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1. 发明授权

US06370435B2 Systems and methods for examining the electrical characteristic of cardiac tissue 有权
公开(公告)号：US06370435B2
公开(公告)日：2002-04-09
申请号：US09783778
申请日：2001-02-14
申请人： Dorin Panescu , David K. Swanson , Mark S. Mirotznik , David S. Schwartzman , Kenneth R. Foster
发明人： Dorin Panescu , David K. Swanson , Mark S. Mirotznik , David S. Schwartzman , Kenneth R. Foster
IPC分类号： A61B504
CPC分类号： A61B5/6855 , A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/6858 , A61B18/00 , A61B2562/0209 , A61B2562/043 , A61N1/056
摘要： Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.

2. 发明授权

US06256540B1 Systems and methods for examining the electrical characteristic of cardiac tissue 失效
标题翻译：检查心脏组织电学特征的系统和方法
公开(公告)号：US06256540B1
公开(公告)日：2001-07-03
申请号：US08888456
申请日：1997-07-07
申请人： Dorin Panescu , David K. Swanson , Mark S. Mirotznik , David S. Schwartzman , Kenneth R. Foster
发明人： Dorin Panescu , David K. Swanson , Mark S. Mirotznik , David S. Schwartzman , Kenneth R. Foster
IPC分类号： A61B504
CPC分类号： A61B5/6855 , A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/6858 , A61B18/00 , A61B2562/0209 , A61B2562/043 , A61N1/056
摘要： Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.
摘要翻译：系统和方法使用三个或更多个间隔开的电极检查心脏组织形态，其中至少两个电极位于心脏内与心内膜组织接触。所述系统和方法将电流透过位于所选择的电极对之间的心脏组织的区域，每对电极中的至少一个位于心脏内。系统和方法至少部分地基于感测组织阻抗而导出位于电极对之间的组织的电特性。系统和方法使得可以使用多个心内膜电极进行心脏组织的电特征的多次测量。可以使用多路复用来促进数据处理。系统和方法还可以鉴定低相对电特征的区域，指示梗死组织，无侵入性手术技术。

3. 发明授权

US06597955B2 Systems and methods for examining the electrical characteristic of cardiac tissue 失效
公开(公告)号：US06597955B2
公开(公告)日：2003-07-22
申请号：US10039211
申请日：2002-01-04
申请人： Dorin Panescu , David K. Swanson , Mark S. Mirotznik , David S. Schwartzman , Kenneth R. Foster
发明人： Dorin Panescu , David K. Swanson , Mark S. Mirotznik , David S. Schwartzman , Kenneth R. Foster
IPC分类号： A61N100
CPC分类号： A61B5/6855 , A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/6858 , A61B18/00 , A61B2562/0209 , A61B2562/043 , A61N1/056
摘要： Systems and methods examine heart tissue morphology using three or more spaced apart electrodes, at least two of which are located within the heart in contact with endocardial tissue. The systems and methods transmit electrical current through a region of heart tissue lying between selected pairs of the electrodes, at least one of the electrodes in each pair being located within the heart. The systems and methods derive the electrical characteristic of tissue lying between the electrode pairs based, at least in part, upon sensing tissue impedances. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.

4. 发明授权

US5447529A Method of using endocardial impedance for determining electrode-tissue contact, appropriate sites for arrhythmia ablation and tissue heating during ablation 失效
标题翻译：使用心内膜阻抗来确定电极组织接触的方法，适当的心律失常消融部位和消融期间的组织加热
公开(公告)号：US5447529A
公开(公告)日：1995-09-05
申请号：US188514
申请日：1994-01-28
申请人： Francis E. Marchlinski , David S. Schwartzman , Mark S. Mirotznik , Kenneth R. Foster , Charles D. Gottleb , Isaac Chang
发明人： Francis E. Marchlinski , David S. Schwartzman , Mark S. Mirotznik , Kenneth R. Foster , Charles D. Gottleb , Isaac Chang
IPC分类号： A61B18/14 , A61N1/05 , A61N1/40 , A61B17/39
CPC分类号： A61N1/025 , A61B18/1492 , A61N1/05 , A61N1/056 , A61N1/40 , A61B18/1402 , A61B2018/00702 , A61B2018/00875 , A61B2018/126 , A61B2034/2051 , A61B2090/065
摘要： A method of locating infarcted myocardial tissue in a beating heart includes the step of inserting an impedance measuring tip of a catheter into the chamber of the beating heart, particularly the left or right ventricle, and measuring the impedance of the endocardium at various locations within the chamber of the beating heart. The values measured are compared to impedance values with a predetermined range of values to identify an infarcted area of myocardium and distinguish such area from normal myocardium. The measurements are also compared to a range of values for an infarction border zone. In accordance with the invention, the infarction border zone may be located. The infarction border zone is a significant source of arrhythmia, and particularly of ventricular tachycardia. Further, in accordance with the methods of the present invention, the risk of arrhythmia in a beating heart may be substantially reduced or eliminated by ablating endocardium within the infarction border zone utilizing the same catheter tip. Impedance measurements may also be utilized to assess the adequacy of the electrode-tissue contact, particularly in a fluid filled body organ or cavity. Further, the effectiveness of the ablation of the tissue may be determined by determining the degree of heating of the tissue by measuring the change in impedance in the area of ablation.
摘要翻译：在搏动心脏中定位梗死心肌组织的方法包括将导管的阻抗测量尖端插入跳动心脏的腔室中，特别是左心室或右心室的步骤，以及测量内心内的不同位置处的心内膜的阻抗心跳的房间。将测量的值与具有预定范围值的阻抗值进行比较，以鉴定心肌的梗塞面积并将该区域与正常心肌区分开。也将测量结果与梗塞边界区域的范围进行比较。根据本发明，可以设置梗塞边界区域。梗死边界区是心律失常的重要来源，特别是室性心动过速。此外，根据本发明的方法，通过利用相同的导管尖端在梗塞边界区域中消融心内膜，可以显着减少或消除跳动心脏中的心律不齐的风险。还可以使用阻抗测量来评估电极 - 组织接触的充分性，特别是在流体填充的身体器官或空腔中。此外，可以通过测量消融区域中的阻抗变化来确定组织的加热程度来确定组织消融的有效性。

5. 发明授权

US5577509A Systems and methods for examining the electrical characteristics and timing of electrical events in cardiac tissue 失效
标题翻译：用于检查心脏组织中电气事件的电特性和时机的系统和方法
公开(公告)号：US5577509A
公开(公告)日：1996-11-26
申请号：US189000
申请日：1994-01-28
申请人： Dorin N. Panescu , David K. Swanson , Mark S. Mirotznik , David S. Schwartzman
发明人： Dorin N. Panescu , David K. Swanson , Mark S. Mirotznik , David S. Schwartzman
IPC分类号： A61B5/042 , A61B5/0452 , A61B5/053 , A61B18/14 , A61B5/04
CPC分类号： A61B5/6855 , A61B18/1492 , A61B5/0422 , A61B5/0452 , A61B5/0535 , A61B5/0538 , A61B5/6858 , A61B18/14 , A61B2017/003 , A61B2018/00214 , A61B2018/00755 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/128 , A61B2562/0209 , A61B2562/043
摘要： Systems and methods examine heart tissue morphology using a pair of electrodes, at least one of which is located in contact with heart tissue. The systems and methods transmit electrical current in a path through the contacted heart tissue between the pair of the electrodes to derive a tissue electrical characteristic based, at least in part, upon sensing the impedance of the tissue lying in the path. The system and methods also sense with at least one of the electrodes the timing of local depolarization events in the contacted heart tissue. The systems and methods make possible the use of multiple endocardial electrodes for taking multiple measurements of the electrical characteristics of heart tissue. Multiplexing can be used to facilitate data processing. The systems and methods also make possible the identification of regions of low relative electrical characteristics, indicative of infarcted tissue, without invasive surgical techniques.
摘要翻译：系统和方法使用一对电极检查心脏组织形态，其中至少一个电极与心脏组织接触。所述系统和方法在通过所述一对电极之间的所接触的心脏组织的路径中传送电流，以至少部分地基于感测位于所述路径中的组织的阻抗而导出组织电特征。该系统和方法还与至少一个电极一起感知接触的心脏组织中局部去极化事件的定时。系统和方法使得可以使用多个心内膜电极进行心脏组织的电特征的多次测量。可以使用多路复用来促进数据处理。系统和方法还可以鉴定低相对电特征的区域，指示梗死组织，无侵入性手术技术。

6. 发明授权

US5673704A Method of using endocardial impedance for determining electrode-tissue contact 失效
标题翻译：使用心内膜阻抗来确定电极组织接触的方法
公开(公告)号：US5673704A
公开(公告)日：1997-10-07
申请号：US654197
申请日：1996-05-28
申请人： Francis E. Marchlinski , David S. Schwartzman , Mark S. Mirotznik , Kenneth R. Foster , Charles D. Gottlieb , Isaac Chang
发明人： Francis E. Marchlinski , David S. Schwartzman , Mark S. Mirotznik , Kenneth R. Foster , Charles D. Gottlieb , Isaac Chang
IPC分类号： A61B18/14 , A61N1/05 , A61N1/40 , A61B17/39
CPC分类号： A61N1/025 , A61B18/1492 , A61N1/05 , A61N1/056 , A61N1/40 , A61B18/1402 , A61B2018/00702 , A61B2018/00875 , A61B2018/126 , A61B2034/2051 , A61B2090/065
摘要： A method of locating infarcted myocardial tissue in a beating heart includes the step of inserting an impedance measuring tip of a catheter into the chamber of the beating heart, particularly the left or right ventricle, and measuring the impedance of the endocardium at various locations within the chamber of the beating heart. The values measured are compared to impedance values with a predetermined range of values to identify an infarcted area of myocardium and distinguish such area from normal myocardium. The measurements are also compared to a range of values for an infarction border zone. In accordance with the invention, the infarction border zone may be located. The infarction border zone is a significant source of arrhythmia, and particularly of ventricular tachycardia. Further, in accordance with the methods of the present invention, the risk of arrhythmia in a beating heart may be substantially reduced or eliminated by ablating endocardium within the infarction border zone utilizing the same catheter tip. Impedance measurements may also be utilized to assess the adequacy of the electrode-tissue contact, particularly in a fluid filled body organ or cavity. Further, the effectiveness of the ablation of the tissue may be determined by determining the degree of heating of the tissue by measuring the change in impedance in the area of ablation.
摘要翻译：在搏动心脏中定位梗死心肌组织的方法包括将导管的阻抗测量尖端插入跳动心脏的腔室中，特别是左心室或右心室的步骤，以及测量内心内的不同位置处的心内膜的阻抗心跳的房间。将测量的值与具有预定范围值的阻抗值进行比较，以鉴定心肌的梗塞面积并将该区域与正常心肌区分开。也将测量结果与梗塞边界区域的范围进行比较。根据本发明，可以设置梗塞边界区域。梗死边界区是心律失常的重要来源，特别是室性心动过速。此外，根据本发明的方法，通过利用相同的导管尖端在梗塞边界区域中消融心内膜，可以显着减少或消除跳动心脏中的心律不齐的风险。还可以使用阻抗测量来评估电极 - 组织接触的充分性，特别是在流体填充的身体器官或空腔中。此外，可以通过测量消融区域中的阻抗变化来确定组织的加热程度来确定组织消融的有效性。

7. 发明申请

US20150232526A1 USE OF RELAXIN TO TREAT ATRIAL FIBRILLATION 审中-公开
标题翻译：使用松弛素治疗椎间盘突出症
公开(公告)号：US20150232526A1
公开(公告)日：2015-08-20
申请号：US14434681
申请日：2013-10-10
申请人： David S. SCHWARTZMAN , Sanjeev G. SHROFF , Guy SALAMA , Charles F. MCTIERNAN
发明人： David S. Schwartzman , Sanjeev G. Shroff , Guy Salama , Charles F. McTiernan
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , A61K38/2221 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial fibrillation.
摘要翻译：本文公开了使用松弛素多肽和类似物或编码这些多肽的核酸分子来治疗或抑制心房颤动的方法。

8. 发明申请

US20090182326A1 DEVICE AND METHOD OF USE FOR FUNCTIONAL ISOLATION OF ANIMAL OR HUMAN TISSUES 有权
标题翻译：用于功能性分离动物或人体组织的装置和方法
公开(公告)号：US20090182326A1
公开(公告)日：2009-07-16
申请号：US12410323
申请日：2009-03-24
申请人： Marco Zenati , David S. Schwartzman , Mark J. Gartner , Daniel T. McKeel
发明人： Marco Zenati , David S. Schwartzman , Mark J. Gartner , Daniel T. McKeel
IPC分类号： A61B18/18 , A61B17/03 , A61B1/018
CPC分类号： A61B17/12013 , A61B18/14 , A61B2017/00243 , A61B2017/00575 , A61B2017/306 , A61B2017/308 , A61B2018/00291
摘要： A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.
摘要翻译：提供了用于功能闭塞左心耳（LAA）的腔的方法和装置。进入LAA是通过心外膜的方法。该装置通过各种非侵入性手段捕获LAA。在使用所提供的装置和方法捕获LAA之后，优选地围绕附件的基部设置夹紧装置。在某些实施例中，附件在腔的功能性闭塞之后仍然是可行的。

9. 发明申请

US20110295060A1 DEVICE AND METHOD OF USE FOR FUNCTIONAL ISOLATION OF ANIMAL OR HUMAN TISSUES 审中-公开
标题翻译：用于功能性分离动物或人体组织的装置和方法
公开(公告)号：US20110295060A1
公开(公告)日：2011-12-01
申请号：US13204383
申请日：2011-08-05
申请人： Marco Zenati , David S. Schwartzman , Mark J. Gartner , Daniel T. McKeel
发明人： Marco Zenati , David S. Schwartzman , Mark J. Gartner , Daniel T. McKeel
IPC分类号： A61B1/00
CPC分类号： A61B17/12013 , A61B18/14 , A61B2017/00243 , A61B2017/00575 , A61B2017/306 , A61B2017/308 , A61B2018/00291
摘要： A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.
摘要翻译：提供了用于功能闭塞左心耳（LAA）的腔的方法和装置。进入LAA是通过心外膜的方法。该装置通过各种非侵入性手段捕获LAA。在使用所提供的装置和方法捕获LAA之后，优选地围绕附件的基部设置夹紧装置。在某些实施例中，附件在腔的功能性闭塞之后仍然是可行的。

10. 发明授权

US08007504B2 Device and method of use for functional isolation of animal or human tissues 有权
标题翻译：用于动物或人体组织功能分离的装置和方法
公开(公告)号：US08007504B2
公开(公告)日：2011-08-30
申请号：US12410323
申请日：2009-03-24
申请人： Marco Zenati , David S. Schwartzman , Mark J. Gartner , Daniel T. McKeel
发明人： Marco Zenati , David S. Schwartzman , Mark J. Gartner , Daniel T. McKeel
IPC分类号： A61B17/08 , A61B17/22
CPC分类号： A61B17/12013 , A61B18/14 , A61B2017/00243 , A61B2017/00575 , A61B2017/306 , A61B2017/308 , A61B2018/00291
摘要： A method and apparatus for functionally occluding the lumen of the left atrial appendage (LAA) is provided. Access to the LAA is through an epicardial approach. The devices function to capture the LAA through various non-invasive means. After capturing the LAA with the devices and methods provided, a clamping device is preferably disposed about the base of the appendage. In certain embodiments, the appendage remains viable subsequent to the functional occlusion of the lumen.
摘要翻译：提供了用于功能闭塞左心耳（LAA）的腔的方法和装置。进入LAA是通过心外膜的方法。该装置通过各种非侵入性手段捕获LAA。在使用所提供的装置和方法捕获LAA之后，优选地围绕附件的基部设置夹紧装置。在某些实施例中，附件在腔的功能性闭塞之后仍然是可行的。

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