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1. 发明申请

WO0066716A3 METHOD FOR PRODUCING ORGANISMS EXHIBITING INCREASED STEROL GLYCOSIDE PRODUCTION AND USE OF THE STEROL GLYCOSIDES 审中-公开
标题翻译：用于生产生物中具有增加STEROLGLYKOSID生产和STEROLGLYKOSIDE的使用
公开(公告)号：WO0066716A3
公开(公告)日：2001-08-09
申请号：PCT/EP0003856
申请日：2000-04-28
申请人： ERWERB UND VERWERTUNG VON SCHU , FORSCHUNGSZENTRUM BORSTEL , HEINZ ERNST , WARNECKE DIRK , ZANK THORSTEN , MUELLER FRANK , ZAEHRINGER ULRICH
发明人： HEINZ ERNST , WARNECKE DIRK , ZANK THORSTEN , MUELLER FRANK , ZAEHRINGER ULRICH
IPC分类号： A61K35/76 , A61K48/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/10 , C12N15/54 , A01H5/00 , A61K31/70 , A61K39/39 , C07J17/00 , C12N1/00 , C12N5/10 , C12N15/62 , C12N15/63 , C12N15/82 , C12P33/00 , C12P33/20 , C12Q1/68
CPC分类号： C12N9/1051 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： The invention relates to a method for producing transgenic organisms including bacteria, fungi, plants and animals, or transgenic cells which exhibit an increased production of steroid glycoside, steroid alkaloid and/or sterol glycoside compared to that of wild-type organisms or cells. The inventive method involves the transfer of DNA sequences which code for sterol glycosyl transferases. The invention also relates to applications of the organisms produced or of the steroid glycosides, steroid alkaloids and/or sterol glycosides synthesized in or by the organisms or cells. Said applications are useful in the pharmaceutical and foodstuff industries as well as for protecting plants.
摘要翻译：本发明涉及一种方法，用于生产转基因生物体，包括细菌，真菌，植物和动物，或转基因细胞相比，增加Steroidglykosid-，Steroidalkaloid-和/或Sterolglykosid生产野生型生物体或细胞，其具有的内容，其中的所述方法包括编码Sterolglykosyltransferasen DNA序列的转移。此外，本发明的药学，食品技术或用于作物保护的涉及生产或或者从生物或细胞的甾体糖苷，和Steroidalkaloid- Sterolglykoside合成的生物体的有益用途。

3. 发明申请

WO2004057001A3 METHOD FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS 审中-公开
标题翻译：生产聚氨酯脂肪酸的方法
公开(公告)号：WO2004057001A3
公开(公告)日：2004-11-04
申请号：PCT/EP0314054
申请日：2003-12-11
申请人： UNIV BRISTOL , NAPIER JOHNATHAN A , SAYANOVA OLGA , LAZARUS COLIN M , QI BAOXIU , HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH
发明人： NAPIER JOHNATHAN A , SAYANOVA OLGA , LAZARUS COLIN M , QI BAOXIU , HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH
IPC分类号： C12N9/02 , C12N9/10 , C12N15/82 , C12P7/64
CPC分类号： C12N9/0083 , C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to an improved process for the specific production of poly-unsaturated omega-3 and omega-6 fatty acids and a process for the production of triglycerides having an increased content of unsaturated fatty acids, in particular omega-3 and omega-6 fatty acids having at least two double bonds and a 20 or 22 carbon atom chain length. The invention relates to the produc-tion of a transgenic organism, preferably a transgenic plant or a transgenic microorganism, hav-ing an increased content of fatty acids, oils or lipids containing C20- or C22- fatty acids with a delta-5, 7, 8, 10 double bond, respectively due to the expression of a delta-8-desaturase and a delta-9- elon-gase from organisms such as plants preferably Algae like Isochrysis galbana or Euglena gracilis. In addition the invention relates to a process for the production of poly unsaturated fatty acids such as Eicosapentaenoic, Arachidonic, Docosapentaenoic or Docosahexaenoic acid through the co- expression of a delta -8-desaturase, a delta-9-elongase and a delta-5 desaturase in organisms such as microorganisms or plants.The invention additionally relates to the use of specific nucleic acid sequences encoding for the aforementioned proteins with delta-8-desaturase-, delta-9-elongase- or delta-5-desaturase-activity, nucleic acid constructs, vectors and organisms containing said nucleic acid sequences. The invention further relates to unsaturated fatty acids and triglycerides having an increased content of at least 1 % by weight of unsaturated fatty acids and use thereof.

4. 发明申请

WO0159128A2 NOVEL ELONGASE GENE AND METHOD FOR PRODUCING MULTIPLE-UNSATURATED FATTY ACIDS 审中-公开
标题翻译：新的长链脂肪酸和生产多种不饱和脂肪酸的方法
公开(公告)号：WO0159128A2
公开(公告)日：2001-08-16
申请号：PCT/EP0101346
申请日：2001-02-08
申请人： BASF AG , HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH , LERCHL JENS , RENZ ANDREAS
发明人： HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH , LERCHL JENS , RENZ ANDREAS
IPC分类号： A01H5/00 , A01K67/027 , A23K1/16 , A23L1/30 , A61K8/30 , A61K8/36 , A61K8/92 , A61K31/201 , A61K31/202 , A61P3/02 , A61P3/06 , A61P9/10 , A61P29/00 , C07K16/40 , C11C3/00 , C12N9/00 , C12N9/10 , C12N15/09 , C12N15/54 , C12N15/82 , C12P7/64 , C12Q1/02 , A61K38/45 , C11B1/00 , C11C1/00 , C12Q1/48 , G01N33/573
CPC分类号： C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The invention relates to a novel elongase gene comprising the sequences cited in sequence SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5 and SEQ ID NO:7 or to homologues, derivatives or analogues thereof. The invention also relates to a gene construct containing these genes or homologues, derivatives or analogues thereof, and to its use. The invention additionally relates to the vectors or transgenic organisms containing an elongase gene comprising the sequence SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5 and SEQ ID NO:7 or containing homologues, derivatives or analogues thereof. The invention relates to the use of the elongase sequences alone or in combination with additional elongases and/or with additional fatty acid biosynthesis genes. The invention relates to a novel elongase gene comprising the sequence SEQ ID NO:1 or to homologues, derivatives or analogues thereof. The invention also relates to a method for producing multiple-unsaturated fatty acids and to a method for introducing DNA into organisms which produce large quantities of oils and, in particular, oils having a high content of unsaturated fatty acids. The invention further relates to an oil and/or to a fatty acid preparation having a high content of multiple-unsaturated fatty acids that contain at least two double bonds and/or to a triacylglycerin preparation having a high content of multiple-unsaturated fatty acids that contain at least two double bonds.
摘要翻译：本发明涉及一种在序列SEQ ID NO与一个NEUS延长酶基因：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO：序列或7-称他们的同系物，衍生物或类似物，涉及一种基因构建体，这些基因或他们的同系物，衍生物或类似物，以及它的用途。本发明还涉及到与序列SEQ ID NO载体或转基因生物的延长酶基因：含有7或它的同系物，衍生物或类似物：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO。此外，本发明涉及单独或与其他延伸酶和/或其他脂肪酸生物合成基因组合使用延长分支酶。本发明涉及具有序列SEQ ID NO：1或其同系物，衍生物或类似物的新型延伸酶基因。此外，本发明涉及生产多不饱和脂肪酸的方法，以及将DNA引入生产大量油类，特别是具有高含量不饱和脂肪酸的油类的生物中的方法。此外，本发明提供了油和/或与多不饱和脂肪酸具有至少两个双键和/或三酰甘油制剂用的多不饱和脂肪酸含量较高具有至少两个双键的涉及高含量的脂肪酸制备。

5. 发明申请

WO2005083053A3 METHOD FOR PRODUCING UNSATURATED OMEGA-3 FATTY ACIDS IN TRANSGENIC ORGANISMS 审中-公开
标题翻译：用于生产不饱和ω-3脂肪酸的转基因生物
公开(公告)号：WO2005083053A3
公开(公告)日：2005-11-10
申请号：PCT/EP2005001865
申请日：2005-02-23
申请人： BASF PLANT SCIENCE GMBH , CIRPUS PETRA , BAUER JOERG , ZANK THORSTEN , HEINZ ERNST
发明人： CIRPUS PETRA , BAUER JOERG , ZANK THORSTEN , HEINZ ERNST
IPC分类号： C12N9/02 , C12N15/82 , C12P7/64 , C12N5/10 , C12N15/53
CPC分类号： C12N9/0071 , C12N9/0004 , C12N15/8247
摘要： The invention relates to a method for producing unsaturated O3 fatty acids, and to a method for producing triglycerides having an increased unsaturated fatty acid content, especially O3 fatty acids with more than three double bonds. The invention also relates to the production of a transgenic organism, preferably a transgenic plant or a transgenic micro-organism, with an increased content of unsaturated O3 double bonds on the basis of the expression of a O3 desaturase of fungi of the pythiacae family, such as the species phytophtora, for example the species and type phytophtora infestans. The invention further relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms containing at least one inventive nucleic acid sequence, at least one vector containing the nucleic acid sequence and/or the nucleic acid constructs, and transgenic organisms containing the cited nucleic acid sequences, nucleic acid constructs and/or vectors. Another part of the invention relates to oils, lipids and/or fatty acids produced according to the inventive method, and to the use thereof. Furthermore, the invention relates to unsaturated fatty acids and triglycerides having an increased unsaturated fatty acid content, and to the use of the same.
摘要翻译：本发明涉及一种用于生产不饱和ω-3脂肪酸和用于生产具有的不饱和脂肪酸含量增加的甘油三酯的制造方法，具有多于三个双键尤其ω-3脂肪酸。本发明涉及产生转基因生物，优选的转基因植物或转基因微生物，其具有具有由于ω-3去饱和酶的来自家庭Pythiaceae的真菌表达ω-3双键的不饱和的ω-3脂肪酸，油或脂质的含量增加如属疫，例如属和种致病疫霉。本发明还涉及包含本发明的至少一种核酸序列，含有包含上述核酸序列，核酸构建体和/或载体的核酸序列和/或核酸构建体，和转基因生物的至少一种载体中的核酸序列，核酸构建体，载体，和生物体。本发明的另一部分涉及根据本发明和它们的使用由该方法产生的油，脂质和/或脂肪酸。本发明还涉及到的不饱和脂肪酸和甘油三酯具有不饱和脂肪酸的含量增加及其用途。

6. 发明申请

WO2005012316A3 METHOD FOR THE PRODUCTION OF MULTIPLY-UNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS 审中-公开
标题翻译：用于生产不饱和脂肪酸的转基因多
公开(公告)号：WO2005012316A3
公开(公告)日：2005-10-06
申请号：PCT/EP2004007957
申请日：2004-07-16
申请人： BASF PLANT SCIENCE GMBH , ZANK THORSTEN , BAUER JOERG , CIRPUS PETRA , ABBADI AMINE , HEINZ ERNST , QIU XIAO , VRINTEN PATRICIA , SPERLING PETRA , DOMERGUE FREDERIC , MEYER ASTRID , KIRSCH JELENA
发明人： ZANK THORSTEN , BAUER JOERG , CIRPUS PETRA , ABBADI AMINE , HEINZ ERNST , QIU XIAO , VRINTEN PATRICIA , SPERLING PETRA , DOMERGUE FREDERIC , MEYER ASTRID , KIRSCH JELENA
IPC分类号： A23D9/00 , C11B1/02 , C12N9/02 , C12N9/10 , C12N15/82 , C12P7/64 , A01K67/027
CPC分类号： C12N15/8247 , A23D9/00 , A23D9/02 , A23L33/115 , A23V2002/00 , C11B1/00 , C12N9/0071 , C12N9/0083 , C12N9/0093 , C12N9/1029 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12Y114/19 , C12Y114/19003 , C12Y203/01199 , Y02P20/52
摘要： The invention relates to a method for the production of multiply-unsaturated fatty acids in an organism, into which nucleic acids have been introduced, which code for polypeptides with Delta-5 elongase activity. Said nucleic acid sequences, optionally with further nucleic acid sequences, coding for polypeptides for the biosynthesis of fatty acids and lipid metabolism, are advantageously expressed in the organism. Nucleic acid sequences coding for a Delta-6 desaturase, a Delta-5 desaturase, Delta-4 desaturase and/or Delta-6 elongase activity are particularly advantageous and, advantageously, said saturases and elongases are derived from Thalassiosira, Euglena or Ostreococcus. The invention further relates to a method for the production of oils and/or triacylglycerides with an increased content of long-chain, multiply-unsaturated fatty acids. A particular embodiment of the invention is a method for the production of unsaturated omega-3 fatty acids and a method for the production of triglycerides with an increased content of unsaturated fatty acids, in particular, of Delta-3 fatty acids with more than three double bonds. Also disclosed is the production of a transgenic organism, preferably a transgenic plant, or a transgenic microorganism with increased content of omega-3 fatty acids, oils or lipids with omega-3 double bonds as a result of the expression of the elongases and desaturases employed in the above method, preferably in combination with omega-3 desaturases, for example a omega-3 desaturase from fungi of the family Pythiaceae such as the genus Phytophtora, for example, the genus and species Phytophtora infestans, or a omega-3 desaturase from algae such as the family Prasinophyceae, for example, the genus Ostreococcus and, particularly, the genus and species Ostreococcus tauri or diatomaceae such as the genus Thalassiosira and, particularly, the genus and species Thalassiosira pseudonana. The invention also relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms containing the nucleic acid sequences and/or the nucleic acid constructs and transgenic organisms containing said nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced according to the above method and use thereof and, furthermore, unsaturated fatty acids and triglycerides with an increased content of unsaturated fatty acids and use thereof.
摘要翻译：本发明涉及一种用于通过核酸的生物体制备的多个unge饱和脂肪酸的方法被引入到生物体中，这对于多肽与Δ-5-延伸酶活性的代码。有利地，这些核酸序列可以在生物体中，任选地与编码所述脂肪酸或脂质的生物合成的多肽的另外的核酸序列表达。特别有利的是编码Δ-4-Desaturaseund /或Δ-6去饱和酶，Δ-5去饱和酶的Δ-6延长酶的活性的核酸序列。有利的是，这些去饱和酶和延伸酶海链藻，裸藻或Ostreococcus。此外，本发明涉及用于生产油和/或三酰基甘油酯与长链多不饱和脂肪酸的升高的内容的处理。此外，在一个优选的实施方案中，本发明涉及用于生产不饱和ω-3脂肪酸和用于生产具有的不饱和脂肪酸含量增加的甘油三酯的方法的过程中，具有超过三个双键尤其ω-3脂肪酸。本发明涉及产生转基因生物，优选的转基因植物或转基因微生物，其具有具有由于延伸酶的表达ω-3双键的不饱和的ω-3脂肪酸，油或脂质的含量增加，并在本发明中连接有利的过程中去饱和酶使用与ω-3去饱和酶，例如，从家庭Pythiaceae的真菌，如属疫ω-3去饱和酶，例如属和种致病疫霉或从藻类ω-3去饱和酶诸如家庭绿枝藻纲例如的属Ostreococcus具体的属和种Ostreococcus桃源或硅藻如海链藻属特别是属和种海链pseudonana。本发明还涉及含有本发明核酸序列的核酸序列，核酸构建体，载体和有机体，将含有包含上述核酸序列，核酸构建体和/或载体的核酸序列和/或核酸构建体，和转基因生物体的载体。本发明的另一部分涉及通过本发明和它们的使用过程中产生的油，脂质和/或脂肪酸。本发明还涉及到的不饱和脂肪酸和甘油三酯具有不饱和脂肪酸的含量增加及其用途。

7. 发明申请

WO2004076617A3 METHOD FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS 审中-公开
标题翻译：生产多种不饱和脂肪酸的方法
公开(公告)号：WO2004076617A3
公开(公告)日：2004-10-28
申请号：PCT/EP2004000771
申请日：2004-01-29
申请人： BASF PLANT SCIENCE GMBH , RENZ ANDREAS , HEINZ ERNST , ABBADI AMINE , DOMERGUE FREDERIC , ZANK THORSTEN
发明人： RENZ ANDREAS , HEINZ ERNST , ABBADI AMINE , DOMERGUE FREDERIC , ZANK THORSTEN
IPC分类号： C12N9/10 , C12N15/82 , C12P7/64
CPC分类号： C12N15/8247 , C12N9/1029 , C12P7/6427 , C12P7/6472
摘要： The invention relates to a method for producing polyunsaturated fatty acids in an organism by introducing nucleic acids coding for polypeptides with acyl-CoA:lysophospholipid-acyl transferase activity into the organism. Advantageously, said nucleic acid sequences can optionally be expressed in the transgenic organism along with additional nucleic acid sequences coding for polypeptides of fatty acid metabolism or lipid metabolism biosynthesis. The invention also relates to the nucleic acid sequences, nucleic acid structures containing said nucleic acid sequences, vectors containing the inventive nucleic acid sequences, and/or the nucleic acid structures and transgenic organisms containing said nucleic acid sequences, nucleic acid structures, and/or vectors. The invention further relates to oils, lipids, and/or fatty acids that are produced according the inventive method, and the use thereof.
摘要翻译：本发明涉及一种用于生产在由核酸的生物体的多不饱和脂肪酸的方法被引入到生物体中，其用于与酰基辅酶A的多肽代码：溶血磷脂酰基转移酶酶活性的编码。有利地，这些核酸序列可以任选地与编码脂肪酸或脂质代谢的生物合成的多肽的其他核酸序列一起在转基因生物体中表达。本发明还涉及核酸序列，含有根据本发明的核酸序列的核酸构建体，包含核酸序列的载体和/或含有上述核酸序列的核酸构建体和转基因生物，核酸构建体和/或载体。本发明的另一部分涉及通过erfindungsgemäbetaen方法制备的油，脂质和/或脂肪酸及其用途。

8. 发明申请

WO2007118751A3 METHOD FOR MODIFYING THE ATP/ADP RATIO IN CELLS 审中-公开
标题翻译：改变细胞中ATP-ADP比率的方法
公开(公告)号：WO2007118751A3
公开(公告)日：2007-12-21
申请号：PCT/EP2007052655
申请日：2007-03-20
申请人： MAX PLANCK INST FUER MOLEKULAR , ZANK THORSTEN , OSWALD OLIVER , BAUER JOERG , VIGEOLAS HELENE , GEIGENBERGER PETER , STITT MARK
发明人： ZANK THORSTEN , OSWALD OLIVER , BAUER JOERG , VIGEOLAS HELENE , GEIGENBERGER PETER , STITT MARK
IPC分类号： C12N15/82 , C07K14/415
CPC分类号： C12N15/8247 , C07K14/805
摘要： The invention relates to a method for modifying the ATP/ADP ratio in a cell, tissue, organ, microorganism or plant by modifying the hemoprotein activity in the cell. The invention also relates to the use of said method.
摘要翻译：本发明涉及通过改变细胞中的血红蛋白活性及其用途来改变细胞，组织，器官，微生物或植物中ATP / ADP比例的方法。

9. 发明申请

WO2007012576A3 COMBINATION OF LIPID METABOLISM PROTEINS AND USES THEREOF 审中-公开
标题翻译：脂质代谢蛋白质的组合及其用途
公开(公告)号：WO2007012576A3
公开(公告)日：2007-08-09
申请号：PCT/EP2006064276
申请日：2006-07-14
申请人： BASF PLANT SCIENCE , ZANK THORSTEN , OSWALD OLIVER
发明人： ZANK THORSTEN , OSWALD OLIVER
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8247 , C07K14/415
摘要： Described herein are inventions in the field of genetic engineering of plants, including combinations of nucleic acid molecules encoding LMPs to improve agronomic, horticultural, and quality traits. This invention relates generally to the combination of nucleic acid sequences encoding proteins that are related to the presence of seed storage compounds in plants. More specifically, the present invention relates to LMP nucleic acid sequences encoding lipid metabolism proteins (LMP) and the use of these combinations of these sequences, their order and direction in the combination, and the regulatory elements used to control expression and transcript termination in these combinations in transgenic plants. In particular, the invention is directed to methods for manipulating fatty acid-related compounds and for increasing oil level and altering the fatty acid composition in plants and seeds. The invention further relates to methods of using these novel combinations of polypeptides to stimulate plant growth and/or to increase yield and/or composition of seed storage compounds.
摘要翻译：本文描述了植物基因工程领域的发明，包括编码LMP的核酸分子的组合以改善农艺学，园艺学和品质性状。本发明一般涉及编码与植物中存在种子储存化合物有关的蛋白质的核酸序列的组合。更具体地，本发明涉及编码脂质代谢蛋白（LMP）的LMP核酸序列以及这些序列的这些组合的使用，它们在组合中的顺序和方向以及用于控制这些序列中的表达和转录终止的调控元件转基因植物中的组合。具体而言，本发明涉及操作脂肪酸相关化合物和提高油含量和改变植物和种子中脂肪酸组成的方法。本发明还涉及使用这些新的多肽组合来刺激植物生长和/或增加种子贮藏化合物的产量和/或组成的方法。

10. 发明申请

WO2005063995A3 SUGAR AND LIPID METABOLISM REGULATORS IN PLANTS VI 审中-公开
标题翻译：植物中的糖和脂肪代谢调节剂六
公开(公告)号：WO2005063995A3
公开(公告)日：2005-10-20
申请号：PCT/IB2004004251
申请日：2004-12-22
申请人： BASF PLANT SCIENCE GMBH , OSWALD OLIVER , BAUER JORG , ZANK THORSTEN
发明人： OSWALD OLIVER , BAUER JORG , ZANK THORSTEN
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8247 , C12N15/8245
摘要： Isolated nucleic acids and proteins associated with lipid and sugar metabolism regulation are provided. In particular, lipid metabolism proteins (LMP) and encoding nucleic acids originating from Arabidopsis thaliana, Brassica napus, and Helianthus annuus are provided. The nucleic acids and proteins are used in methods of producing transgenic plants and modulating levels of seed storage compounds. Preferably, the seed storage compounds are lipids, fatty acids, starches, or seed storage proteins.
摘要翻译：提供了与脂质和糖代谢调节相关的分离的核酸和蛋白质。特别地，提供脂质代谢蛋白（LMP）和编码来自拟南芥，甘蓝型油菜和向日葵的核酸。核酸和蛋白质用于产生转基因植物和调节种子储存化合物水平的方法中。优选地，种子储存化合物是脂质，脂肪酸，淀粉或种子储存蛋白。

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