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1. 发明授权

US06774123B1 Methods and compositions for inactivating viruses 失效
标题翻译：用于灭活病毒的方法和组合物
公开(公告)号：US06774123B1
公开(公告)日：2004-08-10
申请号：US09362337
申请日：1999-07-28
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson , Martin D. Williams
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson , Martin D. Williams
IPC分类号： A61K3183
CPC分类号： A61K31/661 , A61K31/075 , A61K31/14 , A61K31/396 , A61K31/7024 , A61L2/0088 , Y02A50/397
摘要： Methods and compositions for selectively inactivating viruses in biological compositions, including contacting the composition with an organic solvent and an ethyleneimine oligomer inactivating agent, are disclosed.
摘要翻译：公开了用于选择性灭活生物组合物中的病毒的方法和组合物，包括使组合物与有机溶剂和乙烯亚胺低聚物灭活剂接触。

2. 发明授权

US5891705A Method for inactivating a virus 失效
标题翻译：灭活病毒的方法
公开(公告)号：US5891705A
公开(公告)日：1999-04-06
申请号：US835446
申请日：1997-04-08
申请人： Edward I. Budowsky , Samuel K. Ackerman
发明人： Edward I. Budowsky , Samuel K. Ackerman
IPC分类号： A61K39/12 , A61P31/12 , C12N7/06 , C12N7/00 , C12N7/04
CPC分类号： C12N7/00 , C12N2760/18463 , C12N2760/18763 , C12N2770/24163 , C12N2770/32663
摘要： The present invention concerns a method for inactivating a virus for use in e.g. a vaccine, by treating the virus with an ethyleneimine at a pH of less than 7.0, and methods of treatment with the inactivated virus.
摘要翻译：本发明涉及用于灭活病毒的方法。通过用pH小于7.0的乙烯亚胺处理该病毒，以及用灭活病毒处理的方法。

3. 发明授权

US06369048B1 Methods and compositions for inactivating viruses 失效
标题翻译：用于灭活病毒的方法和组合物
公开(公告)号：US06369048B1
公开(公告)日：2002-04-09
申请号：US09005719
申请日：1998-01-12
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson , Martin D. Williams
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson , Martin D. Williams
IPC分类号： A61K3133
CPC分类号： A61K31/661 , A61K31/075 , A61K31/14 , A61K31/396 , A61K31/7024 , A61L2/0088 , Y02A50/397
摘要： Methods and compositions for selectively inactivating viruses in biological compositions, including contacting the composition with an organic solvent and an ethyleneimine oligomer inactivating agent, are disclosed.
摘要翻译：公开了用于选择性灭活生物组合物中的病毒的方法和组合物，包括使组合物与有机溶剂和乙烯亚胺低聚物灭活剂接触。

4. 发明授权

US6093564A Methods and compositions for the selective modification of nucleic acids 失效
标题翻译：用于选择性修饰核酸的方法和组合物
公开(公告)号：US6093564A
公开(公告)日：2000-07-25
申请号：US5606
申请日：1998-01-12
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
IPC分类号： C12N7/04 , A61K31/396 , A61K38/00 , A61K39/00 , A61K39/12 , A61L2/00 , A61P31/00 , A61P31/12 , A61P43/00 , C07D203/02 , C07D203/12 , C12N7/06 , C12N7/00
CPC分类号： C12N7/00 , A61L2/0082 , A61L2/0088 , C12N2740/16063 , C12N2760/16163 , C12N2760/20263 , C12N2770/32363 , C12N2770/32463 , C12N2795/10163
摘要： Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: ##STR1## where each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, and R.sub.8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, and R.sub.8 cannot all be H; R.sub.5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 1 and 10, inclusive are disclosed.
摘要翻译：用于选择性修饰生物组合物中核酸分子的方法和组合物，包括使组合物与具有下式的灭活剂接触：其中R1，R2，R3，R4，R6，R7和R8各自独立地为H或单价含有1至4个碳原子的烃部分（包括端值），条件是R1，R2，R3，R4，R6，R7和R8不能全部为H; R5是含有2至4个碳原子的二价烃部分，包括端值; X是药学上可接受的抗衡离子; n为1〜10的整数，包括端值。

5. 发明授权

US06617157B1 Methods and compositions for the selective modification of nucleic acids 失效
公开(公告)号：US06617157B1
公开(公告)日：2003-09-09
申请号：US09212778
申请日：1998-12-16
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
IPC分类号： A61K3900
CPC分类号： C12N7/00 , A61L2/0082 , A61L2/0088 , C12N2740/16063 , C12N2760/16163 , C12N2760/20263 , C12N2770/32363 , C12N2770/32463 , C12N2795/10163
摘要： Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: where each of R1, R2, R3, R4, R6, R7, and R8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R1, R2, R3, R4, R6, R7, and R8 cannot all be H; R5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 2 and 10, inclusive are disclosed.

6. 发明授权

US5955446A Method of treating herpes infections with 2',5'-oligoadenylate-2',3'-cyclophosphate compounds 失效
标题翻译：用2'，5'-寡腺苷酸2'，3'-环磷酸酯化合物治疗疱疹感染的方法
公开(公告)号：US5955446A
公开(公告)日：1999-09-21
申请号：US784801
申请日：1997-01-16
申请人： Edward I. Budowsky , Samuel K. Ackerman
发明人： Edward I. Budowsky , Samuel K. Ackerman
IPC分类号： C07H19/207 , A01N43/04 , A61K31/70 , A61K31/7076 , A61K31/7084 , A61K31/7088 , A61P31/22 , C07H21/00 , C07H21/02
CPC分类号： A61K31/7048 , A61K31/7076 , A61K31/7125
摘要： The present invention provides methods for treating herpes infections in a subject in need of such treatment, by the administration of 2'-5' oligoadenylate-2',3'-cyclophosphate compounds. Pharmaceutical formulations comprising 2'-5' oligoadenylate-2',3'-cyclophosphate and compounds thereof are also provided.
摘要翻译：本发明提供了通过施用2'-5'寡聚腺苷酸-2'，3'-环磷酸酯化合物治疗需要这种治疗的受试者的疱疹感染的方法。还提供了包含2'-5'寡腺苷酸2'，3'-环磷酸的药物制剂及其化合物。

7. 发明授权

US06468991B1 Method of treating rhinoviral infections 失效
标题翻译：治疗鼻病毒感染的方法
公开(公告)号：US06468991B1
公开(公告)日：2002-10-22
申请号：US08784229
申请日：1997-01-16
申请人： Edward I. Budowsky , Samuel K. Ackerman
发明人： Edward I. Budowsky , Samuel K. Ackerman
IPC分类号： A61K31675
CPC分类号： A61K31/7048 , A61K31/7076 , A61K31/7125
摘要： The present invention provides methods for treating rhinoviral infections in a subject in need of such treatment, by the administration of 2′-5′ oligoadenylates or the analogs thereof. Pharmaceutical formulations comprising 2′-5′ oligoadenylates and analogs thereof are also provided.
摘要翻译：本发明提供了通过施用2'-5'寡聚腺苷酸或其类似物来治疗需要这种治疗的受试者的鼻病毒感染的方法。还提供了包含2'-5'寡聚腺苷酸及其类似物的药物制剂。

8. 发明授权

US06352695B1 Methods and compositions for the selective modification of nucleic acids 失效
标题翻译：用于选择性修饰核酸的方法和组合物
公开(公告)号：US06352695B1
公开(公告)日：2002-03-05
申请号：US08943643
申请日：1997-10-03
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
IPC分类号： A61K3912
CPC分类号： C12N7/00 , A61L2/0082 , A61L2/0088 , C12N2740/16063 , C12N2760/16163 , C12N2760/20263 , C12N2770/32363
摘要： Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: where each of R1, R2, R3, R4, R6, R7, and R8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R1, R2, R3, R4, R6, R7, and R8 cannot all be H; R5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 2 and 10, inclusive are disclosed.
摘要翻译：用于选择性修饰生物组合物中核酸分子的方法和组合物，包括使组合物与具有下式的灭活剂接触：其中R 1，R 2，R 3，R 4，R 6，R 7和R 8各自独立地为H或单价含有1至4个碳原子的烃部分（包括端值），条件是R1，R2，R3，R4，R6，R7和R8不能全部为H; R5是含有2至4个碳原子的二价烃部分，包括端值; X是药学上可接受的抗衡离子; n为2〜10的整数，包括端值。

9. 发明授权

US5837240A Multimeric, recombinant urease vaccine 失效
标题翻译：多聚重组脲酶疫苗
公开(公告)号：US5837240A
公开(公告)日：1998-11-17
申请号：US920095
申请日：1997-08-26
申请人： Cynthia K. Lee , Thomas P. Monath , Samuel K. Ackerman , William D. Thomas , Gopalan Soman , Harold Kleanthous , Richard A. Weltzin , Jacques Pappo , Thomas Ermak , Farshad Guirakhoo , Hitesh Bhagat , Ilene Sussman
发明人： Cynthia K. Lee , Thomas P. Monath , Samuel K. Ackerman , William D. Thomas , Gopalan Soman , Harold Kleanthous , Richard A. Weltzin , Jacques Pappo , Thomas Ermak , Farshad Guirakhoo , Hitesh Bhagat , Ilene Sussman
IPC分类号： A61K38/46 , A61K39/02 , A61K39/106
CPC分类号： A61K39/105 , Y10S514/925 , Y10S514/926 , Y10S514/927
摘要： Methods and compositions are provided for prophylactic and antibacterial therapy for Helicobacter, particularly for Helicobacter pylori, infection of humans. The immunogenic composition of the invention is composed of a plurality of multimeric complexes, each complex being composed of recombinant, enzymatically inactive Helicobacter pylori urease. Each multimeric complex is composed of six Urease A subunits and six Urease B subunits. Alternatively, the composition is composed of a mixture of multimeric complexes, wherein each multimeric complex in the mixture is composed of six Urease A subunits and six Urease B subunits or four Urease A subunits and four Urease B subunits.
摘要翻译：提供了用于幽门螺杆菌的预防和抗菌治疗的方法和组合物，特别是用于幽门螺杆菌，人的感染。本发明的免疫原性组合物由多个多聚体复合物组成，每个复合物由重组的酶促活化的幽门螺旋杆菌脲酶组成。每个多聚体复合物由六个脲酶A亚基和六个脲酶B亚基组成。或者，组合物由多聚体复合物的混合物组成，其中混合物中的每个多聚复合物由六个脲酶A亚基和六个脲酶B亚基或四个脲酶A亚基和四个脲酶B亚基组成。

10. 发明授权

US06720136B2 Solid phase quenching systems 失效
标题翻译：固相淬火系统
公开(公告)号：US06720136B2
公开(公告)日：2004-04-13
申请号：US10166898
申请日：2002-06-11
申请人： Andrei A. Purmal , Samuel K. Ackerman
发明人： Andrei A. Purmal , Samuel K. Ackerman
IPC分类号： C12N706
CPC分类号： C07F9/1651 , A01N1/0205 , A01N1/0215 , A01N1/0278 , A61K35/14 , A61K35/16 , A61M1/3687
摘要： Methods of inactivating contaminants of a biological matrix are disclosed. The methods include the steps of: (a) contacting a biological matrix with an inactivating agent including an aziridino moiety, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a solid support including at least 1 quenching moiety attached to the solid support through covalent bonds, under conditions and for a time sufficient to allow the unreacted agent to bond covalently to the quenching moiety; and (c) separating the solid support and the unreacted agent from the biological matrix, where the unreacted agent is attached to the solid support through covalent bonds.
摘要翻译：公开了灭活生物基质污染物的方法。所述方法包括以下步骤：（a）使生物基质与包含氮丙啶基部分的灭活剂接触，其中所述试剂的一部分与污染物反应并灭活，并且所述试剂的一部分保持未反应; （b）在足以允许未反应的试剂共价键合到猝灭部分的条件下和足以使未反应的试剂共价键合的步骤（a）的产物与包含至少1个通过共价键连接至固体支持物的猝灭部分的固体支持物接触; 和（c）将固体载体和未反应的试剂从生物基质中分离，其中未反应的试剂通过共价键连接到固体支持物上。

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