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1. 发明申请

WO2007042510A2 PROCESS FOR THE PRODUCTION OF ARACHIDONIC ACID AND/OR EICOSAPENTAENOIC ACID 审中-公开
标题翻译：生产阿卡膦酸和/或异柠檬酸的方法
公开(公告)号：WO2007042510A2
公开(公告)日：2007-04-19
申请号：PCT/EP2006067223
申请日：2006-10-10
申请人： ROTHAMSTED RES , NAPIER JOHNATHAN A , SAYANOVA OLGA
发明人： NAPIER JOHNATHAN A , SAYANOVA OLGA
IPC分类号： C12N9/02 , C12N9/10 , C12N15/82
CPC分类号： C12N15/8247 , C12N9/0083 , C12N9/1029
摘要： The present invention relates to a new process for the production of arachidonic acid and/or eicosapentaenoic acid in plants through the co-expression of a ?-12-/?-15- desaturase, ?-9-elongase, ?-8-desaturase and a ?-5-desaturase and a process for the production of lipids or oils having an increased content of unsaturated fatty acids, in particular ?-3 and ?-6 fatty acids having at least two double bonds and a 18 or 20 carbon atom chain length. Preferably the arachidonic acid and eicosapentaenoic acid are produced in at least a 1 :2 ratio. The invention furthermore relates to the production of a transgenic plants, preferably a transgenic crop plant, having an increased content of arachidonic acid and/or ei¬ cosapentaenoic acid, oils or lipids containing Ciß- or C20- fatty acids with a double bond in position ? 5, 8, 9, 11 , 12, 14, 15 or dffthe fatty acid produced, respectively due to the expression of the ?-12-/?-15-desaturase, of the ?-9-elongase, of the ?-8- desaturase and of the ?-5-desaturase in the plant. The expression of the inventive ?- 12-/?-15-desaturase leads preferably to linoleic acid and linolenic acid as products having a double bond in the position ? 9, 12 and 15 of the fatty acid. The invention additionally relates to specific nucleic acid sequences encoding for pro¬ teins with ?-12-/?-15-desaturase-, ?-9-elongase-, ?-8-desaturase- or ?-5-desaturase- activity, nucleic acid constructs, vectors and transgenic plants containing said nucleic acid sequences.
摘要翻译：本发明涉及通过共同表达α-12 /β-15-去饱和酶，α-9-延长酶，α-8-去饱和酶，在植物中生产花生四烯酸和/或二十碳五烯酸的新方法和α-5-去饱和酶的制备方法和具有增加的不饱和脂肪酸含量的脂质或油的方法，特别是具有至少两个双键和18或20个碳原子的α-3和β-6脂肪酸链长。优选花生四烯酸和二十碳五烯酸以至少1:2的比例制备。本发明还涉及生产具有增加的花生四烯酸和/或二十碳五烯酸含量的转基因植物，含有具有双键位置的C 1 -C 20或C 20 - 脂肪酸的油或脂质的转基因植物？ 5，8，9，11，12，14，15，或分别由α-12- /β-15-去饱和酶表达β-9-延伸酶而产生的α- - 去饱和酶和植物中的α-5-去饱和酶。本发明的β-12- /β-15-去饱和酶的表达优选导致亚油酸和亚麻酸作为在位置β具有双键的产物。 9,12和15的脂肪酸。本发明还涉及编码具有α-12 - /β-15-去饱和酶 - ，β-延伸酶 - ，α-8-去饱和酶或α-5-去饱和酶 - 活性的核酸的特异性核酸序列酸构建体，载体和含有所述核酸序列的转基因植物。

2. 发明申请

WO2009133145A1 DESATURASE AND METHOD FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS 审中-公开
标题翻译：在转基因生物中生产聚氨酯脂肪酸的脱脂和方法
公开(公告)号：WO2009133145A1
公开(公告)日：2009-11-05
申请号：PCT/EP2009/055210
申请日：2009-04-29
申请人： BASF PLANT SCIENCE GMBH , BAUER, Joerg , NAPIER, Johnathan A. , SAYANOVA, Olga
发明人： BAUER, Joerg , NAPIER, Johnathan A. , SAYANOVA, Olga
IPC分类号： C12N15/82 , C12N9/02 , C12N15/53 , C12P7/64 , A01H5/00
CPC分类号： C12N15/8247 , C12N9/0083 , C12P7/6427 , C12P7/6436 , C12P7/6472 , C12P7/6481
摘要： The present invention relates to a polynucleotide from Emiliana huxleyi which codes for a desaturase and which can be employed for the recombinant production of polyun- saturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the polynucleotide according to the invention, and to the polypeptides encoded by the polynucleotide. The invention furthermore relates to antibodies against the polypeptide according to the invention. Finally, the invention also relates to production methods for the polyunsaturated fatty acids and for oil, lipid and fatty acid compositions and to their use as drugs, cosmetics, foodstuffs, feedstuffs, preferably fish food, or food supplements.
摘要翻译：本发明涉及编码去饱和酶的Emiliana huxleyi的多核苷酸，其可用于重组生产多聚饱和脂肪酸。本发明还涉及包含根据本发明的多核苷酸的载体，宿主细胞和转基因非人生物以及由多核苷酸编码的多肽。本发明还涉及针对根据本发明的多肽的抗体。最后，本发明还涉及多不饱和脂肪酸和油，脂肪和脂肪酸组合物的制备方法以及它们作为药物，化妆品，食品，饲料，优选鱼食或食品补充剂的用途。

3. 发明申请

WO2007093776A2 NUCLEIC ACID 审中-公开
标题翻译：核酸
公开(公告)号：WO2007093776A2
公开(公告)日：2007-08-23
申请号：PCT/GB2007/000491
申请日：2007-02-13
申请人： BASF PLANT SCIENCE GMBH , NAPIER, Johnathan , SAYANOVA, Olga , VENEGAS CALERON, Monica
发明人： NAPIER, Johnathan , SAYANOVA, Olga , VENEGAS CALERON, Monica
IPC分类号： C12N15/54 , C12N15/53 , C12P7/64 , A01H5/00
CPC分类号： C12N15/8247 , C12N9/0083 , C12N9/1029 , C12P7/6427 , C12P7/6472
摘要： The invention relates to nucleic acid derived from Perkinsus marinus which encodes a 9-elongase, a Δ8-desaturase and a Δ5-desaturase enzyme. All of the coding sequences can be transcribed as a single transcript.
摘要翻译：本发明涉及编码9-延伸酶，Δ8-去饱和酶和Δ5-去饱和酶的源自Perkinsus marinus的核酸。所有的编码序列都可以被转录成单个转录本。

4. 发明申请

WO2007042510A3 PROCESS FOR THE PRODUCTION OF ARACHIDONIC ACID AND/OR EICOSAPENTAENOIC ACID 审中-公开
公开(公告)号：WO2007042510A3
公开(公告)日：2007-04-19
申请号：PCT/EP2006/067223
申请日：2006-10-10
申请人： BASF PLANT SCIENCE GMBH , NAPIER, Johnathan A. , SAYANOVA, Olga
发明人： NAPIER, Johnathan A. , SAYANOVA, Olga
IPC分类号： C12N9/02 , C12N9/10 , C12N15/82
摘要： vectors and transgenic plants containing said nucleic acid sequences.

5. 发明申请

WO2010142522A3 NOVEL FATTY ACID ELONGATION COMPONENTS AND USES THEREOF 审中-公开
标题翻译：新型脂肪酸成分及其用途
公开(公告)号：WO2010142522A3
公开(公告)日：2011-04-14
申请号：PCT/EP2010056936
申请日：2010-05-20
申请人： BASF PLANT SCIENCE CO GMBH , ROTHAMSTED RES LTD , NAPIER JONATHAN A , SAYANOVA OLGA , BEAUDOIN FREDERIC
发明人： NAPIER JONATHAN A , SAYANOVA OLGA , BEAUDOIN FREDERIC
IPC分类号： C12N15/82 , C12N9/02
CPC分类号： C12N15/8247 , C12N9/001 , C12N9/88 , C12P7/6427 , C12P7/6472
摘要： The invention provides isolated nucleic acid molecules which encodes a novel fatty acid nECR. The invention also provides recombinant expression vectors containing nECR nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA.
摘要翻译：本发明提供编码新型脂肪酸nECR的分离的核酸分子。本发明还提供了含有nECR核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及大规模生产长链多不饱和脂肪酸（LCPUFA）如ARA，EPA和DHA的方法。

6. 发明申请

WO2010142522A2 NOVEL FATTY ACID ELONGATION COMPONENTS AND USES THEREOF 审中-公开
标题翻译：新型脂肪酸成分及其用途
公开(公告)号：WO2010142522A2
公开(公告)日：2010-12-16
申请号：PCT/EP2010/056936
申请日：2010-05-20
申请人： BASF PLANT SCIENCE COMPANY GMBH , ROTHAMSTED RESEARCH LTD. , NAPIER, Jonathan A. , SAYANOVA, Olga , BEAUDOIN, Frederic
发明人： NAPIER, Jonathan A. , SAYANOVA, Olga , BEAUDOIN, Frederic
IPC分类号： C12N15/82
CPC分类号： C12N15/8247 , C12N9/001 , C12N9/88 , C12P7/6427 , C12P7/6472
摘要： The invention provides isolated nucleic acid molecules which encodes a novel fatty acid nECR. The invention also provides recombinant expression vectors containing nECR nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA.
摘要翻译：本发明提供编码新型脂肪酸nECR的分离的核酸分子。本发明还提供了含有nECR核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及大规模生产长链多不饱和脂肪酸（LCPUFA）如ARA，EPA和DHA的方法。

7. 发明申请

WO2004057001A3 METHOD FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS 审中-公开
标题翻译：生产聚氨酯脂肪酸的方法
公开(公告)号：WO2004057001A3
公开(公告)日：2004-11-04
申请号：PCT/EP0314054
申请日：2003-12-11
申请人： UNIV BRISTOL , NAPIER JOHNATHAN A , SAYANOVA OLGA , LAZARUS COLIN M , QI BAOXIU , HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH
发明人： NAPIER JOHNATHAN A , SAYANOVA OLGA , LAZARUS COLIN M , QI BAOXIU , HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH
IPC分类号： C12N9/02 , C12N9/10 , C12N15/82 , C12P7/64
CPC分类号： C12N9/0083 , C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to an improved process for the specific production of poly-unsaturated omega-3 and omega-6 fatty acids and a process for the production of triglycerides having an increased content of unsaturated fatty acids, in particular omega-3 and omega-6 fatty acids having at least two double bonds and a 20 or 22 carbon atom chain length. The invention relates to the produc-tion of a transgenic organism, preferably a transgenic plant or a transgenic microorganism, hav-ing an increased content of fatty acids, oils or lipids containing C20- or C22- fatty acids with a delta-5, 7, 8, 10 double bond, respectively due to the expression of a delta-8-desaturase and a delta-9- elon-gase from organisms such as plants preferably Algae like Isochrysis galbana or Euglena gracilis. In addition the invention relates to a process for the production of poly unsaturated fatty acids such as Eicosapentaenoic, Arachidonic, Docosapentaenoic or Docosahexaenoic acid through the co- expression of a delta -8-desaturase, a delta-9-elongase and a delta-5 desaturase in organisms such as microorganisms or plants.The invention additionally relates to the use of specific nucleic acid sequences encoding for the aforementioned proteins with delta-8-desaturase-, delta-9-elongase- or delta-5-desaturase-activity, nucleic acid constructs, vectors and organisms containing said nucleic acid sequences. The invention further relates to unsaturated fatty acids and triglycerides having an increased content of at least 1 % by weight of unsaturated fatty acids and use thereof.

8. 发明申请

WO2011006948A1 NOVEL FATTY ACID DESATURASES AND ELONGASES AND USES THEREOF 审中-公开
标题翻译：新型脂肪酸及其用途及其用途
公开(公告)号：WO2011006948A1
公开(公告)日：2011-01-20
申请号：PCT/EP2010/060178
申请日：2010-07-15
申请人： BASF PLANT SCIENCE COMPANY GMBH , BAUER, Jörg , NAPIER, Johnathan, A. , SAYANOVA, Olga
发明人： BAUER, Jörg , NAPIER, Johnathan, A. , SAYANOVA, Olga
IPC分类号： C07K14/435 , C12N15/82
CPC分类号： C12N15/8247 , C07K14/435 , C12N9/0071 , C12N9/93 , C12Y114/19 , C12Y114/19003 , C12Y114/19004 , C12Y114/19006 , C12Y602/01003
摘要： The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA).
摘要翻译：本发明提供了分离的核酸分子，其编码来自生物Emiliana huxleyi的新型脂肪酸去饱和酶和延伸酶。本发明还提供了含有去饱和酶或延伸酶核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及用于大规模生产长链多不饱和脂肪酸（LCPUFA）的方法。花生四烯酸（ARA），二十碳五烯酸（EPA）或二十二碳六烯酸（DHA）。

9. 发明申请

WO2007051577A3 VERFAHREN ZUR HERSTELLUNG VON γ-LINOLENSÄURE UND/ ODER STEARIDONSÄURE IN TRANSGENEN BRASSICACEAE UND LINACEAE 审中-公开
公开(公告)号：WO2007051577A3
公开(公告)日：2007-05-10
申请号：PCT/EP2006/010408
申请日：2006-10-30
申请人： BASF PLANT SCIENCE GMBH , NAPIER, Johnathan, A. , SAYANOVA, Olga , VENEGAS CALERON, Monica
发明人： NAPIER, Johnathan, A. , SAYANOVA, Olga , VENEGAS CALERON, Monica
IPC分类号： C12N15/82 , C07K14/415
摘要： Die vorliegende Erfindung betrifft die Herstellung von γ-Linolensäure (18:3 Δ6,9,12 ) oder Stearidonsäure (18:4 Δ6,9,12,15 ) oder γ-Linolensäure (18:3 Δ6,9,12 ) und Stearidonsäure (18:4 Δ6,9,12,15 ) in transgenen Pflanzen der Familie Brassicaceae, wobei die transgenen Pflanzen mindestens 10 Gew-% Ölsäure bezogen auf den Gesamtfettsäuregehalt enthalten und durch die Aktivität der im Verfahren verwendeten Δ-6-Desaturasen einen erhöhten Gehalt an Δ-6-C 18 -Fettsäuren aufweisen. Außerdem betrifft die Erfindung neue Nukleinsäuresequenzen, die für die im Verfahren verwendeten Δ-6-Desatu rasen codieren, Genkonstrukte enthaltend diese Nukleinsäuresequenzen, einen Vektor und transgene Pflanzen enthaltend mindestens eine Nukleinsäuresequenz bzw. ein Genkonstrukt.

10. 发明申请

WO2003072784A1 DELTA 6-DESATURASES FROM PRIMULACEAE, EXPRESSING PLANTS AND PUFA-CONTAINING OILS 审中-公开
标题翻译：来自PRIMULACEAE的DELTA 6-脱氧核糖核酸，表达植物和含PUFA的油
公开(公告)号：WO2003072784A1
公开(公告)日：2003-09-04
申请号：PCT/EP2003/001161
申请日：2003-02-06
申请人： ROTHAMSTED EXPERIMENTAL STATION , NAPIER, Johnathan, A. , SAYANOVA, Olga
发明人： NAPIER, Johnathan, A. , SAYANOVA, Olga
IPC分类号： C12N15/53
CPC分类号： C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to an improved method for the specific production of unsaturated ω-3 fatty acids and a method for the production of triglycerides having an increased content of unsaturated fatty acids, in particular ω-3 fatty acids having more than three double bonds. The invention relates to the production of a transgenic organism, preferably a transgenic plant or a transgenic microorganism, having an increased content of fatty acids, oils or lipids having Δ 6 double bonds due to the expression of a Δ 6-desaturase from Primulaceae. The invention additionally relates to expression cassettes containing a nucleic acid sequence, a vector and organisms containing at least one nucleic acid sequence or an expression cassette. The invention further relates to unsaturated fatty acids and triglycerides having an increased content of unsaturated fatty acids and use thereof.
摘要翻译：本发明涉及用于特异性生产不饱和ω-3脂肪酸的改进方法以及生产具有增加的不饱和脂肪酸含量，特别是具有多于三个双键的ω-3脂肪酸的甘油三酸酯的方法。本发明涉及转基因生物，优选转基因植物或转基因微生物的生产，其具有增加的具有DELTA 6双键的脂肪酸，油或脂质含量，这是由于来自菜ace科的DELTA6-去饱和酶的表达。本发明还涉及含有核酸序列，载体和含有至少一个核酸序列或表达盒的生物体的表达盒。本发明还涉及具有增加的不饱和脂肪酸含量的不饱和脂肪酸和甘油三酸酯及其用途。

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