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1. 发明专利

CA2682480A1 AN ENZYME FOR THE PRODUCTION OF METHYLMALONYL-COENZYME A OR ETHYLMALONYL-COENZYME A AND USE THEREOF 未知
公开(公告)号：CA2682480A1
公开(公告)日：2008-10-09
申请号：CA2682480
申请日：2008-03-27
申请人： ALBERT LUDWIG UNI FREIBURG , EVONIK DEGUSSA GMBH
发明人： ALBER BIRGIT , ERB TOBIAS JUERGEN , FUCHS GEORG , MARX ACHIM , POETTER MARKUS
IPC分类号： C12N9/02 , C12P7/42
摘要： The invention relates to an isolated DNA selected from among the followin g sequences: a) a sequence according to SEQ.-ID No. 01; b) an intron-free se quence derived from a sequence according to a) and coding for the same prote in or peptide as the sequence according to SEQ.-ID No. 01; c) a sequence cod ing for a protein or peptide comprising the amino acid sequence according to SEQ.-ID No. 02; d) a sequence that is at least 80 percent identical to a se quence according to a) to c); e) a sequence which hybridizes with the antise nse strand of a sequence according to one of groups a) to d) or would hybrid ize taking into account degeneracy of the genetic code; f) a derivative of a sequence according to one of groups a) to e), said derivative being obtaine d by substituting, adding, inverting, and/or deleting one or more bases; g) a sequence corresponding to SEQ.-ID No. 01 within the degeneracy of the gene tic code; h) a sequence having neutral sense mutations of SEQ.-ID No. 01; an d i) a sequence that is complementary to a sequence according to one of grou ps a) to h). The invention further relates to a vector, the use of said vect or for transforming a cell, a transformed cell, a polypeptide, cells genetic ally modified in relation to the wild type thereof, a method for producing a genetically modified cell, the genetically modified cell obtained using sai d method, the use of said cell, and a method for producing 3-hydroxyisobutyr ic acid or a derivative thereof.

2. 发明专利

BRPI0809556A2 未知
公开(公告)号：BRPI0809556A2
公开(公告)日：2014-09-16
申请号：BRPI0809556
申请日：2008-03-27
申请人： EVONIK DEGUSSA GMBH , ALBERT LUDWIG UNI FREIBURG
发明人： POETTER MARKUS , MARX ACHIM , FUCHS GEORG , ALBER BIRGIT , ERB TOBIAS JUERGEN
IPC分类号： C12N9/02 , C12P7/42
摘要： The present invention relates to an isolated DNA, which is selected from the following sequences: a) a sequence according to SEQ ID No. 01, b) an intron-free sequence that is derived from a sequence according to a) and encodes the same protein or peptide as the sequence according to SEQ ID No. 01, c) a sequence that encodes a protein or peptide, which comprises the amino acid sequence according to SEQ ID No. 02, d) a sequence that is at least 80% identical to a sequence according to a) to c), e) a sequence that hybridizes with the antisense strand of a sequence according to one of the groups a) to d) or would hybridize taking into account degeneration of the genetic code, f) a derivative of a sequence according to one of the groups a) to e) obtained by substitution, addition, inversion and/or deletion of one or more bases, g) a sequence that corresponds to SEQ ID No. 01 within the degeneration of the genetic code, h) a sequence with neutral sense mutations of SEQ ID No. 01, and i) a sequence complementary to a sequence according to one of the groups a) to h). The invention further relates to a vector, the use of this vector for transformation of a cell, a transformed cell, a polypeptide, cells genetically engineered relative to their wild type, a method of production of a genetically engineered cell, the genetically engineered cell obtainable by this method, the use of this cell and a method of production of 3-hydroxyisobutyric acid or of a derivative thereof.

3. 发明专利

ZA200906751B Enzyme for the production of methylmalonyl coenzyme A or ethylmalonyl coenzyme A, and use thereof 未知
公开(公告)号：ZA200906751B
公开(公告)日：2010-06-30
申请号：ZA200906751
申请日：2009-09-28
申请人： EVONIK DEGUSSA GMBH , ALBERT LUDWIG UNI FREIBURG
发明人： POETTER MARKUS , MARX ACHIM , FUCHS GEORG , ALBER BIRGIT , ERB TOBIAS JUERGEN
IPC分类号： C12N20100101 , C12P20100101
摘要： The present invention relates to an isolated DNA, which is selected from the following sequences: a) a sequence according to SEQ ID No. 01, b) an intron-free sequence that is derived from a sequence according to a) and encodes the same protein or peptide as the sequence according to SEQ ID No. 01, c) a sequence that encodes a protein or peptide, which comprises the amino acid sequence according to SEQ ID No. 02, d) a sequence that is at least 80% identical to a sequence according to a) to c), e) a sequence that hybridizes with the antisense strand of a sequence according to one of the groups a) to d) or would hybridize taking into account degeneration of the genetic code, f) a derivative of a sequence according to one of the groups a) to e) obtained by substitution, addition, inversion and/or deletion of one or more bases, g) a sequence that corresponds to SEQ ID No. 01 within the degeneration of the genetic code, h) a sequence with neutral sense mutations of SEQ ID No. 01, and i) a sequence complementary to a sequence according to one of the groups a) to h). The invention further relates to a vector, the use of this vector for transformation of a cell, a transformed cell, a polypeptide, cells genetically engineered relative to their wild type, a method of production of a genetically engineered cell, the genetically engineered cell obtainable by this method, the use of this cell and a method of production of 3-hydroxyisobutyric acid or of a derivative thereof.

4. 发明专利

JP2011101643A Candida tropicalis cell and use thereof 审中-公开
标题翻译： CANDIDA TROPICALIS细胞及其用途
公开(公告)号：JP2011101643A
公开(公告)日：2011-05-26
申请号：JP2010253092
申请日：2010-11-11
申请人： Evonik Degussa Gmbh , エボニックデグサゲーエムベーハーEvonik Degussa GmbH
发明人： POETTER MARKUS , HENNEMANN HANS-GEORG , SCHAFFER STEFFEN , HAAS THOMAS DR
IPC分类号： C12N1/19 , C12N15/09 , C12P7/42 , C12P7/62 , C12R1/74
CPC分类号： C12P7/62 , C07C51/347 , C07C67/42 , C07C227/06 , C07C227/08 , C12N1/16 , C12N9/004 , C12N9/0042 , C12P7/42 , C12P7/625 , C12P13/04 , C12Y101/01001
摘要： PROBLEM TO BE SOLVED: To find a means for providing ω-hydroxycarboxylic acids or ω-hydroxycarboxylic acid esters in a sufficient amount especially in a medium enclosing cells by fermentation. SOLUTION: The Candida tropicalis cell, especially Candida tropicalis cell from strain ATCC20336 is a cell having reduced activity of at least one enzyme encoded by an intron-free nucleic acid sequence selected from two groups including a specific group in comparison with a wild type of the cell. The use of the cell is provided. The methods for producing ω-hydroxycarboxylic acids and ω-hydroxycarboxylic acid esters are provided. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：寻找一种提供足够量的ω-羟基羧酸或ω-羟基羧酸酯的方法，特别是在通过发酵包围细胞的介质中。解决方案：来自菌株ATCC20336的热带假丝酵母细胞，特别是热带念珠菌（Candida tropicalis）细胞是一种细胞，其具有比野生型野生型包含特定组的两组内含子核酸序列编码的至少一种酶的活性降低单元格的类型提供了电池的使用。提供了生产ω-羟基羧酸和ω-羟基羧酸酯的方法。版权所有（C）2011，JPO＆INPIT

5. 发明申请

WO2007141208A3 MICROBIOLOGICAL PRODUCTION OF 3-HYDROXYISOBUTYRIC ACID 审中-公开
标题翻译：微生物制剂3-羟基异
公开(公告)号：WO2007141208A3
公开(公告)日：2008-03-20
申请号：PCT/EP2007055394
申请日：2007-06-01
申请人： EVONIK DEGUSSA GMBH , UNIV ALBERT LUDWIGS FREIBURG , MARX ACHIM , POETTER MARKUS , BUCHHOLZ STEFAN , MAY ALEXANDER , SIEGERT HERMANN , ALBER BIRGIT , FUCHS GEORG , EGGELING LOTHAR
发明人： MARX ACHIM , POETTER MARKUS , BUCHHOLZ STEFAN , MAY ALEXANDER , SIEGERT HERMANN , ALBER BIRGIT , FUCHS GEORG , EGGELING LOTHAR
IPC分类号： C12P7/42 , C07C57/04 , C12N9/02 , C12P7/52
CPC分类号： C12P7/42 , C08F120/06 , C08F120/10 , C12N9/0008 , C12N9/001 , C12N9/1096 , C12N9/16 , C12N9/88 , C12P7/40 , C12P7/52 , C12P7/625 , C12Y102/04004 , C12Y103/99012 , C12Y206/01042 , C12Y301/02004 , C12Y402/01017
摘要： The present invention relates to a cell which has been genetically modified by comparison with its wild type in such a way that it is able to form more, by comparison with its wild type, 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid via methylmalonate semialdehyde or 3-hydroxybutyryl-coenzyme A as precursors. The invention also relates to a method for producing a genetically modified cell, to the genetically modified cell obtainable by this method, to a method for producing 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid, to a method for producing methacrylic acid or methacrylic esters, and to a method for producing polymethacrylic acid or polymethacrylic esters. The present invention further relates to an isolated DNA, to a vector, to the use of this vector for transforming a cell, to a transformed cell, and to a polypeptide.
摘要翻译：是能够形成作为前体，本发明涉及已经被改变在这样的基因相比，它的野生型，即，相对于它的野生型更3-羟基异丁酸或基于3-羟基聚羟基烷酸酯甲基丙二酸半醛或3-羟基丁酰基辅酶A细胞，本发明还涉及一种方法，用于通过该方法生产遗传修饰的细胞，获得遗传修饰的细胞，为3-羟基异丁酸的制备方法或基于3-羟基异丁酸，用于生产甲基丙烯酸或甲基丙烯酸酯的方法，和一种方法对于聚甲基丙烯酸或聚甲基丙烯酸的制备。本发明还涉及一种分离的DNA，载体，用于细胞，转化的细胞的转化使用这种载体的，和多肽。

6. 发明申请

WO2013024114A3 BIOTECHNOLOGICAL SYNTHESIS PROCESS OF OMEGA-FUNCTIONALIZED CARBON ACIDS AND CARBON ACID ESTERS FROM SIMPLE CARBON SOURCES 审中-公开
标题翻译：从简单的碳源OMEGA官能化的酸和羧酸酯的生物合成方法
公开(公告)号：WO2013024114A3
公开(公告)日：2013-05-30
申请号：PCT/EP2012065941
申请日：2012-08-15
申请人： EVONIK DEGUSSA GMBH , SCHAFFER STEFFEN , DECKER NICOLE , GIELEN JASMIN , HAEGER HARALD , HAAS THOMAS , POETTER MARKUS , HENNEMANN HANS-GEORG , WESSEL MIRJA , VOLLAND MICHAEL
发明人： SCHAFFER STEFFEN , DECKER NICOLE , GIELEN JASMIN , HAEGER HARALD , HAAS THOMAS , POETTER MARKUS , HENNEMANN HANS-GEORG , WESSEL MIRJA , VOLLAND MICHAEL
IPC分类号： C12N9/10 , C12N9/00 , C12N9/88 , C12P1/04
CPC分类号： C12P13/02 , C08G69/08 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0014 , C12N9/0077 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/40 , C12P7/42 , C12P7/6409 , C12P7/6436 , C12P13/005 , Y02P20/52
摘要： The invention relates to a biotechnological process for the preparation of functionalized carbon acids and functionalized carbon acid esters from simple carbon sources.
摘要翻译：本发明涉及一种用于生产从简单碳源官能羧酸和官能化羧酸酯的生物技术方法。

7. 发明专利

HUE032045T2 Primer alkoholok oxidálása és aminálása 未知
公开(公告)号：HUE032045T2
公开(公告)日：2017-08-28
申请号：HUE12735553
申请日：2012-07-17
申请人： EVONIK DEGUSSA GMBH
发明人： POETTER MARKUS , HAAS THOMAS , PFEFFER JAN CHRISTOPH , SKERRA ARNE , KROUTIL WOLFGANG , LERCHNER ALEXANDRA , SATTLER JOHANN H , SCHAFFER STEFFEN , TAUBER KATHARINA CHRISTIN
IPC分类号： C12P13/00

8. 发明专利

SG192825A1 LIQUID CATION EXCHANGER 未知
公开(公告)号：SG192825A1
公开(公告)日：2013-09-30
申请号：SG2013062583
申请日：2011-12-01
申请人： EVONIK DEGUSSA GMBH
发明人： ERHARDT FRANK , HAAS THOMAS , ROOS MARTIN , DEMICOLI DANIEL , POETTER MARKUS , SCHUBERT ANJA , PFEFFER JAN CHRISTOPH , TACKE THOMAS , HAEGER HARALD , PFENNIG ANDREAS , PRZYBYLSKI-FREUND MARIE-DOMINIQUE
摘要： 34Liquid Cation Exchanger Abstract5 The invention relates to a method for removing an organic compound having one ormore positive charges from an aqueous solution. Said method consists of the following steps a) the aqueous solution containing the organic compound, and a hydrophobicorganic solution which contains a hydrophobic liquid cation exchanger having one or more negative charges and a negative total charge, are provided, b) the aqueous solution10 and the organic solution are brought into contact with each other and c) the organic solution is separated from the aqueous solution.(No suitable figure)

9. 发明专利

DE102007015583A1 未知
公开(公告)号：DE102007015583A1
公开(公告)日：2008-10-02
申请号：DE102007015583
申请日：2007-03-29
申请人： UNIV ALBERT LUDWIGS FREIBURG , EVONIK DEGUSSA GMBH
发明人： POETTER MARKUS , MARX ACHIM , FUCHS GEORG , ALBER BIRGIT , ERB TOBIAS JUERGEN
IPC分类号： C07K14/195 , C12N1/00 , C12N15/31
摘要： The present invention relates to an isolated DNA, which is selected from the following sequences: a) a sequence according to SEQ ID No. 01, b) an intron-free sequence that is derived from a sequence according to a) and encodes the same protein or peptide as the sequence according to SEQ ID No. 01, c) a sequence that encodes a protein or peptide, which comprises the amino acid sequence according to SEQ ID No. 02, d) a sequence that is at least 80% identical to a sequence according to a) to c), e) a sequence that hybridizes with the antisense strand of a sequence according to one of the groups a) to d) or would hybridize taking into account degeneration of the genetic code, f) a derivative of a sequence according to one of the groups a) to e) obtained by substitution, addition, inversion and/or deletion of one or more bases, g) a sequence that corresponds to SEQ ID No. 01 within the degeneration of the genetic code, h) a sequence with neutral sense mutations of SEQ ID No. 01, and i) a sequence complementary to a sequence according to one of the groups a) to h). The invention further relates to a vector, the use of this vector for transformation of a cell, a transformed cell, a polypeptide, cells genetically engineered relative to their wild type, a method of production of a genetically engineered cell, the genetically engineered cell obtainable by this method, the use of this cell and a method of production of 3-hydroxyisobutyric acid or of a derivative thereof.

10. 发明专利

HUE044453T2 Biokatalitikus oxidációs eljárás alkl-géntermékkel 未知
公开(公告)号：HUE044453T2
公开(公告)日：2019-10-28
申请号：HUE11713717
申请日：2011-03-15
申请人： EVONIK DEGUSSA GMBH
发明人： POETTER MARKUS , SCHMID ANDREAS , BUEHLER BRUNO , HENNEMANN HANS-GEORG , JULSING MATTIJS KAMIEL , SCHAFFER STEFFEN , HAAS THOMAS , SCHREWE MANFRED , CORNELISSEN SJEF , ROOS MARTIN , HÄGER HARALD
IPC分类号： C07K14/21 , C12N15/09 , C12P7/00 , C12P7/04

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