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1. 发明授权

US06617157B1 Methods and compositions for the selective modification of nucleic acids 失效
公开(公告)号：US06617157B1
公开(公告)日：2003-09-09
申请号：US09212778
申请日：1998-12-16
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
IPC分类号： A61K3900
CPC分类号： C12N7/00 , A61L2/0082 , A61L2/0088 , C12N2740/16063 , C12N2760/16163 , C12N2760/20263 , C12N2770/32363 , C12N2770/32463 , C12N2795/10163
摘要： Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: where each of R1, R2, R3, R4, R6, R7, and R8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R1, R2, R3, R4, R6, R7, and R8 cannot all be H; R5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 2 and 10, inclusive are disclosed.

2. 发明授权

US06774123B1 Methods and compositions for inactivating viruses 失效
标题翻译：用于灭活病毒的方法和组合物
公开(公告)号：US06774123B1
公开(公告)日：2004-08-10
申请号：US09362337
申请日：1999-07-28
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson , Martin D. Williams
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson , Martin D. Williams
IPC分类号： A61K3183
CPC分类号： A61K31/661 , A61K31/075 , A61K31/14 , A61K31/396 , A61K31/7024 , A61L2/0088 , Y02A50/397
摘要： Methods and compositions for selectively inactivating viruses in biological compositions, including contacting the composition with an organic solvent and an ethyleneimine oligomer inactivating agent, are disclosed.
摘要翻译：公开了用于选择性灭活生物组合物中的病毒的方法和组合物，包括使组合物与有机溶剂和乙烯亚胺低聚物灭活剂接触。

3. 发明授权

US06720136B2 Solid phase quenching systems 失效
标题翻译：固相淬火系统
公开(公告)号：US06720136B2
公开(公告)日：2004-04-13
申请号：US10166898
申请日：2002-06-11
申请人： Andrei A. Purmal , Samuel K. Ackerman
发明人： Andrei A. Purmal , Samuel K. Ackerman
IPC分类号： C12N706
CPC分类号： C07F9/1651 , A01N1/0205 , A01N1/0215 , A01N1/0278 , A61K35/14 , A61K35/16 , A61M1/3687
摘要： Methods of inactivating contaminants of a biological matrix are disclosed. The methods include the steps of: (a) contacting a biological matrix with an inactivating agent including an aziridino moiety, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a solid support including at least 1 quenching moiety attached to the solid support through covalent bonds, under conditions and for a time sufficient to allow the unreacted agent to bond covalently to the quenching moiety; and (c) separating the solid support and the unreacted agent from the biological matrix, where the unreacted agent is attached to the solid support through covalent bonds.
摘要翻译：公开了灭活生物基质污染物的方法。所述方法包括以下步骤：（a）使生物基质与包含氮丙啶基部分的灭活剂接触，其中所述试剂的一部分与污染物反应并灭活，并且所述试剂的一部分保持未反应; （b）在足以允许未反应的试剂共价键合到猝灭部分的条件下和足以使未反应的试剂共价键合的步骤（a）的产物与包含至少1个通过共价键连接至固体支持物的猝灭部分的固体支持物接触; 和（c）将固体载体和未反应的试剂从生物基质中分离，其中未反应的试剂通过共价键连接到固体支持物上。

4. 发明授权

US06403359B1 Solid phase quenching systems 失效
公开(公告)号：US06403359B1
公开(公告)日：2002-06-11
申请号：US09161078
申请日：1998-09-25
申请人： Andrei A. Purmal , Samuel K. Ackerman
发明人： Andrei A. Purmal , Samuel K. Ackerman
IPC分类号： C12N706
CPC分类号： C07F9/1651 , A01N1/0205 , A01N1/0215 , A01N1/0278 , A61K35/14 , A61K35/16 , A61M1/3687
摘要： Methods of inactivating contaminants of a biological matrix are disclosed. The methods include the steps of: (a) contacting a biological matrix with an inactivating agent including an aziridino moiety, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a solid support including at least 1 quenching moiety attached to the solid support through covalent bonds, under conditions and for a time sufficient to allow the unreacted agent to bond covalently to the quenching moiety; and (c) separating the solid support and the unreacted agent from the biological matrix, where the unreacted agent is attached to the solid support through covalent bonds.

5. 发明授权

US06369048B1 Methods and compositions for inactivating viruses 失效
标题翻译：用于灭活病毒的方法和组合物
公开(公告)号：US06369048B1
公开(公告)日：2002-04-09
申请号：US09005719
申请日：1998-01-12
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson , Martin D. Williams
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson , Martin D. Williams
IPC分类号： A61K3133
CPC分类号： A61K31/661 , A61K31/075 , A61K31/14 , A61K31/396 , A61K31/7024 , A61L2/0088 , Y02A50/397
摘要： Methods and compositions for selectively inactivating viruses in biological compositions, including contacting the composition with an organic solvent and an ethyleneimine oligomer inactivating agent, are disclosed.
摘要翻译：公开了用于选择性灭活生物组合物中的病毒的方法和组合物，包括使组合物与有机溶剂和乙烯亚胺低聚物灭活剂接触。

6. 发明授权

US6093564A Methods and compositions for the selective modification of nucleic acids 失效
标题翻译：用于选择性修饰核酸的方法和组合物
公开(公告)号：US6093564A
公开(公告)日：2000-07-25
申请号：US5606
申请日：1998-01-12
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
IPC分类号： C12N7/04 , A61K31/396 , A61K38/00 , A61K39/00 , A61K39/12 , A61L2/00 , A61P31/00 , A61P31/12 , A61P43/00 , C07D203/02 , C07D203/12 , C12N7/06 , C12N7/00
CPC分类号： C12N7/00 , A61L2/0082 , A61L2/0088 , C12N2740/16063 , C12N2760/16163 , C12N2760/20263 , C12N2770/32363 , C12N2770/32463 , C12N2795/10163
摘要： Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: ##STR1## where each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, and R.sub.8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, and R.sub.8 cannot all be H; R.sub.5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 1 and 10, inclusive are disclosed.
摘要翻译：用于选择性修饰生物组合物中核酸分子的方法和组合物，包括使组合物与具有下式的灭活剂接触：其中R1，R2，R3，R4，R6，R7和R8各自独立地为H或单价含有1至4个碳原子的烃部分（包括端值），条件是R1，R2，R3，R4，R6，R7和R8不能全部为H; R5是含有2至4个碳原子的二价烃部分，包括端值; X是药学上可接受的抗衡离子; n为1〜10的整数，包括端值。

7. 发明授权

US06617101B1 Lipophilic quenching of viral inactivating agents 失效
标题翻译：病毒灭活剂的亲脂性猝灭
公开(公告)号：US06617101B1
公开(公告)日：2003-09-09
申请号：US09656243
申请日：2000-09-06
申请人： Clark M. Edson , Andrei A. Purmal , Samuel K. Ackerman
发明人： Clark M. Edson , Andrei A. Purmal , Samuel K. Ackerman
IPC分类号： A01N102
CPC分类号： C12N7/00 , C12N2700/00 , C12Q2549/125
摘要： Methods and compositions for the inactivation and removal of contaminants of a biological composition are disclosed. The methods include the steps of: (a) contacting the biological composition with an inactivating agent including an aziridino moiety, such as ethyleneimine, an oligomer of ethyleneimine, or a haloderivative salt of either ethyleneimine or an oligomer of ethyleneimine, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a lipophilic quenching agent including at least one quenching moiety attached to a lipophilic moiety, under conditions and for a time sufficient to allow the unreacted agent to bond covalently to the quenching moiety; and (c) separating the lipophilic quenching agent and the quenched inactivating agent from the biological composition.
摘要翻译：公开了用于灭活和去除生物组合物污染物的方法和组合物。所述方法包括以下步骤：（a）使生物组合物与灭活剂接触，所述灭活剂包括氮丙啶基部分，例如乙烯亚胺，乙烯亚胺的低聚物，乙烯亚胺或乙烯亚胺的低聚物的卤化还原盐，其中一部分药剂与污染物反应并灭活，并且一部分药剂保持未反应; （b）在足以允许未反应的试剂共价键合到猝灭部分的条件下和足够长的时间使步骤（a）的产物与包含至少一个与亲油部分连接的猝灭部分的亲脂性猝灭剂接触; 和（c）从生物组合物中分离亲脂性猝灭剂和淬灭的灭活剂。

8. 发明授权

US06617100B2 Solid phase quenching systems 失效
标题翻译：固相淬火系统
公开(公告)号：US06617100B2
公开(公告)日：2003-09-09
申请号：US09260375
申请日：1999-03-01
申请人： Andrei A. Purmal , Samuel K. Ackerman
发明人： Andrei A. Purmal , Samuel K. Ackerman
IPC分类号： C12N706
CPC分类号： C07F9/1651 , A01N1/0215 , A01N1/0231 , A61K35/14 , A61K35/16 , A61M1/3687
摘要： The invention features a method of inactivating a contaminant, such as a virus, of a biological composition. The method includes the steps of: (a) contacting the biological composition with an inactivating agent including an aziridino moiety or a haloderivative salt thereof, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a composition which includes one quenching moiety under conditions and for a time sufficient to allow the inactivating agent to bond covalently to the quenching moiety; and (c) separating the quenching moiety and the quenched inactivating agent from the biological composition.
摘要翻译：本发明的特征在于使生物组合物的污染物如病毒灭活的方法。该方法包括以下步骤：（a）使生物组合物与包含氮丙啶基部分或其卤代衍生盐的灭活剂接触，其中一部分试剂与污染物反应并使其失活，并且一部分试剂保持未反应; （b）使步骤（a）的产物与包含一个猝灭部分的组合物在足以允许失活剂与猝灭部分共价键合的条件下进行接触; 和（c）从生物组合物中分离淬灭部分和淬灭的灭活剂。

9. 发明授权

US06352695B1 Methods and compositions for the selective modification of nucleic acids 失效
标题翻译：用于选择性修饰核酸的方法和组合物
公开(公告)号：US06352695B1
公开(公告)日：2002-03-05
申请号：US08943643
申请日：1997-10-03
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
IPC分类号： A61K3912
CPC分类号： C12N7/00 , A61L2/0082 , A61L2/0088 , C12N2740/16063 , C12N2760/16163 , C12N2760/20263 , C12N2770/32363
摘要： Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: where each of R1, R2, R3, R4, R6, R7, and R8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R1, R2, R3, R4, R6, R7, and R8 cannot all be H; R5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 2 and 10, inclusive are disclosed.
摘要翻译：用于选择性修饰生物组合物中核酸分子的方法和组合物，包括使组合物与具有下式的灭活剂接触：其中R 1，R 2，R 3，R 4，R 6，R 7和R 8各自独立地为H或单价含有1至4个碳原子的烃部分（包括端值），条件是R1，R2，R3，R4，R6，R7和R8不能全部为H; R5是含有2至4个碳原子的二价烃部分，包括端值; X是药学上可接受的抗衡离子; n为2〜10的整数，包括端值。

10. 发明授权

US6150109A Lipophilic quenching of viral inactivating agents 失效
公开(公告)号：US6150109A
公开(公告)日：2000-11-21
申请号：US237136
申请日：1999-01-25
申请人： Clark M. Edson , Andrei A. Purmal , Samuel K. Ackerman
发明人： Clark M. Edson , Andrei A. Purmal , Samuel K. Ackerman
IPC分类号： C12N7/04 , A61K35/14 , A61K35/20 , A61K35/24 , A61K35/26 , A61K35/50 , A61K35/52 , A61K38/00 , A61P31/12 , C07D203/06 , C07D203/12 , C07F9/165 , C07F9/6539 , C07K14/47 , C12N7/06 , C12R1/92 , C12Q1/68 , A61K48/00 , C07H21/04
CPC分类号： C12N7/00 , C12N2700/00 , C12Q2549/125
摘要： Methods and compositions for the inactivation and removal of contaminants of a biological composition are disclosed. The methods include the steps of: (a) contacting the biological composition with an inactivating agent including an aziridino moiety, such as ethyleneimine, an oligomer of ethyleneimine, or a haloderivative salt of either ethyleneimine or an oligomer of ethyleneimine, where a portion of the agent reacts with and inactivates the contaminant, and a portion of the agent remains unreacted; (b) contacting the product of step (a) with a lipophilic quenching agent including at least one quenching moiety attached to a lipophilic moiety, under conditions and for a time sufficient to allow the unreacted agent to bond covalently to the quenching moiety; and (c) separating the lipophilic quenching agent and the quenched inactivating agent from the biological composition.

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