN HISTOLOGY 审中-公开
标题翻译：光学荧光成像在组织学中的应用
公开(公告)号：US20130052637A1
公开(公告)日：2013-02-28
申请号：US13598583
申请日：2012-08-29
申请人： Joy Kovar , Jiyan Chen , Daniel R. Draney , D. Michael Olive , William M. Volcheck , Xinshe Xu , Ananda G. Lugade , Narasimhachari Narayanan
发明人： Joy Kovar , Jiyan Chen , Daniel R. Draney , D. Michael Olive , William M. Volcheck , Xinshe Xu , Ananda G. Lugade , Narasimhachari Narayanan
IPC分类号： G01N21/75 , G01N21/64
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0041 , C07D209/14 , C07D403/14 , C07D493/10 , C07K14/485 , C08B37/0012 , C09B23/0066
摘要： Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
摘要翻译：公开了可用于近红外（NIR）光谱范围内的无创成像的化合物和方法。 NIR对肿瘤检测和跟踪非常敏感。该申请公开了用配体缀合的荧光探针靶向具有肿瘤的细胞表面受体，其特异性地允许相对于可忽略的动物自体荧光检测肿瘤。

9. 发明申请

US20060063247A1 Cyanine dyes 有权
标题翻译：花青染料
公开(公告)号：US20060063247A1
公开(公告)日：2006-03-23
申请号：US11267643
申请日：2005-11-04
申请人： Ananda Lugade , Narasimhachari Narayanan , Daniel Draney
发明人： Ananda Lugade , Narasimhachari Narayanan , Daniel Draney
IPC分类号： C12N9/00 , C07K17/14 , C07K16/46
CPC分类号： G01N33/582 , C09B23/0008 , C09B23/0066 , C09B23/086 , G01N33/533
摘要： A compound of the formula (I) wherein Z is O, S, or NR35 wherein R35 is H or alkyl; R1-R5 are each independently H, alkyl, halo, carboxyl, amino, or SO3−Cat+, wherein Cat+ is a cation and at least one of R1-R5 is SO3−Cat+; R6 and R7 are each H, alkyl, or optionally, together with the (a) group to which they are bonded, form a ring; m and n are each independently integers from 0 to 5; X and Y are each independently O, S, Se or CR19R20, wherein R19 and R20 are each independently alkyl, or optionally form a ring together with the carbon atom to which they are bonded; R8 and R13 are each independently alkyl, (CH2)rR25 or (CH2)rR18; wherein at least one of R8 and R13 (CH2)rR18 and wherein r is an integer from 1 to 50, and R25 is a functional group that does not directly react with a carboxyl, hydroxyl, amino, or a thiol group, and R18 is a functional group that can react with a carboxyl, hydroxyl, amino, or thiol group; and R9-R12 and R14-R17 are each independently H, alkyl, halo, amino, sulfonato, R21 COOH, R21OR22, R21SR22, or R21COOR22 wherein R21 is a bond or alkylene and R22 is alkyl, or optionally R11 and R12 together with the atoms to which they are bonded form an aromatic ring, or optionally R16 and R17 together with the atoms to which they are bonded form an aromatic ring. Methods of dye-labeling biomolecules with the compound of formula (I) and dye-labeled biomolecules are also provided.
摘要翻译：式（I）的化合物

10. 发明授权

US09574085B2 Biocompatible N, N-disubstituted sulfonamide-containing fluorescent dye labels 有权
标题翻译：生物相容性N，N-二取代磺酰胺荧光染料标记
公开(公告)号：US09574085B2
公开(公告)日：2017-02-21
申请号：US12065387
申请日：2006-09-01
申请人： Narasimhachari Narayanan , Kevin Groves , Jeffrey D. Peterson , Milind Rajopadhye
发明人： Narasimhachari Narayanan , Kevin Groves , Jeffrey D. Peterson , Milind Rajopadhye
IPC分类号： A61K49/00 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C09B23/08 , C07D209/14 , C09B23/01 , G01N33/533 , G01N33/537 , G01N33/58
CPC分类号： C09B23/086 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D401/14 , C07D403/06 , C07D403/14 , C09B23/0066 , C09B23/083 , G01N33/533 , G01N33/537 , G01N33/582
摘要： This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译：本发明涉及新的荧光化学实体，特别是包含生物相容性N，N-二取代磺酰胺荧光染料的荧光分子。本发明还涉及这种分子的相应的反应性形式。本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。

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