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1. 发明公开

CN106177938A 鸭病毒性肝炎二价灭活疫苗及其制备方法无效
公开(公告)号：CN106177938A
公开(公告)日：2016-12-07
申请号：CN201610781512.5
申请日：2016-08-30
申请人：哈药集团生物疫苗有限公司
发明人：宋扬 , 藏玉婷 , 郑铁鑫 , 尹尧 , 丁国杰 , 梁宛楠 , 王彬 , 张凤强
IPC分类号： A61K39/295 , A61K39/29 , A61P31/14 , C12N7/06
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/70 , C12N7/00 , C12N2770/32434 , C12N2770/32463
摘要：本发明公开了一种鸭病毒性肝炎二价灭活疫苗及其制备方法，属于鸭病毒性肝炎二价灭活疫苗的制备领域。本发明首先公开了一种鸭病毒性肝炎二价灭活疫苗，包括：鸭肝炎病毒SD株灭活疫苗和鸭肝炎病毒JS株灭活疫苗。本发明所述鸭病毒性肝炎二价灭活疫苗的安全性好，免疫后诱导的中和抗体效价高于单价疫苗，而且雏鸭的被动保护期长，对种鸭的免疫持续期长达5个月，能够有针对性的防治1型和3型鸭甲肝病毒引起的鸭病毒性肝炎。本发明进一步公开了一种所述鸭病毒性肝炎二价灭活疫苗的制备方法，包括：将鸭肝炎病毒SD株灭活疫苗和鸭肝炎病毒JS株灭活疫苗混合均匀，即得。本发明鸭病毒性肝炎二价灭活疫苗的制备方法简单，能够规模化生产。

2. 发明授权

US06991929B1 Hepatitis A vaccines 失效
标题翻译：甲型肝炎疫苗
公开(公告)号：US06991929B1
公开(公告)日：2006-01-31
申请号：US09807659
申请日：1999-10-08
申请人： Erik D′Hondt
发明人： Erik D′Hondt
IPC分类号： C12N7/02
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55572 , A61K2039/70 , C12N2730/10134 , C12N2770/32434 , C12N2770/32451 , C12N2770/32463 , C12N2770/32471
摘要： A process for the production of inactivated Hepatitis A virus substantially free of host cell contamination is described, the process comprising: a) culturing Hepatitis A virus and harvesting a Hepatitis A preparation; b) treating said Hepatitis A preparation with a protease; and thereafter c) separating intact virus from protease digested material; d) inactivating said virus. Also described are vaccines comprising the inactivated Hepatitis A virus, preferably in combination with strong adjuvants.
摘要翻译：描述了生产基本上不含宿主细胞污染的灭活的甲型肝炎病毒的方法，该方法包括：a）培养甲型肝炎病毒并收获甲型肝炎制剂; b）用蛋白酶处理所述甲型肝炎制剂; 然后c）将完整的病毒与蛋白酶消化的材料分离; d）使所述病毒失活。还描述了包含灭活的甲型肝炎病毒的疫苗，优选与强佐剂组合。

3. 发明授权

US6093564A Methods and compositions for the selective modification of nucleic acids 失效
标题翻译：用于选择性修饰核酸的方法和组合物
公开(公告)号：US6093564A
公开(公告)日：2000-07-25
申请号：US5606
申请日：1998-01-12
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
IPC分类号： C12N7/04 , A61K31/396 , A61K38/00 , A61K39/00 , A61K39/12 , A61L2/00 , A61P31/00 , A61P31/12 , A61P43/00 , C07D203/02 , C07D203/12 , C12N7/06 , C12N7/00
CPC分类号： C12N7/00 , A61L2/0082 , A61L2/0088 , C12N2740/16063 , C12N2760/16163 , C12N2760/20263 , C12N2770/32363 , C12N2770/32463 , C12N2795/10163
摘要： Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: ##STR1## where each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, and R.sub.8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, and R.sub.8 cannot all be H; R.sub.5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 1 and 10, inclusive are disclosed.
摘要翻译：用于选择性修饰生物组合物中核酸分子的方法和组合物，包括使组合物与具有下式的灭活剂接触：其中R1，R2，R3，R4，R6，R7和R8各自独立地为H或单价含有1至4个碳原子的烃部分（包括端值），条件是R1，R2，R3，R4，R6，R7和R8不能全部为H; R5是含有2至4个碳原子的二价烃部分，包括端值; X是药学上可接受的抗衡离子; n为1〜10的整数，包括端值。

4. 发明申请

US20050112144A1 Hepatitis A vaccines 审中-公开
标题翻译：甲型肝炎疫苗
公开(公告)号：US20050112144A1
公开(公告)日：2005-05-26
申请号：US10878094
申请日：2004-06-28
申请人： Erik D'Hondt
发明人： Erik D'Hondt
IPC分类号： C12N7/06 , A61K39/29 , A61K39/295 , A61P1/16 , A61P31/12 , C12N7/02
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55572 , A61K2039/70 , C12N2730/10134 , C12N2770/32434 , C12N2770/32451 , C12N2770/32463 , C12N2770/32471
摘要： A process for the production of inactivated Hepatitis A virus substantially free of host cell contamination is described, the process comprising: a)culturing Hepatitis A virus and harvesting a Hepatitis A preparation; b) treating said Hepatitis A preparation with a protease; and thereafter c) separating intact virus from protease-digested material; d) inactivating said virus. Also described are vaccines comprising the inactivated Hepatitis A virus, preferably in combination with strong adjuvants.
摘要翻译：描述了生产基本上不含宿主细胞污染的灭活的甲型肝炎病毒的方法，该方法包括：a）培养甲型肝炎病毒并收获甲型肝炎制剂; b）用蛋白酶处理所述甲型肝炎制剂; 然后c）将完整病毒与蛋白酶消化的材料分离; d）使所述病毒失活。还描述了包含灭活的甲型肝炎病毒的疫苗，优选与强佐剂组合。

5. 发明申请

US20040053316A1 Methods and compositions for the selective modification of nucleic acids 审中-公开
标题翻译：用于选择性修饰核酸的方法和组合物
公开(公告)号：US20040053316A1
公开(公告)日：2004-03-18
申请号：US10653782
申请日：2003-09-03
申请人： V.I. Technologies, Inc.
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
IPC分类号： C12Q001/68 , C07H021/04 , A61K031/396
CPC分类号： C12N7/00 , A61L2/0082 , A61L2/0088 , C12N2740/16063 , C12N2760/16163 , C12N2760/20263 , C12N2770/32363 , C12N2770/32463 , C12N2795/10163
摘要： Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: 1 where each of R1, R2, R3, R4, R6, R7, and R8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R1, R2, R3, R4, R6, R7, and R8 cannot all be H; R5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 2 and 10, inclusive are disclosed.
摘要翻译：用于选择性修饰生物组合物中核酸分子的方法和组合物，包括使组合物与具有下式的灭活剂接触：其中R1，R2，R3，R4，R6，R7和R8各自独立地为H或单价含有1至4个碳原子的烃部分（包括端值），条件是R1，R2，R3，R4，R6，R7和R8不能全部为H; R5是含有2至4个碳原子的二价烃部分，包括端值; X是药学上可接受的抗衡离子; n为2〜10的整数，包括端值。

6. 发明公开

EP0915648A4 EP0915648A4 - 失效
标题翻译： EP0915648A4 - Google专利
公开(公告)号：EP0915648A4
公开(公告)日：1999-05-19
申请号：EP96929846
申请日：1996-08-29
IPC分类号： A61K38/00 , A61K35/14 , A61K35/16 , A61K35/50 , A61K35/52 , A61K38/16 , A61K38/21 , A61K38/22 , A61K38/27 , A61K38/28 , A61K38/43 , A61K39/00 , A61K39/12 , A61K39/125 , A61K39/145 , A61K39/15 , A61K39/155 , A61K39/21 , A61K39/215 , A61K39/23 , A61K39/235 , A61K39/245 , A61L2/00 , A61L2/16 , A61L2/18 , C07D203/08 , C07D203/12 , C12N5/00 , C12N7/06 , C12N15/12 , A01N1/00
CPC分类号： C12N7/00 , A61K39/00 , A61L2/0088 , A61L2/18 , C07D203/08 , C07D203/12 , C12N7/06 , C12N2730/10163 , C12N2740/16063 , C12N2770/32463 , C12N2795/18163
摘要： Inactivating viruses in a biological compsn. employs an ethyleneimine oligomer of formula (I) where n = 0-3. Also claimed are killed vaccines obtd. by inactivation with (I), devices for the treatment of blood or blood fractions and a method of immunizing a subject against a virus.

7. 发明授权

US06617157B1 Methods and compositions for the selective modification of nucleic acids 失效
公开(公告)号：US06617157B1
公开(公告)日：2003-09-09
申请号：US09212778
申请日：1998-12-16
申请人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
发明人： Edward I. Budowsky , Samuel K. Ackerman , Andrei A. Purmal , Clark M. Edson
IPC分类号： A61K3900
CPC分类号： C12N7/00 , A61L2/0082 , A61L2/0088 , C12N2740/16063 , C12N2760/16163 , C12N2760/20263 , C12N2770/32363 , C12N2770/32463 , C12N2795/10163
摘要： Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: where each of R1, R2, R3, R4, R6, R7, and R8 is, independently, H or a monovalent hydrocarbon moiety containing between 1 and 4 carbon atoms, inclusive, provided that R1, R2, R3, R4, R6, R7, and R8 cannot all be H; R5 is a divalent hydrocarbon moiety containing between 2 and 4 carbon atoms, inclusive; X is a pharmaceutically acceptable counter-ion; and n is an integer between 2 and 10, inclusive are disclosed.

8. 发明授权

US6114108A Methods and compositions for the selective modification of viral nucleic acids 失效
标题翻译：用于选择性修饰病毒核酸的方法和组合物
公开(公告)号：US6114108A
公开(公告)日：2000-09-05
申请号：US521245
申请日：1995-08-29
申请人： Edward I. Budowsky
发明人： Edward I. Budowsky
IPC分类号： A61K38/00 , A61K35/14 , A61K35/16 , A61K35/50 , A61K35/52 , A61K38/16 , A61K38/21 , A61K38/22 , A61K38/27 , A61K38/28 , A61K38/43 , A61K39/00 , A61K39/12 , A61K39/125 , A61K39/145 , A61K39/15 , A61K39/155 , A61K39/21 , A61K39/215 , A61K39/23 , A61K39/235 , A61K39/245 , A61L2/00 , A61L2/16 , A61L2/18 , C07D203/08 , C07D203/12 , C12N5/00 , C12N7/06 , C12N15/12 , A01N1/02
CPC分类号： C12N7/00 , A61K39/12 , A61L2/0088 , C07D203/08 , C07D203/12 , C12N2730/10163 , C12N2740/16063 , C12N2770/32463 , C12N2795/18163
摘要： The means and methods of inactivating viruses and other organisms in cell-containing or biopolymer-containing compositions comprising contacting such compositions with selective ethyleneimine oligomer inactivating agents are disclosed. The means and methods of this invention selectively modify functional nucleic acids in a cell-containing or biopolymer-containing composition using selective ethyleneimine oligomer inactivating agents, such as the trimer or tetramer without significant alteration of proteins or other biopolymers.
摘要翻译：公开了使包含含细胞或生物聚合物的组合物中的病毒和其它生物体灭活的方法和方法，包括使这些组合物与选择性乙烯亚胺低聚物灭活剂接触。本发明的方法和方法使用选择性乙烯亚胺低聚物失活剂（例如三聚体或四聚体）选择性地修饰含细胞或含生物聚合物的组合物中的功能性核酸，而不会显着改变蛋白质或其他生物聚合物。

9. 发明授权

US5663043A Method for inactivating non-enveloped viruses using a viricide-potentiating agent with a photoactivatible virucide 失效
标题翻译：使用杀病毒剂增强剂与光活化型病毒杀灭剂灭活非包膜病毒的方法
公开(公告)号：US5663043A
公开(公告)日：1997-09-02
申请号：US368780
申请日：1995-01-04
申请人： Charles M. Zepp , Donald L. Heefner
发明人： Charles M. Zepp , Donald L. Heefner
IPC分类号： A61L2/00 , C12N7/06 , A01N1/02
CPC分类号： C12N7/00 , A61L2/0011 , A61L2/0088 , C12N2710/10363 , C12N2750/14363 , C12N2770/32463 , C12N2770/32663
摘要： Method for inactivating non-enveloped viruses using a viricide-potentiating agent. In a preferred embodiment, the method may be used to inactivate non-enveloped viruses present within a sample of whole blood or a blood product and comprises (a) adding to the blood sample a photoactivatable viricide, such as a psoralen, hypericin, methylene blue, toluidine blue or the like, which, when activated, is effective in inactivating enveloped viruses; (b) adding to the blood sample a viricide-potentiating chemical agent that increases the sensitivity of non-enveloped viruses to the activated viricide; and (c) activating the photoactivatable viricide. Preferably, the viricide-potentiating chemical agent includes a first moiety which possesses an affinity for a component of the non-enveloped virus and a second moiety which includes a lipid tail, the first and second moieties being structurally interrelated so that, when the first moiety becomes associated with a component of the non-enveloped virus, the second moiety penetrates or at least partially surrounds the viral capsid of the non-enveloped virus. Examples of the chemical agent include cationic lipopolyamines, such as dioctadecylamidoglycylspermine.
摘要翻译：使用杀病毒剂增效剂灭活非包膜病毒的方法。在优选的实施方案中，该方法可用于灭活全血或血液制品样品中存在的非包膜病毒，并且包括（a）向血液样品中加入可光活化的杀戮剂，例如补骨脂素，金丝桃素，亚甲基蓝甲苯胺蓝等，其在活化时有效灭活包膜病毒; （b）向血液样品中加入增加非包膜病毒对活化杀戮剂的敏感性的杀病剂增效化学试剂; 和（c）活化可光活化杀戮剂。优选地，杀病毒剂增强化学试剂包括对非包膜病毒的组分具有亲和力的第一部分和包含脂质尾部的第二部分，第一和第二部分在结构上相互关联，使得当第一部分变得与非包膜病毒的组分相关联，第二部分渗透或至少部分地包围非包膜病毒的病毒衣壳。化学试剂的实例包括阳离子脂多胺，如双十八烷基酰氨基甘氨酰精胺。

10. 发明申请

WO0023574A3 HEPATITIS A VACCINES 审中-公开
公开(公告)号：WO0023574A3
公开(公告)日：2000-07-27
申请号：PCT/EP9907765
申请日：1999-10-08
申请人： SMITHKLINE BEECHAM BIOLOG , HONDT ERIK D
发明人： D HONDT ERIK
IPC分类号： C12N7/06 , A61K39/29 , A61K39/295 , A61P1/16 , A61P31/12 , C12N7/02 , C12N7/00
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55572 , A61K2039/70 , C12N2730/10134 , C12N2770/32434 , C12N2770/32451 , C12N2770/32463 , C12N2770/32471
摘要： A process for the production of inactivated Hepatitis A virus substantially free of host cell contamination is described, the process comprising: a) culturing Hepatitis A virus and harvesting a hepatitis A preparation; b) treating said hepatitis A preparation with a protease; and thereafter c) separating intact virus from protease-digested material; d) inactivating said virus. Also described are vaccines comprising the inactivated hepatitis A virus, preferably in combination with strong adjuvants.
摘要翻译：描述了生产基本上无宿主细胞污染的灭活的甲型肝炎病毒的方法，该方法包括：a）培养甲型肝炎病毒并收获甲型肝炎制剂; b）用蛋白酶处理所述甲型肝炎制剂; 然后c）从蛋白酶消化的材料中分离完整的病毒; d）灭活所述病毒。还描述了包含灭活的甲型肝炎病毒的疫苗，优选与强佐剂组合。

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