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1. 发明申请

WO2004057001A3 METHOD FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS 审中-公开
标题翻译：生产聚氨酯脂肪酸的方法
公开(公告)号：WO2004057001A3
公开(公告)日：2004-11-04
申请号：PCT/EP0314054
申请日：2003-12-11
申请人： UNIV BRISTOL , NAPIER JOHNATHAN A , SAYANOVA OLGA , LAZARUS COLIN M , QI BAOXIU , HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH
发明人： NAPIER JOHNATHAN A , SAYANOVA OLGA , LAZARUS COLIN M , QI BAOXIU , HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH
IPC分类号： C12N9/02 , C12N9/10 , C12N15/82 , C12P7/64
CPC分类号： C12N9/0083 , C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to an improved process for the specific production of poly-unsaturated omega-3 and omega-6 fatty acids and a process for the production of triglycerides having an increased content of unsaturated fatty acids, in particular omega-3 and omega-6 fatty acids having at least two double bonds and a 20 or 22 carbon atom chain length. The invention relates to the produc-tion of a transgenic organism, preferably a transgenic plant or a transgenic microorganism, hav-ing an increased content of fatty acids, oils or lipids containing C20- or C22- fatty acids with a delta-5, 7, 8, 10 double bond, respectively due to the expression of a delta-8-desaturase and a delta-9- elon-gase from organisms such as plants preferably Algae like Isochrysis galbana or Euglena gracilis. In addition the invention relates to a process for the production of poly unsaturated fatty acids such as Eicosapentaenoic, Arachidonic, Docosapentaenoic or Docosahexaenoic acid through the co- expression of a delta -8-desaturase, a delta-9-elongase and a delta-5 desaturase in organisms such as microorganisms or plants.The invention additionally relates to the use of specific nucleic acid sequences encoding for the aforementioned proteins with delta-8-desaturase-, delta-9-elongase- or delta-5-desaturase-activity, nucleic acid constructs, vectors and organisms containing said nucleic acid sequences. The invention further relates to unsaturated fatty acids and triglycerides having an increased content of at least 1 % by weight of unsaturated fatty acids and use thereof.

2. 发明申请

WO0159128A2 NOVEL ELONGASE GENE AND METHOD FOR PRODUCING MULTIPLE-UNSATURATED FATTY ACIDS 审中-公开
标题翻译：新的长链脂肪酸和生产多种不饱和脂肪酸的方法
公开(公告)号：WO0159128A2
公开(公告)日：2001-08-16
申请号：PCT/EP0101346
申请日：2001-02-08
申请人： BASF AG , HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH , LERCHL JENS , RENZ ANDREAS
发明人： HEINZ ERNST , ZANK THORSTEN , ZAEHRINGER ULRICH , LERCHL JENS , RENZ ANDREAS
IPC分类号： A01H5/00 , A01K67/027 , A23K1/16 , A23L1/30 , A61K8/30 , A61K8/36 , A61K8/92 , A61K31/201 , A61K31/202 , A61P3/02 , A61P3/06 , A61P9/10 , A61P29/00 , C07K16/40 , C11C3/00 , C12N9/00 , C12N9/10 , C12N15/09 , C12N15/54 , C12N15/82 , C12P7/64 , C12Q1/02 , A61K38/45 , C11B1/00 , C11C1/00 , C12Q1/48 , G01N33/573
CPC分类号： C12N9/1029 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The invention relates to a novel elongase gene comprising the sequences cited in sequence SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5 and SEQ ID NO:7 or to homologues, derivatives or analogues thereof. The invention also relates to a gene construct containing these genes or homologues, derivatives or analogues thereof, and to its use. The invention additionally relates to the vectors or transgenic organisms containing an elongase gene comprising the sequence SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5 and SEQ ID NO:7 or containing homologues, derivatives or analogues thereof. The invention relates to the use of the elongase sequences alone or in combination with additional elongases and/or with additional fatty acid biosynthesis genes. The invention relates to a novel elongase gene comprising the sequence SEQ ID NO:1 or to homologues, derivatives or analogues thereof. The invention also relates to a method for producing multiple-unsaturated fatty acids and to a method for introducing DNA into organisms which produce large quantities of oils and, in particular, oils having a high content of unsaturated fatty acids. The invention further relates to an oil and/or to a fatty acid preparation having a high content of multiple-unsaturated fatty acids that contain at least two double bonds and/or to a triacylglycerin preparation having a high content of multiple-unsaturated fatty acids that contain at least two double bonds.
摘要翻译：本发明涉及一种在序列SEQ ID NO与一个NEUS延长酶基因：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO：序列或7-称他们的同系物，衍生物或类似物，涉及一种基因构建体，这些基因或他们的同系物，衍生物或类似物，以及它的用途。本发明还涉及到与序列SEQ ID NO载体或转基因生物的延长酶基因：含有7或它的同系物，衍生物或类似物：1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO。此外，本发明涉及单独或与其他延伸酶和/或其他脂肪酸生物合成基因组合使用延长分支酶。本发明涉及具有序列SEQ ID NO：1或其同系物，衍生物或类似物的新型延伸酶基因。此外，本发明涉及生产多不饱和脂肪酸的方法，以及将DNA引入生产大量油类，特别是具有高含量不饱和脂肪酸的油类的生物中的方法。此外，本发明提供了油和/或与多不饱和脂肪酸具有至少两个双键和/或三酰甘油制剂用的多不饱和脂肪酸含量较高具有至少两个双键的涉及高含量的脂肪酸制备。

3. 发明申请

WO0066716A3 METHOD FOR PRODUCING ORGANISMS EXHIBITING INCREASED STEROL GLYCOSIDE PRODUCTION AND USE OF THE STEROL GLYCOSIDES 审中-公开
标题翻译：用于生产生物中具有增加STEROLGLYKOSID生产和STEROLGLYKOSIDE的使用
公开(公告)号：WO0066716A3
公开(公告)日：2001-08-09
申请号：PCT/EP0003856
申请日：2000-04-28
申请人： ERWERB UND VERWERTUNG VON SCHU , FORSCHUNGSZENTRUM BORSTEL , HEINZ ERNST , WARNECKE DIRK , ZANK THORSTEN , MUELLER FRANK , ZAEHRINGER ULRICH
发明人： HEINZ ERNST , WARNECKE DIRK , ZANK THORSTEN , MUELLER FRANK , ZAEHRINGER ULRICH
IPC分类号： A61K35/76 , A61K48/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/10 , C12N15/54 , A01H5/00 , A61K31/70 , A61K39/39 , C07J17/00 , C12N1/00 , C12N5/10 , C12N15/62 , C12N15/63 , C12N15/82 , C12P33/00 , C12P33/20 , C12Q1/68
CPC分类号： C12N9/1051 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： The invention relates to a method for producing transgenic organisms including bacteria, fungi, plants and animals, or transgenic cells which exhibit an increased production of steroid glycoside, steroid alkaloid and/or sterol glycoside compared to that of wild-type organisms or cells. The inventive method involves the transfer of DNA sequences which code for sterol glycosyl transferases. The invention also relates to applications of the organisms produced or of the steroid glycosides, steroid alkaloids and/or sterol glycosides synthesized in or by the organisms or cells. Said applications are useful in the pharmaceutical and foodstuff industries as well as for protecting plants.
摘要翻译：本发明涉及一种方法，用于生产转基因生物体，包括细菌，真菌，植物和动物，或转基因细胞相比，增加Steroidglykosid-，Steroidalkaloid-和/或Sterolglykosid生产野生型生物体或细胞，其具有的内容，其中的所述方法包括编码Sterolglykosyltransferasen DNA序列的转移。此外，本发明的药学，食品技术或用于作物保护的涉及生产或或者从生物或细胞的甾体糖苷，和Steroidalkaloid- Sterolglykoside合成的生物体的有益用途。

4. 发明申请

WO9949052A3 PROCESSIVE GLYCOSYLTRANSFERASE 审中-公开
标题翻译：进行性糖基转移酶
公开(公告)号：WO9949052A3
公开(公告)日：2000-03-02
申请号：PCT/DE9900857
申请日：1999-03-25
申请人： GVS GES FUER ERWERB UND VERWER , FORSCHUNGSZENTRUM BORSTEL , WOLTER FRANK P , JORASCH PETRA , HEINZ ERNST , ZAEHRINGER ULRICH
发明人： WOLTER FRANK P , JORASCH PETRA , HEINZ ERNST , ZAEHRINGER ULRICH
IPC分类号： C12N1/21 , C12N9/10 , C12N15/54 , C07H15/06 , C07H15/10 , C12N15/62 , C12P19/18
CPC分类号： C12N9/1051 , C12N9/1048
摘要： The invention relates to a protein which presents identical or different catalytically active domains of glycosyltransferases and has a processive action. In particular, the same protein is successively active in at least two successive process steps.
摘要翻译：本发明涉及的蛋白质。它有糖基转移酶和进行性活性的相同或不同的催化活性结构域。特别地，相同的蛋白质是在至少两个连续的工艺步骤依次活性。

5. 发明申请

WO2004090123A2 Delta-4 DESATURASES FROM EUGLENA GRACILIS, EXPRESSING PLANTS, AND OILS CONTAINING PUFA 审中-公开
标题翻译：来自小眼虫Δ-4去饱和酶，表达植物和多不饱和脂肪酸含油
公开(公告)号：WO2004090123A2
公开(公告)日：2004-10-21
申请号：PCT/EP2004003628
申请日：2004-04-06
申请人： BASF PLANT SCIENCE GMBH , CIRPUS PETRA , BAUER JOERG , MEYER ASTRID , HEINZ ERNST , ZAEHRINGER ULRICH
发明人： CIRPUS PETRA , BAUER JOERG , MEYER ASTRID , HEINZ ERNST , ZAEHRINGER ULRICH
IPC分类号： C12N9/02 , C12N15/82 , C12N9/00
CPC分类号： C12N9/0071 , C12N15/8247
摘要： The invention relates to an improved method for the specific production of unsaturated omega-3 fatty acids and a method for producing triglycerides containing an increased number of unsaturated fatty acids, especially omega-3 fatty acids comprising more than three double bonds. Disclosed is the production of a transgenic organism, preferably a transgenic plant, or a transgenic microorganism containing an increased number of fatty acids, oils, or lipids comprising Delta-4 double bonds as a result of a Delta-4 desaturase being expressed from Euglena gracilis. The invention further relates to expression cassettes containing a nucleic acid sequence, a vector, and organisms containing at least one nucleic acid sequence or an expression cassette. Also disclosed are unsaturated fatty acids and triglycerides having an increased fatty acid content and the use thereof. Fatty acids and triglycerides are used in a plurality of application in the food industry, in animal nutrition, cosmetics, and pharmaceuticals and are suitable for many different applications depending on whether free saturated or unsaturated fatty acids or triglycerides having an increased saturated or unsaturated fatty acid content are used.
摘要翻译：本发明涉及一种用于不饱和ω-3脂肪酸的具体赫斯位置和用于生产具有的不饱和脂肪酸含量增加的甘油三酯的方法的改进方法中，具有超过三个双键尤其ω-3脂肪酸。本发明涉及生产转基因生物，优选的转基因植物或转基因微生物，其具有的脂肪酸，油或脂类具有由于来自小眼虫的Δ-4去饱和酶的表达Δ-4个双键的含量增加。 urthermore，本发明涉及含有核酸序列，载体的表达盒和生物体含有至少一种核酸序列或表达盒。本发明还涉及不饱和脂肪酸和与Trigiyceride的不饱和脂肪酸含量增加及其用途。脂肪酸和Trigiyceride有多种食品工业中的应用，动物营养，化妆品和药品。取决于它们是否是游离饱和或不饱和脂肪酸或甘油三酯的饱和或不饱和脂肪酸的含量增加，它们适用于不同的应用。

6. 发明申请

WO02057465A3 METHOD FOR PRODUCING POLYUNSATURATED FATTY ACIDS, NOVEL BIOSYNTHESIS GENES AND NOVEL PLANT EXPRESSION CONSTRUCTS 审中-公开
标题翻译：用于生产多不饱和脂肪酸，合成新的和新工厂的表达构建
公开(公告)号：WO02057465A3
公开(公告)日：2003-06-12
申请号：PCT/EP0200462
申请日：2002-01-18
申请人： BASF PLANT SCIENCE GMBH , LERCHL JENS , RENZ ANDREAS , HEINZ ERNST , DOMERGUE FREDERIC , ZAEHRINGER ULRICH
发明人： LERCHL JENS , RENZ ANDREAS , HEINZ ERNST , DOMERGUE FREDERIC , ZAEHRINGER ULRICH
IPC分类号： A01H5/00 , A01K67/027 , A23D9/007 , A23L1/30 , A61K8/30 , A61K8/34 , A61K8/37 , A61K31/201 , A61K31/202 , A61K31/231 , A61K31/232 , A61K31/7088 , A61K36/00 , A61K39/395 , A61K45/00 , A61P3/06 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/02 , C12N15/09 , C12N15/53 , C12N15/82 , C12P7/64 , C12Q1/02 , C12Q1/26 , G01N33/15 , G01N33/50 , C11B1/00 , C12N15/11 , C12P7/62 , C12Q1/68 , G01N33/573
CPC分类号： C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The invention relates to a method for producing unsaturated fatty acids comprising at least two double bonds, and a method for producing triglycerides having an increased content of polyunsaturated fatty acids comprising at least two double bonds. The invention also relates to the advantageous use of the nucleic acid sequences of SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 9, SEQ ID NO: 11 or SEQ ID NO: 18 in the inventive methods, and for producing a transgenic organism, preferably a transgenic plant or a transgenic micro-organism having an increased content of fatty acids, oils or lipids containing unsaturated C18, C20, or C22 fatty acids. The invention further relates to novel desaturases comprising the sequences of SEQ ID NO. 1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 11, or the homologues, derivatives or analogues thereof, and gene constructs comprising said genes or the homologues, derivatives or analogues thereof, in addition to the use of the same, either alone or combined with biosynthesis genes of polyunsaturated fatty acids, as advantageously represented in SEQ ID NO: 7 and SEQ ID NO: 9. Furthermore, the invention relates to isolated nucleic acid sequences, expression cassettes containing said nucleic acid sequences, vectors, and transgenic organisms containing at least one nucleic acid sequence or an expression cassette. The invention also relates to unsaturated fatty acids comprising at least two double bonds and triglycerides having an increased content of unsaturated fatty acids comprising at least two double bonds, and the use of the same. Finally, the invention relates to multi-expression cassettes for seed-specific expression, in addition to vectors or organisms comprising a desaturase gene, either alone or combined with other desaturases having the sequence of SEQ ID NO: 7 and/or elongase genes having the sequence of ID NO: 9 or the homologues, derivatives or analogues of the same, expressed by means of the above-mentioned expression cassettes.
摘要翻译：本发明涉及一种用于制备具有至少两个双键和/或用于生产甘油三酯的具有多不饱和脂肪酸与多不饱和脂肪酸具有至少两个双键的至少höhtem含量增加的内容的方法的不饱和脂肪酸的方法。本发明还涉及有利地使用的核酸序列的SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5，SEQ ID NO：9，SEQ ID NO：11或SEQ ID NO：18中的过程和用于生产的转基因生物体，优选转基因植物或具有脂肪酸，油或脂类具有不饱和C18，C20，C22或脂肪酸含量增加的转基因微生物。本发明还涉及新的去饱和酶与序列SEQ ID号 1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO：11或它的同系物，衍生物或它们的类似物，和包含所述基因的基因构建体或他们的同系物，衍生物或类似物，并单独或与生物合成基因组合使用它们polyungesätigter 脂肪酸，例如有利地在SEQ ID NO：9：7和SEQ ID NO。本发明还涉及分离的核酸序列; 表达盒包含Nukleinesäuresequenzen。载体，以及含有至少一种核酸序列或表达盒的转基因生物。本发明还涉及一种具有至少两个双键和具有具有至少两个双键和其用途的不饱和脂肪酸含量增加的甘油三酯不饱和脂肪酸。本发明还涉及用于种子特异性表达，其包括单独或与具有SEQ ID NO：1的序列的其它去饱和酶组合的去饱和酶基因的多表达盒和载体或生物体：7和/或延长酶基因与去SEQ ID NO：9或它的同系物，衍生物或类似物包括使用vesagter的表达盒。

7. 发明申请

WO0000593A3 SPHINGOLIPID-DESATURASE 审中-公开
标题翻译：鞘脂脱饱和
公开(公告)号：WO0000593A3
公开(公告)日：2000-08-10
申请号：PCT/DE9901859
申请日：1999-06-25
申请人： GVS GES FUER ERWERB UND VERWER , HEINZ ERNST , ZAEHRINGER ULRICH , SPERLING PETRA , SCHMIDT HERMANN
发明人： HEINZ ERNST , ZAEHRINGER ULRICH , SPERLING PETRA , SCHMIDT HERMANN
IPC分类号： A23L33/10 , A61K8/68 , A61Q19/00 , C12N9/02 , C12N15/53 , C12N15/82 , A23L1/30 , A61K7/48 , C07H15/10
CPC分类号： C12N9/0083 , A01K2217/05 , A23L33/10 , A23V2002/00 , A61K8/68 , A61Q19/00 , C12N15/8247 , A23V2250/30
摘要： The invention relates to enzymes which selectively introduce a double bond in the sphingobase of the ceramide residual of sphingolipids and of capnoids. The invention also relates to DNA sequences which code for these enzymes, to the use of the enzymes and DNA sequences for modifying the content and/or the structure of sphingolipids, the catabolites thereof and/or their synthetic subsequent products in transgenic cells and/or organisms. In addition, a method is provided for producing sphingolipids and capnoids with an unsaturated sphingobase.
摘要翻译：本发明涉及一种酶，其选择性地引入鞘脂和Capnoiden和编码这些酶的DNA序列的神经酰胺Sphingobase双键。本发明还涉及使用的酶和DNA序列的改变，其鞘脂分解代谢产物和/或它们的合成衍生物在转基因细胞和/或生物体的内容和/或结构。此外，公开了一种用于鞘脂和Capnoiden的制备方法具有不饱和Sphingobase。

8. 发明申请

WO2004073728A3 COMPOSITIONS COMPRISING FETAL HEMOGLOBIN AND BACTERIAL ENDOTOXIN AND OPTIONALLY ADDITIONAL FETAL LIVER COMPONENTS 审中-公开
标题翻译：包含天门冬氨酸和细菌内毒素和可选择性添加剂的组合物
公开(公告)号：WO2004073728A3
公开(公告)日：2004-10-07
申请号：PCT/EP2004001553
申请日：2004-02-18
申请人： CLINIQUE LA PRAIRIE RES SA , WESTPHAL OTTO , WAELLI THIERRY , GORCZYNSKI REGINALD , MUELLER SILKE , MACH JEAN-PIERRE , HARTMANN ALFRED , BESSLER WOLFGANG , HOFMANN PETRA , ZAEHRINGER ULRICH , ALEXANDER CHRISTIAN , VOR DEM ESCHE ULRICH , ULMER ARTUR J , VERDINI ANTONIO
发明人： WESTPHAL OTTO , WAELLI THIERRY , GORCZYNSKI REGINALD , MUELLER SILKE , MACH JEAN-PIERRE , HARTMANN ALFRED , BESSLER WOLFGANG , HOFMANN PETRA , ZAEHRINGER ULRICH , ALEXANDER CHRISTIAN , VOR DEM ESCHE ULRICH , ULMER ARTUR J , VERDINI ANTONIO
IPC分类号： A61K35/407 , A61K35/74 , A61K38/00 , A61K38/17 , A61K38/42 , A61K39/02 , A61P35/00 , A61P37/00
CPC分类号： A61K35/407 , A23L33/10 , A61K35/74 , A61K38/42 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the gamma-chain thereof, and optionally, components which are present in the fetal liver in addition to HbF. The composition is delivered to humans in a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that endotoxin and fetal hemoglobin partial structures display a pronounced synergistic biomedical activity. The biomedical effect of fetal hemoglobin and its partial structures is surprisingly not based on a classical hemoglobin function as an oxygen transporter but related to a modulation of endotoxin-mediated bioactivity. This biomedical activity is surprisingly also observed after oral application of the composition. The composition of the invention finds a variety of applications which have in common the stimulation of the immune system and the reversion in polarization of cytokines and chemokines from a Th2-directed response to a Th1-type response. The proposed applications would therefore include the treatment of allergic conditions, malignancies, chronic infections, autoimmune phenomena and age-related imbalances.
摘要翻译：本发明涉及代表包含细菌内毒素，胎儿血红蛋白或更特别是不含血红素的衍生物或其γ链，以及除了HbF之外存在于胎肝中的成分的新的免疫调节原理的药物组合物。组合物以药学上可接受的载体和/或稀释剂递送给人。根据本发明，惊奇地发现内毒素和胎儿血红蛋白部分结构显示出明显的协同生物医学活性。胎儿血红蛋白及其部分结构的生物医学效应令人惊讶地不是基于作为氧转运蛋白的经典血红蛋白功能，而是与内毒素介导的生物活性的调节有关。在口服施用组合物后，也观察到该生物医学活性。本发明的组合物发现各种各样的应用，其具有共同的刺激免疫系统和从Th2导向的Th1型反应的细胞因子和趋化因子的极化反转。因此，所提出的申请将包括治疗过敏性疾病，恶性肿瘤，慢性感染，自身免疫现象和年龄相关的不平衡。

9. 发明申请

WO0170756A3 LIPOPOLYSACCHARIDES (LPS) EXTRACTED FROM ESCHERICHIA COLI 审中-公开
标题翻译：大肠杆菌脂多糖
公开(公告)号：WO0170756A3
公开(公告)日：2002-05-02
申请号：PCT/EP0103153
申请日：2001-03-20
申请人： PHARMA ZENTRALE GMBH , PROPPERT HANS , MALINKA JUERGEN , SCHULZE JUERGEN , SONNENBORN ULRICH , ZAEHRINGER ULRICH , ULMER ARTUR , RIETSCHEL ERNST THEODOR
发明人： PROPPERT HANS , MALINKA JUERGEN , SCHULZE JUERGEN , SONNENBORN ULRICH , ZAEHRINGER ULRICH , ULMER ARTUR , RIETSCHEL ERNST THEODOR
IPC分类号： C12P19/26 , A61K31/715 , A61P35/00 , C08B37/00 , C12P19/04 , C12R1/19 , E21D20/00 , A61K39/02
CPC分类号： C12P19/04 , C08B37/00
摘要： The invention relates to lipopolysaccharides extracted from E. coli DSM 6601. This LPS differs from the known LPS extracted from E. coli in particular with regard to the phosphorylated sugar moiety of the core and to the degree of polymerization of the O-chain. The A lipoid corresponds structurally and biologically to the classic type of E. coli . The inventive LPS is not only suitable for identifying the coli strain which carries it, but also provides the latter with a reduced pathogenic capability, whilst retaining its immunomodulative effect.
摘要翻译：本发明涉及脂多糖从 E. 大肠杆菌的DSM 6601这LPS从先前已知的从LPS的 E是不同。大肠杆菌的特别是核心的磷酸化糖部分和在O形链的聚合度。脂A结构上和生物学上对应于供的 E. 大肠杆菌的常规类型。描述的LPS是不仅适用于它的识别轴承（E.coli）菌株，而且还赋予了它降低致病性，同时保留其免疫调节效应。

10. 发明专利

CA2510462A1 METHOD FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS 未知
公开(公告)号：CA2510462A1
公开(公告)日：2004-07-08
申请号：CA2510462
申请日：2003-12-11
申请人： UNIV BRISTOL
发明人： HEINZ ERNST , NAPIER JOHNATHAN A , SAYANOVA OLGA , LAZARUS COLIN M , ZAEHRINGER ULRICH , QI BAOXIU , ZANK THORSTEN
IPC分类号： C12N9/02 , C12N9/10 , C12N15/82 , C12P7/64
摘要： The present invention relates to an improved process for the specific production of poly-unsaturated omega-3 and omega-6 fatty acids and a process for the production of triglycerides having an increased content of unsaturat ed fatty acids, in particular omega-3 and omega-6 fatty acids having at least t wo double bonds and a 20 or 22 carbon atom chain length. The invention relates to the produc-tion of a transgenic organism, preferably a transgenic plant or a transgenic microorganism, hav-ing an increased content of fatty acids, oils or lipids containing C20- or C22- fatty acids with a delta-5, 7, 8, 10 double bond, respectively due to the expression of a delta-8-desaturase and a delta -9- elon-gase from organisms such as plants preferably Algae like Isochrysis galbana or Euglena gracilis. In addition the invention relates to a process for the production of poly unsaturated fatty acids such as Eicosapentaenoic, Arachidonic, Docosapentaenoic or Docosahexaenoic acid through the co- expression of a delta -8-desaturase, a delta-9-elongase and a delta-5 desaturase in organisms such as microorganisms or plants.The invention additionally relates to the use of specific nucleic acid sequences encoding for the aforementioned proteins with delta-8-desaturase-, delta-9-elongase- or delta-5-desaturase-activity, nucleic acid constructs, vectors and organisms containing said nucleic acid sequences. The invention further relates to unsaturated fatty acids and triglycerides having an increased content of at least 1 % by weight of unsaturated fatty acids and use thereof.

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