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1. 发明公开

CN1140410A 维生素E及其衍生物防止经酞菁和光线消毒的红细胞的损伤无效
公开(公告)号：CN1140410A
公开(公告)日：1997-01-15
申请号：CN95191495.2
申请日：1995-02-03
申请人：纽约血库公司
发明人： E·本-赫 , S·赖克恩 , B·霍罗韦茨
IPC分类号： A61K31/355 , A61K41/00 , C07D311/76 , C12N7/04 , C12N13/00
CPC分类号： A61L2/0047 , A61K31/355 , A61K35/18 , A61K41/0019 , A61K41/0023 , A61K41/0038 , A61K41/0042 , A61K41/0071 , A61L2/0011 , A61L2/0035 , A61L2/0052 , A61L2/0076 , A61L2/08 , A61L2/10 , A61L2202/22 , C12N7/00 , C12N13/00 , C12N2760/20261 , C12N2760/20263
摘要：本发明公开了一种照射含细胞组合物(特别是含红细胞组合物)的改良方法，其中在照射之前、期间或之后向含细胞组合物中加入维生素E或其衍生物。维生素E或其衍生物的加入对该组合物中的细胞有保护作用，但对病毒无保护作用。与经过其中不使用维生素E或其衍生物的相似方法处理的细胞比较，使用本发明方法照射的细胞表现出细胞中K+渗漏量的降低和细胞膜中负电荷丧失的减少。另外，用本方法消毒红血细胞在贮存期间更易保存并且其在活体内的循环寿命也得到了极大提高。

2. 发明公开

CN103570823A 从含白蛋白的溶液制备白蛋白的方法和在含白蛋白的溶液中使用辛酸盐使病毒灭活的方法无效复审申请
公开(公告)号：CN103570823A
公开(公告)日：2014-02-12
申请号：CN201310306682.4
申请日：2013-07-19
申请人：基立福有限公司
发明人：莱宾·威托尔德 , 伯恩斯·道格 , 罗思·纳坦 , 霍塔·约安
IPC分类号： C07K14/765 , C12N7/06
CPC分类号： A01N37/02 , C07K14/76 , C12N7/00 , C12N2760/20263 , C12N2770/24363 , C07K14/765 , C12N7/06
摘要：本文中所描述的是从包含白蛋白的溶液制备白蛋白的方法和在包含白蛋白的溶液中使用辛酸盐使病毒灭活的方法。从包含白蛋白的溶液制备白蛋白的方法包括：调节该溶液的蛋白质浓度至低于5%；调节该溶液的pH至pH5以下；加入辛酸或辛酸钠；提高溶液温度高于20°C；和温育该溶液。

3. 发明公开

CN1129139A 吡咯类在生物活性蛋白溶液中作为杀病毒剂的用途无效
公开(公告)号：CN1129139A
公开(公告)日：1996-08-21
申请号：CN95105157.1
申请日：1995-04-10
申请人：美国拜尔公司
发明人： M·B·多布金 , P·K·吴 , G·B·达夫
IPC分类号： A61K38/00 , A61K39/395 , A61K35/14 , A01N43/50
CPC分类号： C12N7/00 , A61L2/0088 , C12N2720/12063 , C12N2760/20263 , C12N2770/32663
摘要：在水溶液中利用可溶性吡咯作为生物学活性蛋白制剂的杀病毒剂。

4. 发明公开

CN105121636A 非复制型病毒衍生颗粒及其用途无效
公开(公告)号：CN105121636A
公开(公告)日：2015-12-02
申请号：CN201380071341.1
申请日：2013-12-20
申请人：渥太华医院研究所
发明人：大卫·康拉德 , 科里·巴滕舒克 , 法布里斯·勒伯夫 , 约翰·卡梅伦·贝尔
IPC分类号： C12N7/06 , A61K35/768 , A61P35/00
CPC分类号： A61K35/766 , A61K45/06 , C07K14/005 , C12N7/00 , C12N7/045 , C12N7/06 , C12N2760/20021 , C12N2760/20032 , C12N2760/20061 , C12N2760/20222 , C12N2760/20232 , C12N2760/20261 , C12N2760/20263 , A61K2300/00
摘要：本文中描述了缺乏在细胞之间扩散的能力并对永生化细胞具有向性的非复制型弹状病毒衍生颗粒。所述非复制型弹状病毒衍生颗粒可具有对永生化细胞的溶细胞向性。还描述了缺乏在细胞之间扩散的能力但具有先天性和/或适应性免疫刺激特性的非复制型弹状病毒衍生颗粒。

5. 发明申请

WO1994028120A1 PROCESS FOR THE STERILIZATION OF BIOLOGICAL COMPOSITIONS AND THE PRODUCT PRODUCED THEREBY 审中-公开
标题翻译：生物组合物灭菌和生产产品的方法
公开(公告)号：WO1994028120A1
公开(公告)日：1994-12-08
申请号：PCT/US1994006077
申请日：1994-05-27
申请人： NEW YORK BLOOD CENTER, INC.
发明人： NEW YORK BLOOD CENTER, INC. , HOROWITZ, Bernard , WILLIAMS, Bolanle , MARGOLIS-NUNNO, Henrietta , CHIN, Sing, N.
IPC分类号： C12N13/00
CPC分类号： A61K41/0019 , A61K41/0023 , A61K41/0038 , A61K41/0057 , A61K41/0066 , A61K41/0071 , A61L2/0011 , A61L2/0082 , C12N7/00 , C12N2760/20263 , C12N2770/32663 , C12N2795/10163
摘要： The present invention concerns the product produced by inactivating exracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or inactivation of cells and without significant loss of labile proteins or other valuable biological components also contained therein, the inactivation process comprising subjecting said composition to a virucidally effective amount of irradiation in the presence of (a) a mixture of a compound that quenches type (I) photodynamic reactions and a compound that quenches type (II) photodynatic reactions of (b) a bifunctional compound that is capable of quenching both type (I) and type (II) reactions, to thereby inactivate said virus while retaining functionality of said composition. The composition is advantageously subjected to the irradiation and the mixture of compounds or bifunctional compound in the presence of an irradiation sensitizer. Moreover, the process can be advantageously combined with a different virucidal method to enhance virus inactivation.
摘要翻译：本发明涉及通过在生物组合物中灭活细胞内或细胞内病原体病毒而产生的产物，而不会导致细胞的实质性破坏或灭活，并且不含有其中还含有的不稳定蛋白质或其它有价值的生物成分的显着损失，所述灭活方法包括将所述组合物在（a）猝灭类型（I）光动力学反应的化合物和猝灭类型（II）光动力学反应的化合物的混合物（b）能够淬灭两者的双功能化合物的存在下的杀病毒有效量的照射类型（I）和类型（II）反应，从而使所述病毒灭活同时保留所述组合物的功能。组合物有利地在照射敏化剂的存在下进行照射和化合物或双官能化合物的混合物。此外，该方法可以有利地与不同的杀病毒方法组合以增强病毒灭活。

6. 发明授权

EP0457196B1 Photodynamic inactivation of viruses in cell-containing compositions 失效
标题翻译：在细胞组合物的光动力病毒灭活
公开(公告)号：EP0457196B1
公开(公告)日：2001-08-22
申请号：EP91107556.2
申请日：1991-05-09
申请人： New York Blood Center, Inc.
发明人： Horowitz, Bernard , Valinski, Jay E. , Geacintov, Nicholas E. , Williams, Bolanle , Rywkin, Shanti B. , Nunno, Henrietta
IPC分类号： C12N7/04 , A61L2/00 , A61L2/08 , A61K41/00
CPC分类号： A61L2/0052 , A61K41/0019 , A61K41/0023 , A61K41/0038 , A61K41/0071 , A61L2/0011 , A61L2/10 , A61L2202/22 , C12N7/00 , C12N7/06 , C12N2760/20263
摘要： The present invention concerns the product produced by inactivating extracellular lipid enveloped pathogenic virus or intracellular pathogenic virus in a composition containing >1 X 10 cells/ml and said virus without incurring substantial disruption or inactivation of such cells, the inactivation process comprising contacting the composition with a virucidally effective amount of at least one photoreactive compound having an absorption maximum of >/= 630 nm, light and an oxidizer, thereby substantially to inactivate the virus with retention of cell functionality, greater than 80%. The present invention also concerns the product produced by inactivating virus in a biological composition without incurring substantial disruption or inactivation thereof, the inactivation process comprising contacting said composition with a virucidally effective amount of at least one photoreactive compound, light, and a quencher thereby to inactivate said virus while retaining functionality of said substance.

7. 发明公开

EP0796094A1 VITAMIN E AND DERIVATIVES PREVENT DAMAGE IN RED CELLS STERILIZED BY PHTHALOCYANINES AND LIGHT 失效
标题翻译：维生素E及其衍生物防止用灭菌酞菁和淡红色的血细胞的损伤
公开(公告)号：EP0796094A1
公开(公告)日：1997-09-24
申请号：EP95908792.0
申请日：1995-02-03
申请人： New York Blood Center, Inc.
发明人： BEN-HUR, Ehud , RYWKIN, Shanti , HOROWITZ, Bernard
IPC分类号： A61K31 , A61K35 , A61K41 , A61L2 , A61P7 , A61P31 , C07D311 , C07D487 , C12N7 , C12N13
CPC分类号： A61L2/0047 , A61K31/355 , A61K35/18 , A61K41/0019 , A61K41/0023 , A61K41/0038 , A61K41/0042 , A61K41/0071 , A61L2/0011 , A61L2/0035 , A61L2/0052 , A61L2/0076 , A61L2/08 , A61L2/10 , A61L2202/22 , C12N7/00 , C12N13/00 , C12N2760/20261 , C12N2760/20263
摘要： An improved process is disclosed for photodynamically inactivating viruses in red blood cell containing compositions by adding vitamin E or a derivative thereof, such as Trolox, to the red blood cell and photosensitizer containing composition prior to irradiation. Addition of vitamin E or derivative thereof is protective of the red blood cells but not the viruses to be inactivated. Cells irradiated in this manner exhibit reduced leakage of potassium ion, and reduced loss of negative charges from the cell membrane compared to cells treated in the absence of vitamin E or derivative. Red blood cells sterilized by this method are better preserved during storage and their life-time in the circulation in vivo is enhanced.

8. 发明申请

US20040053316A1 Methods and compositions for the selective modification of nucleic acids 审中-公开
标题翻译：用于选择性修饰核酸的方法和组合物
公开(公告)号：US20040053316A1
公开(公告)日：2004-03-18
申请号：US10653782
申请日：2003-09-03
申请人： V.I. Technologies, Inc.
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
IPC分类号： C12Q001/68 , C07H021/04 , A61K031/396
CPC分类号： C12N7/00 , A61L2/0082 , A61L2/0088 , C12N2740/16063 , C12N2760/16163 , C12N2760/20263 , C12N2770/32363 , C12N2770/32463 , C12N2795/10163
摘要： Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: 1 where each of R1, R2, R3, R4, R6, R7, and R8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R1, R2, R3, R4, R6, R7, and R8 cannot all be H; R5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 2 and 10, inclusive are disclosed.
摘要翻译：用于选择性修饰生物组合物中核酸分子的方法和组合物，包括使组合物与具有下式的灭活剂接触：其中R1，R2，R3，R4，R6，R7和R8各自独立地为H或单价含有1至4个碳原子的烃部分（包括端值），条件是R1，R2，R3，R4，R6，R7和R8不能全部为H; R5是含有2至4个碳原子的二价烃部分，包括端值; X是药学上可接受的抗衡离子; n为2〜10的整数，包括端值。

9. 发明申请

US20030202986A1 Methods and compositions for the selective modification of nucleic 审中-公开
标题翻译：用于选择性修饰核酸的方法和组合物
公开(公告)号：US20030202986A1
公开(公告)日：2003-10-30
申请号：US10406875
申请日：2003-04-04
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
IPC分类号： A61K039/12 , C07H021/04 , A61M031/00 , A61K031/396
CPC分类号： C12N7/00 , A61L2/0082 , A61L2/0088 , C12N2740/16063 , C12N2760/16163 , C12N2760/20263 , C12N2770/32363
摘要： Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: 1 where each of R1, R2, R3, R4, R6, R7, and R8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R1, R2, R3, R4, R6, R7, and R8 cannot all be H; R5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 2 and 10, inclusive are disclosed.
摘要翻译：用于选择性修饰生物组合物中核酸分子的方法和组合物，包括使组合物与具有下式的灭活剂接触：其中R 1，R 2，R 3，R 4，R 6，R 7和R 8各自独立地为H 或含有1至4个碳原子的单价烃部分（包括端值），条件是R 1，R 2，R 3，R 4，R 6，R 7和R 8不能全部为H; R5是含有2至4个碳原子的二价烃部分，包括端值; X是药学上可接受的抗衡离子; n为2〜10的整数，包括端值。

10. 发明授权

US06294361B1 Processes for photoreactive inactivation of a virus in blood cell or coagulation factor containing compositions and use thereof for preparing compositions useful for transfusion 失效
标题翻译：用于血液细胞中的病毒的光反应灭活或含凝血因子的组合物的方法及其用于制备用于输血的组合物的用途
公开(公告)号：US06294361B1
公开(公告)日：2001-09-25
申请号：US08958768
申请日：1997-10-26
申请人： Bernard Horowitz , Jay E. Valinsky , Nicholas E. Geacintov , Bolanle Williams , Shanti B. Rywkin , Henrietta Nunno
发明人： Bernard Horowitz , Jay E. Valinsky , Nicholas E. Geacintov , Bolanle Williams , Shanti B. Rywkin , Henrietta Nunno
IPC分类号： C12N1300
CPC分类号： C12N7/00 , A61K41/0019 , A61K41/0023 , A61K41/0038 , A61L2/0011 , C12N2740/16063 , C12N2760/20263
摘要： The present invention concerns a process for inactivating an extracellular lipid enveloped human pathogenic virus and/or an intracellular human pathogenic virus which may be present in a blood cell composition containing ≧1×109 cells/ml by contacting that composition with a virucidally effective amount of at least one photoreactive compound having an absorption maximum of ≧630 nm, light and oxygen and/or a quencher. In one embodiment of the invention, the process is conducted under conditions whereby a structural integrity of greater than 80% of at least one type of blood cell contained within said composition is retained. Another embodiment of the invention relates to a process for inactivating an extracellular lipid enveloped human pathogenic virus and/or an intracellular human pathogenic virus which may be present in a composition containing at least one coagulation factor while retaining at least 77% of said coagulation factor by contacting said composition with a virucidally effective amount of at least one photoreactive compound, light and a quencher. The processes of the invention can be used to prepare blood products, which, in turn, are suitable for transfusion into a recipient in need of such transfusion.
摘要翻译：本发明涉及一种灭活细胞外脂质包膜的人类病原体病毒和/或细胞内人类病原体病毒的方法，该方法可以存在于含有≥1×10 9个细胞/ ml的血液细胞组合物中，通过使该组合物与病毒有效量的至少一种光吸收最大值> 630nm的光反应性化合物，光和氧和/或猝灭剂。在本发明的一个实施方案中，该方法在保持所述组合物中所含的至少一种类型的血细胞的大于80％的结构完整性的条件下进行。本发明的另一个实施方案涉及用于灭活细胞外脂质包膜的人类病原体病毒和/或细胞内人致病性病毒的方法，所述细胞外脂质包封的人类病原体病毒和/或细胞内人致病性病毒可存在于含有至少一种凝血因子的组合物中，同时将至少77％的所述凝血因子保留使所述组合物与杀病毒有效量的至少一种光反应性化合物，光和猝灭剂接触。本发明的方法可以用于制备血液制品，血液制品又适合于输血到需要这种输血的接受者中。

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