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    • 9. 发明专利
    • AN ENZYME FOR THE PRODUCTION OF METHYLMALONYL-COENZYME A OR ETHYLMALONYL-COENZYME A AND USE THEREOF
    • CA2682480A1
    • 2008-10-09
    • CA2682480
    • 2008-03-27
    • ALBERT LUDWIG UNI FREIBURGEVONIK DEGUSSA GMBH
    • ALBER BIRGITERB TOBIAS JUERGENFUCHS GEORGMARX ACHIMPOETTER MARKUS
    • C12N9/02C12P7/42
    • The invention relates to an isolated DNA selected from among the followin g sequences: a) a sequence according to SEQ.-ID No. 01; b) an intron-free se quence derived from a sequence according to a) and coding for the same prote in or peptide as the sequence according to SEQ.-ID No. 01; c) a sequence cod ing for a protein or peptide comprising the amino acid sequence according to SEQ.-ID No. 02; d) a sequence that is at least 80 percent identical to a se quence according to a) to c); e) a sequence which hybridizes with the antise nse strand of a sequence according to one of groups a) to d) or would hybrid ize taking into account degeneracy of the genetic code; f) a derivative of a sequence according to one of groups a) to e), said derivative being obtaine d by substituting, adding, inverting, and/or deleting one or more bases; g) a sequence corresponding to SEQ.-ID No. 01 within the degeneracy of the gene tic code; h) a sequence having neutral sense mutations of SEQ.-ID No. 01; an d i) a sequence that is complementary to a sequence according to one of grou ps a) to h). The invention further relates to a vector, the use of said vect or for transforming a cell, a transformed cell, a polypeptide, cells genetic ally modified in relation to the wild type thereof, a method for producing a genetically modified cell, the genetically modified cell obtained using sai d method, the use of said cell, and a method for producing 3-hydroxyisobutyr ic acid or a derivative thereof.