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1. 发明申请

WO2009121785A3 METHOD FOR DERACEMIZATION OF SECONDARY ALCOHOLS 审中-公开
标题翻译：仲醇的方法去外消旋
公开(公告)号：WO2009121785A3
公开(公告)日：2010-07-01
申请号：PCT/EP2009053576
申请日：2009-03-26
申请人： EVONIK DEGUSSA GMBH , DINGERDISSEN UWE , PFEFFER JAN , KROUTIL WOLFGANG , GRUBER CHRISTIAN , VOSS CONSTANCE
发明人： DINGERDISSEN UWE , PFEFFER JAN , KROUTIL WOLFGANG , GRUBER CHRISTIAN , VOSS CONSTANCE
IPC分类号： C12P7/02 , C12P41/00
CPC分类号： C12P41/002 , C12N9/0006 , C12P7/02
摘要： The invention relates to a method for enzymatic deracemization of enantiomer mixtures of secondary alcohols through a combination of oxidation and reduction reactions by way of stereoselective alcohol dehydrogenases and cofactors thereof, wherein formally an enantiomer of an optically active secondary alcohol is selectively oxidized to the corresponding ketone, which is then selectively reduced to the optical antipode, whereas the reduced form of the cofactor is made available for the reduction reaction through an additive enzyme, characterized in that two alcohol dehydrogenases with opposite stereoselectivity and different cofactor selectivity are used for the oxidation and reduction reaction, as are the two associated different cofactors, and the oxidized and reduced cofactors are merged together in a parallel enzymatic reaction with the additive enzyme, wherein the direction of the deracemization in the direction of one of the two enantiomers can be controlled by the selection of the two alcohol dehydrogenases and through the selectivity difference of the additive enzyme for the two cofactors.
摘要翻译：本发明涉及一种通过氧化和还原反应的组合仲醇的对映体混合物的酶促去外消旋通过立体选择性醇脱氢酶的手段和那些辅因子，其特征在于，正式的光学活性仲醇的对映体被选择性地氧化为相应的酮，然后将其有选择地将光学对映体，而辅因子用于使用提供了一种附加的酶的还原反应的还原形式被减少，其特点是在具有相反的立体选择性和不同的辅因子以及相关联的两个不同的辅因子的氧化或用于两个醇脱氢酶。还原反应中使用，并且氧化和还原辅助因子与加入酶到彼此并发酶反应，进行其中去外消旋的朝向两个对映体之一由两个醇脱氢酶的选择或其它酶的选择性差的基础上，方向是可控的辅助因子两者。

2. 发明专利

HUE032045T2 Primer alkoholok oxidálása és aminálása 未知
公开(公告)号：HUE032045T2
公开(公告)日：2017-08-28
申请号：HUE12735553
申请日：2012-07-17
申请人： EVONIK DEGUSSA GMBH
发明人： POETTER MARKUS , HAAS THOMAS , PFEFFER JAN CHRISTOPH , SKERRA ARNE , KROUTIL WOLFGANG , LERCHNER ALEXANDRA , SATTLER JOHANN H , SCHAFFER STEFFEN , TAUBER KATHARINA CHRISTIN
IPC分类号： C12P13/00

3. 发明专利

AT546541T 未知
公开(公告)号：AT546541T
公开(公告)日：2012-03-15
申请号：AT09727980
申请日：2009-03-26
申请人： EVONIK DEGUSSA GMBH
发明人： DINGERDISSEN UWE , PFEFFER JAN , KROUTIL WOLFGANG , GRUBER CHRISTIAN , VOSS CONSTANCE
IPC分类号： C12P7/02 , C12N9/04 , C12P41/00
摘要： The invention relates to a process for enzymatic deracemization of enantiomer mixtures of secondary alcohols by a combination of oxidation and reduction reactions by means of stereoselective alcohol dehydrogenases and the cofactors thereof, wherein one enantiomer of an optically active secondary alcohol is in a formal sense selectively oxidized to the corresponding ketone, which is subsequently reduced selectively to the optical antipode, while the reduced form of the cofactor is provided for the reduction reaction by means of an additional enzyme, characterized in that two alcohol dehydrogenases with opposite stereoselectivity and different cofactor selectivity and the two corresponding, different cofactors are used for the oxidation and reduction reactions, and the oxidized and reduced cofactors are interconverted in a parallel enzymatic reaction with the additional enzyme, the direction of the deracemization toward one of the two enantiomers being controllable by the selection of the two alcohol dehydrogenases or using the selectivity difference of the additional enzyme for the two cofactors.

4. 发明专利

HK1206784A1 METHOD FOR AEROBICALLY PRODUCING ALANINE OR A COMPOUND PRODUCED USING ALANINE 未知
公开(公告)号：HK1206784A1
公开(公告)日：2016-01-15
申请号：HK15107455
申请日：2015-08-04
申请人： EVONIK DEGUSSA GMBH
发明人： HENNEMANN HANS-GEORG , SCHAFFER STEFFEN , WESSEL MIRJA , PTTER MARKUS , PFEFFER JAN CHRISTOPH , HAAS THOMAS , CORTHALS JASMIN , ECKL EVA-MARIA , ROEDER SILVANA , KROUTIL WOLFGANG , SKERRA ARNE
IPC分类号： C12N20060101 , C12P20060101

6. 发明专利

HUE037086T2 Eljárás alanin aerob elõállítására 未知
公开(公告)号：HUE037086T2
公开(公告)日：2018-08-28
申请号：HUE13715159
申请日：2013-03-25
申请人： EVONIK DEGUSSA GMBH
发明人： HENNEMANN HANS-GEORG , SCHAFFER STEFFEN , WESSEL MIRJA , POETTER MARKUS , PFEFFER JAN CHRISTOPH , HAAS THOMAS , CORTHALS JASMIN , ECKL EVA-MARIA , ROEDER SILVANA , KROUTIL WOLFGANG , SKERRA ARNE
IPC分类号： C12N1/21 , C12P13/00 , C12P13/06

7. 发明专利

ES2669225T3 Procedimiento para la producción aerobia de alanina 未知
公开(公告)号：ES2669225T3
公开(公告)日：2018-05-24
申请号：ES13715159
申请日：2013-03-25
申请人： EVONIK DEGUSSA GMBH
发明人： HENNEMANN HANS-GEORG , SCHAFFER STEFFEN , WESSEL MIRJA , PÖTTER MARKUS , PFEFFER JAN CHRISTOPH , HAAS THOMAS , CORTHALS JASMIN , ECKL EVA-MARIA , ROEDER SILVANA , KROUTIL WOLFGANG , SKERRA ARNE
IPC分类号： C12N1/21 , C12P13/00 , C12P13/06
摘要： Procedimiento para la producción de alanina, que comprende a) la puesta a disposición de una célula que exprime alanina-deshidrogenasa recombinante, b) el cultivo bajo condiciones aerobias en presencia de una fuente de nitrógeno inorgánica en una fase acuosa, y c) la puesta en contacto de la célula con una fase hidrófoba orgánica, tratándose de una célula procariota o eucariota inferior en el caso de la célula.

8. 发明专利

ES2604335T3 Oxidación y aminación de alcoholes primarios 未知
公开(公告)号：ES2604335T3
公开(公告)日：2017-03-06
申请号：ES12735553
申请日：2012-07-17
申请人： EVONIK DEGUSSA GMBH
发明人： PÖTTER MARKUS , HAAS THOMAS , PFEFFER JAN , SKERRA ARNE , KROUTIL WOLFGANG , LERCHNER ALEXANDRA , SATTLER JOHANN , SCHAFFER STEFFEN , TAUBER KATHARINA
IPC分类号： C12P13/00
摘要： Procedimiento procedimiento para la oxidación de alcoholes, que comprende los pasos a) puesta a disposición de un alcohol primario de la fórmula HO-(CH2)x-R1, siendo seleccionado R1 a partir del grupo que comprende -OH, -SH, -NH2 y -COOR2, siendo x al menos 3, y siendo seleccionado R2 a partir del grupo que comprende H, alquilo y arilo, b) oxidación del alcohol primario mediante puesta en contacto con una alcohol deshidrogenasa dependiente de NAD(P)+, y c) puesta en contacto del producto de oxidación del paso a) con una transaminasa, tratándose en el caso de la NAD(P)+-alcohol deshidrogenasa y/o de la transaminasa, de un enzima recombinante o aislado.

9. 发明专利

CA2844090A1 OXIDATION AND AMINATION OF SECONDARY ALCOHOLS 未知
公开(公告)号：CA2844090A1
公开(公告)日：2013-02-14
申请号：CA2844090
申请日：2012-07-27
申请人： EVONIK DEGUSSA GMBH
发明人： HAAS THOMAS , POTTER MARKUS , PFEFFER JAN CHRISTOPH , KROUTIL WOLFGANG , SKERRA ARNE , LERCHNER ALEXANDRA , TAUBER KATHARINA CHRISTIN , SATTLER JOHANN H , SCHAFFER STEFFEN
IPC分类号： C12P13/00 , C12N9/00 , C12N9/04 , C12N9/10 , C12P13/04
摘要： The invention relates to a method comprising the following steps: a) providing a secondary alcohol; b) oxidizing the secondary alcohol by bringing said alcohol into contact with an NAD(P)+-dependent alcohol dehydrogenase; and c) bringing the oxidation product of step a) into contact with a transaminase, wherein the NAD(P)+-dependent alcohol dehydrogenase and/or the transaminase are/is a recombinant or isolated enzyme. The invention further relates to a whole cell catalyst for carrying out the method and to the use of such a whole cell catalyst for oxidizing a secondary alcohol.

10. 发明专利

SG10201608182TA METHOD FOR AEROBICALLY PRODUCING ALANINE OR A COMPOUND PRODUCED USING ALANINE 未知
公开(公告)号：SG10201608182TA
公开(公告)日：2016-11-29
申请号：SG10201608182T
申请日：2013-03-25
申请人： EVONIK DEGUSSA GMBH
发明人： HENNEMANN HANS-GEORG , SCHAFFER STEFFEN , WESSEL MIRJA , PÖTTER MARKUS , PFEFFER JAN CHRISTOPH , HAAS THOMAS , CORTHALS JASMIN , ECKL EVA-MARIA , ROEDER SILVANA , KROUTIL WOLFGANG , SKERRA ARNE

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