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1. 发明申请

WO2007141208A3 MICROBIOLOGICAL PRODUCTION OF 3-HYDROXYISOBUTYRIC ACID 审中-公开
标题翻译：微生物制剂3-羟基异
公开(公告)号：WO2007141208A3
公开(公告)日：2008-03-20
申请号：PCT/EP2007055394
申请日：2007-06-01
申请人： EVONIK DEGUSSA GMBH , UNIV ALBERT LUDWIGS FREIBURG , MARX ACHIM , POETTER MARKUS , BUCHHOLZ STEFAN , MAY ALEXANDER , SIEGERT HERMANN , ALBER BIRGIT , FUCHS GEORG , EGGELING LOTHAR
发明人： MARX ACHIM , POETTER MARKUS , BUCHHOLZ STEFAN , MAY ALEXANDER , SIEGERT HERMANN , ALBER BIRGIT , FUCHS GEORG , EGGELING LOTHAR
IPC分类号： C12P7/42 , C07C57/04 , C12N9/02 , C12P7/52
CPC分类号： C12P7/42 , C08F120/06 , C08F120/10 , C12N9/0008 , C12N9/001 , C12N9/1096 , C12N9/16 , C12N9/88 , C12P7/40 , C12P7/52 , C12P7/625 , C12Y102/04004 , C12Y103/99012 , C12Y206/01042 , C12Y301/02004 , C12Y402/01017
摘要： The present invention relates to a cell which has been genetically modified by comparison with its wild type in such a way that it is able to form more, by comparison with its wild type, 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid via methylmalonate semialdehyde or 3-hydroxybutyryl-coenzyme A as precursors. The invention also relates to a method for producing a genetically modified cell, to the genetically modified cell obtainable by this method, to a method for producing 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid, to a method for producing methacrylic acid or methacrylic esters, and to a method for producing polymethacrylic acid or polymethacrylic esters. The present invention further relates to an isolated DNA, to a vector, to the use of this vector for transforming a cell, to a transformed cell, and to a polypeptide.
摘要翻译：是能够形成作为前体，本发明涉及已经被改变在这样的基因相比，它的野生型，即，相对于它的野生型更3-羟基异丁酸或基于3-羟基聚羟基烷酸酯甲基丙二酸半醛或3-羟基丁酰基辅酶A细胞，本发明还涉及一种方法，用于通过该方法生产遗传修饰的细胞，获得遗传修饰的细胞，为3-羟基异丁酸的制备方法或基于3-羟基异丁酸，用于生产甲基丙烯酸或甲基丙烯酸酯的方法，和一种方法对于聚甲基丙烯酸或聚甲基丙烯酸的制备。本发明还涉及一种分离的DNA，载体，用于细胞，转化的细胞的转化使用这种载体的，和多肽。

2. 发明专利

DE102007059248A1 Recombinant cell capable of converting bicarbonate to organic compounds utilizes a 16-step metabolic pathway starting with acetyl coenzyme A 未知
公开(公告)号：DE102007059248A1
公开(公告)日：2009-06-10
申请号：DE102007059248
申请日：2007-12-07
申请人： UNIV ALBERT LUDWIGS FREIBURG , EVONIK DEGUSSA GMBH
发明人： MARX ACHIM , POETTER MARKUS , HAAS THOMAS , FUCHS GEORG , BERG IVAN , KOCKELKORN DANIEL
IPC分类号： C12N1/00 , C12P7/42
摘要： Recombinant cell capable of converting bicarbonate to organic compounds with at least two carbon atoms utilizes a 16-step metabolic pathway starting with acetyl coenzyme A. Recombinant cell capable of converting bicarbonate to organic compounds with at least two carbon atoms utilizes the following metabolic pathway: acetyl coenzyme A (plus bicarbonate) to malonyl coenzyme A to malonate semialdehyde to 3-hydroxypropionate to 3-hydroxypropionyl coenzyme A to acryloyl coenzyme A to propionyl coenzyme A (plus bicarbonate) to (S)-methylmalonyl coenzyme A to (R)-methylmalonyl coenzyme A to succinate semialdehyde to 4-hydroxybutyric acid to 4-hydroxybutyryl coenzyme A to crotonyl coenzyme A to 3-hydroxybutyryl coenzyme A to acetoacetyl coenzyme A to acetyl coenzyme A (2 equivalents). Independent claims are also included for: (1) producing organic compounds with at least two carbon atoms by contacting a recombinant cell as above with a bicarbonate-containing nutrient medium; (2) producing acrylic acid or acrylate esters by producing 3-hydroxypropionic acid as above, dehydrating it and optionally esterifying the resulting acrylic acid; (3) producing methacrylic acid or methacrylate esters by producing 3-hydroxyisobutyric acid as above, dehydrating it and optionally esterifying the resulting methacrylic acid; (4) producing poly(meth)acrylic acid or poly(meth)acrylate esters by radical polymerization of (meth)acrylic acid or (meth)acrylate esters produced as above.

3. 发明专利

DE102007015583A1 未知
公开(公告)号：DE102007015583A1
公开(公告)日：2008-10-02
申请号：DE102007015583
申请日：2007-03-29
申请人： UNIV ALBERT LUDWIGS FREIBURG , EVONIK DEGUSSA GMBH
发明人： POETTER MARKUS , MARX ACHIM , FUCHS GEORG , ALBER BIRGIT , ERB TOBIAS JUERGEN
IPC分类号： C07K14/195 , C12N1/00 , C12N15/31
摘要： The present invention relates to an isolated DNA, which is selected from the following sequences: a) a sequence according to SEQ ID No. 01, b) an intron-free sequence that is derived from a sequence according to a) and encodes the same protein or peptide as the sequence according to SEQ ID No. 01, c) a sequence that encodes a protein or peptide, which comprises the amino acid sequence according to SEQ ID No. 02, d) a sequence that is at least 80% identical to a sequence according to a) to c), e) a sequence that hybridizes with the antisense strand of a sequence according to one of the groups a) to d) or would hybridize taking into account degeneration of the genetic code, f) a derivative of a sequence according to one of the groups a) to e) obtained by substitution, addition, inversion and/or deletion of one or more bases, g) a sequence that corresponds to SEQ ID No. 01 within the degeneration of the genetic code, h) a sequence with neutral sense mutations of SEQ ID No. 01, and i) a sequence complementary to a sequence according to one of the groups a) to h). The invention further relates to a vector, the use of this vector for transformation of a cell, a transformed cell, a polypeptide, cells genetically engineered relative to their wild type, a method of production of a genetically engineered cell, the genetically engineered cell obtainable by this method, the use of this cell and a method of production of 3-hydroxyisobutyric acid or of a derivative thereof.

4. 发明专利

BRPI0809556A2 未知
公开(公告)号：BRPI0809556A2
公开(公告)日：2014-09-16
申请号：BRPI0809556
申请日：2008-03-27
申请人： EVONIK DEGUSSA GMBH , ALBERT LUDWIG UNI FREIBURG
发明人： POETTER MARKUS , MARX ACHIM , FUCHS GEORG , ALBER BIRGIT , ERB TOBIAS JUERGEN
IPC分类号： C12N9/02 , C12P7/42
摘要： The present invention relates to an isolated DNA, which is selected from the following sequences: a) a sequence according to SEQ ID No. 01, b) an intron-free sequence that is derived from a sequence according to a) and encodes the same protein or peptide as the sequence according to SEQ ID No. 01, c) a sequence that encodes a protein or peptide, which comprises the amino acid sequence according to SEQ ID No. 02, d) a sequence that is at least 80% identical to a sequence according to a) to c), e) a sequence that hybridizes with the antisense strand of a sequence according to one of the groups a) to d) or would hybridize taking into account degeneration of the genetic code, f) a derivative of a sequence according to one of the groups a) to e) obtained by substitution, addition, inversion and/or deletion of one or more bases, g) a sequence that corresponds to SEQ ID No. 01 within the degeneration of the genetic code, h) a sequence with neutral sense mutations of SEQ ID No. 01, and i) a sequence complementary to a sequence according to one of the groups a) to h). The invention further relates to a vector, the use of this vector for transformation of a cell, a transformed cell, a polypeptide, cells genetically engineered relative to their wild type, a method of production of a genetically engineered cell, the genetically engineered cell obtainable by this method, the use of this cell and a method of production of 3-hydroxyisobutyric acid or of a derivative thereof.

5. 发明专利

AU2008234951A1 Enzyme for the production of methylmalonyl coenzyme A or ethylmalonyl coenzyme A, and use thereof 未知
公开(公告)号：AU2008234951A1
公开(公告)日：2008-10-09
申请号：AU2008234951
申请日：2008-03-27
申请人： ALBERT LUDWIG UNIV FREIBURG , EVONIK DEGUSSA GMBH
发明人： ERB TOBIAS JURGEN , POTTER MARKUS , FUCHS GEORG , MARX ACHIM , ALBER BIRGIT
IPC分类号： C12N9/02 , C12P7/42
摘要： The present invention relates to an isolated DNA, which is selected from the following sequences: a) a sequence according to SEQ ID No. 01, b) an intron-free sequence that is derived from a sequence according to a) and encodes the same protein or peptide as the sequence according to SEQ ID No. 01, c) a sequence that encodes a protein or peptide, which comprises the amino acid sequence according to SEQ ID No. 02, d) a sequence that is at least 80% identical to a sequence according to a) to c), e) a sequence that hybridizes with the antisense strand of a sequence according to one of the groups a) to d) or would hybridize taking into account degeneration of the genetic code, f) a derivative of a sequence according to one of the groups a) to e) obtained by substitution, addition, inversion and/or deletion of one or more bases, g) a sequence that corresponds to SEQ ID No. 01 within the degeneration of the genetic code, h) a sequence with neutral sense mutations of SEQ ID No. 01, and i) a sequence complementary to a sequence according to one of the groups a) to h). The invention further relates to a vector, the use of this vector for transformation of a cell, a transformed cell, a polypeptide, cells genetically engineered relative to their wild type, a method of production of a genetically engineered cell, the genetically engineered cell obtainable by this method, the use of this cell and a method of production of 3-hydroxyisobutyric acid or of a derivative thereof.

6. 发明专利

CA2682480A1 AN ENZYME FOR THE PRODUCTION OF METHYLMALONYL-COENZYME A OR ETHYLMALONYL-COENZYME A AND USE THEREOF 未知
公开(公告)号：CA2682480A1
公开(公告)日：2008-10-09
申请号：CA2682480
申请日：2008-03-27
申请人： ALBERT LUDWIG UNI FREIBURG , EVONIK DEGUSSA GMBH
发明人： ALBER BIRGIT , ERB TOBIAS JUERGEN , FUCHS GEORG , MARX ACHIM , POETTER MARKUS
IPC分类号： C12N9/02 , C12P7/42
摘要： The invention relates to an isolated DNA selected from among the followin g sequences: a) a sequence according to SEQ.-ID No. 01; b) an intron-free se quence derived from a sequence according to a) and coding for the same prote in or peptide as the sequence according to SEQ.-ID No. 01; c) a sequence cod ing for a protein or peptide comprising the amino acid sequence according to SEQ.-ID No. 02; d) a sequence that is at least 80 percent identical to a se quence according to a) to c); e) a sequence which hybridizes with the antise nse strand of a sequence according to one of groups a) to d) or would hybrid ize taking into account degeneracy of the genetic code; f) a derivative of a sequence according to one of groups a) to e), said derivative being obtaine d by substituting, adding, inverting, and/or deleting one or more bases; g) a sequence corresponding to SEQ.-ID No. 01 within the degeneracy of the gene tic code; h) a sequence having neutral sense mutations of SEQ.-ID No. 01; an d i) a sequence that is complementary to a sequence according to one of grou ps a) to h). The invention further relates to a vector, the use of said vect or for transforming a cell, a transformed cell, a polypeptide, cells genetic ally modified in relation to the wild type thereof, a method for producing a genetically modified cell, the genetically modified cell obtained using sai d method, the use of said cell, and a method for producing 3-hydroxyisobutyr ic acid or a derivative thereof.

7. 发明专利

ZA200906751B Enzyme for the production of methylmalonyl coenzyme A or ethylmalonyl coenzyme A, and use thereof 未知
公开(公告)号：ZA200906751B
公开(公告)日：2010-06-30
申请号：ZA200906751
申请日：2009-09-28
申请人： EVONIK DEGUSSA GMBH , ALBERT LUDWIG UNI FREIBURG
发明人： POETTER MARKUS , MARX ACHIM , FUCHS GEORG , ALBER BIRGIT , ERB TOBIAS JUERGEN
IPC分类号： C12N20100101 , C12P20100101
摘要： The present invention relates to an isolated DNA, which is selected from the following sequences: a) a sequence according to SEQ ID No. 01, b) an intron-free sequence that is derived from a sequence according to a) and encodes the same protein or peptide as the sequence according to SEQ ID No. 01, c) a sequence that encodes a protein or peptide, which comprises the amino acid sequence according to SEQ ID No. 02, d) a sequence that is at least 80% identical to a sequence according to a) to c), e) a sequence that hybridizes with the antisense strand of a sequence according to one of the groups a) to d) or would hybridize taking into account degeneration of the genetic code, f) a derivative of a sequence according to one of the groups a) to e) obtained by substitution, addition, inversion and/or deletion of one or more bases, g) a sequence that corresponds to SEQ ID No. 01 within the degeneration of the genetic code, h) a sequence with neutral sense mutations of SEQ ID No. 01, and i) a sequence complementary to a sequence according to one of the groups a) to h). The invention further relates to a vector, the use of this vector for transformation of a cell, a transformed cell, a polypeptide, cells genetically engineered relative to their wild type, a method of production of a genetically engineered cell, the genetically engineered cell obtainable by this method, the use of this cell and a method of production of 3-hydroxyisobutyric acid or of a derivative thereof.

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