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1. 发明授权

US06213862B1 Method and apparatus for venting/opening eviscerating/cropping, inspecting and cleaning of poultry 失效
标题翻译：排气/打开剔除/切除，检查和清洁家禽的方法和装置
公开(公告)号：US06213862B1
公开(公告)日：2001-04-10
申请号：US09538163
申请日：2000-03-29
申请人： Eugene G. Martin , Scott A. Cook , Michael E. Lease
发明人： Eugene G. Martin , Scott A. Cook , Michael E. Lease
IPC分类号： A22C2106
CPC分类号： A22B5/0094 , A22C21/06
摘要： A poultry processing machine is provided which automatically vents and opens the poultry, eviscerates the poultry, displays the poultry for inspection, and either provides a normal or radical clean out procedure to the poultry. When the poultry is being physically processed, it is maintained in a generally stationary position with respect to the surface supporting the poultry processor to provide for uniform positioning of the poultry on the conveyor. Further, the poultry is positioned in a generally horizontal position during the venting and opening, eviscerating and cleaning procedures, to facilitate removing the unwanted materials from the poultry without increasing the risk of contamination. The eviscerating station uses an eviscerating tool which includes an opening sized to receive the viscera package therethrough during the eviscerating process to prevent damage to the viscera package. The clean out station automatically recognizes whether a particular poultry is to receive the normal or radical clean out procedure, thereby reducing processing time.
摘要翻译：提供家禽加工机，自动通风和打开家禽，剔除家禽，展示家禽进行检查，并向家禽提供正常或彻底的清洁程序。当家禽被物理加工时，它相对于支撑家禽处理器的表面保持在大致静止的位置，以提供家禽在输送机上的均匀定位。此外，家禽在通气和打开，去内脏和清洁过程期间定位在大致水平的位置，以便于在不增加污染风险的情况下从家禽中除去不想要的物质。剔骨站使用内脏工具，其包括开口尺寸以在内脏过程中通过其接纳内脏包以防止损害内脏包装。清洁站自动识别特定家禽是否接收正常或根本清除程序，从而缩短处理时间。

2. 发明授权

US06186881B1 Method and apparatus for venting/opening, eviscerating/cropping, inspecting and cleaning of poultry 失效
标题翻译：排气/打开，取内脏/种植，检查和清洁家禽的方法和装置
公开(公告)号：US06186881B1
公开(公告)日：2001-02-13
申请号：US09014342
申请日：1998-01-27
申请人： Eugene G. Martin , Michael J. Curtis , Scott A. Cook , Sheldon L. Horst , Michael E. Lease , Thomas M. McCarty , Duane E. Newswanger
发明人： Eugene G. Martin , Michael J. Curtis , Scott A. Cook , Sheldon L. Horst , Michael E. Lease , Thomas M. McCarty , Duane E. Newswanger
IPC分类号： A22C2100
CPC分类号： A22B5/0094 , A22C21/06
摘要： A poultry processing machine is provided which automatically vents and opens the poultry, eviscerates the poultry, displays the poultry for inspection, and either provides a normal or radical clean out procedure to the poultry. When the poultry is being physically processed, it is maintained in a generally stationary position with respect to the surface supporting the poultry processor to provide for uniform positioning of the poultry on the conveyor. Further, the poultry is positioned in a generally horizontal position during the venting and opening, eviscerating and cleaning procedures, to facilitate removing the unwanted materials from the poultry without increasing the risk of contamination. The eviscerating station uses an eviscerating tool which includes an opening sized to receive the viscera package therethrough during the eviscerating process to prevent damage to the viscera package. The clean out station automatically recognizes whether a particular poultry is to receive the normal or radical clean out procedure, thereby reducing processing time.
摘要翻译：提供家禽加工机，自动通风和打开家禽，剔除家禽，展示家禽进行检查，并向家禽提供正常或彻底的清洁程序。当家禽被物理加工时，它相对于支撑家禽处理器的表面保持在大致静止的位置，以提供家禽在输送机上的均匀定位。此外，家禽在通气和打开，去内脏和清洁过程期间定位在大致水平的位置，以便于在不增加污染风险的情况下从家禽中除去不想要的物质。剔骨站使用内脏工具，其包括开口尺寸以在内脏过程中通过其接纳内脏包以防止损害内脏包装。清洁站自动识别特定家禽是否接收正常或根本清除程序，从而缩短处理时间。

3. 发明授权

US06328645B1 Method and apparatus for venting/opening, of poultry 失效
标题翻译：家禽排泄/打开的方法和装置
公开(公告)号：US06328645B1
公开(公告)日：2001-12-11
申请号：US09536375
申请日：2000-03-28
申请人： Eugene G. Martin , Scott A. Cook , Sheldon L. Horst , Michael E. Lease
发明人： Eugene G. Martin , Scott A. Cook , Sheldon L. Horst , Michael E. Lease
IPC分类号： A22C2106
CPC分类号： A22B5/0094 , A22C21/06
摘要： A poultry processing machine is provided which automatically vents and opens the poultry, eviscerates the poultry, displays the poultry for inspection, and either provides a normal or radical clean out procedure to the poultry. When the poultry is being physically processed, it is maintained in a generally stationary position with respect to the surface supporting the poultry processor to provide for uniform positioning of the poultry on the conveyor. Further, the poultry is positioned in a generally horizontal position during the venting and opening, eviscerating and cleaning procedures, to facilitate removing the unwanted materials from the poultry without increasing the risk of contamination. The eviscerating station uses an eviscerating tool which includes an opening sized to receive the viscera package therethrough during the eviscerating process to prevent damage to the viscera package. The clean out station automatically recognizes whether a particular poultry is to receive the normal or radical clean out procedure, thereby reducing processing time.
摘要翻译：提供家禽加工机，自动通风和打开家禽，剔除家禽，展示家禽进行检查，并向家禽提供正常或彻底的清洁程序。当家禽被物理加工时，它相对于支撑家禽处理器的表面保持在大致静止的位置，以提供家禽在输送机上的均匀定位。此外，家禽在通气和打开，去内脏和清洁过程期间定位在大致水平的位置，以便于在不增加污染风险的情况下从家禽中除去不想要的物质。剔骨站使用内脏工具，其包括开口尺寸以在内脏过程中通过其接纳内脏包以防止损害内脏包装。清洁站自动识别特定家禽是否接收正常或根本清除程序，从而缩短处理时间。

4. 发明授权

US06227960B1 Eviscerating tool 失效
标题翻译：掏膛工具
公开(公告)号：US06227960B1
公开(公告)日：2001-05-08
申请号：US09656783
申请日：2000-09-07
申请人： Eugene G. Martin , Michael J. Curtis , Scott A. Cook , Sheldon L. Horst , Michael E. Lease , Thomas M. McCarty , Duane E. Newswanger
发明人： Eugene G. Martin , Michael J. Curtis , Scott A. Cook , Sheldon L. Horst , Michael E. Lease , Thomas M. McCarty , Duane E. Newswanger
IPC分类号： A22C2106
CPC分类号： A22B5/0094 , A22C21/06
摘要： A poultry processing machine is provided which automatically vents and opens the poultry, eviscerates the poultry, displays the poultry for inspection, and either provides a normal or radical clean out procedure to the poultry. When the poultry is being physically processed, it is maintained in a generally stationary position with respect to the surface supporting the poultry processor to provide for uniform positioning of the poultry on the conveyor. Further, the poultry is positioned in a generally horizontal position during the venting and opening, eviscerating and cleaning procedures, to facilitate removing the unwanted materials from the poultry without increasing the risk of contamination. The eviscerating station uses an eviscerating tool which includes an opening sized to receive the viscera package therethrough during the eviscerating process to prevent damage to the viscera package. The clean out station automatically recognizes whether a particular poultry is to receive the normal or radical clean out procedure, thereby reducing processing time.
摘要翻译：提供家禽加工机，自动通风和打开家禽，剔除家禽，展示家禽进行检查，并向家禽提供正常或彻底的清洁程序。当家禽被物理加工时，它相对于支撑家禽处理器的表面保持在大致静止的位置，以提供家禽在输送机上的均匀定位。此外，家禽在通气和打开，去内脏和清洁过程期间定位在大致水平的位置，以便于在不增加污染风险的情况下从家禽中除去不想要的物质。剔骨站使用内脏工具，其包括开口尺寸以在内脏过程中通过其接纳内脏包以防止损害内脏包装。清洁站自动识别特定家禽是否接收正常或根本清除程序，从而缩短处理时间。

5. 发明授权

US6165062A Method and apparatus for venting/opening, eviscerating/cropping, inspecting and cleaning of poultry. 失效
标题翻译：排气/打开，取内脏/种植，检查和清洁家禽的方法和装置。
公开(公告)号：US6165062A
公开(公告)日：2000-12-26
申请号：US537927
申请日：2000-03-29
申请人： Eugene G. Martin , Scott A. Cook
发明人： Eugene G. Martin , Scott A. Cook
IPC分类号： A22C21/06 , A22B5/18
CPC分类号： A22B5/0094 , A22C21/06
摘要： A poultry processing machine is provided which automatically vents and opens the poultry, eviscerates the poultry, displays the poultry for inspection, and either provides a normal or radical clean out procedure to the poultry. When the poultry is being physically processed, it is maintained in a generally stationary position with respect to the surface supporting the poultry processor to provide for uniform positioning of the poultry on the conveyor. Further, the poultry is positioned in a generally horizontal position during the venting and opening, eviscerating and cleaning procedures, to facilitate removing the unwanted materials from the poultry without increasing the risk of contamination. The eviscerating station uses an eviscerating tool which includes an opening sized to receive the viscera package therethrough during the eviscerating process to prevent damage to the viscera package. The clean out station automatically recognizes whether a particular poultry is to receive the normal or radical clean out procedure, thereby reducing processing time.
摘要翻译：提供家禽加工机，自动通风和打开家禽，剔除家禽，展示家禽进行检查，并向家禽提供正常或彻底的清洁程序。当家禽被物理加工时，它相对于支撑家禽处理器的表面保持在大致静止的位置，以提供家禽在输送机上的均匀定位。此外，家禽在通气和打开，去内脏和清洁过程期间定位在大致水平的位置，以便于在不增加污染风险的情况下从家禽中除去不想要的物质。剔骨站使用内脏工具，其包括开口尺寸以在内脏过程中通过其接纳内脏包以防止损害内脏包装。清洁站自动识别特定家禽是否接收正常或根本清除程序，从而缩短处理时间。

6. 发明授权

US07544500B2 Process for the production of a reversibly inactive acidified plasmin composition 无效
标题翻译：用于生产可逆失活的酸化纤溶酶组合物的方法
公开(公告)号：US07544500B2
公开(公告)日：2009-06-09
申请号：US10692105
申请日：2003-10-23
申请人： Rita T. Bradley , Scott A. Cook , Christopher A. Dadd , Jonathan D. Kent , Marina N. Korneyeva , Valery V. Novokhatny , James F. Rebbeor , Christopher J. Stenland , Jonathan S. Strauss , Jarrett C. Terry , Jeffrey A. Yuziuk
发明人： Rita T. Bradley , Scott A. Cook , Christopher A. Dadd , Jonathan D. Kent , Marina N. Korneyeva , Valery V. Novokhatny , James F. Rebbeor , Christopher J. Stenland , Jonathan S. Strauss , Jarrett C. Terry , Jeffrey A. Yuziuk
IPC分类号： C12N9/50 , C12N9/68 , C12N9/70
CPC分类号： A61K38/4833 , A61K38/484 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , C12N9/6435 , C12Y304/21007
摘要： Disclosed is both a process for producing a reversibly inactive acidified plasmin by activating plasminogen and a process for producing a purified plasminogen. The produced plasmin is isolated and stored with a low pH-buffering capacity agent to provide a substantially stable formulation. The purified plasminogen is typically purified from a fraction obtained in the separation of immunoglobulin from Fraction II+III chromatographic process and eluted at a low pH. The reversibly inactive acidified plasmin may be used in the administration of a thrombolytic therapy.
摘要翻译：本发明公开了通过活化纤溶酶原产生可逆失活的酸化纤溶酶的方法和用于产生纯化的纤溶酶原的方法。分离产生的纤溶酶并用低pH缓冲能力试剂储存以提供基本上稳定的制剂。纯化的纤溶酶原通常从从级分II + III色谱法分离免疫球蛋白获得的级分中纯化，并在低pH下洗脱。可逆惰性的酸化纤溶酶可以用于溶栓治疗的施用。

7. 发明授权

US06955917B2 Chromatographic method for high yield purification and viral inactivation of antibodies 有权
标题翻译：用于高产率纯化和病毒灭活抗体的色谱法
公开(公告)号：US06955917B2
公开(公告)日：2005-10-18
申请号：US10270918
申请日：2002-10-15
申请人： Patricia Alred , Scott A. Cook , Wytold R. Lebing , Douglas C. Lee , Hanns-Ingolf Paul , Klaus-Peter Radtke
发明人： Patricia Alred , Scott A. Cook , Wytold R. Lebing , Douglas C. Lee , Hanns-Ingolf Paul , Klaus-Peter Radtke
IPC分类号： A61L2/00 , C07K16/06 , C07K16/00 , C07K1/14 , C07K1/36
CPC分类号： A61L2/0088 , C07K16/065
摘要： An improved process for the purification of antibodies from human plasma or other sources is disclosed. The process involves suspension of the antibodies at pH 3.8 to 4.5 followed by addition of caprylic acid and a pH shift to pH 5.0 to 5.2. A precipitate of contaminating proteins, lipids and caprylate forms and is removed, while the majority of the antibodies remain in solution. Sodium caprylate is again added to a final concentration of not less than about 15 mM. This solution is incubated for 1 hour at 25° C. to effect viral inactivation. A precipitate (mainly caprylate) is removed and the clear solution is diluted with purified water to reduce ionic strength. Anion exchange chromatography using two different resins is utilized to obtain an exceptionally pure IgG with subclass distribution similar to the starting distribution. The method maximizes yield and produces a gamma globulin with greater than 99% purity. The resin columns used to obtain a high yield of IgG retain IgM and IgA. IgA and IgM may be eluted from these resins in high yield and purity.
摘要翻译：公开了一种用于从人血浆或其他来源纯化抗体的改进方法。该方法包括将抗体在pH 3.8至4.5下悬浮，然后加入辛酸，并将pH转变至pH5.5至5.2。污染蛋白质，脂质和辛酸盐形式的沉淀物被除去，而大多数抗体保留在溶液中。再加入辛酸钠，终浓度不低于约15mM。将该溶液在25℃孵育1小时以进行病毒灭活。除去沉淀物（主要是辛酸盐），并用净化水稀释澄清溶液以降低离子强度。使用两种不同树脂的阴离子交换色谱法获得特异纯的IgG，其亚类分布类似于起始分布。该方法使产量最大化，产生纯度高于99％的γ球蛋白。用于获得高产量的IgG的树脂柱保留IgM和IgA。 IgA和IgM可以以高产率和纯度从这些树脂中洗脱出来。

8. 再颁专利

USRE44558E1 Chromatographic method for high yield purification and viral inactivation of antibodies 有权
公开(公告)号：USRE44558E1
公开(公告)日：2013-10-22
申请号：US13553364
申请日：2012-07-19
申请人： Patricia Alred , Scott A. Cook , Wytold R. Lebing , Douglas C. Lee , Hanns-Ingolf Paul , Klaus-Peter Radtke
发明人： Patricia Alred , Scott A. Cook , Wytold R. Lebing , Douglas C. Lee , Hanns-Ingolf Paul , Klaus-Peter Radtke
IPC分类号： C07K16/00 , C07K1/30
CPC分类号： A61L2/0088 , A61L2/18 , A61L2/23 , C07K16/065
摘要： An improved process for the purification of antibodies from human plasma or other sources is disclosed. The process involves suspension of the antibodies at pH 3.8 to 4.5 followed by addition of caprylic acid and a pH shift to pH 5.0 to 5.2. A precipitate of contaminating proteins, lipids and caprylate forms and is removed, while the majority of the antibodies remain in solution. Sodium caprylate is again added to a final concentration of not less than about 15 mM. This solution is incubated for 1 hour at 25° C. to effect viral inactivation. A precipitate (mainly caprylate) is removed and the clear solution is diluted with purified water to reduce ionic strength. Anion exchange chromatography using two different resins is utilized to obtain an exceptionally pure IgG with subclass distribution similar to the starting distribution. The method maximizes yield and produces a gamma globulin with greater than 99% purity. The resin columns used to obtain a high yield of IgG retain IgM and IgA. IgA and IgM may be eluted from these resins in high yield and purity.

9. 再颁专利

USRE43655E1 Chromatographic method for high yield purification and viral inactivation of antibodies 有权
标题翻译：用于高产率纯化和病毒灭活抗体的色谱法
公开(公告)号：USRE43655E1
公开(公告)日：2012-09-11
申请号：US11873878
申请日：2007-10-17
申请人： Wytold R. Lebing , Douglas C. Lee , Klaus-Peter Radtke , Scott A. Cook , Hanns-Ingolf Paul , Patricia Alred
发明人： Wytold R. Lebing , Douglas C. Lee , Klaus-Peter Radtke , Scott A. Cook , Hanns-Ingolf Paul , Patricia Alred
IPC分类号： C07K16/00 , C07K1/14 , C07K1/30 , C07K1/36
CPC分类号： A61L2/0088 , A61L2/18 , A61L2/23 , C07K16/065
摘要： An improved process for the purification of antibodies from human plasma or other sources is disclosed. The process involves suspension of the antibodies at pH 3.8 to 4.5 followed by addition of caprylic acid and a pH shift to pH 5.0 to 5.2. A precipitate of contaminating proteins, lipids and caprylate forms and is removed, while the majority of the antibodies remain in solution. Sodium caprylate is again added to a final concentration of not less than about 15 mM. This solution is incubated for 1 hour at 25° C. to affect viral inactivation. A precipitate (mainly caprylate) is removed and the clear solution is diluted with purified water to reduce ionic strength. Anion exchange chromatography using two different resins is utilized to obtain an exceptionally pure IgG with subclass distribution similar to the starting distribution. The method maximizes yield and produces a gamma globulin with greater than 99% purity. The resin columns used to obtain a high yield of IgG retain IgM and IgA. IgA and IgM may be eluted from these resins in high yield and purity.
摘要翻译：公开了一种用于从人血浆或其他来源纯化抗体的改进方法。该方法包括将抗体在pH 3.8至4.5下悬浮，然后加入辛酸，并将pH转变至pH5.5至5.2。污染蛋白质，脂质和辛酸盐形式的沉淀物被除去，而大多数抗体保留在溶液中。再加入辛酸钠，终浓度不低于约15mM。将该溶液在25℃孵育1小时以影响病毒灭活。除去沉淀物（主要是辛酸盐），并用净化水稀释澄清溶液以降低离子强度。使用两种不同树脂的阴离子交换色谱法获得特异纯的IgG，其亚类分布类似于起始分布。该方法使产量最大化，产生纯度高于99％的γ球蛋白。用于获得高产量的IgG的树脂柱保留IgM和IgA。 IgA和IgM可以以高产率和纯度从这些树脂洗脱出来。

10. 发明申请

US20110237781A1 METHOD OF PREPARING ALPHA-1 PROTEINASE INHIBITOR 审中-公开
标题翻译：制备ALPHA-1蛋白酶抑制剂的方法
公开(公告)号：US20110237781A1
公开(公告)日：2011-09-29
申请号：US13002429
申请日：2009-07-17
申请人： Wytold Lebing , Scott A. Cook , Christopher A. Dadd
发明人： Wytold Lebing , Scott A. Cook , Christopher A. Dadd
IPC分类号： C07K1/36
CPC分类号： C07K14/8125
摘要： Purification of α-1 proteinase inhibitor (α-1 PI) from solutions comprising α-1 PI is accomplished using hydrophobic interaction chromatography (HIC). In some embodiments, purification of α-1 PI is accomplished by precipitation of contaminating proteins from a starting solution comprising α-1 PI, such as human plasma, followed by anion exchange resin chromatography prior to HIC. Further purification may be accomplished by an optional cation exchange chromatography subsequent to anion exchange chromatography but prior to HIC. Some embodiments of the invention also include virus removal and/or inactivation by methods such as nano filtration and such as contact with a non-ionic detergent. The methods of the present invention result in greater yield, purity, and pathogenic clearance of plasma fractions than known methods.
摘要翻译：使用疏水相互作用色谱（HIC）实现从包含α-1 PI的溶液中纯化α-1蛋白酶抑制剂（α-1 PI）。在一些实施方案中，通过从包含α-1PI的起始溶液（例如人血浆）中沉淀污染性蛋白，然后在HIC之前进行阴离子交换树脂色谱来完成α-1 PI的纯化。进一步纯化可以通过阴离子交换层析之后但在HIC之前的任选的阳离子交换层析来完成。本发明的一些实施方案还包括通过诸如纳米过滤的方法和诸如与非离子型洗涤剂接触的病毒去除和/或灭活。与已知方法相比，本发明的方法产生更高的产量，纯度和血浆级分的致病性清除。

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