专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130052637A1 OPTICAL FLUORESCENT IMAGING IN HISTOLOGY 审中-公开
标题翻译：光学荧光成像在组织学中的应用
公开(公告)号：US20130052637A1
公开(公告)日：2013-02-28
申请号：US13598583
申请日：2012-08-29
申请人： Joy Kovar , Jiyan Chen , Daniel R. Draney , D. Michael Olive , William M. Volcheck , Xinshe Xu , Ananda G. Lugade , Narasimhachari Narayanan
发明人： Joy Kovar , Jiyan Chen , Daniel R. Draney , D. Michael Olive , William M. Volcheck , Xinshe Xu , Ananda G. Lugade , Narasimhachari Narayanan
IPC分类号： G01N21/75 , G01N21/64
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0041 , C07D209/14 , C07D403/14 , C07D493/10 , C07K14/485 , C08B37/0012 , C09B23/0066
摘要： Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
摘要翻译：公开了可用于近红外（NIR）光谱范围内的无创成像的化合物和方法。 NIR对肿瘤检测和跟踪非常敏感。该申请公开了用配体缀合的荧光探针靶向具有肿瘤的细胞表面受体，其特异性地允许相对于可忽略的动物自体荧光检测肿瘤。

2. 发明申请

US20120258048A1 OPTICAL FLUORESCENT IMAGING 有权
标题翻译：光学荧光成像
公开(公告)号：US20120258048A1
公开(公告)日：2012-10-11
申请号：US13525136
申请日：2012-06-15
申请人： Joy Kovar , Jiyan Chen , Daniel R. Draney , D. Michael Olive , William M. Volcheck , Xinshe Xu , Ananda G. Lugade , Narasimhachari Narayanan
发明人： Joy Kovar , Jiyan Chen , Daniel R. Draney , D. Michael Olive , William M. Volcheck , Xinshe Xu , Ananda G. Lugade , Narasimhachari Narayanan
IPC分类号： C07D209/14 , C07D209/60 , A61K49/00
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0041 , C07D209/14 , C07D403/14 , C07D493/10 , C07K14/485 , C08B37/0012 , C09B23/0066
摘要： Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
摘要翻译：公开了可用于近红外（NIR）光谱范围内的无创成像的化合物和方法。 NIR对肿瘤检测和跟踪非常敏感。该申请公开了用配体缀合的荧光探针靶向具有肿瘤的细胞表面受体，其特异性地允许相对于可忽略的动物自体荧光检测肿瘤。

3. 发明授权

US07597878B2 Optical fluorescent imaging 有权
标题翻译：光学荧光成像
公开(公告)号：US07597878B2
公开(公告)日：2009-10-06
申请号：US11419457
申请日：2006-05-19
申请人： Joy Kovar , Jiyan Chen , Daniel R. Draney , D. Michael Olive , William M. Volcheck , Xinshe Xu , Ananda G. Lugade , Narasimhachari Narayanan
发明人： Joy Kovar , Jiyan Chen , Daniel R. Draney , D. Michael Olive , William M. Volcheck , Xinshe Xu , Ananda G. Lugade , Narasimhachari Narayanan
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0041 , C07D209/14 , C07D403/14 , C07D493/10 , C07K14/485 , C08B37/0012 , C09B23/0066
摘要： Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
摘要翻译：公开了可用于近红外（NIR）光谱范围内的无创成像的化合物和方法。 NIR对肿瘤检测和跟踪非常敏感。该申请公开了用配体缀合的荧光探针靶向具有肿瘤的细胞表面受体，其特异性地允许相对于可忽略的动物自体荧光检测肿瘤。

4. 发明授权

US08303936B2 Optical fluorescent imaging 有权
标题翻译：光学荧光成像
公开(公告)号：US08303936B2
公开(公告)日：2012-11-06
申请号：US13525136
申请日：2012-06-15
申请人： Daniel R. Draney , Ananda G. Lugade , Narasimhachari Narayanan , Joy Kovar , D. Michael Olive
发明人： Daniel R. Draney , Ananda G. Lugade , Narasimhachari Narayanan , Joy Kovar , D. Michael Olive
IPC分类号： A61K49/00
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0041 , C07D209/14 , C07D403/14 , C07D493/10 , C07K14/485 , C08B37/0012 , C09B23/0066
摘要： Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
摘要翻译：公开了可用于近红外（NIR）光谱范围内的无创成像的化合物和方法。 NIR对肿瘤检测和跟踪非常敏感。该申请公开了用配体缀合的荧光探针靶向具有肿瘤的细胞表面受体，其特异性地允许相对于可忽略的动物自体荧光检测肿瘤。

5. 发明授权

US08227621B2 Cyanine dyes and methods of use 有权
标题翻译：花青染料及其使用方法
公开(公告)号：US08227621B2
公开(公告)日：2012-07-24
申请号：US11423675
申请日：2006-06-12
申请人： Xinzhan Peng , Xinshe Xu , Daniel R. Draney , Garrick M. Little , Jiyan Chen , William M. Volcheck , Charles Prescott
发明人： Xinzhan Peng , Xinshe Xu , Daniel R. Draney , Garrick M. Little , Jiyan Chen , William M. Volcheck , Charles Prescott
IPC分类号： C07D209/56 , A61B5/00
CPC分类号： G01N33/542 , C09B23/0066 , C09B23/083 , G01N33/532
摘要： The present invention provides for cyanine dyes as near IR quenchers. The cyanine dyes have absorption wavelengths in the near-infrared region of about 650-900 nm and are essentially non-fluorescent. The dyes of the invention have at least one linking group. The present invention also provides substantially non-fluorescent, NIR probes. Biological assays based on these novel, substantially non-fluorescent, NIR probes are also provided.
摘要翻译：本发明提供花青染料作为近红外猝灭剂。花青染料在约650-900nm的近红外区域具有吸收波长，并且基本上是非荧光的。本发明的染料具有至少一个连接基团。本发明还提供基本上非荧光的NIR探针。还提供了基于这些新颖的，基本上非荧光的NIR探针的生物测定。

6. 发明申请

US20100080758A1 OPTICAL FLUORESCENT IMAGING 审中-公开
标题翻译：光学荧光成像
公开(公告)号：US20100080758A1
公开(公告)日：2010-04-01
申请号：US12572674
申请日：2009-10-02
申请人： Daniel R. Draney , Ananda G. Lugade , Narasimhachari Narayanan
发明人： Daniel R. Draney , Ananda G. Lugade , Narasimhachari Narayanan
IPC分类号： A61K49/00 , C07D209/58 , C07D209/02 , C07D401/14
CPC分类号： A61K49/0056 , A61K49/0032 , A61K49/0041 , C07D209/14 , C07D403/14 , C07D493/10 , C07K14/485 , C08B37/0012 , C09B23/0066
摘要： Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
摘要翻译：公开了可用于近红外（NIR）光谱范围内的无创成像的化合物和方法。 NIR对肿瘤检测和跟踪非常敏感。该申请公开了用配体缀合的荧光探针靶向具有肿瘤的细胞表面受体，其特异性地允许相对于可忽略的动物自体荧光检测肿瘤。

7. 发明授权

US07504089B2 Cyanine dyes 有权
标题翻译：花青染料
公开(公告)号：US07504089B2
公开(公告)日：2009-03-17
申请号：US11267643
申请日：2005-11-04
申请人： Ananda G. Lugade , Narasimhachari Narayanan , Daniel R. Draney
发明人： Ananda G. Lugade , Narasimhachari Narayanan , Daniel R. Draney
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00
CPC分类号： G01N33/582 , C09B23/0008 , C09B23/0066 , C09B23/086 , G01N33/533
摘要： A compound of the formula (I) wherein the variables are defined herein. Methods of dye-labeling biomolecules with the compound of formula (I) and dye-labeled biomolecules are also provided.
摘要翻译：式（I）的化合物，其中变量在本文中定义。还提供了用式（I）化合物和染料标记的生物分子染色标记生物分子的方法。

8. 发明授权

US06995274B2 Cyanine dyes 有权
标题翻译：花青染料
公开(公告)号：US06995274B2
公开(公告)日：2006-02-07
申请号：US10354812
申请日：2003-01-28
申请人： Ananda G. Lugade , Narasimhachari Narayanan , Daniel R. Draney
发明人： Ananda G. Lugade , Narasimhachari Narayanan , Daniel R. Draney
IPC分类号： C07D487/04
CPC分类号： G01N33/582 , C09B23/0008 , C09B23/0066 , C09B23/086 , G01N33/533
摘要： A compound of the formula (I) wherein Z is O, S, or NR35 wherein R35 is H or alkyl; R1–R5 are each independently H, alkyl, halo, carboxyl, amino, or SO3−Cat+, wherein Cat+ is a cation and at least one of R1–R5 is SO3−Cat+; R6 and R7 are each H, alkyl, or optionally, together with the (a) group to which they are bonded, form a ring; m and n are each independently integers from 0 to 5; X and Y are each independently O, S, Se or CR19R20, wherein R19 and R20 are each independently alkyl, or optionally form a ring together with the carbon atom to which they are bonded; R8 and R13 are each independently alkyl, (CH2)rR25 or (CH2)rR18; wherein at least one of R8 and R13 (CH2)rR18 and wherein r is an integer from 1 to 50, and R25 is a functional group that does not directly react with a carboxyl, hydroxyl, amino, or a thiol group, and R18 is a functional group that can react with a carboxyl, hydroxyl, amino, or thiol group; and R9–R12 and R14–R17 are each independently H, alkyl, halo, amino, sulfonato, R21 COOH, R21OR22, R21SR22, or R21COOR22 wherein R21 is a bond or alkylene and R22 is alkyl, or optionally R11 and R12 together with the atoms to which they are bonded form an aromatic ring, or optionally R16 and R17 together with the atoms to which they are bonded form an aromatic ring. Methods of dye-labeling biomolecules with the compound of formula (I) and dye-labeled biomolecules are also provided.
摘要翻译：化学式（I）化合物id =“CHEM-US-00001”num =“000

9. 发明申请

US20100323389A1 FLUORESCENT IMAGING WITH SUBSTITUTED CYANINE DYES 有权
标题翻译：荧光成像与替代的氰基染料
公开(公告)号：US20100323389A1
公开(公告)日：2010-12-23
申请号：US12820077
申请日：2010-06-21
申请人： Xinshe Xu , Daniel R. Draney
发明人： Xinshe Xu , Daniel R. Draney
IPC分类号： C12Q1/02 , C07D403/06 , C07K14/00 , C07K16/00 , C07K14/475
CPC分类号： G01N33/582 , C09B23/0008 , C09B23/0066 , C09B23/083 , C09B23/086
摘要： Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
摘要翻译：公开了可用于近红外光谱范围内的无创成像的化合物和方法。呈现式I的花青化合物：其中Q是选自以下的聚甲炔桥的一部分：还包括式I化合物的生物缀合物，用化合物标记生物分子的方法和成像方法。

10. 发明授权

US08481752B2 Fluorescent imaging with substituted cyanine dyes 有权
标题翻译：用取代花青染料进行荧光成像
公开(公告)号：US08481752B2
公开(公告)日：2013-07-09
申请号：US12820077
申请日：2010-06-21
申请人： Xinshe Xu , Daniel R. Draney
发明人： Xinshe Xu , Daniel R. Draney
IPC分类号： C12Q1/04 , C07K16/00 , C07D209/56 , C07D209/02
CPC分类号： G01N33/582 , C09B23/0008 , C09B23/0066 , C09B23/083 , C09B23/086
摘要： Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
摘要翻译：公开了可用于近红外光谱范围内的无创成像的化合物和方法。呈现式I的花青化合物：其中Q是选自以下的聚甲炔桥的一部分：还包括式I化合物的生物缀合物，用化合物标记生物分子的方法和成像方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式