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1. 发明授权

US08263085B2 Gammaretrovirus associated with cancer 失效
标题翻译：与癌症相关的瘤胃病毒
公开(公告)号：US08263085B2
公开(公告)日：2012-09-11
申请号：US11903756
申请日：2007-09-24
申请人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
发明人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
IPC分类号： A61K39/21 , C12N5/071 , C12N7/00
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
摘要翻译：本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒的方法（例如，在个体中）; 识别抑制病毒的药剂的方法; 诱导对病毒的免疫应答的方法; 治疗与个体（例如癌症如前列腺癌）中XMRV存在相关的疾病的方法; 检测无症状癌症的方法（例如前列腺癌）; 识别患有癌症风险的个体（例如前列腺癌）的方法; 和用于检测病毒的工具包。

2. 发明申请

US20140116271A1 Vegetable Fermenting Kitchenware 审中-公开
标题翻译：蔬菜发酵厨具
公开(公告)号：US20140116271A1
公开(公告)日：2014-05-01
申请号：US14070370
申请日：2013-11-01
申请人： Karen Wang Diggs , Eric A. Klein
发明人： Karen Wang Diggs , Eric A. Klein
IPC分类号： A23B7/10
CPC分类号： A23B7/105 , B65D51/2892 , C12C9/00
摘要： A kitchenware apparatus and container for producing fermented vegetables, such as sauerkraut, comprising a screw top or Mason jar, a threaded jar lid with moat and an oblong top slot opening, an inverted cup that fits within the moat, a plunger sized to fit within the neck of the jar and having a keyed handle that extends up through the slot in the lid, and a compression spring. The lid moat and inverted cup comprise an airlock or one way valve that allows fermentation gases to escape but prevents outside air from entering. The screw lid, spring and plunger comprise a press that compresses the fermenting vegetables to press juice from the vegetables and to hold the vegetables under the liquid surface to prevent mold or other spoilage and to prevent browning.
摘要翻译：一种用于生产发酵蔬菜（例如酸菜）的厨具和容器，其包括螺旋顶或梅森罐，具有护城河的带螺纹的罐盖和长方形的顶部槽口，配合在护城河内的倒杯，尺寸适合于其内的柱塞罐的颈部并具有向上延伸穿过盖中的狭槽的键柄，以及压缩弹簧。盖护城河和倒杯包括允许发酵气体逸出但防止外部空气进入的气闸或单向阀。螺杆盖，弹簧和柱塞包括压榨机，其压缩发酵蔬菜以从蔬菜中榨汁并将蔬菜保持在液体表面下方以防止霉变或其它腐败并防止褐变。

3. 发明申请

US20130040369A1 Gammaretrovirus Associated With Cancer 审中-公开
标题翻译：与癌症相关的恶性肿瘤病毒
公开(公告)号：US20130040369A1
公开(公告)日：2013-02-14
申请号：US13551286
申请日：2012-07-17
申请人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
发明人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
IPC分类号： C12N7/00 , C07K14/15
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
摘要翻译：本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒的方法（例如，在个体中）; 识别抑制病毒的药剂的方法; 诱导对病毒的免疫应答的方法; 治疗与个体（例如癌症如前列腺癌）中XMRV存在相关的疾病的方法; 检测无症状癌症的方法（例如前列腺癌）; 识别患有癌症风险的个体（例如前列腺癌）的方法; 和用于检测病毒的工具包。

4. 发明授权

US5751245A Vehicle route and schedule exception reporting system 失效
标题翻译：车辆路线和时间表异常报告系统
公开(公告)号：US5751245A
公开(公告)日：1998-05-12
申请号：US610590
申请日：1996-03-07
申请人： James M. Janky , Eric A. Klein , John F. Schipper
发明人： James M. Janky , Eric A. Klein , John F. Schipper
IPC分类号： G01S5/00 , G08G1/123 , G01S5/04 , G01C21/00 , G06F7/70
CPC分类号： G08G1/202 , G01S5/0027 , G01S2205/002
摘要： A route exception reporting apparatus is mounted in a mobile shipping vehicle having a predetermined geographic route. The shipping vehicle may be a self-propelled vehicle containing cargo or may also be a separable self-contained shipping container carried on a transportation vehicle. At least a portion of the predetermined route is stored in the apparatus on board the shipping vehicle. The apparatus is provided with a geographic locating means for determining the shipping vehicle location, a comparator means for comparing the shipping vehicle location with at least one point of the predetermined route and a communication means for communicating with a central station. The apparatus is configured to communicate the shipping vehicle location to the central station when the comparator means computes a difference between the shipping vehicle location at a particular point in time and the predetermined route point corresponding with that particular time point which exceeds a predetermined limit. The central station may be provided with an alarm and display means for notifying personnel at the central station of the occurrence of a route location exception.
摘要翻译：路线异常报告装置安装在具有预定地理路线的移动运输车辆中。运输车辆可以是包含货物的自行式车辆，也可以是运输车辆上携带的可分离的独立运输集装箱。预定路线的至少一部分被存储在船上的装置中。该装置设置有用于确定运输车辆位置的地理定位装置，用于将运输车辆位置与预定路线的至少一个点进行比较的比较装置和用于与中心站通信的通信装置。该装置被配置为当比较器装置计算特定时间点上的运输车辆位置与对应于超过预定极限的该特定时间点的预定路线点之间的差异时，将运输车辆位置通信给中心站。中央车站可以设置有报警和显示装置，用于通知中心站的人员出现路线位置异常。

5. 发明授权

US09717260B2 Vegetable fermenting kitchenware 有权
公开(公告)号：US09717260B2
公开(公告)日：2017-08-01
申请号：US14070370
申请日：2013-11-01
申请人： Karen Wang Diggs , Eric A. Klein
发明人： Karen Wang Diggs , Eric A. Klein
IPC分类号： A23B7/10 , C12C3/00 , B65D51/28
CPC分类号： A23B7/105 , B65D51/2892 , C12C9/00
摘要： A kitchenware apparatus and container for producing fermented vegetables, such as sauerkraut, comprising a screw top or Mason jar, a threaded jar lid with moat and an oblong top slot opening, an inverted cup that fits within the moat, a plunger sized to fit within the neck of the jar and having a keyed handle that extends up through the slot in the lid, and a compression spring. The lid moat and inverted cup comprise an airlock or one way valve that allows fermentation gases to escape but prevents outside air from entering. The screw lid, spring and plunger comprise a press that compresses the fermenting vegetables to press juice from the vegetables and to hold the vegetables under the liquid surface to prevent mold or other spoilage and to prevent browning.

6. 发明授权

US08917459B2 Ergonomic vertical vision redirection 有权
标题翻译：人体工学垂直视觉重定向
公开(公告)号：US08917459B2
公开(公告)日：2014-12-23
申请号：US13479129
申请日：2012-05-23
申请人： Eric A. Klein , Adam Norton
发明人： Eric A. Klein , Adam Norton
IPC分类号： G02B3/08 , G02C7/02
CPC分类号： G02B3/08 , A63B33/002 , A63B2208/02 , A63B2225/12 , A63B2244/19 , G02B5/189 , G02B27/005 , G02C7/022 , G02C7/06 , G02C7/14 , G02C2202/20
摘要： An ergonomic vertical redirection vision system comprises glasses or goggles with lenses modified to include a fresnel prism that vertically redirects light. The curved fresnel prism is a novel curved refractive element with unique advantages compared to a flat fresnel prism. The curved fresnel prism may be achromatized by the addition of an appropriate diffractive surface thereby creating a hybrid achromat or diffractive/refractive optical element (DROE). Looking through the modified eyewear will redirect the user's visual field up or down, depending on the configuration. Upward vision redirection improves ergonomics and aerodynamics for several sports including bicycle riding, swimming, downhill ski racing, and motorcycle racing. Downward vision redirection improves the ergonomics of reading a book, working on a laptop or pad computer, or taking notes in a class.
摘要翻译：符合人体工程学的垂直重定向视觉系统包括眼镜或护目镜，镜片被修改为包括使光线垂直重定向的菲涅耳棱镜。弯曲的菲涅耳棱镜是一种新颖的弯曲折射元件，与平坦的菲涅尔棱镜相比具有独特的优势。弯曲的菲涅尔棱镜可以通过添加适当的衍射面而被消色差，从而产生混合的消色差或衍射/折射光学元件（DROE）。查看修改后的眼镜会根据配置重定向用户的视野。向上的视觉重定向改善了人体工程学和空气动力学，包括骑自行车，游泳，下坡滑雪赛车和摩托车赛车等多项运动。向下视力重定向提高了阅读书籍，在笔记本电脑或平板电脑上工作或在课堂上进行笔记的人体工程学。

7. 发明申请

US20100166797A1 Gammaretrovirus associated with cancer 失效
标题翻译：与癌症相关的瘤胃病毒
公开(公告)号：US20100166797A1
公开(公告)日：2010-07-01
申请号：US11903756
申请日：2007-09-24
申请人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
发明人： Robert H. Silverman , Eric A. Klein , Graham Casey , Joseph DeRisi , Don Ganem
IPC分类号： A61K39/21 , C12N7/00 , C07K2/00 , C12N15/74 , C12N5/10 , C07K16/00 , C12Q1/70 , A61K39/00 , A61P35/00 , A61P31/12 , A61P37/04
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
摘要翻译：本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒的方法（例如，在个体中）; 识别抑制病毒的药剂的方法; 诱导对病毒的免疫应答的方法; 治疗与个体（例如癌症如前列腺癌）中XMRV存在相关的疾病的方法; 检测无症状癌症的方法（例如前列腺癌）; 识别患有癌症风险的个体（例如前列腺癌）的方法; 和用于检测病毒的工具包。

8. 发明授权

US06419649B1 Erotic stimulation device 有权
标题翻译：色情刺激装置
公开(公告)号：US06419649B1
公开(公告)日：2002-07-16
申请号：US09543050
申请日：2000-04-05
申请人： Eric A. Klein
发明人： Eric A. Klein
IPC分类号： A61H100
CPC分类号： A44C15/0035 , A61H19/30 , A61H19/34 , A61H19/50 , A61H21/00 , A61H23/0263 , A61H2201/1604 , Y10S601/16
摘要： A sexual aid device comprising a battery powered electric vibrator which attaches to the user's tongue. The first embodiment attaches to the tongue using a post (18) which is inserted through a hole previously pierced in the tongue. The assembled device is shaped roughly like a dumbbell consisting of a post (18) with retainers mounted at either end. Post (18) has a diameter narrow enough to fit through the tongue hole, but the retainers have larger diameter and cannot slip through the hole. An electric vibrator motor (14) is incorporated into one of the retainers. At least one of the retainers must be removable to allow device insertion. An electric battery (13) may be mounted in the same retainer as the vibrator motor (14) or in the other retainer. The second embodiment attaches to the tongue using suction, constriction, and friction. The front end of the device houses a vibrator mechanism comprising a vibrator motor (14), battery (13), and switch (38) in a moisture resistant housing (11). A pliable plastic mouthpiece (31) is mounted at the rear of the device. The interior of mouthpiece (31) forms a tongue cup (32) into which the user inserts the tongue. Tongue cup (32), when partially evacuated of air, acts as the means of attachment to the tongue. A sealing lip (33) circles the rim of tongue cup (32). Sealing lip (33) both constricts the tongue and forms an airtight seal against the skin of the tongue. Concentric friction ridges (34) circle the interior of tongue cup (32). Friction ridges (34) grip the tongue and act as secondary air seals.
摘要翻译：一种性帮助装置，包括附接到使用者舌头的电池供电电动振动器。第一实施例使用插入通过先前在舌头中刺穿的孔的柱（18）来附接舌头。组装的装置的形状大体上类似于由安装在任一端的保持器的柱（18）组成的哑铃。柱（18）的直径足够窄以穿过舌孔，但是保持器具有较大的直径并且不能穿过该孔。电动振动电动机（14）被并入其中一个保持器。至少一个保持器必须是可拆卸的，以允许设备插入。电池（13）可以安装在与振动电动机（14）相同的保持器中，或者安装在另一保持器中。第二实施例使用抽吸，收缩和摩擦附接到舌头。装置的前端容纳振动器机构，该振动器机构包括在防潮壳体（11）中的振动器电动机（14），电池（13）和开关（38）。一个柔软的塑料接口（31）安装在设备的后部。口部（31）的内部形成舌部（32），使用者插入舌头（32）。当部分疏散空气时，舌杯（32）充当舌头的附着装置。密封唇缘（33）围绕舌杯（32）的边缘。密封唇（33）都会收缩舌头并形成与舌头皮肤密封的密封。同心摩擦脊（34）环绕舌杯（32）的内部。摩擦脊（34）夹住舌头并充当二次空气密封。

9. 发明申请

US20130222757A1 ERGONOMIC VERTICAL VISION REDIRECTION 有权
公开(公告)号：US20130222757A1
公开(公告)日：2013-08-29
申请号：US13479129
申请日：2012-05-23
申请人： Eric A. Klein , Adam Norton
发明人： Eric A. Klein , Adam Norton
IPC分类号： G02C7/14 , A63B33/00 , G02C7/06
CPC分类号： G02B3/08 , A63B33/002 , A63B2208/02 , A63B2225/12 , A63B2244/19 , G02B5/189 , G02B27/005 , G02C7/022 , G02C7/06 , G02C7/14 , G02C2202/20
摘要： An ergonomic vertical redirection vision system comprises glasses or goggles with lenses modified to include a fresnel prism that vertically redirects light. The curved fresnel prism is a novel curved refractive element with unique advantages compared to a flat fresnel prism. The curved fresnel prism may be achromatized by the addition of an appropriate diffractive surface thereby creating a hybrid achromat or diffractive/refractive optical element (DROE). Looking through the modified eyewear will redirect the user's visual field up or down, depending on the configuration. Upward vision redirection improves ergonomics and aerodynamics for several sports including bicycle riding, swimming, downhill ski racing, and motorcycle racing. Downward vision redirection improves the ergonomics of reading a book, working on a laptop or pad computer, or taking notes in a class.
摘要翻译：符合人体工程学的垂直重定向视觉系统包括眼镜或护目镜，镜片被修改为包括使光线垂直重定向的菲涅耳棱镜。弯曲的菲涅耳棱镜是一种新颖的弯曲折射元件，与平坦的菲涅尔棱镜相比具有独特的优势。弯曲的菲涅尔棱镜可以通过添加适当的衍射面而被消色差，从而产生混合的消色差或衍射/折射光学元件（DROE）。查看修改后的眼镜会根据配置重定向用户的视野。向上的视觉重定向改善了人体工程学和空气动力学，包括骑自行车，游泳，下坡滑雪赛车和摩托车赛车等多项运动。向下视力重定向提高了阅读书籍，在笔记本电脑或平板电脑上工作或在课堂上进行笔记的人体工程学。

10. 发明申请

US20100184015A1 METHOD FOR DETECTION OF XMRV 审中-公开
标题翻译：检测XMRV的方法
公开(公告)号：US20100184015A1
公开(公告)日：2010-07-22
申请号：US12645181
申请日：2009-12-22
申请人： Robert H. Silverman , Eric A. Klein , Christopher J. Weight , Carvell T. Nguyen , Jaydip Das Gupta
发明人： Robert H. Silverman , Eric A. Klein , Christopher J. Weight , Carvell T. Nguyen , Jaydip Das Gupta
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6886 , C12Q1/702 , C12Q2600/16
摘要： The present invention relates to the identification of Xenotropic murine leukemia virus (XMRV) nucleic acid by polymerase chain reaction (PCR) analysis (e.g., real time PCR (RT/PCR); nested RT/PCR using Tth DNA polymerase and Hot start polymerase) and the uses thereof. In particular, the invention provides methods for the detection, and in particular early detection, of XMRV in RNA isolated from samples (e.g., urine samples; expressed prostate secretion (EPS)) of prostate cancer patients and normal individuals.
摘要翻译：本发明涉及通过聚合酶链反应（PCR）分析（例如实时PCR（RT / PCR）;使用Tth DNA聚合酶和热启动聚合酶进行嵌套RT / PCR）鉴定异构鼠类白血病病毒（XMRV）及其用途。特别地，本发明提供了用于检测并特别是早期检测前列腺癌患者和正常个体的样品（例如尿液样品，表达的前列腺分泌物（EPS））的RNA中的XMRV的方法。

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