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1. 发明授权

US08170828B2 Test method using memory programmed with tests and protocol to communicate between device under test and tester 有权
标题翻译：使用测试和协议编程的存储器的测试方法在被测设备和测试仪之间进行通信
公开(公告)号：US08170828B2
公开(公告)日：2012-05-01
申请号：US12479580
申请日：2009-06-05
申请人： Patrick D. McNamara , Douglas C. Lee , Alan R. Gilchrist , Sung-Wook Kang , Craig A. Pietrow
发明人： Patrick D. McNamara , Douglas C. Lee , Alan R. Gilchrist , Sung-Wook Kang , Craig A. Pietrow
IPC分类号： G01R31/317 , G01R31/3181 , G01R31/3193
CPC分类号： G01R31/2834 , G01R31/31725 , G01R31/31726
摘要： In an embodiment, a test method is implemented to test an integrated circuit that includes at least one processor. The method may include programming a memory to which the integrated circuit is coupled during testing with one or more test programs. The integrated circuit may be booted, and the processor may execute the test programs from the memory. In one embodiment, the memory may also store a control program that may manage the execution of the tests. In an embodiment, the control program may also implement a protocol to communicate with the ATE to perform the testing. The protocol may be implemented over a set of general purpose input/output (I/O) pins, for example. Using the protocol and test vectors on the ATE, the tests may be selected and executed, and test results may be reported.
摘要翻译：在一个实施例中，实施测试方法来测试包括至少一个处理器的集成电路。该方法可以包括在使用一个或多个测试程序进行测试期间对集成电路耦合的存储器进行编程。集成电路可以引导，并且处理器可以从存储器执行测试程序。在一个实施例中，存储器还可以存储可以管理测试的执行的控制程序。在一个实施例中，控制程序还可以实现与ATE通信以执行测试的协议。该协议可以例如通过一组通用输入/输出（I / O）引脚来实现。在ATE上使用协议和测试向量，可以选择和执行测试，并且可以报告测试结果。

2. 发明申请

US20100196875A1 HUMAN ERYTHROVIRUS 审中-公开
标题翻译：人类红斑狼疮
公开(公告)号：US20100196875A1
公开(公告)日：2010-08-05
申请号：US12523309
申请日：2008-01-15
申请人： Douglas C. Lee , Todd M. Gieman , Chris Glenn , Burton Beams , Brett Buno , Lori Rinckel
发明人： Douglas C. Lee , Todd M. Gieman , Chris Glenn , Burton Beams , Brett Buno , Lori Rinckel
IPC分类号： C12Q1/70 , C07H21/04 , C12N7/01
CPC分类号： C12Q1/701 , C12N7/00 , C12N2750/14221
摘要： Nucleic acid molecules derived from sequences of novel human parvovirus B19 variant genomes are provided. Also provided are assays and kits comprising the nucleic acid molecules.
摘要翻译：提供了源自新型人细小病毒B19变种基因组序列的核酸分子。还提供了包含核酸分子的测定和试剂盒。

3. 发明授权

US06307028B1 Chromatographic method for high yield purification and viral inactivation of antibodies 有权
标题翻译：用于高产率纯化和病毒灭活抗体的色谱法
公开(公告)号：US06307028B1
公开(公告)日：2001-10-23
申请号：US09270724
申请日：1999-03-17
申请人： Wytold Lebing , Patricia Alred , Douglas C. Lee , Hanns-Ingolf Paul
发明人： Wytold Lebing , Patricia Alred , Douglas C. Lee , Hanns-Ingolf Paul
IPC分类号： C07K136
CPC分类号： A61L2/0088 , A61L2/18 , A61L2/23 , C07K16/065
摘要： An improved process for the purification of antibodies from human plasma or other sources is disclosed. The process involves suspension of the antibodies at pH 3.8 to 4.5 followed by addition of caprylic acid and a pH shift to pH 5.0 to 5.2. A precipitate of contaminating proteins, lipids and caprylate forms and is removed, while the majority of the antibodies remain in solution. Sodium caprylate is again added to a final concentration of not less than about 15 mM. This solution is incubated for 1 hour at 25° C. to effect viral inactivation. A precipitate (mainly caprylate) is removed and the clear solution is diluted with purified water to reduce ionic strength. Anion exchange chromatography using two different resins is utilized to obtain an exceptionally pure IgG with subclass distribution similar to the starting distribution. The method maximizes yield and produces a gamma globulin with greater than 99% purity. The resin columns used to obtain a high yield of IgG, retain IgM and IgA, respectively. IgA and IgM may be eluted in high yield and purity.
摘要翻译：公开了一种用于从人血浆或其他来源纯化抗体的改进方法。该方法包括将抗体在pH 3.8至4.5下悬浮，然后加入辛酸，并将pH转变至pH5.5至5.2。污染蛋白质，脂质和辛酸盐形式的沉淀物被除去，而大多数抗体保留在溶液中。再加入辛酸钠，终浓度不低于约15mM。将该溶液在25℃孵育1小时以进行病毒灭活。除去沉淀物（主要是辛酸盐），并用净化水稀释澄清溶液以降低离子强度。使用两种不同树脂的阴离子交换色谱法获得特异纯的IgG，其亚类分布类似于起始分布。该方法使产量最大化，产生纯度高于99％的γ球蛋白。用于获得高产量的IgG的树脂柱分别保留IgM和IgA。可以以高产率和纯度洗脱IgA和IgM。

4. 发明授权

US08918680B2 Trace queue for peripheral component 有权
标题翻译：外设组件的跟踪队列
公开(公告)号：US08918680B2
公开(公告)日：2014-12-23
申请号：US13355661
申请日：2012-01-23
申请人： Diarmuid P. Ross , Douglas C. Lee
发明人： Diarmuid P. Ross , Douglas C. Lee
IPC分类号： G06F11/00
CPC分类号： G06F11/0745 , G06F11/0778
摘要： In an embodiment, a peripheral component may include multiple sources of commands, such as command queues and/or macro memories. The commands may be performed in the peripheral component and may result in an error. The peripheral component may include a trace queue into which the commands may be written, independent of the source of the commands. Thus, the trace queue may provide a record of recently performed commands.
摘要翻译：在一个实施例中，外围组件可以包括多个命令源，诸如命令队列和/或宏存储器。这些命令可以在外围部件中执行，并且可能导致错误。外围组件可以包括可以写入命令的跟踪队列，而不依赖于命令的来源。因此，跟踪队列可以提供最近执行的命令的记录。

5. 发明申请

US20140015573A1 METHOD AND APPARATUS TO AUTOMATICALLY SCALE DLL CODE FOR USE WITH SLAVE DLL OPERATING AT A DIFFERENT FREQUENCY THAN A MASTER DLL 有权
标题翻译：用于自动缩放DLL代码的方法和设备，用于在不同频率下运行的从站DLL DLL
公开(公告)号：US20140015573A1
公开(公告)日：2014-01-16
申请号：US13546540
申请日：2012-07-11
申请人： Diarmuid P. Ross , Douglas C. Lee , David S. Warren
发明人： Diarmuid P. Ross , Douglas C. Lee , David S. Warren
IPC分类号： H03L7/08
CPC分类号： H03L7/0812
摘要： A method and apparatus for scaling a DLL code for a slave DLL operating at a different frequency than a master DLL is disclosed. An apparatus includes a master DLL coupled to receive a first clock signal and a group of series-coupled slave DLLs coupled to receive a second clock signal. The master DLL may provide a specified fraction of a cycle of the first clock signal. Scaling circuitry coupled between the master DLL and the group of slave DLLs may determine a ratio of frequencies of the first clock signal to the second clock signal. Based on the ratio and a delay code from the first DLL, the scaling circuitry may generate an adjusted delay code received by the group of slave DLLs to set a delay for the second clock signal to the specified fraction.
摘要翻译：公开了一种用于缩放以与主DLL不同的频率工作的从动DLL的DLL代码的方法和装置。一种装置包括耦合以接收第一时钟信号的主DLL和耦合以接收第二时钟信号的一组串联耦合的从动DLL。主DLL可以提供第一时钟信号的周期的指定分数。耦合在主DLL和从属DLL组之间的缩放电路可以确定第一时钟信号与第二时钟信号的频率之比。基于比率和来自第一DLL的延迟码，缩放电路可以生成由从属DLL组接收的经调整的延迟码，以将第二时钟信号的延迟设置为指定的分数。

6. 发明授权

US08520455B2 Method and apparatus for training a DLL in a memory subsystem 有权
标题翻译：用于训练存储器子系统中的DLL的方法和装置
公开(公告)号：US08520455B2
公开(公告)日：2013-08-27
申请号：US13347175
申请日：2012-01-10
申请人： Diarmuid P. Ross , Douglas C. Lee
发明人： Diarmuid P. Ross , Douglas C. Lee
IPC分类号： G11C7/00
CPC分类号： G11C8/18
摘要： A method and apparatus for training a DLL in a memory subsystem is disclosed. In one embodiment, a memory subsystem includes a memory coupled to convey data read therefrom on one or more channels. Each memory channel may include a delay locked loop (DLL) configured to apply a desired amount of delay to a data strobe signal received from the memory during a read operation. Upon detecting a read request, a controller may initiate a training procedure in which the DLL is trained to the desired delay. During the training procedure, an input clock signal may be provided to the DLL. The delay within the DLL may be adjusted until an output clock signal has a desired phase relationship with the input clock signal. Once the desired phase relationship is attained, the training procedure may be terminated and the DLL input may be switched to receive the data strobe signal.
摘要翻译：公开了一种用于训练存储器子系统中的DLL的方法和装置。在一个实施例中，存储器子系统包括耦合以在一个或多个信道上传送从其读取的数据的存储器。每个存储器通道可以包括被配置为在读取操作期间从存储器接收的数据选通信号施加期望量的延迟的延迟锁定环（DLL）。在检测到读取请求时，控制器可以启动训练程序，其中将DLL训练到期望的延迟。在训练过程中，可以向DLL提供输入时钟信号。可以调整DLL内的延迟，直到输出时钟信号与输入时钟信号具有期望的相位关系。一旦达到期望的相位关系，则可以终止训练过程，并且可以切换DLL输入以接收数据选通信号。

7. 发明申请

US20130191693A1 Trace Queue for Peripheral Component 有权
标题翻译：外围组件的跟踪队列
公开(公告)号：US20130191693A1
公开(公告)日：2013-07-25
申请号：US13355661
申请日：2012-01-23
申请人： Diarmuid P. Ross , Douglas C. Lee
发明人： Diarmuid P. Ross , Douglas C. Lee
IPC分类号： G06F11/34 , G06F12/02 , G06F13/14
CPC分类号： G06F11/0745 , G06F11/0778
摘要： In an embodiment, a peripheral component may include multiple sources of commands, such as command queues and/or macro memories. The commands may be performed in the peripheral component and may result in an error. The peripheral component may include a trace queue into which the commands may be written, independent of the source of the commands. Thus, the trace queue may provide a record of recently performed commands.
摘要翻译：在一个实施例中，外围组件可以包括多个命令源，诸如命令队列和/或宏存储器。这些命令可以在外围部件中执行并且可能导致错误。外围组件可以包括可以写入命令的跟踪队列，而不依赖于命令的来源。因此，跟踪队列可以提供最近执行的命令的记录。

8. 发明授权

US08332543B2 Command queue for peripheral component 有权
公开(公告)号：US08332543B2
公开(公告)日：2012-12-11
申请号：US13359533
申请日：2012-01-27
申请人： Douglas C. Lee , Diarmuid P. Ross , Tahoma M. Toelkes
发明人： Douglas C. Lee , Diarmuid P. Ross , Tahoma M. Toelkes
IPC分类号： G06F3/00 , G06F13/00
CPC分类号： G06F13/1642 , G06F13/126 , Y02D10/14
摘要： In an embodiment, a peripheral component configured to control an external interface of an integrated circuit. For example, the peripheral component may be a memory interface unit such as a flash memory interface unit. The internal interface to the peripheral component may be shared between data transfers to/from the external interface and control communications to the peripheral component. The peripheral component may include a command queue configured to store a set of commands to perform a transfer on the interface. A control circuit may be coupled to the command queue and may read the commands and communicate with an interface controller to cause a transfer on the interface responsive to the commands. In an embodiment, a macro memory may store command sequences to be performed in response to a macro command in the command queue. In an embodiment, an operand queue may store operand data for use by the commands.

9. 发明申请

US20100312517A1 Test Method Using Memory Programmed with Tests and Protocol To Communicate between Device Under Test and Tester 有权
标题翻译：使用测试和协议的内存测试方法在被测设备和测试仪之间进行通信
公开(公告)号：US20100312517A1
公开(公告)日：2010-12-09
申请号：US12479580
申请日：2009-06-05
申请人： Patrick D. McNamara , Douglas C. Lee , Alan R. Gilchrist , Sung-Wook Kang , Craig A. Pietrow
发明人： Patrick D. McNamara , Douglas C. Lee , Alan R. Gilchrist , Sung-Wook Kang , Craig A. Pietrow
IPC分类号： G01R31/02 , G06F19/00
CPC分类号： G01R31/2834 , G01R31/31725 , G01R31/31726
摘要： In an embodiment, a test method is implemented to test an integrated circuit that includes at least one processor. The method may include programming a memory to which the integrated circuit is coupled during testing with one or more test programs. The integrated circuit may be booted, and the processor may execute the test programs from the memory. In one embodiment, the memory may also store a control program that may manage the execution of the tests. In an embodiment, the control program may also implement a protocol to communicate with the ATE to perform the testing. The protocol may be implemented over a set of general purpose input/output (I/O) pins, for example. Using the protocol and test vectors on the ATE, the tests may be selected and executed, and test results may be reported.
摘要翻译：在一个实施例中，实施测试方法来测试包括至少一个处理器的集成电路。该方法可以包括在使用一个或多个测试程序进行测试期间对集成电路耦合的存储器进行编程。集成电路可以引导，并且处理器可以从存储器执行测试程序。在一个实施例中，存储器还可以存储可以管理测试的执行的控制程序。在一个实施例中，控制程序还可以实现与ATE通信以执行测试的协议。该协议可以例如通过一组通用输入/输出（I / O）引脚来实现。在ATE上使用协议和测试向量，可以选择和执行测试，并且可以报告测试结果。

10. 发明授权

US06437102B1 Method of separating prions from biological materials 有权
标题翻译：从生物材料中分离朊病毒的方法
公开(公告)号：US06437102B1
公开(公告)日：2002-08-20
申请号：US09638275
申请日：2000-08-14
申请人： Douglas C. Lee , Steve R. Petteway , Christopher J. Stenland
发明人： Douglas C. Lee , Steve R. Petteway , Christopher J. Stenland
IPC分类号： A23J100
CPC分类号： C07K1/30 , C07K14/47 , Y10S435/962 , Y10S435/975
摘要： Disclosed is a method for separating prions from biological materials. The method includes adding a polyalkylene glycol, such as polyethylene glycol, to a solution of the biological material such that a precipitate containing the prion is formed. This precipitate is then separated from the solution of biological material, thereby removing prions. Biological materials include biologically derived fluids, such as cerebrospinal fluid, biological samples, such as brain homogenates, blood plasma fractions, and aqueous solutions of recombinantly produced products. The disclosed method provides an effective process for the removal of these infectious materials from the biological materials, which may be further processed to provide the therapeutic compositions.
摘要翻译：公开了从生物材料中分离朊病毒的方法。该方法包括将聚亚烷基二醇例如聚乙二醇加入到生物材料的溶液中，使得形成含有朊病毒的沉淀物。然后将该沉淀物与生物材料的溶液分离，从而除去朊病毒。生物材料包括生物衍生的流体，如脑脊液，生物样品，如脑匀浆，血浆级分和重组产物的水溶液。所公开的方法提供了从生物材料中去除这些感染性物质的有效方法，其可进一步加工以提供治疗组合物。

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